3-chloro-1H-pyrazole
- CAS No.
- 14339-33-4
- Chemical Name:
- 3-chloro-1H-pyrazole
- Synonyms
- EOS-61387;3-Chloroyrazole;3-Chloropyrazole;5-Chloropyrazole;3-chloro-1H-pyrazole;1H-Pyrazole, 3-chloro-
- CBNumber:
- CB42593960
- Molecular Formula:
- C3H3ClN2
- Molecular Weight:
- 102.52
- MDL Number:
- MFCD12756597
- MOL File:
- 14339-33-4.mol
| Melting point | 40 °C |
|---|---|
| Boiling point | 250.9±13.0 °C(Predicted) |
| Density | 1.405±0.06 g/cm3(Predicted) |
| storage temp. | under inert gas (nitrogen or Argon) at 2-8°C |
| form | powder |
| pka | 11.04±0.10(Predicted) |
| color | White |
| InChI | InChI=1S/C3H3ClN2/c4-3-1-2-5-6-3/h1-2H,(H,5,6) |
| InChIKey | IJPFBRONCJOTTA-UHFFFAOYSA-N |
| SMILES | N1C=CC(Cl)=N1 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302-H315-H319-H335 |
| Precautionary statements | P261-P280-P312 |
| HS Code | 2933992000 |
3-chloro-1H-pyrazole price More Price(52)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Activate Scientific | AS225214 | 3-Chloro-1H-pyrazole 98% | 14339-33-4 | 1g | $31 | 2026-06-04 | Buy |
| Activate Scientific | AS225214 | 3-Chloro-1H-pyrazole 98% | 14339-33-4 | 5g | $101 | 2026-06-04 | Buy |
| Apolloscientific | OR183405 | 3-Chloro-1H-pyrazole 98% | 14339-33-4 | 1g | $36 | 2026-06-04 | Buy |
| Activate Scientific | AS225214 | 3-Chloro-1H-pyrazole 98% | 14339-33-4 | 25g | $411 | 2026-06-04 | Buy |
| Apolloscientific | OR183405 | 3-Chloro-1H-pyrazole 98% | 14339-33-4 | 5g | $127 | 2026-06-04 | Buy |
3-chloro-1H-pyrazole Chemical Properties, Uses, Production
Uses
5-Chloro-1h-pyrazole is used in preparation of aminoquinazolines as P2X3 inhibitors.
Synthesis
1820-80-0
14339-33-4
General procedure for the synthesis of 3-chloro-1H-pyrazole from 3-aminopyrazole: Concentrated hydrochloric acid (20 mL) was slowly added to a solution of acetonitrile (600 mL) containing 1H-pyrazol-3-amine (20.0 g, 241 mmol), followed by the addition of copper(II) chloride (65.0 g, 481 mmol) at 0 °C. The reaction mixture was stirred at 0 °C for 30 min followed by dropwise addition of isoamyl nitrite (56.4 g, 481 mmol). The reaction mixture was continued to be stirred at room temperature for 2 days. After completion of the reaction, the reaction was quenched with 10% aqueous ammonia solution (1 L). The aqueous phase was extracted with ethyl acetate (5 x 500 mL) and the combined organic phases were washed with saturated brine, dried over anhydrous sodium sulfate, filtered and concentrated. The residue was purified by silica gel column chromatography (eluent: hexane/ethyl acetate=20:1) to afford the target product 3-chloro-1H-pyrazole (10.3 g, 42% yield) as a green oil.1H NMR (400 MHz, CDCl3): δ 12.84 (br s, 1H), 7.62 (s, 1H), 6.29 (s, 1H).
References
[1] Patent: WO2018/85247, 2018, A1. Location in patent: Paragraph 00296; 00297
3-chloro-1H-pyrazole Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Henan Yingchuang Chemical Co., Ltd. | 18260259434 | 3591654775@qq.com | China | 320 | 58 |
| Energy Chemical | 400-0056266 | sales8178@energy-chemical.com | China | 44850 | 61 |
| Accela ChemBio Co.,Ltd. | 021-50795510 4000665055 | marketing@accelachem.com | China | 10972 | 64 |
| ZEROSCHEM.CO.,LTD. | 10-61256048 13810278579; | sales@zeroschem.com | China | 1401 | 59 |
| Acorn PharmaTech Co., Ltd. | 025-58395930 | sales@acornpharma.com | China | 982 | 60 |
| Nanjing Norris-Pharm Technology Co., Ltd | 13901585132 | sales@norris-pharm.com | China | 8869 | 55 |
| Shanghai Jian Chao Chemical Technology Co., Ltd. | 150-2103-5486 18017383231 | 983544897@qq.com | China | 9335 | 55 |
| Shanghai Aladdin Bio-Chem Technology Co.,LTD | 400-6206333 13167063860 | anhua.mao@aladdin-e.com | China | 29977 | 65 |
| Suzhou Sino Rare Chemical Co., Ltd. | 0512-62857507 | sales@sinorarechem.com | China | 999 | 58 |
| Bide Pharmatech Ltd. | 400-164-7117 18317119277 | product02@bidepharm.com | China | 40000 | 60 |
