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1-(2-Fluoro-6-(trifluoromethyl)benzyl)-6-methylpyrimidine-2,4(1H,3H)-dione

1-(2-Fluoro-6-(trifluoromethyl)benzyl)-6-methylpyrimidine-2,4(1H,3H)-dione structure

CAS No.: 830346-47-9

Chemical Name:: 1-(2-Fluoro-6-(trifluoromethyl)benzyl)-6-methylpyrimidine-2,4(1H,3H)-dione

Synonyms: 1-[2-Fluoro-6-(trifluoromethyl)benzyl]-6-methylpyrimidine-2,4(1H,3H)-dione;1-[2-fluoro-6-(trifluoromethyl)benzyl]-6-methyl-2,4(1H,3H)-pyrimidinedione;Elagolix Impurity 27;elagolix intermediate;elagolix intermediate 4;Elagolix Sodium Intermediate;4-fluoro-.alpha.-(1-methylethyl)-, (.alpha.S)-;1-[2-fluoro-6-(trifluoromethyl)benzyl]-6-methylpyrimi;1-[2-fluoro-6-(trifluoromethyl)benzyl]-6-methylpyrimid;1-[2-fluoro-6-(trifluoromethyl)benzyl]-6-methylpyrimidine-2,...

CBNumber:: CB42552431

Molecular Formula:: C13H10F4N2O2

Molecular Weight:: 302.22

MDL Number:: MFCD00792491

MOL File:: 830346-47-9.mol

MSDS File:: SDS

Last updated:2026-05-28 02:44:57

Product description	Number	Pack Size	Price
1-(2-Fluoro-6-(trifluoromethyl)benzyl)-6-methylpyrimidine-2,4(1H,3H)-dione 95+%	F56656	100mg	$13
1-(2-Fluoro-6-(trifluoromethyl)benzyl)-6-methylpyrimidine-2,4(1H,3H)-dione 95+%	F56656	250mg	$17
1-(2-Fluoro-6-(trifluoromethyl)benzyl)-6-methylpyrimidine-2,4(1H,3H)-dione 95+%	F56656	1g	$19
1-(2-Fluoro-6-(trifluoromethyl)benzyl)-6-methylpyrimidine-2,4(1H,3H)-dione 98%	AA0036CS	1g	$8
1-(2-Fluoro-6-(trifluoromethyl)benzyl)-6-methylpyrimidine-2,4(1H,3H)-dione 95%	AA0036CS	5g	$16
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1-(2-Fluoro-6-(trifluoromethyl)benzyl)-6-methylpyrimidine-2,4(1H,3H)-dione Properties

Density	1.413±0.06 g/cm3(Predicted)
storage temp.	Sealed in dry,Room Temperature
pka	9.49±0.40(Predicted)
Appearance	White to off-white Solid
InChI	InChI=1S/C13H10F4N2O2/c1-7-5-11(20)18-12(21)19(7)6-8-9(13(15,16)17)3-2-4-10(8)14/h2-5H,6H2,1H3,(H,18,20,21)
InChIKey	IJRKKZXPXBTHER-UHFFFAOYSA-N
SMILES	C1(=O)N(CC2=C(C(F)(F)F)C=CC=C2F)C(C)=CC(=O)N1
FDA UNII	T74U83WSC9

SAFETY

Risk and Safety Statements

Symbol(GHS)	GHS07
Signal word	Warning
Hazard statements	H302-H315-H319-H335
Precautionary statements	P261-P305+P351+P338

1-(2-Fluoro-6-(trifluoromethyl)benzyl)-6-methylpyrimidine-2,4(1H,3H)-dione price More Price(23)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Synthonix	F56656	1-(2-Fluoro-6-(trifluoromethyl)benzyl)-6-methylpyrimidine-2,4(1H,3H)-dione 95+%	830346-47-9	100mg	$13	2026-05-06	Buy
Synthonix	F56656	1-(2-Fluoro-6-(trifluoromethyl)benzyl)-6-methylpyrimidine-2,4(1H,3H)-dione 95+%	830346-47-9	250mg	$17	2026-05-06	Buy
Synthonix	F56656	1-(2-Fluoro-6-(trifluoromethyl)benzyl)-6-methylpyrimidine-2,4(1H,3H)-dione 95+%	830346-47-9	1g	$19	2026-05-06	Buy
aablocks	AA0036CS	1-(2-Fluoro-6-(trifluoromethyl)benzyl)-6-methylpyrimidine-2,4(1H,3H)-dione 98%	830346-47-9	1g	$8	2026-05-28	Buy
aablocks	AA0036CS	1-(2-Fluoro-6-(trifluoromethyl)benzyl)-6-methylpyrimidine-2,4(1H,3H)-dione 95%	830346-47-9	5g	$16	2026-05-28	Buy

Product number	Packaging	Price	Buy
F56656	100mg	$13	Buy
F56656	250mg	$17	Buy
F56656	1g	$19	Buy
AA0036CS	1g	$8	Buy
AA0036CS	5g	$16	Buy

1-(2-Fluoro-6-(trifluoromethyl)benzyl)-6-methylpyrimidine-2,4(1H,3H)-dione Chemical Properties,Uses,Production

Uses

1-(2-Fluoro-6-(trifluoromethyl)benzyl)-6-methylpyrimidine-2,4(1H,3H)-dione is a pharmaceutical intermediate ingredient used in the preparation of Elagolix sodium, which is FDA-approved for the treatment of pain associated with moderate to severe pain associated with endometriosis.

Synthesis

1-(2-FLUORO-6-(TRIFLOROMETHYL)BENZYL)UREA

830346-46-8

1694-31-1

1-(2-Fluoro-6-(trifluoromethyl)benzyl)-6-methylpyrimidine-2,4(1H,3H)-dione

830346-47-9

Using 1-(2-fluoro-6-(trifluoromethyl)benzyl)urea (2.568 g, 10.9 mmol) and tert-butyl acetoacetate (5.0 g) in toluene (125 mL), the mixture was briefly heated to reflux using a Dean-Stark splitter. Subsequently, tert-butyl acetoacetate (5.0 g) was added and heating to reflux was continued for 4 hours. Next, p-toluenesulfonic acid monohydrate (2.82 g, 14.8 mmol) was added and reflux was continued for 1 hour. Upon completion of the reaction, toluene was replaced with isopropanol (i-PrOH) and the volume of the solution was concentrated to approximately 30 mL. The solution was stirred overnight at room temperature to crystallize the product. The crystallized product was collected by filtration and washed with a small amount of isopropanol to give 2.01 g of 1-(2-fluoro-6-(trifluoromethyl)benzyl)-6-methylpyrimidine-2,4(1H,3H)-dione in 63% yield. The product was analyzed by LCMS (ESI) at m/z 303.0 (MH+).

References

[1] Patent: WO2009/62087, 2009, A1. Location in patent: Page/Page column 8

1-(2-Fluoro-6-(trifluoromethyl)benzyl)-6-methylpyrimidine-2,4(1H,3H)-dione synthesis

Synthesis of 1-(2-Fluoro-6-(trifluoromethyl)benzyl)-6-methylpyrimidine-2,4(1H,3H)-dione from 6-Methyluracil and 2-FLUORO-6-(TRIFLUOROMETHYL)BENZYL BROMIDE

1-(2-Fluoro-6-(trifluoromethyl)benzyl)-6-methylpyrimidine-2,4(1H,3H)-dione Preparation Products And Raw materials

Raw materials

1-(2-FLUORO-6-(TRIFLOROMETHYL)BENZYL)UREA tert-Butyl acetoacetate p-Toluenesulfonic acid monohydrate Toluene

Preparation Products

1-[2-fluoro-6-(trifluoromethyl)benzyl]-5-iodo-6-methylpyrimidine-2,4(1H,3H)-dione

1-(2-Fluoro-6-(trifluoromethyl)benzyl)-6-methylpyrimidine-2,4(1H,3H)-dione Suppliers

Global( 212)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
SHANGHAI SAGACHEM CO., LTD.	+86-02168404722 +86-13816115801	david_si@shjlchem.com	China	217	58
Hebei Xinsheng New Material Technology Co., LTD.	+86-16632316109	xinshengkeji@xsmaterial.com	China	1082	58
Capot Chemical Co.,Ltd.	+86-（0）57185586718 +86-13336195806	sales@capot.com	China	29626	60
Beijing Cooperate Pharmaceutical Co.,Ltd	010-60279497	sales01@cooperate-pharm.com	CHINA	1796	55
ATK CHEMICAL COMPANY LIMITED	+undefined-21-51877795	ivan@atkchemical.com	China	32998	60
career henan chemical co	+86-0371-86658258	sales@coreychem.com	China	29766	58
Zhejiang ZETian Fine Chemicals Co. LTD	18957127338	stella@zetchem.com	China	2993	58
Jinan Carbotang Biotech Co.,Ltd.	+8615866703830	figo.gao@foxmail.com	China	8491	58
Shandong ruiyue Biological Technology Co.，Ltd.	008615066100122（Lily wechat）	513075341@qq.com	CHINA	52	58
Alchem Pharmtech,Inc.	8485655694	sales@alchempharmtech.com	United States	63645	58

Supplier	Advantage
SHANGHAI SAGACHEM CO., LTD.	58
Hebei Xinsheng New Material Technology Co., LTD.	58
Capot Chemical Co.,Ltd.	60
Beijing Cooperate Pharmaceutical Co.,Ltd	55
ATK CHEMICAL COMPANY LIMITED	60
career henan chemical co	58
Zhejiang ZETian Fine Chemicals Co. LTD	58
Jinan Carbotang Biotech Co.,Ltd.	58
Shandong ruiyue Biological Technology Co.，Ltd.	58
Alchem Pharmtech,Inc.	58

View Lastest Price from 1-(2-Fluoro-6-(trifluoromethyl)benzyl)-6-methylpyrimidine-2,4(1H,3H)-dione manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2026-08-08	1-[2-Fluoro-6-(trifluoromethyl)benzyl]-6-methylpyrimidine-2,4(1H,3H)-dione 830346-47-9		1kg	99.0%min	800kg	Hangzhou ICH Biofarm Co., Ltd
2023-11-16	Benzeneacetic acid, 4-fluoro-.alpha.-(1-methylethyl)-, (.alpha.S)- 830346-47-9	$25.00-35.00	1kg	99%	20 Ton	Hebei Xinsheng New Material Technology Co., LTD.
2021-07-13	1-[2-Fluoro-6-(trifluoromethyl)benzyl]-6-methylpyrimidine-2,4(1H,3H)-dione 830346-47-9	$10.00-15.00	1KG	99%+ HPLC		Zhuozhou Wenxi import and Export Co., Ltd

1-[2-Fluoro-6-(trifluoromethyl)benzyl]-6-methylpyrimidine-2,4(1H,3H)-dione
830346-47-9
99.0%min
Hangzhou ICH Biofarm Co., Ltd

Benzeneacetic acid, 4-fluoro-.alpha.-(1-methylethyl)-, (.alpha.S)-
830346-47-9
$25.00-35.00
99%
Hebei Xinsheng New Material Technology Co., LTD.

1-[2-Fluoro-6-(trifluoromethyl)benzyl]-6-methylpyrimidine-2,4(1H,3H)-dione
830346-47-9
$10.00-15.00
99%+ HPLC
Zhuozhou Wenxi import and Export Co., Ltd

1-(2-Fluoro-6-(trifluoromethyl)benzyl)-6-methylpyrimidine-2,4(1H,3H)-dione Spectrum

1-(2-Fluoro-6-(trifluoromethyl)benzyl)-6-methylpyrimidine-2,4(1H,3H)-dione(830346-47-9)¹HNMR

830346-47-9(1-(2-Fluoro-6-(trifluoromethyl)benzyl)-6-methylpyrimidine-2,4(1H,3H)-dione)Related Search:

Savolitinib 1-(2-FLUORO-6-(TRIFLOROMETHYL)BENZYL)UREA 1-((2-(dimethoxymethyl)-5,6,7,8-tetrahydro-1,8-naphthyridin-3-yl)methyl)-4-methylpiperazin-2-one Piperazine, 1-[(6-broMo-3-pyridinyl)Methyl]-4-ethyl- O-(2-(vinyloxy)ethyl)hydroxylamine

5-(2-Fluoro-3-methoxyphenyl)-1-[[2-fluoro-6-(trifluoromethyl)phenyl]methyl]-6-methyl-2,4(1H,3H)-pyrimidinedione 3-[(2R)-2-Amino-2-phenylethyl]-5-(2-fluoro-3-methoxyphenyl)-1-[[2-fluoro-6-(trifluoromethyl)phenyl]methyl]-6-methyl-2,4(1H,3H)-pyrimidinedione 5-Bromo-1-(2-fluoro-6-trifluoromethyl-benzyl)-6-methyl-1H-pyrimidine-2,4-dione 1-[2-fluoro-6-(trifluoromethyl)benzyl]-5-iodo-6-methylpyrimidine-2,4(1H,3H)-dione

1of2

Benzeneacetic acid, 4-fluoro-.alpha.-(1-methylethyl)-, (.alpha.S)- 1-(2-Fluoro-6-trifluoromethyl-benzyl)-6-methyl-1H-pyrimidine-2,4-dione 1-[[2-fluoro-6-(trifluoromethyl)phenyl]methyl]-6-methylpyrimidine-2,4-dione 2,4(1H,3H)-Pyrimidinedione, 1-[[2-fluoro-6-(trifluoromethyl)phenyl]methyl]-6-methyl- 4-fluoro-.alpha.-(1-methylethyl)-, (.alpha.S)- elagolix intermediate elagolix intermediate 4 1-[2-Fluoro-6-(trifluoromethyl)benzyl]-6-methylpyrimidine-2,4(1H,3H)-dione 1-[2-fluoro-6-(trifluoromethyl)benzyl]-6-methyl-2,4(1H,3H)-pyrimidinedione 1-[[2-Fluoro-6-(trifluoromethyl)phenyl]methyl]-6-methyl-2,4(1H,3H)-pyrimidinedione 1-[2-Fluoro-6-(trifluoromethyl)benzyl]-6-methylpyrimidine- 2-2,4(1H,3H)-dione 1-(2-Flouro-6-(triflouromethyl)benzyl)-6-methylpyrimidine-2,4-(1H,3H)-dione Elagolix Sodium Intermediate Elagolix Impurity 27 1-[2-fluoro-6-(trifluoromethyl)benzyl]-6-methylpyrimidine-2,... 1-[2-fluoro-6-(trifluoromethyl)benzyl]-6-methylpyrimi 1-[2-fluoro-6-(trifluoromethyl)benzyl]-6-methylpyrimid 1-{[2-fluoro-6-(trifluoromethyl)phenyl]methyl}-6-methyl-1,2,3,4-tetrahydropyrimidine-2,4-dione 1-{2- Fluoro -6- trifluoromethyl - benzyl )-6- mcthyl -1H- pyrimidine -2,4- dione Benzeneacetic acid, 4-fluoro-.alpha.-(1-ethylethyl)-,(.alpha.S)- 830346-47-9 830346-47-9