Pamoic acid
- CAS No.
- 130-85-8
- Chemical Name:
- Pamoic acid
- Synonyms
- EMBONIC ACID;Pamoic;PaMoic aci;Pamic acid;PAMOIC ACID;PalMer acid;Pamuric acid;PamoicAcid98%;EMBIONIC ACID;PamoicAcid>
- CBNumber:
- CB4262523
- Molecular Formula:
- C23H16O6
- Molecular Weight:
- 388.37
- MDL Number:
- MFCD00004079
- MOL File:
- 130-85-8.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Product description | Number | Pack Size | Price |
| Pamoic acid ≥97.0% (T) | 45150 | 100g | $142 |
| Pamoic acid United States Pharmacopeia (USP) Reference Standard | 1493000 | 250mg | $440 |
| Pamoic Acid >95.0%(T) | P0761 | 25g | $24 |
| Pamoic Acid ≥98% | 13946 | 50g | $53 |
| Pamoic Acid ≥98% | 13946 | 100g | $98 |
| More product size | |||
| Melting point | ≥300 °C (dec.) |
|---|---|
| Boiling point | 434.1°C (rough estimate) |
| Density | 1.2472 (rough estimate) |
| refractive index | 1.4593 (estimate) |
| storage temp. | Sealed in dry,Room Temperature |
| solubility | Soluble in nitrobenzene, pyridine |
| form | Crystalline Powder |
| pka | 2.67±0.30(Predicted) |
| color | Yellow to yellow-green |
| Water Solubility | PRACTICALLY INSOLUBLE |
| Merck | 14,7005 |
| BRN | 901319 |
| InChI | 1S/C23H16O6/c24-20-16(14-7-3-1-5-12(14)9-18(20)22(26)27)11-17-15-8-4-2-6-13(15)10-19(21(17)25)23(28)29/h1-10,24-25H,11H2,(H,26,27)(H,28,29) |
| InChIKey | WLJNZVDCPSBLRP-UHFFFAOYSA-N |
| SMILES | OC(=O)c1cc2ccccc2c(Cc3c(O)c(cc4ccccc34)C(O)=O)c1O |
| CAS DataBase Reference | 130-85-8(CAS DataBase Reference) |
| FDA UNII | 7RRQ8QZ38N |
| EPA Substance Registry System | 2-Naphthalenecarboxylic acid, 4,4'-methylenebis[3-hydroxy- (130-85-8) |
| UNSPSC Code | 41116107 |
| NACRES | NA.24 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H319-H335 | |||||||||
| Precautionary statements | P305+P351+P338-P261-P280a-P304+P340-P405-P501a | |||||||||
| PPE | dust mask type N95 (US), Eyeshields, Gloves | |||||||||
| Hazard Codes | Xi,Xn | |||||||||
| Risk Statements | 36/37/38-48-41-37/38-20/21/22 | |||||||||
| Safety Statements | 26-36-45-36/37/39-22 | |||||||||
| WGK Germany | 3 | |||||||||
| RTECS | QL2180000 | |||||||||
| TSCA | TSCA listed | |||||||||
| HS Code | 29182990 | |||||||||
| Storage Class | 11 - Combustible Solids | |||||||||
| Toxicity | eye-rbt 100 mg MOD FCTOD7 20,573,82 | |||||||||
| REACH Registrations | Active | |||||||||
| NFPA 704 |
|
Pamoic acid price More Price(86)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 45150 | Pamoic acid ≥97.0% (T) | 130-85-8 | 100g | $142 | 2026-04-30 | Buy |
| Sigma-Aldrich | 1493000 | Pamoic acid United States Pharmacopeia (USP) Reference Standard | 130-85-8 | 250mg | $440 | 2026-04-30 | Buy |
| TCI Chemical | P0761 | Pamoic Acid >95.0%(T) | 130-85-8 | 25g | $24 | 2026-04-30 | Buy |
| Cayman Chemical | 13946 | Pamoic Acid ≥98% | 130-85-8 | 50g | $53 | 2026-04-30 | Buy |
| Cayman Chemical | 13946 | Pamoic Acid ≥98% | 130-85-8 | 100g | $98 | 2026-04-30 | Buy |
Pamoic acid Chemical Properties,Uses,Production
Chemical Properties
Pamoic acid is yellow to yellow-green crystalline powder
Uses
Agonist of the orphan G protein-coupled receptor GPR35: a potent activator of extracellular signal-regulated kinase and β-arrestin2 with antinociceptive activity. Used as an inhibitor in the real-time fluorescence enzymatic characterization study of specialized human DNA polymerases.
Uses
Pamoic acid is used in preparation of repository derivatives of medicinal agents, used in pharmacology to increase the solubility of a drug in water.
Definition
ChEBI: Pamoic acid is a dicarboxylic acid. It is functionally related to a 2-naphthoic acid. It is a conjugate acid of a pamoate(2-).
General Description
Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.
Biological Activity
(1)Pamoic acid can inhibit Cas9 endonuclease activity. It effectively blocks bacterial or mammalian genome editing mediated by SpyCas9, SauCas9 or BE4 base editors at multiple endogenous gene loci. In addition, pamoic acid displays substrate competitive and PAM binding site occupancy mechanisms that selectively inhibit linear DNA cleavage compared to Cas9 cleavage of superhelical DNA. Importantly, pamoic acid pharmacologically modulates Cas9-mediated genome editing in mice.
(2)GPR35 activation by Pamoic acid may increase the phosphorylation of ERK1/2, which in turn initiates an anti-inflammatory signal by suppressing NF-κB-dependent inflammatory genes.
Safety Profile
Poison by intraperitoneal route. An eye irritant. When heated to decomposition it emits acrid smoke and irritating fumes.
Pamoic acid Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Henan Bao Enluo International TradeCo.，LTD | +86-17331933971 | deasea125996@gmail.com | China | 2472 | 58 |
| Taizhou Creating Bio-pharm co., ltd. | 0576-88827176; +8613586099526 | post@creatingbiopharm.com | China | 224 | 58 |
| Shaanxi Xianhe Biotech Co., Ltd | +86-17709210191; +8617709210191 | Jerry@xhobio.com | China | 906 | 58 |
| Capot Chemical Co.,Ltd. | +86-（0）57185586718 +86-13336195806 | sales@capot.com | China | 29640 | 60 |
| Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | info@tianfuchem.com | China | 21587 | 55 |
| Shanghai Time Chemicals CO., Ltd. | +86-021-57951555 +8617317452075 | jack.li@time-chemicals.com | China | 1803 | 55 |
| Chembon Pharmaceutical Co., Ltd. | +86-28-8425-2981 | CHINA | 722 | 55 | |
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 33024 | 60 |
| career henan chemical co | +86-0371-86658258 +8613203830695 | sales@coreychem.com | China | 29815 | 58 |
| Jinan Chenghui-Shuangda Chemical Co.,Ltd | +86-531-58897082 | ericqiao@jnchsd.com | CHINA | 158 | 58 |
View Lastest Price from Pamoic acid manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-06-08 | Pamoic acid
130-85-8
|
0.99 | RongNa Biotechnology Co.,Ltd | ||||
 |
2026-06-08 | Pamoic acid
130-85-8
|
1kg | 0.99 | 1000kg | Shaanxi Xianhe Biotech Co., Ltd | ||
 |
2026-05-28 | Pamoic acid
130-85-8
|
1KG | 0.99 | 10T | Taizhou Creating Bio-pharm co., ltd. |
-
- Pamoic acid
130-85-8
- 0.99
- RongNa Biotechnology Co.,Ltd
-
- Pamoic acid
130-85-8
- $0.00
- 0.99
- Shaanxi Xianhe Biotech Co., Ltd
-
- Pamoic acid
130-85-8
- 0.99
- Taizhou Creating Bio-pharm co., ltd.
130-85-8(Pamoic acid)Related Search:
1of4
