PR104
- CAS No.
- 851627-62-8
- Chemical Name:
- PR104
- Synonyms
- PR104;PR-104/104A;PR 104;PR104;GZSOKPMDWVRVMG-UHFFFAOYSA-N;2-[N-(2-bromoethyl)-2,4-dinitro-6-(2-phosphonooxyethylcarbamoyl)anilino]ethyl methanesulfonate;2-((2-Bromoethyl)(2,4-dinitro-6-((2-(phosphonooxy)ethyl)carbamoyl)phenyl)amino)ethyl methanesulfonate;Benzamide, 2-[(2-bromoethyl)[2-[(methylsulfonyl)oxy]ethyl]amino]-3,5-dinitro-N-[2-(phosphonooxy)ethyl]-
- CBNumber:
- CB42655673
- Molecular Formula:
- C14H20BrN4O12PS
- Molecular Weight:
- 579.27
- MDL Number:
- MFCD25976844
- MOL File:
- 851627-62-8.mol
| storage temp. | 4°C, away from moisture and light |
|---|---|
| form | Solid |
| color | White to yellow |
| NCI Dictionary of Cancer Terms | PR-104 |
| FDA UNII | V16D2ZT7DT |
| NCI Drug Dictionary | PR-104 |
PR104 Chemical Properties,Uses,Production
Uses
PR-104 is a selective hypoxia-activated DNA cross-linking agent and can be used for the research of multiple tumor xenograft models. PR-104, as a nitrogen mustard pre-proagent, is converted efficiently to the more lipophilic dinitrobenzamide mustards alcohol PR-104A[1].
in vivo
PR-104 (0.56 mmol/kg; i.v. or i.p.; 0~2 hours) makes the plasma area under the curve. PR-104 (0.23 mmol/kg; i.p.; 100 days) shows antitumor activity[1].
| Animal Model: | CD-1nu/nu mice |
| Dosage: | 0.56 mmol/kg (Pharmacokinetics Analysis) |
| Administration: | I.v. or i.p. |
| Result: | The plasma area under the curve. |
| Animal Model: | CD1-Foxn1nu mice |
| Dosage: | 0.23 mmol/kg |
| Administration: | I.p. |
| Result: | Showed antitumor activity. |
References
[1] Patterson AV, et al. Mechanism of action and preclinical antitumor activity of the novel hypoxia-activated DNA cross-linking agent PR-104. Clin Cancer Res. 2007;13(13):3922-3932. DOI:10.1158/1078-0432.CCR-07-0478
PR104 Preparation Products And Raw materials
Raw materials
Preparation Products
PR104 Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Hangzhou MolCore BioPharmatech Co.,Ltd. | +86-057181025280; +8617767106207 | sales@molcore.com | China | 49734 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354; | support@targetmol.com | United States | 39031 | 58 |
| SPIRO PHARMA | eric_feng1954@126.com | China | 9248 | 55 | |
| Absin Bioscience Inc. | 021-38015121 18438616290 | lanwu@univ-bio.com | China | 24731 | 58 |
| TargetMol Chemicals Inc. | 4008200310 | marketing@tsbiochem.com | China | 24989 | 58 |
| Shanghai Yifei Biotechnology Co. , Ltd. | 021-65675885 18964387627 | customer_service@efebio.com | China | 11973 | 58 |
| RD International Technology Co., Limited | 18024082417 | market@ubiochem.com | China | 9835 | 58 |
| Jiangsu Aikon Biopharmaceutical R&D Co.,Ltd. | 025-66061636 18013972705 | qqyang@aikonchem.com | China | 10151 | 58 |
| Biosynth Biological Technology (Suzhou) Co Ltd | 51288865780 | sales@biosynth.com | China | 6051 | 58 |
| Adooq Bioscience LLC | 400-025-6535 | sales@adooq.cn | China | 6215 | 58 |
