Toceranib Phosphate
- CAS No.
- 874819-74-6
- Chemical Name:
- Toceranib Phosphate
- Synonyms
- PHA 291639E;SU11654 phosphate;Toxinib phosphate;PHA 291639 phosphate;Toceranib (phosphate);PHA 291639E (phosphate);Toceranib phosphate(SU 11654);Toceranib phosphate - Bio-X ?;Toceranib (PHA 291639) phosphate;5-[(Z)-(5-fluoro-2-oxo-1H-indol-3-ylidene)methyl]-2,4-dimethyl-N-(2-pyrrolidin-1-ylethyl)-1H-pyrrole-3-carboxamide
- CBNumber:
- CB42563239
- Molecular Formula:
- C22H28FN4O6P
- Molecular Weight:
- 494.46
- MDL Number:
- MFCD25372034
- MOL File:
- 874819-74-6.mol
| Melting point | >270°C (dec.) |
|---|---|
| storage temp. | -20°C Freezer |
| solubility | DMSO (Slightly, Heated) |
| form | Solid |
| color | Yellow to Dark Orange |
| InChIKey | AOORBROPMMRREB-HBPAQXCTSA-N |
| SMILES | P(O)(O)(O)=O.C(/C1NC(C)=C(C(=O)NCCN2CCCC2)C=1C)=C1/C(NC2=CC=C(F)C=C/12)=O |
| FDA UNII | 24F9PF7J3R |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302-H315-H319-H335 |
| Precautionary statements | P261-P305+P351+P338 |
Toceranib Phosphate price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| TRC | T525503 | ToceranibPhosphate | 874819-74-6 | 100mg | $60 | 2021-12-16 | Buy |
| TRC | T525503 | ToceranibPhosphate | 874819-74-6 | 10mg | $45 | 2021-12-16 | Buy |
| Biosynth Carbosynth | BT162330 | Toceranib phosphate | 874819-74-6 | 5mg | $50 | 2021-12-16 | Buy |
| ChemScene | CS-1231 | Toceranibphosphate | 874819-74-6 | 10mg | $50 | 2021-12-16 | Buy |
| AK Scientific | 6555BB | Toceranibphosphate | 874819-74-6 | 10mg | $120 | 2021-12-16 | Buy |
Toceranib Phosphate Chemical Properties,Uses,Production
Description
Toceranib phosphate is a kinase inhibitor with both antitumor and antiangiogenic activity through inhibition of KIT, vascular endothelial growth factor receptor 2, and PDGFRβ. It is a receptor tyrosine kinase inhibitor and is used in the treatment of canine mast cell tumor also called mastocytoma. It may also have an anti-angiogenic effect.
Uses
Toceranib Phosphate is a useful compound in the treatment of chemotherapy-induced diarrhea.
Side effects
Common side effects of Toceranib Phosphate may include diarrhoea, decreased or lack of appetite, claudication or weight loss. Less common side effects include muscle pain, low white blood cell count, low blood protein levels, blood clots (which may appear as swelling in the legs or difficulty breathing), pancreatitis, loss of nose colour, changes in skin hair, nosebleeds, seizures, high blood pressure and itching. Serious side effects include prolonged loss of appetite, severe diarrhoea or bloody stools, bruising or bleeding. In cats, gastrointestinal effects, low blood counts, liver and kidney problems, and hair loss have been reported.
in vivo
Administration of Toceranib phosphate (PHA 291639 phosphate) significantly decreases the number and percentage of Treg in the peripheral blood of dogs with cancer. Dogs receiving Toceranib phosphate (PHA 291639 phosphate) and cyclophosphamide (CYC) demonstrate a significant increase in serum concentrations of IFN-γ, which is inversely correlated with Treg numbers after 6 weeks of combination treatment[3].
target
KIT
IC 50
PDGFRβ: 5 nM (Ki); Flk-1: 6 nM (Ki)
Toceranib Phosphate Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Masteam Bio-tech Co., Ltd. | +86-15200345168 +86-15200345168 | bruce.lei@masteam.com | CHINA | 151 | 58 |
| Hpets Biotech Company (Chongqing) Co.,ltd | +8613340353813 | info@hanpets.com | China | 26 | 58 |
| S&Y Biochem Co.,Ltd | +8617774091612 | marketing@sybiochem.com | China | 180 | 58 |
| Shanghai Daken Advanced Materials Co.,Ltd | +86-2158073036 | info@dakenam.com | China | 19919 | 58 |
| Nanjing ChemLin Chemical Industry Co., Ltd. | 025-83697070 | product@chemlin.com.cn | CHINA | 3009 | 60 |
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 33024 | 60 |
| Biochempartner | 0086-13720134139 | candy@biochempartner.com | CHINA | 965 | 58 |
| BOC Sciences | +1-631-485-4226 | inquiry@bocsci.com | United States | 19552 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 32268 | 58 |
| Hubei Ipure Biology Co., Ltd | +8613367258412 | ada@ipurechemical.com | China | 10244 | 58 |
View Lastest Price from Toceranib Phosphate manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2025-04-27 | Toceranib Phosphate
874819-74-6
|
US $1.00 / kg | 0.1kg | 99 | 100 | S&Y Biochem Co.,Ltd | |
 |
2025-04-04 | Toceranib Phosphate
874819-74-6
|
US $0.00-0.00 / kg | 1kg | 98% | 1Ton | Henan Aochuang Chemical Co.,Ltd. | |
 |
2024-11-17 | Toceranib Phosphate
874819-74-6
|
US $41.00-85.00 / mg | 98% | 10g | TargetMol Chemicals Inc. |
-
- Toceranib Phosphate
874819-74-6
- US $1.00 / kg
- 99
- S&Y Biochem Co.,Ltd
-
- Toceranib Phosphate
874819-74-6
- US $0.00-0.00 / kg
- 98%
- Henan Aochuang Chemical Co.,Ltd.
-
- Toceranib Phosphate
874819-74-6
- US $41.00-85.00 / mg
- 98%
- TargetMol Chemicals Inc.