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Cilengitide trifluoroacetate

Cilengitide trifluoroacetate Structure
Cilengitide trifluoroacetate structure
CAS No.
199807-35-7
Chemical Name:
Cilengitide trifluoroacetate
Synonyms
Cilengitide TFA;cyclo[RGDf(N-Me-Val);Cilengitide (TFA salt);EMD 121974; NSC 707544;EMD 121974 trifluoroacetate;Cilengitide trifluoroacetate;Cilengitide TFA (EMD 121974);2-((2S,5R,8S,11S)-5-Benzyl-11-(3-guanidinopropyl)-8-isopropyl-7-methyl-3,6,9,12,15-pentaoxo-1,4,7,10,13-pentaazacyclopentadecan-2-yl)acetic acid trifluoroacetate
CBNumber:
CB42610252
Molecular Formula:
C29H41F3N8O9
Molecular Weight:
702.6792496
MDL Number:
MFCD22665738
MOL File:
199807-35-7.mol
Last updated:2025-04-18 09:52:22
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Cilengitide trifluoroacetate Properties

storage temp. Inert atmosphere,Store in freezer, under -20°C
solubility DMSO:100.0(Max Conc. mg/mL);142.31(Max Conc. mM)
Water:15.63(Max Conc. mg/mL);22.24(Max Conc. mM)
form Solid
color White to off-white
Water Solubility Water: 25 mg/mL (35.58 mM)

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS07
Signal word  Warning
Hazard statements  H302-H315-H319-H335
Precautionary statements  P261-P305+P351+P338

Cilengitide trifluoroacetate price

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
AK Scientific 7746EJ Cilengitidetrifluoroacetate 199807-35-7 1mg $141 2021-12-16 Buy
ChemScene CS-0006160 CilengitideTFA 98.85% 199807-35-7 5mg $150 2021-12-16 Buy
ChemScene CS-0006160 CilengitideTFA 98.85% 199807-35-7 10mg $250 2021-12-16 Buy
ChemScene CS-0006160 CilengitideTFA 98.85% 199807-35-7 25mg $450 2021-12-16 Buy
DC Chemicals DC7561 Cilengitide(TFAsalt) >98% 199807-35-7 100mg $450 2021-12-16 Buy
Product number Packaging Price Buy
7746EJ 1mg $141 Buy
CS-0006160 5mg $150 Buy
CS-0006160 10mg $250 Buy
CS-0006160 25mg $450 Buy
DC7561 100mg $450 Buy

Cilengitide trifluoroacetate Chemical Properties,Uses,Production

Uses

Cilengitide is a potent and selective integrin inhibitor for αvβ3 and αvβ5 receptor, with IC50 values of 4 nM and 79 nM, respectively.

in vivo

In nude mice bearing M21-L melanoma tumors, Cilengitide dose i.p. at 10, 50, and 250 μg three times per week demonstrate inhibition of tumor growth with a reduction in both tumor volume (55%, 75%, and 89%, respectively) and tumor weight (23%, 38%, and 61%, respectively), when compared to controls[2]. In the rat model studied, the systemic pharmacokinetics of i.p. Cilengitide are not affected by ILP with Cilengitide alone or ILP with Cilengitide plus Melphalan, TNF or both. Systemic Cilengitide levels reach around 20 μg/mL (approximately 35 μM) within 10 min of i.p. administration and continued to rise to approximately 40 μg/mL (approximately 70 μM) in the first hour. Thereafter Cilengitide levels in serum drop with an elimination half-life of 2.1 hr[3].

References

[1] Hariharan S, et al. Assessment of the biological and pharmacological effects of the alpha nu beta3 and alpha nu beta5 integrinreceptor antagonist, Cilengitide (EMD 121974), in patients with advanced solid tumors. Ann Oncol. 2007 Aug;18(8):1400-7. DOI:10.1093/annonc/mdm140
[2] Kim YH, et al. Combination therapy of cilengitide with belotecan against experimental glioblastoma. Int J Cancer. 2013 Aug 1;133(3):749-56. DOI:10.1002/ijc.28058
[3] Ten Hagen TL, et al. The αVβ3/αVβ5 integrin inhibitor cilengitide augments tumor response to melphalan isolated limb perfusion in a sarcoma model. Int J Cancer. 2012 Nov 13. DOI:10.1002/ijc.27940

Cilengitide trifluoroacetate Preparation Products And Raw materials

Raw materials

Trifluoroacetic acid

Preparation Products

Cilengitide trifluoroacetate Suppliers

Global( 50)Suppliers
Supplier Tel Email Country ProdList Advantage
Adachibio Inc. 		+81-8027837258 sales@adachi-bio.com Japan 992 58
BOC Sciences 		+1-631-485-4226 inquiry@bocsci.com United States 19552 58
career henan chemical co 		+86-0371-86658258 +8613203830695 factory@coreychem.com China 29807 58
Zhejiang J&C Biological Technology Co.,Limited 		+1-2135480471 +1-2135480471 sales@sarms4muscle.com China 10473 58
Nextpeptide Inc 		+86-0571-81612335 +8613336028439 sales@nextpeptide.com China 19908 58
InvivoChem 		+1-708-310-1919 +1-13798911105 sales@invivochem.cn United States 6391 58
TargetMol Chemicals Inc. 		support@targetmol.com United States 38663 58
ShenZhen Trendseen Biological Technology Co.,Ltd. 		13417589054 trendseenbio@gmail.com China 11681 58
Wuhan Topule Biopharmaceutical Co., Ltd 		+8618327326525 masar@topule.com China 8467 58
Aladdin Scientific 		tp@aladdinsci.com United States 57505 58
Supplier Advantage
Adachibio Inc. 		58
BOC Sciences 		58
career henan chemical co 		58
Zhejiang J&C Biological Technology Co.,Limited 		58
Nextpeptide Inc 		58
InvivoChem 		58
TargetMol Chemicals Inc. 		58
ShenZhen Trendseen Biological Technology Co.,Ltd. 		58
Wuhan Topule Biopharmaceutical Co., Ltd 		58
Aladdin Scientific 		58

View Lastest Price from Cilengitide trifluoroacetate manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
Cilengitide trifluoroacetate pictures 2020-01-13 Cilengitide trifluoroacetate
199807-35-7
 US $1.00 / g 1g 95-99% 1ton Career Henan Chemical Co
Cilengitide trifluoroacetate Cilengitide (TFA salt) EMD 121974 trifluoroacetate EMD 121974; NSC 707544 Cilengitide TFA Cilengitide TFA (EMD 121974) 2-((2S,5R,8S,11S)-5-Benzyl-11-(3-guanidinopropyl)-8-isopropyl-7-methyl-3,6,9,12,15-pentaoxo-1,4,7,10,13-pentaazacyclopentadecan-2-yl)acetic acid trifluoroacetate cyclo[RGDf(N-Me-Val) 199807-35-7