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OTX015

OTX015 Structure
OTX015 structure
CAS No.
202590-98-5
Chemical Name:
OTX015
Synonyms
Birabresib;MK-8628;OTX-015;OTX 015;MK8628;OTX015;MK 8628;OXT-015;CS-1013;OTX015(OTX-015)
CBNumber:
CB42666673
Molecular Formula:
C25H22ClN5O2S
Molecular Weight:
491.99
MDL Number:
MFCD26960949
MOL File:
202590-98-5.mol
MSDS File:
SDS
TDS File:
TDS
Last updated:2026-06-01 12:03:18
Product description Number Pack Size Price
OTX015 ≥98% (HPLC) SML1605 5MG $269
OTX015 ≥98% (HPLC) SML1605 25MG $1050
OTX 015 O0482 10MG $145
OTX 015 O0482 50MG $505
OTX015 ≥95% 15947 1mg $54
More product size
Request For Quotation

OTX015 Properties

Melting point 220 °C
Density 1.45±0.1 g/cm3(Predicted)
storage temp. 2-8°C
solubility ≥24.6 mg/mL in DMSO; insoluble in H2O; ≥106 mg/mL in EtOH with gentle warming
form powder
pka 10.05±0.26(Predicted)
color white to light brown
InChIKey GNMUEVRJHCWKTO-FQEVSTJZSA-N
SMILES N12C(C)=NN=C1[C@H](CC(NC1=CC=C(O)C=C1)=O)N=C(C1=CC=C(Cl)C=C1)C1C(C)=C(C)SC=12
FDA UNII X40LKS49S3
UNSPSC Code 12352200
NACRES NA.77

SAFETY

Risk and Safety Statements

Symbol(GHS)  Exclamation Mark (GHS07)
GHS07
Signal word  Warning
Hazard statements  H302-H315-H319-H335
Precautionary statements  P261-P305+P351+P338
WGK Germany  WGK 3
HS Code  2934.99.3900
Storage Class 11 - Combustible Solids

OTX015 price More Price(108)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich SML1605 OTX015 ≥98% (HPLC) 202590-98-5 5MG $269 2026-04-30 Buy
Sigma-Aldrich SML1605 OTX015 ≥98% (HPLC) 202590-98-5 25MG $1050 2026-04-30 Buy
TCI Chemical O0482 OTX 015 202590-98-5 10MG $145 2026-04-30 Buy
TCI Chemical O0482 OTX 015 202590-98-5 50MG $505 2026-04-30 Buy
Cayman Chemical 15947 OTX015 ≥95% 202590-98-5 1mg $54 2026-04-30 Buy
Product number Packaging Price Buy
SML1605 5MG $269 Buy
SML1605 25MG $1050 Buy
O0482 10MG $145 Buy
O0482 50MG $505 Buy
15947 1mg $54 Buy

OTX015 Chemical Properties,Uses,Production

Description

OTX015 is a potent BET bromodomain inhibitor with EC50 ranging from 10 to 19 nM for BRD2, BRD3, and BRD4 in cell-free assays. Phase 1.

Features

Orally bioavailable BRD2/3/4-selective inhibitor that has been tested in Phase I clinical trials for treatment of Haematological Malignancies.

In vitro

OTX015 inhibits the binding of BRD2, BRD3, and BRD4 to AcH4 with IC50 ranging from 92 to 112 nM, and inhibits the growth of a variety of human cancer cell lines with GI50 ranging from 60 to 200 nM. OTX015 results in rapid down-regulation of c-MYC expression, and show the synergistic anti-proliferative effects in combination with ALK inhibitors in ALKpos ALCL cell lines.

In vivo

OTX015 (p.o.) significantly inhibits the growth of Ty82 BRD-NUT midline carcinoma tumors in nude mice by 79% at 100 mg/kg qd and 61% at 10 mg/kg bid, respectively.

Description

The bromodomain and extra terminal domain (BET) family of proteins, including BRD2, BRD3, and BRD4, play a key role in many cellular processes, including inflammatory gene expression, mitosis, and viral/host interaction by controlling the assembly of histone acetylation-dependent chromatin complexes. OTX015 is an orally bioavailable, small molecule inhibitor of BRD2, BRD3, and BRD4 (EC50s = 10-19 nM). It displays antiproliferative effects at a sub-micromolar range in vitro in a wide range of solid tumor types and leukemias, downregulating c-Myc expression and inducing cell cycle arrest and apoptosis. At 100 mg/kg, OTX015 has been shown to inhibit the growth of Ty82 BRD-NUT midline carcinoma tumors in nude mice by 79%.

Uses

(S)-2-(4-(4-Chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl)-N-(4-hydroxyphenyl)acetamide is an orally bioavailable, inhibitor of BRD2, BRD3, and BRD4 to AcH4 and shows anti-tumor activity in vitro and in vivo tumor models.

Definition

ChEBI: 6h-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepine-6-acetamide, 4-(4-chlorophenyl)-n-(4-hydroxyphenyl)-2,3,9-trimethyl-, (6s)- is an organonitrogen heterocyclic compound and an organosulfur heterocyclic compound.

Biochem/physiol Actions

It binds to bromodomain and extra-terminal domain (BET) proteins and inhibits their binding to the chromatin. This in turn prevents gene transcription. OTX015 has been shown to inhibit proliferation of cells in haematological malignancies.

target

BRD2

storage

Store at -20°C

References

[1] J. NOEL. Abstract C244: Development of the BET bromodomain inhibitor OTX015.[J]. Molecular Cancer Therapeutics, 2013, 12 1. DOI: 10.1158/1535-7163.targ-13-c244
[2] M. COUDE. Preclinical Study Of The Bromodomain Inhibitor OTX015 In Acute Myeloid (AML) and Lymphoid (ALL) Leukemias[J]. Blood, 2013, 122 1: 4218-4218. DOI: 10.1182/blood.v122.21.4218.4218
[3] M. BOI. Abstract A219: OTX015, a bromodomain and extraterminal inhibitor, represents a novel agent for ALK positive anaplastic large cell lymphoma.[J]. Molecular Cancer Therapeutics, 2013, 12 1. DOI: 10.1158/1535-7163.targ-13-a219

OTX015 Preparation Products And Raw materials

Raw materials

Preparation Products

OTX015 Suppliers

Global( 200)Suppliers
Supplier Tel Email Country ProdList Advantage
ATK CHEMICAL COMPANY LIMITED 		+undefined-21-51877795 ivan@atkchemical.com China 33024 60
Zhejiang ZETian Fine Chemicals Co. LTD 		+8618957127338 stella@zetchem.com China 2994 58
Biochempartner 		0086-13720134139 candy@biochempartner.com CHINA 965 58
Jilin Chinese Academy of Sciences - Yanshen Technology Co., Ltd. 		0431-80514535 13634302652 Extension@chemextension.com CHINA 967 58
career henan chemical co 		+86-0371-86658258 +8613203830695 factory@coreychem.com China 29792 58
Shanghai Daeyeon Chemicals Co., Ltd 		021-64478606 +8615900664856 daeyeon001@vip.163.com China 2062 58
TargetMol Chemicals Inc. 		+1-781-999-5354; +17819995354 marketing@targetmol.com United States 32466 58
Dideu Industries Group Limited 		+86-29-89586680 +86-15129568250 1026@dideu.com China 20582 58
Wuhan Fortuna Chemical Co., Ltd 		+86-27-59207850 info@fortunachem.com China 5983 58
BOC Sciences 		16314854226; +16314854226 inquiry@bocsci.com United States 19853 58
Supplier Advantage
ATK CHEMICAL COMPANY LIMITED 		60
Zhejiang ZETian Fine Chemicals Co. LTD 		58
Biochempartner 		58
Jilin Chinese Academy of Sciences - Yanshen Technology Co., Ltd. 		58
career henan chemical co 		58
Shanghai Daeyeon Chemicals Co., Ltd 		58
TargetMol Chemicals Inc. 		58
Dideu Industries Group Limited 		58
Wuhan Fortuna Chemical Co., Ltd 		58
BOC Sciences 		58

View Lastest Price from OTX015 manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
OTX015 pictures 2026-06-05 OTX015
202590-98-5
 1mg 98%min 50mg WUHAN FORTUNA CHEMICAL CO., LTD
Birabresib pictures 2026-06-01 Birabresib
202590-98-5
 $41.00-87.00 99.93% 10g TargetMol Chemicals Inc.
6H-?Thieno[3,?2-?f]?[1,?2,?4]?triazolo[4,?3-?a]?[1,?4]?diazepine-?6-?acetamide, 4-?(4-?chlorophenyl)?-?N-?(4-?hydroxyphenyl)?-?2,?3,?9-?trimethyl-?, (6S)?- pictures 2019-12-23 6H-?Thieno[3,?2-?f]?[1,?2,?4]?triazolo[4,?3-?a]?[1,?4]?diazepine-?6-?acetamide, 4-?(4-?chlorophenyl)?-?N-?(4-?hydroxyphenyl)?-?2,?3,?9-?trimethyl-?, (6S)?-
202590-98-5
 $1.00 1g Min98% HPLC Career Henan Chemical Co
  • OTX015 pictures
  • OTX015
    202590-98-5
  • $0.00
  • 98%min
  • WUHAN FORTUNA CHEMICAL CO., LTD
  • Birabresib pictures
  • Birabresib
    202590-98-5
  • $41.00-87.00
  • 99.93%
  • TargetMol Chemicals Inc.

OTX015 Spectrum

OTX015(202590-98-5)1HNMR

202590-98-5(OTX015)Related Search:

(+)-JQ-1 I-BET151 (GSK1210151A) RVX-208 CPI-203 I-BET-762
PFI-1

1of2

CS-1013 OXT-015 OTX 015; OTX015;MK-8628; MK 8628; MK8628;OTX-015 OTX015(OTX-015) 6H-Thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepine-6-acetamide, 4-(4-chlorophenyl)-N-(4-hydroxyphenyl)-2,3,9-trimethyl-, (6S)- MK 8628 MK8628 OTX015;OTX 015;OTX-015 2-((6S)-4-(4-chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl)-N-(4-hydroxyphenyl)acetamide OTX-015 (Birabresib) OTX015(MK-8628,Birabresib) OTX015; OTX-015; OTX 015; MK-8628; MK 8628; MK8628; BIRABRESIB. OTX015 (S)-4-(4-Chlorophenyl)-N-(4-hydroxyphenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepine-6-acetamide (6S)-4-(4-chlorophenyl)-N-(4-hydroxyphenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepine-6-acetamide (S)-4-(4-Chlorophenyl)-N-(4-hydroxyphenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepine-6-acetamide OTX-015 Birabresib(OTX-015) OTX015 USP/EP/BP Venadaparib Impurity 93 Birabresib, 10 mM in DMSO Birabresib MK-8628 OTX 015 OTX-015 202590-98-5 2202590-98-5 Inhibitors