ChemicalBook >> CAS DataBase List >>(S)-2-(4-(piperidin-3-yl)phenyl)-2H-indazole-7-carboxaMide

(S)-2-(4-(piperidin-3-yl)phenyl)-2H-indazole-7-carboxaMide

(S)-2-(4-(piperidin-3-yl)phenyl)-2H-indazole-7-carboxaMide structure

CAS No.: 1038915-64-8

Chemical Name:: (S)-2-(4-(piperidin-3-yl)phenyl)-2H-indazole-7-carboxaMide

Synonyms: Niraparib Tosylate Monohydrate;Zejula;Niraparib hydrochloride;CS-787;EOS-62286;MK-4827 (HCl);Niraparib HCl;Niraparib HCl (MK-4827);MK-4827 (hydrochloride);MK-4827, Niraparib HCl salt

CBNumber:: CB42553458

Molecular Formula:: C19H20N4O

Molecular Weight:: 320.3883

MDL Number:: MFCD20502397

MOL File:: 1038915-64-8.mol

MSDS File:: SDS

TDS File:: TDS

Last updated:2026-05-28 02:47:08

Product description	Number	Pack Size	Price
Niraparib hydrochloride	NRB91564	50mg	$540
Niraparib hydrochloride	NRB91564	100mg	$865
Niraparib hydrochloride 99.41%	CS-2282	5mg	$76
Niraparib hydrochloride 99.41%	CS-2282	10mg	$108
Niraparib hydrochloride 99.41%	CS-2282	25mg	$152
More product size

Request For Quotation

(S)-2-(4-(piperidin-3-yl)phenyl)-2H-indazole-7-carboxaMide Properties

Melting point	144 °C
storage temp.	Store at -20°C
solubility	Soluble in DMSO
form	Solid
color	White to light yellow
InChI	InChI=1/C19H20N4O/c20-19(24)17-5-1-3-15-12-23(22-18(15)17)16-8-6-13(7-9-16)14-4-2-10-21-11-14/h1,3,5-9,12,14,21H,2,4,10-11H2,(H2,20,24)/t14-/s3
InChIKey	PCHKPVIQAHNQLW-WDHUHKLTNA-N
SMILES	N1=C2C(C=CC=C2C(N)=O)=CN1C1=CC=C([C@@H]2CCCNC2)C=C1 \|&1:16,r\|
FDA UNII	L4JFC1PHCI
NCI Dictionary of Cancer Terms	niraparib tosylate monohydrate; Zejula
NCI Drug Dictionary	niraparib tosylate monohydrate

SAFETY

Risk and Safety Statements

Symbol(GHS)	GHS07
Signal word	Warning
Hazard statements	H302-H315-H319-H335
Precautionary statements	P264-P270-P301+P312-P330-P501-P280-P302+P352-P321-P332+P313-P362-P305+P351+P338-P337+P313-P261-P271-P304+P340-P312-P403+P233-P405

(S)-2-(4-(piperidin-3-yl)phenyl)-2H-indazole-7-carboxaMide price

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Biosynth	NRB91564	Niraparib hydrochloride	1038915-64-8	50mg	$540	2026-06-04	Buy
Biosynth	NRB91564	Niraparib hydrochloride	1038915-64-8	100mg	$865	2026-06-04	Buy
ChemScene	CS-2282	Niraparib hydrochloride 99.41%	1038915-64-8	5mg	$76	2026-06-04	Buy
ChemScene	CS-2282	Niraparib hydrochloride 99.41%	1038915-64-8	10mg	$108	2026-06-04	Buy
ChemScene	CS-2282	Niraparib hydrochloride 99.41%	1038915-64-8	25mg	$152	2026-06-04	Buy

Product number	Packaging	Price	Buy
NRB91564	50mg	$540	Buy
NRB91564	100mg	$865	Buy
CS-2282	5mg	$76	Buy
CS-2282	10mg	$108	Buy
CS-2282	25mg	$152	Buy

(S)-2-(4-(piperidin-3-yl)phenyl)-2H-indazole-7-carboxaMide Chemical Properties,Uses,Production

Uses

Niraparib hydrochloride (MK-4827 hydrochloride) is a highly potent and orally bioavailable PARP1 and PARP2 inhibitor with IC50s of 3.8 and 2.1 nM, respectively. Niraparib hydrochloride leads to inhibition of repair of DNA damage, activates apoptosis and shows anti-tumor activity[1][2][3].

in vivo

Niraparib is well tolerated and demonstrates efficacy as a single agent in a xenograft model of BRCA-1 deficient cancer. Niraparib is well tolerated in vivo and demonstrates efficacy as a single agent in a xenograft model of BRCA-1 deficient cancer. Niraparib is characterized by acceptable pharmacokinetics in rats with plasma clearance of 28 (mL/min)/kg, very high volume of distribution (Vd_ss=6.9 L/kg), long terminal half-life (t_1/2=3.4 h), and excellent bioavailability, F = 65%^[1]. Niraparib enhances radiation response of p53 mutant Calu-6 tumor in both cases, with the single daily dose of 50 mg/kg being more effective than 25 mg/kg given twice daily^[3].

IC 50

PARP-2: 2.1 nM (IC₅₀); PARP-1: 3.8 nM (IC₅₀); V-PARP: 330 nM (IC₅₀); TANK-1: 570 nM (IC₅₀); PARP-3: 1300 nM (IC₅₀)

References

[1] Jones P, et al. Discovery of 2-{4-[(3S)-piperidin-3-yl]phenyl}-2H-indazole-7-carboxamide (MK-4827): a novel oral poly(ADP-ribose)polymerase (PARP) inhibitor efficacious in BRCA-1 and -2 mutant tumors. J Med Chem. 2009 Nov 26;52(22):7170-85. DOI:10.1021/jm901188v
[2] Bridges KA, et al. Niraparib (MK-4827), a novel poly(ADP-Ribose) polymerase inhibitor, radiosensitizes human lung and breast cancer cells. Oncotarget. 2014 Jul 15;5(13):5076-86. DOI:10.18632/oncotarget.2083
[3] Wang L, et al. MK-4827, a PARP-1/-2 inhibitor, strongly enhances response of human lung and breast cancer xenografts to radiation. Invest New Drugs. 2012 Dec;30(6):2113-20. DOI:10.1007/s10637-011-9770-x
[4] Mirza MR, et al. Niraparib Maintenance Therapy in Platinum-Sensitive, Recurrent Ovarian Cancer. N Engl J Med. 2016 Dec 1;375(22):2154-2164. DOI:10.1056/NEJMoa1611310

(S)-2-(4-(piperidin-3-yl)phenyl)-2H-indazole-7-carboxaMide Preparation Products And Raw materials

Raw materials

Preparation Products

(S)-2-(4-(piperidin-3-yl)phenyl)-2H-indazole-7-carboxaMide Suppliers

Global( 112)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Henan Tianfu Chemical Co.,Ltd.	+86-0371-55170693 +86-19937530512	info@tianfuchem.com	China	21587	55
ATK CHEMICAL COMPANY LIMITED	+undefined-21-51877795	ivan@atkchemical.com	China	33024	60
career henan chemical co	+86-0371-86658258 +8613203830695	sales@coreychem.com	China	29815	58
BOC Sciences	+1-631-485-4226	inquiry@bocsci.com	United States	19936	58
Alchem Pharmtech,Inc.	8485655694	sales@alchempharmtech.com	United States	63687	58
Shanghai Yingrui Biopharma Co.,Ltd	21-33585366	export01@shyrchem.com	CHINA	1319	58
TargetMol Chemicals Inc.	+1-781-999-5354; +17819995354	marketing@targetmol.com	United States	32466	58
Hubei Ipure Biology Co., Ltd	+8613367258412	ada@ipurechemical.com	China	10236	58
HANGZHOU CLAP TECHNOLOGY CO.,LTD	86-571-88216897,88216896 13588875226	sales@hzclap.com	CHINA	6312	58
Zhejiang J&C Biological Technology Co.,Limited	+1-2135480471 +1-2135480471;	sales@sarms4muscle.com	China	10473	58

Supplier	Advantage
Henan Tianfu Chemical Co.,Ltd.	55
ATK CHEMICAL COMPANY LIMITED	60
career henan chemical co	58
BOC Sciences	58
Alchem Pharmtech,Inc.	58
Shanghai Yingrui Biopharma Co.,Ltd	58
TargetMol Chemicals Inc.	58
Hubei Ipure Biology Co., Ltd	58
HANGZHOU CLAP TECHNOLOGY CO.,LTD	58
Zhejiang J&C Biological Technology Co.,Limited	58

View Lastest Price from (S)-2-(4-(piperidin-3-yl)phenyl)-2H-indazole-7-carboxaMide manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2026-05-05	(S)-2-(4-(piperidin-3-yl)phenyl)-2H-indazole-7-carboxaMide 1038915-64-8		1kg	99%	20 tons	Zibo Hangyu Biotechnology Development Co., Ltd
2026-04-22	Niraparib hydrochloride 1038915-64-8	$34.00-80.00		99.85%	10g	TargetMol Chemicals Inc.
2024-11-26	Niraparib tosylate 1038915-64-8		1kg	99%, Single impurity＜0.1	1 ton	Nanjing Fred Technology Co., Ltd

(S)-2-(4-(piperidin-3-yl)phenyl)-2H-indazole-7-carboxaMide
1038915-64-8
99%
Zibo Hangyu Biotechnology Development Co., Ltd

Niraparib hydrochloride
1038915-64-8
$34.00-80.00
99.85%
TargetMol Chemicals Inc.

Niraparib tosylate
1038915-64-8
99%, Single impurity＜0.1
Nanjing Fred Technology Co., Ltd

(S)-2-(4-(piperidin-3-yl)phenyl)-2H-indazole-7-carboxaMide Spectrum

(S)-2-(4-(piperidin-3-yl)phenyl)-2H-indazole-7-carboxaMide(1038915-64-8)¹HNMR

1038915-64-8((S)-2-(4-(piperidin-3-yl)phenyl)-2H-indazole-7-carboxaMide)Related Search:

Nintedanib (S)-tert-butyl 3-(4-aMinophenyl)piperidine-1-carboxylate 4-(3-PYRIDYL)ANILINE N-(tert-butyl)-1H-indazole-7-carboxamide 4-piperidin-3-ylaniline

4-(3-Piperidyl)aniline Dihydrochloride Methyl 3-formyl-2-nitrobenzoate tert-butyl (S)-3-(4-bromophenyl)piperidine-1-carboxylate Niraparib Niraparib tosylate

MK-4827 (tosylate) 3-(4-Bromophenyl)piperidine-1-carboxylic acid tert-butyl ester Piperidine, 3-(4-bromophenyl)- tert-butyl (3S)-3-{4-[7-(aminocarbonyl)-2H-indazol-2-yl]phenyl}piperidine-1-carboxylate (S)-3-(4-Bromophenyl)piperidine

3-(4-AMINO-PHENYL)-PIPERIDINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER (R)-tert-butyl 3-(4-aMinophenyl)piperidine-1-carboxylate MK-4827 (R-enantioMer)

1of4

MK-4827 (HCl) MK-4827 (hydrochloride) CS-787 Niraparib(MK4827) hydrochloride 2-[4-[(3S)-piperidin-3-yl]phenyl]indazole-7-carboxamide,hydrochloride 2H-Indazole-7-carboxamide, 2-[4-(3S)-3-piperidinylphenyl]-, hydrochloride (1:1) EOS-62286 MK-4827, Niraparib HCl salt (3S)-3-[4-[7-(aminocarbonyl)-2H-indazol-2-yl]phenyl]piperidinium chloride (S)-2-(4-(piperidin-3-yl)phenyl)-2H-indazole-7-carboxamide dihydrochloride Niraparib HCl (MK-4827) 2-[4-(3S)-3-Piperidinylphenyl]-2H-indazole-7-carboxamide hydrochloride (1:1) (S)-2-(4-(Piperidin-3-yl)phenyl)-2H-indazole-7-carboxamide hydrochloride MK-4827 hydrochloride|||MK-4827 (hydrochloride) Niraparib hydrochloride, 10 mM in DMSO 2-[4-(3S)Piperidin-3-ylphenyl]-2H-indazol-7-carboxamide HCl Niraparib HCl Niraparib hydrochloride Niraparib Tosylate Monohydrate Zejula 1038915-64-8 API