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ChemicalBook >> CAS DataBase List >>(S)-2-(4-(piperidin-3-yl)phenyl)-2H-indazole-7-carboxaMide

(S)-2-(4-(piperidin-3-yl)phenyl)-2H-indazole-7-carboxaMide

(S)-2-(4-(piperidin-3-yl)phenyl)-2H-indazole-7-carboxaMide Structure
(S)-2-(4-(piperidin-3-yl)phenyl)-2H-indazole-7-carboxaMide structure
CAS No.
1038915-64-8
Chemical Name:
(S)-2-(4-(piperidin-3-yl)phenyl)-2H-indazole-7-carboxaMide
Synonyms
CS-787;Zejula;EOS-62286;MK-4827 (HCl);MK-4827 (hydrochloride);Niraparib hydrochloride;Niraparib HCl (MK-4827);MK-4827, Niraparib HCl salt;Niraparib Tosylate Monohydrate;Niraparib(MK4827) hydrochloride
CBNumber:
CB42553458
Molecular Formula:
C19H20N4O
Molecular Weight:
320.3883
MDL Number:
MFCD20502397
MOL File:
1038915-64-8.mol
MSDS File:
SDS
Last updated:2026-04-17 13:05:51
Product description Number Pack Size Price
Niraparib(hydrochloride) 99.80% CS-2282 5mg $70
MK-4827hydrochloride B1163 5mg $95
Niraparib(hydrochloride) 99.80% CS-2282 10mg $100
MK-4827hydrochloride B1163 10mg $168
Niraparib(hydrochloride) 99.80% CS-2282 50mg $180
More product size
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(S)-2-(4-(piperidin-3-yl)phenyl)-2H-indazole-7-carboxaMide Properties

Melting point 144 °C
storage temp. Store at -20°C
solubility Soluble in DMSO
form Solid
color White to light yellow
InChI InChI=1/C19H20N4O/c20-19(24)17-5-1-3-15-12-23(22-18(15)17)16-8-6-13(7-9-16)14-4-2-10-21-11-14/h1,3,5-9,12,14,21H,2,4,10-11H2,(H2,20,24)/t14-/s3
InChIKey PCHKPVIQAHNQLW-WDHUHKLTNA-N
SMILES N1=C2C(C=CC=C2C(N)=O)=CN1C1=CC=C([C@@H]2CCCNC2)C=C1 |&1:16,r|
NCI Dictionary of Cancer Terms niraparib tosylate monohydrate; Zejula
FDA UNII L4JFC1PHCI
NCI Drug Dictionary niraparib tosylate monohydrate

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS07
Signal word  Warning
Hazard statements  H302-H315-H319-H335
Precautionary statements  P264-P270-P301+P312-P330-P501-P280-P302+P352-P321-P332+P313-P362-P305+P351+P338-P337+P313-P261-P271-P304+P340-P312-P403+P233-P405

(S)-2-(4-(piperidin-3-yl)phenyl)-2H-indazole-7-carboxaMide price

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
ChemScene CS-2282 Niraparib(hydrochloride) 99.80% 1038915-64-8 5mg $70 2021-12-16 Buy
ApexBio Technology B1163 MK-4827hydrochloride 1038915-64-8 5mg $95 2021-12-16 Buy
ChemScene CS-2282 Niraparib(hydrochloride) 99.80% 1038915-64-8 10mg $100 2021-12-16 Buy
ApexBio Technology B1163 MK-4827hydrochloride 1038915-64-8 10mg $168 2021-12-16 Buy
ChemScene CS-2282 Niraparib(hydrochloride) 99.80% 1038915-64-8 50mg $180 2021-12-16 Buy
Product number Packaging Price Buy
CS-2282 5mg $70 Buy
B1163 5mg $95 Buy
CS-2282 10mg $100 Buy
B1163 10mg $168 Buy
CS-2282 50mg $180 Buy

(S)-2-(4-(piperidin-3-yl)phenyl)-2H-indazole-7-carboxaMide Chemical Properties,Uses,Production

Uses

Niraparib hydrochloride (MK-4827 hydrochloride) is a highly potent and orally bioavailable PARP1 and PARP2 inhibitor with IC50s of 3.8 and 2.1 nM, respectively. Niraparib hydrochloride leads to inhibition of repair of DNA damage, activates apoptosis and shows anti-tumor activity[1][2][3].

in vivo

Niraparib is well tolerated and demonstrates efficacy as a single agent in a xenograft model of BRCA-1 deficient cancer. Niraparib is well tolerated in vivo and demonstrates efficacy as a single agent in a xenograft model of BRCA-1 deficient cancer. Niraparib is characterized by acceptable pharmacokinetics in rats with plasma clearance of 28 (mL/min)/kg, very high volume of distribution (Vdss=6.9 L/kg), long terminal half-life (t1/2=3.4 h), and excellent bioavailability, F = 65%[1]. Niraparib enhances radiation response of p53 mutant Calu-6 tumor in both cases, with the single daily dose of 50 mg/kg being more effective than 25 mg/kg given twice daily[3].

IC 50

PARP-2: 2.1 nM (IC50); PARP-1: 3.8 nM (IC50); V-PARP: 330 nM (IC50); TANK-1: 570 nM (IC50); PARP-3: 1300 nM (IC50)

References

[1] Jones P, et al. Discovery of 2-{4-[(3S)-piperidin-3-yl]phenyl}-2H-indazole-7-carboxamide (MK-4827): a novel oral poly(ADP-ribose)polymerase (PARP) inhibitor efficacious in BRCA-1 and -2 mutant tumors. J Med Chem. 2009 Nov 26;52(22):7170-85. DOI:10.1021/jm901188v
[2] Bridges KA, et al. Niraparib (MK-4827), a novel poly(ADP-Ribose) polymerase inhibitor, radiosensitizes human lung and breast cancer cells. Oncotarget. 2014 Jul 15;5(13):5076-86. DOI:10.18632/oncotarget.2083
[3] Wang L, et al. MK-4827, a PARP-1/-2 inhibitor, strongly enhances response of human lung and breast cancer xenografts to radiation. Invest New Drugs. 2012 Dec;30(6):2113-20. DOI:10.1007/s10637-011-9770-x
[4] Mirza MR, et al. Niraparib Maintenance Therapy in Platinum-Sensitive, Recurrent Ovarian Cancer. N Engl J Med. 2016 Dec 1;375(22):2154-2164. DOI:10.1056/NEJMoa1611310

(S)-2-(4-(piperidin-3-yl)phenyl)-2H-indazole-7-carboxaMide Preparation Products And Raw materials

Raw materials

Preparation Products

(S)-2-(4-(piperidin-3-yl)phenyl)-2H-indazole-7-carboxaMide Suppliers

Global( 113)Suppliers
Supplier Tel Email Country ProdList Advantage
Henan Tianfu Chemical Co.,Ltd. 		+86-0371-55170693 +86-19937530512 info@tianfuchem.com China 21592 55
ATK CHEMICAL COMPANY LIMITED 		+undefined-21-51877795 ivan@atkchemical.com China 33024 60
career henan chemical co 		+86-0371-86658258 +8613203830695 sales@coreychem.com China 29822 58
Alchem Pharmtech,Inc. 		8485655694 sales@alchempharmtech.com United States 63687 58
Shanghai Yingrui Biopharma Co.,Ltd 		21-33585366 export01@shyrchem.com CHINA 1319 58
TargetMol Chemicals Inc. 		+1-781-999-5354; +17819995354 marketing@targetmol.com United States 32467 58
Hubei Ipure Biology Co., Ltd 		+8613367258412 ada@ipurechemical.com China 10236 58
HANGZHOU CLAP TECHNOLOGY CO.,LTD 		86-571-88216897,88216896 13588875226 sales@hzclap.com CHINA 6312 58
Zhejiang J&C Biological Technology Co.,Limited 		+1-2135480471 +1-2135480471; sales@sarms4muscle.com China 10473 58
Henan Alfa Chemical Co., Ltd 		+8615838112936 sale03@alfachem.cn China 9659 58
Supplier Advantage
Henan Tianfu Chemical Co.,Ltd. 		55
ATK CHEMICAL COMPANY LIMITED 		60
career henan chemical co 		58
Alchem Pharmtech,Inc. 		58
Shanghai Yingrui Biopharma Co.,Ltd 		58
TargetMol Chemicals Inc. 		58
Hubei Ipure Biology Co., Ltd 		58
HANGZHOU CLAP TECHNOLOGY CO.,LTD 		58
Zhejiang J&C Biological Technology Co.,Limited 		58
Henan Alfa Chemical Co., Ltd 		58

View Lastest Price from (S)-2-(4-(piperidin-3-yl)phenyl)-2H-indazole-7-carboxaMide manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
Niraparib hydrochloride pictures 2026-04-17 Niraparib hydrochloride
1038915-64-8
 US $34.00-80.00 / mg 99.85% 10g TargetMol Chemicals Inc.
(S)-2-(4-(piperidin-3-yl)phenyl)-2H-indazole-7-carboxaMide pictures 2025-06-03 (S)-2-(4-(piperidin-3-yl)phenyl)-2H-indazole-7-carboxaMide
1038915-64-8
 US $0.10-0.30 / kg 1kg 99% 20 tons Zibo Hangyu Biotechnology Development Co., Ltd
Niraparib tosylate pictures 2024-11-26 Niraparib tosylate
1038915-64-8
 US $0.00-0.00 / kg 1kg 99%, Single impurity＜0.1 1 ton Nanjing Fred Technology Co., Ltd
  • Niraparib tosylate pictures
  • Niraparib tosylate
    1038915-64-8
  • US $0.00-0.00 / kg
  • 99%, Single impurity＜0.1
  • Nanjing Fred Technology Co., Ltd

(S)-2-(4-(piperidin-3-yl)phenyl)-2H-indazole-7-carboxaMide Spectrum

(S)-2-(4-(piperidin-3-yl)phenyl)-2H-indazole-7-carboxaMide(1038915-64-8)1HNMR

1038915-64-8((S)-2-(4-(piperidin-3-yl)phenyl)-2H-indazole-7-carboxaMide)Related Search:

Nintedanib (S)-tert-butyl 3-(4-aMinophenyl)piperidine-1-carboxylate 4-(3-PYRIDYL)ANILINE N-(tert-butyl)-1H-indazole-7-carboxamide 4-piperidin-3-ylaniline
4-(3-Piperidyl)aniline Dihydrochloride Methyl 3-formyl-2-nitrobenzoate tert-butyl (S)-3-(4-bromophenyl)piperidine-1-carboxylate Niraparib Niraparib tosylate
MK-4827 (tosylate) 3-(4-Bromophenyl)piperidine-1-carboxylic acid tert-butyl ester Piperidine, 3-(4-bromophenyl)- tert-butyl (3S)-3-{4-[7-(aminocarbonyl)-2H-indazol-2-yl]phenyl}piperidine-1-carboxylate (S)-3-(4-Bromophenyl)piperidine
3-(4-AMINO-PHENYL)-PIPERIDINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER (R)-tert-butyl 3-(4-aMinophenyl)piperidine-1-carboxylate MK-4827 (R-enantioMer)

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MK-4827 (HCl) MK-4827 (hydrochloride) CS-787 Niraparib(MK4827) hydrochloride 2-[4-[(3S)-piperidin-3-yl]phenyl]indazole-7-carboxamide,hydrochloride Zejula Niraparib hydrochloride 2H-Indazole-7-carboxamide, 2-[4-(3S)-3-piperidinylphenyl]-, hydrochloride (1:1) Niraparib Tosylate Monohydrate EOS-62286 MK-4827, Niraparib HCl salt (3S)-3-[4-[7-(aminocarbonyl)-2H-indazol-2-yl]phenyl]piperidinium chloride (S)-2-(4-(piperidin-3-yl)phenyl)-2H-indazole-7-carboxamide dihydrochloride Niraparib HCl (MK-4827) 2-[4-(3S)-3-Piperidinylphenyl]-2H-indazole-7-carboxamide hydrochloride (1:1) (S)-2-(4-(Piperidin-3-yl)phenyl)-2H-indazole-7-carboxamide hydrochloride MK-4827 hydrochloride|||MK-4827 (hydrochloride) Niraparib hydrochloride, 10 mM in DMSO 2-[4-(3S)Piperidin-3-ylphenyl]-2H-indazol-7-carboxamide HCl 1038915-64-8 API