N-Methoxy-N,2,2-trimethylpropanamide
- CAS No.
- 64214-60-4
- Chemical Name:
- N-Methoxy-N,2,2-trimethylpropanamide
- Synonyms
- N-Methoxy-N,2,2-trimethylpropanamide;Propanamide, N-methoxy-N,2,2-trimethyl-
- CBNumber:
- CB42565293
- Molecular Formula:
- C7H15NO2
- Molecular Weight:
- 145.2
- MDL Number:
- MFCD11847426
- MOL File:
- 64214-60-4.mol
- MSDS File:
- SDS
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302+H312+H332 |
| Precautionary statements | P501-P261-P270-P271-P264-P280-P362+P364-P301+P312+P330-P302+P352+P312-P304+P340+P312 |
| HS Code | 2928009090 |
N-Methoxy-N,2,2-trimethylpropanamide price More Price(25)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Apolloscientific | OR959868 | N-Methoxy-N,2,2-trimethylpropanamide >95% | 64214-60-4 | 1g | $28 | 2026-06-04 | Buy |
| Apolloscientific | OR959868 | N-Methoxy-N,2,2-trimethylpropanamide >95% | 64214-60-4 | 5g | $97 | 2026-06-04 | Buy |
| Apolloscientific | OR959868 | N-Methoxy-N,2,2-trimethylpropanamide >95% | 64214-60-4 | 25g | $327 | 2026-06-04 | Buy |
| Apolloscientific | OR959868 | N-Methoxy-N,2,2-trimethylpropanamide >95% | 64214-60-4 | 100g | $1271 | 2026-06-04 | Buy |
| Matrix Scientific | 188534 | N-methoxy-N-methylpivalamide | 64214-60-4 | 5.00g | $478 | 2026-05-18 | Buy |
N-Methoxy-N,2,2-trimethylpropanamide Chemical Properties, Uses, Production
Synthesis
1117-97-1
75-98-9
64214-60-4
GENERAL PROCEDURE: Methoxymethylamine (0.360 g, 6.0 mmol) and valproic acid (0.244 g, 2.0 mmol) were dissolved in anhydrous toluene (10 mL) and stirred for 10 min at 0 °C. Subsequently, a solution of phosphorus trichloride (0.137 g, 1.0 mmol) in anhydrous toluene (2 mL) was slowly added dropwise to the reaction mixture. After the dropwise addition, the reaction mixture was gradually warmed up to room temperature and stirring was continued for 0.5 h at 60 °C. The progress of the reaction was monitored by thin layer chromatography (TLC) and after confirming the completion of the reaction, the mixture was cooled to room temperature. The reaction was quenched with saturated sodium bicarbonate solution (20 mL) and subsequently extracted with ethyl acetate (3 x 10 mL). The organic phases were combined and dried over anhydrous magnesium sulfate. The solvent was removed by concentration under reduced pressure to give the crude product. The crude product was purified by column chromatography (silica gel, petroleum ether-ethyl acetate, 3:2) to afford N-methoxy-N,2,2-trimethylpropionamide (3a) as a colorless oil. Yield: 320 mg (97%).
References
[1] Synthesis (Germany), 2014, vol. 46, # 3, p. 320 - 330
[2] Journal of Organic Chemistry, 2004, vol. 69, # 25, p. 8984 - 8986
N-Methoxy-N,2,2-trimethylpropanamide Preparation Products And Raw materials
Raw materials
Preparation Products
N-Methoxy-N,2,2-trimethylpropanamide Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Adamas Reagent, Ltd. | 400-6009262 15618770481 | yhx@titansci.com | China | 14098 | 59 |
| Sci General Material & Chemical Ltd | 021-58388037;21-58388037 13472507714 | 35177634@qq.com;1589045147@qq.com | China | 795 | 55 |
| Shanghai Topbiochem Technology Co., Ltd | +86-21-60341587 | sales@topbiochem.com | China | 6166 | 58 |
| Jiangsu Aikon Biopharmaceutical R&D co.,Ltd. | 025-66113011 13913916777 | cfzhang@aikonchem.com | China | 19902 | 55 |
| 9ding chemical ( Shanghai) Limited | 4009209199 | sales@9dingchem.com | China | 18201 | 56 |
| EnliPharma Technology Co., Ltd | 0551-66399836 18955197623 | sales@enlipharma.com | China | 1875 | 55 |
| Guangzhou Isun Pharmaceutical Co., Ltd | 020-39119399 18927568969 | isunpharm@qq.com | China | 4773 | 55 |
| Shanghai Carlow Chemicals Co., Ltd. | 21-33526724 18930996265 | info@carlowchem.com | China | 1996 | 58 |
| Mashilabs (Shanghai) Co.,Ltd. | 19916721580 | mafarm@126.com | China | 4534 | 58 |
| Changsha Jing Kang New Material Technology Co., Ltd. | 0731-85118349 18874718518 | 877634463@qq.com | China | 1998 | 50 |
