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3,5-Di-tert-butylsalicylaldehyde

3,5-Di-tert-butylsalicylaldehyde structure

CAS No.: 37942-07-7

Chemical Name:: 3,5-Di-tert-butylsalicylaldehyde

Synonyms: 3,5-DI-TERT-BUTYL-2-HYDROXYBENZALDEHYDE;3,5-DI-T-BUTYL-2-HYDROXYBENZALDEHYDE;3,5-Bis(tert-butyl)-2-hydroxybenzaldehyde;Dapagliflozin Impurity 108;3,5-DI-TBUTYLSALICYLALDEHYDE;3,5- di Ding JishuiYang Quan;3,5-Di-tert-butylsalicylaldehyd;3,5-DI-TERT-BUTYLSALICYLALDEHYDE;3,5-di-tert-Butyl Salicylaldehtde;Ditert-butyl-2-hydroxybenzaldehyde

CBNumber:: CB4262967

Molecular Formula:: C15H22O2

Molecular Weight:: 234.33

MDL Number:: MFCD00191998

MOL File:: 37942-07-7.mol

MSDS File:: SDS

TDS File:: TDS

Last updated:2026-05-28 03:44:59

Product description	Number	Pack Size	Price
3,5-Di-tert-butyl-2-hydroxybenzaldehyde 99%	140414	5g	$55.7
3,5-Di-tert-butyl-2-hydroxybenzaldehyde 99%	140414	25g	$67.4
3,5-Di-tert-butylsalicylaldehyde >98.0%(GC)	D2646	5g	$23
3,5-Di-tert-butylsalicylaldehyde >98.0%(GC)	D2646	25g	$37
3,5-Di-t-butyl-2-hydroxybenzaldehyde	TRC-D428150-5G	5g	$70
More product size

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3,5-Di-tert-butylsalicylaldehyde Properties

Melting point	59-61 °C(lit.)
Boiling point	277.6±35.0 °C(Predicted)
Density	1.006±0.06 g/cm3(Predicted)
storage temp.	Keep in dark place,Sealed in dry,Room Temperature
solubility	Soluble in DMSO and methanol.
form	Solid
pka	9.78±0.23(Predicted)
color	Off-White to Light Yellow
Sensitive	Air Sensitive
BRN	1877810
InChI	InChI=1S/C15H22O2/c1-14(2,3)11-7-10(9-16)13(17)12(8-11)15(4,5)6/h7-9,17H,1-6H3
InChIKey	RRIQVLZDOZPJTH-UHFFFAOYSA-N
SMILES	C(=O)C1=CC(C(C)(C)C)=CC(C(C)(C)C)=C1O
CAS DataBase Reference	37942-07-7(CAS DataBase Reference)
FDA UNII	KQA2N5HW8Z
UNSPSC Code	12352100
NACRES	NA.22

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS07

Signal word

Warning

Hazard statements

H315-H319-H335

Precautionary statements

P261-P264-P271-P280-P302+P352-P305+P351+P338

target organs

Respiratory system

PPE

dust mask type N95 (US), Eyeshields, Gloves

Hazard Codes

Risk Statements

36/37/38

Safety Statements

26-36

WGK Germany

Hazard Note

Irritant

HS Code

29124990

Storage Class

11 - Combustible Solids

Hazard Classifications

Eye Irrit. 2
Skin Irrit. 2
STOT SE 3

REACH Registrations

Active

NFPA 704

	1
2		0

3,5-Di-tert-butylsalicylaldehyde price More Price(84)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	140414	3,5-Di-tert-butyl-2-hydroxybenzaldehyde 99%	37942-07-7	5g	$55.7	2026-04-30	Buy
Sigma-Aldrich	140414	3,5-Di-tert-butyl-2-hydroxybenzaldehyde 99%	37942-07-7	25g	$67.4	2026-04-30	Buy
TCI Chemical	D2646	3,5-Di-tert-butylsalicylaldehyde >98.0%(GC)	37942-07-7	5g	$23	2026-04-30	Buy
TCI Chemical	D2646	3,5-Di-tert-butylsalicylaldehyde >98.0%(GC)	37942-07-7	25g	$37	2026-04-30	Buy
TRC	TRC-D428150-5G	3,5-Di-t-butyl-2-hydroxybenzaldehyde	37942-07-7	5g	$70	2026-06-03	Buy

Product number	Packaging	Price	Buy
140414	5g	$55.7	Buy
140414	25g	$67.4	Buy
D2646	5g	$23	Buy
D2646	25g	$37	Buy
TRC-D428150-5G	5g	$70	Buy

3,5-Di-tert-butylsalicylaldehyde Chemical Properties,Uses,Production

Chemical Properties

3,5-Di-tert-butylsalicylaldehyde is white to yellow powder or chunks or crystal or crystalline powder

Uses

3,5-Di-tert-butylsalicylaldehyde is a salicylaldehyde derivative with antibacterial activity used in the preparation nickel complexes. 3,5-Di-tert-butylsalicylaldehyde is structurally related to 3,5-di-t-butylcatechol (DTCAT) but is not as potent an activator of rat skeletal muscle ryanodine receptor Ca2+ channel (RyRC).

Uses

3,5-Di-tert-butyl-2-hydroxybenzaldehyde is used in the synthesis of Mn(III)-salen complex and its diamino precursor 5,6-diamino-5,6-dideoxy-1,2-O-isopropylidene-3-O-methyl-β-L-idofuranose, chiral Schiff base ligand for an enantioselective copper-catalyzed addition of phenyl acetylene to imines, chiral oxazolidine ligand for the enantioselective addition of diethyl zinc to aldehydes and tin Schiff base complexes with histidine analogues. It has antibacterial activity and is used in the preparation nickel complexes. It is structurally related to 3,5-di-t-butylcatechol (DTCAT) but is not as potent an activator of rat skeletal muscle ryanodine receptor Ca2+ channel (RyRC).

Uses

3,5-Di-tert-butyl-2-hydroxybenzaldehyde was used in the synthesis of

Mn(III)-salen complex and its diamino precursor 5,6-diamino-5,6-dideoxy-1,2-O-isopropylidene-3-O-methyl-β-L-idofuranose
chiral Schiff base ligand for an enantioselective copper-catalyzed addition of phenylacetylene to imines
chiral oxazolidine ligand for the enantioselective addition of diethylzinc to aldehydes
tin Schiff base complexes with histidine analogues

Definition

ChEBI: 3,5-di-tert-butyl-2-hydroxybenzaldehyde is a hydroxybenzaldehyde.

Synthesis Reference(s)

The Journal of Organic Chemistry, 59, p. 1939, 1994 DOI: 10.1021/jo00086a062
Tetrahedron, 46, p. 793, 1990 DOI: 10.1016/S0040-4020(01)81362-4
Tetrahedron Letters, 13, p. 4205, 1972 DOI: 10.1016/S0040-4039(01)94276-5

General Description

3,5-Di-tert-butyl-2-hydroxybenzaldehyde undergoes condensation reaction with

methyl-2-{N-(2′-aminoethane)}-amino-1-cyclopentenedithiocarboxylate to yield Schiff base ligand
N,N-diethyl-2-methyl-1,4-phenylenediamine during the synthesis of copper(II) and cobalt(II) complexes of salicylaldimine

Synthesis

500mL cigar-shaped bottle was added 2,4-di-tert-butylphenol 50mmol, paraformaldehyde 500mmol, sodium hydroxide 150mmol, triethylamine 100mmol, tetrahydrofuran 100mL, 90 C heating reflux stirring reaction, TLC tracking the reaction process, the reaction was completed and reduced to room temperature. Hydrochloric acid was added to the reaction solution, stirring, until the reaction solution was clarified, layered, the aqueous phase was extracted with ethyl acetate, the organic phases were combined and washed with saturated brine, dried with anhydrous sodium sulfate, filtered, the solvent was spun off, and purified by column chromatography (n-hexane:ethyl acetate = 30:1) to obtain the product 10.56 g, yield 90.16%.

3,5-Di-tert-butylsalicylaldehyde synthesis

Synthesis of 3,5-Di-tert-butylsalicylaldehyde from Formaldehyde and 2,4-Di-tert-butylphenol

3,5-Di-tert-butylsalicylaldehyde Preparation Products And Raw materials

Raw materials

Preparation Products

(R)-(+)-2-Methyl-2-propanesulfinamide 1,4,7,10,13-PENTAOXA-16-AZACYCLOOCTADECANE (S,S)-(+)-N,N'-BIS(3,5-DI-TERT-BUTYLSALICYLIDENE)-1,2-CYCLOHEXANEDIAMINE 2,4-di-tert-butyl-6-[(E)-(hydroxyimino)methyl]phenol Phenol, 2,2'-[(1R,2R)-1,2-cyclohexanediylbis(nitrilomethylidyne)]bis[4,6-bis(1,1-dimethylethyl)-

3,5-Di-tert-butylsalicylaldehyde Suppliers

Global( 454)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Hebei Chuanghai Biotechnology Co., Ltd	+8615531151365	mina@chuanghaibio.com	China	18126	58
Hebei Zhuanglai Chemical Trading Co Ltd	+86-16264648883	niki@zlchemi.com	China	7245	58
Capot Chemical Co.,Ltd.	+86-（0）57185586718 +86-13336195806	sales@capot.com	China	29640	60
Henan Tianfu Chemical Co.,Ltd.	+86-0371-55170693 +86-19937530512	info@tianfuchem.com	China	21586	55
career henan chemical co	+86-0371-86658258 +8613203830695	sales@coreychem.com	China	29812	58
Shenzhen Nexconn Pharmatechs Ltd	+86-755-89396905 +86-15013857715	admin@nexconn.com	China	10403	58
Jinan Finer Chemical Co., Ltd	+86-531-88989536 +86-15508631887	sales@finerchem.com	China	2950	58
Changzhou Ditong Chemical Co.,Ltd	+86-0519-88298848	info@edengenechem.com	China	2165	58
Alchem Pharmtech,Inc.	8485655694	sales@alchempharmtech.com	United States	63687	58
CONIER CHEM AND PHARMA LIMITED	+8618523575427	sales@conier.com	China	49979	58

Supplier	Advantage
Hebei Chuanghai Biotechnology Co., Ltd	58
Hebei Zhuanglai Chemical Trading Co Ltd	58
Capot Chemical Co.,Ltd.	60
Henan Tianfu Chemical Co.,Ltd.	55
career henan chemical co	58
Shenzhen Nexconn Pharmatechs Ltd	58
Jinan Finer Chemical Co., Ltd	58
Changzhou Ditong Chemical Co.,Ltd	58
Alchem Pharmtech,Inc.	58
CONIER CHEM AND PHARMA LIMITED	58

View Lastest Price from 3,5-Di-tert-butylsalicylaldehyde manufacturers

Update time	Product	Min. Order	Purity	Supply Ability	Manufacturer
2026-06-24	3,5-Di-tert-butylsalicylaldehyde 37942-07-7	1KG	98%min	30tons/month	WUHAN FORTUNA CHEMICAL CO., LTD
2026-06-15	3,5-Bis(1,1-dimethylethyl)-2-hydroxy-benzaldehyde 37942-07-7	1KG	≥99%	200mt/year	Jinan Finer Chemical Co., Ltd
2026-02-02	3,5-Di-tert-butylsalicylaldehyde 37942-07-7	10mg	99%HPLC	2000tons	Shaanxi Dideu Medichem Co. Ltd

3,5-Di-tert-butylsalicylaldehyde
37942-07-7
$0.00
98%min
WUHAN FORTUNA CHEMICAL CO., LTD

3,5-Bis(1,1-dimethylethyl)-2-hydroxy-benzaldehyde
37942-07-7
$0.00
≥99%
Jinan Finer Chemical Co., Ltd

3,5-Di-tert-butylsalicylaldehyde
37942-07-7
99%HPLC
Shaanxi Dideu Medichem Co. Ltd

3,5-Di-tert-butylsalicylaldehyde Spectrum

3,5-Di-tert-butylsalicylaldehyde(37942-07-7)¹HNMR 3,5-Di-tert-butylsalicylaldehyde(37942-07-7)FT-IR 3,5-Di-tert-butylsalicylaldehyde(37942-07-7)IR

37942-07-7(3,5-Di-tert-butylsalicylaldehyde)Related Search:

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THIOGLYCOLIC ACID N-BUTYL ESTER 3,5-DI-TERT-BUTYL-2-METHOXYBENZALDEHYDE 1-[3,5-DI(TERT-BUTYL)-2-HYDROXYPHENYL]ETHAN-1-ONE

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3,5- di Ding JishuiYang Quan 3,5-Di-tert-butylsalicylaldehyde, 95+% 3, 5-2 tertiary butyl salicylaldehyde 3,5-Di-tert-butylsalicylaldehyde 3,5-Di-tert-butyl-2-hydroxybenzaldehyde 99% 2-Hydroxy-3,5-di-tert-butylbenzaldehyde 3,5-DI-TBUTYLSALICYLALDEHYDE 3,5-DI-T-BUTYL-2-HYDROXYBENZALDEHYDE 3,5-DI-TERT-BUTYLSALICYLALDEHYDE 3,5-bis(1,1-dimethylethyl)-2-hydroxy-benzaldehyde BENZALDEHYDE, 3,5-BIS(1,1-DIMETHYLETHYL)-2-HYDROXY- 3,5-di-tert-Butyl Salicylaldehtde Ditert-butyl-2-hydroxybenzaldehyde 3,5-DI-TER-BUTYL-2-HYDROXYBENZYLALDEHYDE 3,5-DITERT-BUTYL-2-HYDROXYBENZALEDHYDE 3,5-Di-tert-butyl-2-hydroxybenzaldehyde,3,5-Di-tert-butylsalicylaldehyde 3,5-Bis(tert-butyl)salicylaldehyde 3,5-Di-tert-butyl-2-hydroxybenzaldehyde ,99% 3,5-Bis(tert-butyl)-2-hydroxybenzaldehyde 99% 3,5-Bis(tert-butyl)salicylaldehyde, 2,4-Bis(tert-butyl)-6-formylphenol 3,5-Di-tert-butyl-2-hydroxybenzaldehyde, 99%, for synthesis 3,5-Di-tert-butylsalicylaldehyde> Dapagliflozin Impurity 108 high quality 3,5-Bis(1,1-dimethylethyl)-2-hydroxy-benzaldehyde 3,5-Di-tert-butylsalicylaldehydene 3,5-Di-tert-butylsalicylaldehyd 3,5-Di-tert-butyl-2-hydroxybenzaldehyde 3,5-DI-TERT-BUTYL-2-HYDROXYBENZALDEHYDE 3,5-Bis(tert-butyl)-2-hydroxybenzaldehyde 37942-07-7 37492-07-7 39742-09-7 37942-04-7 HOC6H2CCH332CHO ALDEHYDE Carbonyl Compounds C10 to C21 Building Blocks Aldehydes Organic Building Blocks Building Blocks C13-C60 Carbonyl Compounds Chemical Synthesis Organic Building Blocks Aromatic Aldehydes & Derivatives (substituted) Aldehydes Phenyls & Phenyl-Het Phenyls & Phenyl-Het Achiral Oxygen 37942-07-7