Description
JWH 200 is an aminoalkylindole that acts as a cannabinoid (CB) receptor agonist, binding the CB1 receptor with high-affinity (IC50 = 7.8-42 nM).1,2 JWH 200 is one of several synthetic CBs which have been included in smoking mixtures.3 JWH 200 7-hydroxyindole metabolite is expected to be a urinary metabolite of JWH 200 based on the metabolism of the closely related JWH 015 and JWH 018.4,5WARNING This product is not for human or veterinary use.
References
[1] MICHAEL A. EISSENSTAT. Aminoalkylindoles: Structure-Activity Relationships of Novel Cannabinoid Mimetics[J]. Journal of Medicinal Chemistry, 1995, 38 16: 3094-3105. DOI: 10.1021/jm00016a013
[2] JOHN W HUFFMAN . 3-Indolyl-1-naphthylmethanes: new cannabimimetic indoles provide evidence for aromatic stacking interactions with the CB1 cannabinoid receptor[J]. Bioorganic & Medicinal Chemistry, 2003, 11 4: Pages 539-549. DOI: 10.1016/s0968-0896(02)00451-0
[3] RURI KIKURA-HANAJIRI Yukihiro G Nahoko Uchiyama. Survey of current trends in the abuse of psychotropic substances and plants in Japan[J]. Legal Medicine, 2011, 13 3: Pages 109-115. DOI: 10.1016/j.legalmed.2011.02.003
[4] QIANG ZHANG. Identification of in vitro metabolites of JWH-015, an aminoalkylindole agonist for the peripheral cannabinoid receptor (CB2) by HPLC-MS/MS[J]. Analytical and Bioanalytical Chemistry, 2006, 386 5: 1345-1355. DOI: 10.1007/s00216-006-0717-6
[5] TIM SOBOLEVSKY Grigory R Ilya Prasolov. Detection of JWH-018 metabolites in smoking mixture post-administration urine[J]. Forensic science international, 2010, 200 1: Pages 141-147. DOI: 10.1016/j.forsciint.2010.04.003
