1,4-DiMethyl-5-(4,4,5,5-tetraMethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole
- CAS No.
- 1047644-76-7
- Chemical Name:
- 1,4-DiMethyl-5-(4,4,5,5-tetraMethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole
- Synonyms
- 1,4-DiMethylpyrazole-5-boronic Acid Pinacol Ester;(1,4-DIMETHYL-1H-PYRAZOL-5-YL)BORONIC ACID PINACOL ESTER;1,4-Dimethyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl);1,4-dimethyl-5-(tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyra...;1,4-dimethyl-5-(tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole;1,4-Dimethyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyrazole;1,4-DiMethyl-5-(4,4,5,5-tetraMethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole;1H-Pyrazole, 1,4-dimethyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-
- CBNumber:
- CB42595535
- Molecular Formula:
- C11H19BN2O2
- Molecular Weight:
- 222.09
- MDL Number:
- MFCD12400853
- MOL File:
- 1047644-76-7.mol
- MSDS File:
- SDS
| storage temp. | Inert atmosphere,Store in freezer, under -20°C |
|---|---|
| form | solid |
| Appearance | White to off-white Solid |
| InChI | InChI=1S/C11H19BN2O2/c1-8-7-13-14(6)9(8)12-15-10(2,3)11(4,5)16-12/h7H,1-6H3 |
| InChIKey | NOZSCXDKBYFTBH-UHFFFAOYSA-N |
| SMILES | N1(C)C(B2OC(C)(C)C(C)(C)O2)=C(C)C=N1 |
| UNSPSC Code | 12352200 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H319-H315-H335 |
| Precautionary statements | P264-P280-P302+P352-P321-P332+P313-P362-P264-P280-P305+P351+P338-P337+P313P |
1,4-DiMethyl-5-(4,4,5,5-tetraMethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole price More Price(43)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| TCI Chemical | D6559 | 1,4-Dimethyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole min. 98.0 % | 1047644-76-7 | 1G | $63 | 2026-04-30 | Buy |
| Matrix Scientific | 119173 | 1,4-Dimethyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole | 1047644-76-7 | 1.00g | $208 | 2026-05-18 | Buy |
| Matrix Scientific | 119173 | 1,4-Dimethyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole | 1047644-76-7 | 5.00g | $635 | 2026-05-18 | Buy |
| aablocks | AA003DM4 | 1,4-Dimethyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole 95% | 1047644-76-7 | 100mg | $8 | 2026-05-28 | Buy |
| aablocks | AA003DM4 | 1,4-Dimethyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole 97% | 1047644-76-7 | 250mg | $9 | 2026-05-28 | Buy |
1,4-DiMethyl-5-(4,4,5,5-tetraMethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole Chemical Properties, Uses, Production
Synthesis
1072-68-0
61676-62-8
1047644-76-7
General procedure for the synthesis of 1,4-dimethylpyrazole-5-boronic acid pinacol ester from 1,4-dimethylpyrazole and isopropanol pinacol borate: 1. 1,4-dimethyl-1H-pyrazole (480.0 mg, 4.993 mmol) was dissolved in tetrahydrofuran (20 mL, 300 mmol) at 0 °C and a hexane solution of 1.6 M n-butyllithium (4.7 mL, 7.5 mmol) was slowly added. 2. The reaction solution was stirred at room temperature for 1 hr and then cooled to -78 °C. 3. 2-isopropoxy-4,4,5,5-tetramethyl-1,3,2-dioxaborolane (1.63 mL, 7.99 mmol) was added to the cooled reaction solution. 4. The reaction mixture was stirred at -78 °C for 0.5 h and then slowly warmed to 0 °C (0.5 h). 5. Upon completion of the reaction, the reaction was quenched with saturated saline and extracted with ethyl acetate (3×). 6. The organic phases were combined, washed with saturated brine, dried over anhydrous sodium sulfate and concentrated under reduced pressure. 7. The residue was purified by fast column chromatography using a gradient elution of ethyl acetate/hexane (0-60%). 8. Purification afforded 142 mg of the target product 1,4-dimethyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole as a white solid.
References
[1] Patent: WO2008/98104, 2008, A1. Location in patent: Page/Page column 90
[2] Patent: US2013/96144, 2013, A1. Location in patent: Paragraph 0171; 0172
[3] Patent: WO2014/143768, 2014, A1. Location in patent: Page/Page column 109; 110
1,4-DiMethyl-5-(4,4,5,5-tetraMethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Changsha Luxing Bio-Chem Technology Co., Ltd. | 0731-88827538 15574813303 | luxingbc@126.com | China | 1975 | 65 |
| Adamas Reagent, Ltd. | 400-6009262 15618770481 | yhx@titansci.com | China | 14098 | 59 |
| Accela ChemBio Co.,Ltd. | 021-50795510 4000665055 | marketing@accelachem.com | China | 10972 | 64 |
| Shanghai Sunway Pharmaceutical Technology Co., Ltd | 13761987713 | hxzheng@sunwaypharm.cn | China | 8663 | 57 |
| Shanghai Jian Chao Chemical Technology Co., Ltd. | 150-2103-5486 18017383231 | 983544897@qq.com | China | 9336 | 55 |
| Bide Pharmatech Ltd. | 400-164-7117 18317119277 | product02@bidepharm.com | China | 40000 | 60 |
| Shanghai HuanChuan Industry Co.,Ltd. | 021-61478794 | sales@hcshhai.com | China | 9781 | 50 |
| Chengdu Aslee Biopharmaceuticals, Inc | 028-85305008 02885305008 | 2306208234@qq.com | China | 1006 | 50 |
| Shanghai Rong Lin Medical Technology Co., Ltd. | 18602194589 | lincy-110@163.com | China | 873 | 58 |
| Cool Pharm, Ltd | 021-60455363 18019463053 | sales@coolpharm.com | China | 8455 | 58 |
View Latest Price from 1,4-DiMethyl-5-(4,4,5,5-tetraMethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
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2024-10-22 | 1,4-DiMethyl-5-(4,4,5,5-tetraMethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole
1047644-76-7
|
$1.00 | 1g | 85.0-99.8% | 20ton | Career Henan Chemica Co |
-
- 1,4-DiMethyl-5-(4,4,5,5-tetraMethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole
1047644-76-7
- $1.00
- 85.0-99.8%
- Career Henan Chemica Co
