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SC 66

SC 66 Structure
SC 66 structure
CAS No.
871361-88-5
Chemical Name:
SC 66
Synonyms
SC 66;CS-2480;SC66;SC 66;SC66, 10 mM in DMSO;SC-66, Allosteric Akt inhibitor;2E,?6E-?BIS(4-?PYRIDINYLMETHYLENE)-?CYCLOHEXA;(2E,6E)-2,6-Bis(pyridin-4-ylmethylene)cyclohexanone;(2E,6E)-2,6-Bis(4-pyridinylmethylene)-cyclohexanone;Cyclohexanone, 2,6-bis(4-pyridinylMethylene)-, (2E,6E)-;Akt,SC 66,PKB,Protein kinase B,SC-66,SC66,Inhibitor,inhibit,Apoptosis
CBNumber:
CB42565930
Molecular Formula:
C18H16N2O
Molecular Weight:
276.33
MDL Number:
MFCD05025493
MOL File:
871361-88-5.mol
Last updated:2025-04-17 18:22:24
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SC 66 Properties

storage temp. Sealed in dry,2-8°C
solubility DMSO: ≥5mg/mL (warmed)
form powder
color faint yellow to dark yellow
UNSPSC Code 12352200

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS07
Signal word  Warning
Hazard statements  H302-H315-H319-H335
Precautionary statements  P261-P305+P351+P338
WGK Germany  3

SC 66 price More Price(36)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Cayman Chemical 10876 SC-66 ≥98% 871361-88-5 5mg $38 2024-03-01 Buy
Cayman Chemical 10876 SC-66 ≥98% 871361-88-5 10mg $71 2024-03-01 Buy
Cayman Chemical 10876 SC-66 ≥98% 871361-88-5 25mg $166 2024-03-01 Buy
Cayman Chemical 10876 SC-66 ≥98% 871361-88-5 100mg $510 2024-03-01 Buy
Tocris 4398 SC66 ≥98%(HPLC) 871361-88-5 50 $378 2021-12-16 Buy
Product number Packaging Price Buy
10876 5mg $38 Buy
10876 10mg $71 Buy
10876 25mg $166 Buy
10876 100mg $510 Buy
4398 50 $378 Buy

SC 66 Chemical Properties,Uses,Production

Description

Akt activation requires binding of its pleckstrin homology domain (PHD) to membrane-associated phosphatidylinositol-3,4,5-trisphosphate (PIP3) or phosphatidylinositol-3,4-bisphosphate (PIP2). Increased Akt activity, e.g., through a gain-of-function mutation in the PHD of Akt1, is pivotal to many types of cancer. Activated Akt may be regulated by various events, including ubiquitination-mediated deactivation. SC-66 is an allosteric inhibitor of Akt that facilitates both ubiquitination and deactivation of Akt. At 4 μg/ml, SC-66 inhibits Akt activity in HEK293T cells and in HEK293 cells stably expressing Akt with the gain-of-function pleckstrin homology domain mutation, promoting cell death. In nude mice inoculated with HEK293T cells, SC-66 (15 mg/kg) suppresses tumor growth.

Uses

SC 66 is an analog of curcumin that can inhibit the activity of ATP-binding cassette transporters in cancer multidrug resistance.

in vivo

To demonstrate the effectiveness in vivo of SC66 on HCC, a mouse xenograft tumor model of Hep3B cells is used. When tumors became palpable, at a size of about 150 mm3, mice are randomized into three groups of 6 animals each. The treated group receive SC66 at 15 and 25 mg/kg twice a week via i.p. injection, while the untreated group receive the vehicle alone. Treatment with 25 mg/Kg SC66 significantly reduces tumor volume to 37% on day 17 when compared with tumors of the untreated group[1].

storage

-20°C

SC 66 Preparation Products And Raw materials

Raw materials

Preparation Products

SC 66 Suppliers

Global( 102)Suppliers
Supplier Tel Email Country ProdList Advantage
ATK CHEMICAL COMPANY LIMITED 		+undefined-21-51877795 ivan@atkchemical.com China 33024 60
career henan chemical co 		+86-0371-86658258 +8613203830695 factory@coreychem.com China 29807 58
SHANGHAI T&W PHARMACEUTICAL CO., LTD. 		+86-021-61551413 +8618813727289 contact@trustwe.com China 5738 58
TargetMol Chemicals Inc. 		+1-781-999-5354 +1-00000000000 marketing@targetmol.com United States 32268 58
InvivoChem 		+1-708-310-1919 +1-13798911105 sales@invivochem.cn United States 6391 58
Nantong HI-FUTURE Biology Co., Ltd. 		+undefined18051384581 sales@chemhifuture.com China 3135 58
TargetMol Chemicals Inc. 		support@targetmol.com United States 38663 58
ShenZhen Trendseen Biological Technology Co.,Ltd. 		13417589054 trendseenbio@gmail.com China 11681 58
LEAPCHEM CO., LTD. 		+86-852-30606658 market18@leapchem.com China 43340 58
Jilin Chinese Academy of Sciences-yanshen Technology 		+undefined18143011203 info@chemextension.com China 42056 58
Supplier Advantage
ATK CHEMICAL COMPANY LIMITED 		60
career henan chemical co 		58
SHANGHAI T&W PHARMACEUTICAL CO., LTD. 		58
TargetMol Chemicals Inc. 		58
InvivoChem 		58
Nantong HI-FUTURE Biology Co., Ltd. 		58
TargetMol Chemicals Inc. 		58
ShenZhen Trendseen Biological Technology Co.,Ltd. 		58
LEAPCHEM CO., LTD. 		58
Jilin Chinese Academy of Sciences-yanshen Technology 		58

View Lastest Price from SC 66 manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
SC66 pictures 2024-11-19 SC66
871361-88-5
 US $40.00-97.00 / mg 99.6% 10g TargetMol Chemicals Inc.
SC 66 pictures 2019-12-24 SC 66
871361-88-5
 US $1.00 / g 1g 99% 20kg Career Henan Chemical Co
  • SC66 pictures
  • SC66
    871361-88-5
  • US $40.00-97.00 / mg
  • 99.6%
  • TargetMol Chemicals Inc.
  • SC 66 pictures
  • SC 66
    871361-88-5
  • US $1.00 / g
  • 99%
  • Career Henan Chemical Co

871361-88-5(SC 66)Related Search:

4-ThiazolecarboxaMide, N-(6-benzoyl-1H-benziMidazol-2-yl)-2-(1-thieno[3,2-d]pyriMidin-4-yl-4-piperidinyl)- 2-AMino-6-chloro-α-cyano-3-(ethoxycarbonyl)-4H-1-benzopyran-4-acetic Acid Ethyl Ester SC-514 SC 57461A α,α-Diphenyl-4-[(3-pyridinylmethylene)amino]-1-piperazinepentanenitrile
SC 66 Cyclohexanone, 2,6-bis(4-pyridinylMethylene)-, (2E,6E)- (2E,6E)-2,6-Bis(4-pyridinylmethylene)-cyclohexanone CS-2480 SC66;SC 66 (2E,6E)-2,6-Bis(pyridin-4-ylmethylene)cyclohexanone Akt,SC 66,PKB,Protein kinase B,SC-66,SC66,Inhibitor,inhibit,Apoptosis 2E,?6E-?BIS(4-?PYRIDINYLMETHYLENE)-?CYCLOHEXA SC-66, Allosteric Akt inhibitor SC66, 10 mM in DMSO 871361-88-5