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VE 822

VE 822 Structure
VE 822 structure
CAS No.
1232416-25-9
Chemical Name:
VE 822
Synonyms
Berzosertib;M6620;VX970 (VE-822);VX970;VE 822;M 6620;M-6620;CS-1487;M-66207;VE822; VE 822
CBNumber:
CB42667115
Molecular Formula:
C24H25N5O3S
Molecular Weight:
463.55
MDL Number:
MFCD27976794
MOL File:
1232416-25-9.mol
MSDS File:
SDS
Last updated:2026-05-11 19:39:08
Product description Number Pack Size Price
VE-822 ≥98% 24198 5mg $30
VE-822 ≥98% 24198 10mg $57
5-(4-(Isopropylsulfonyl)phenyl)-3-(3-(4-((methylamino)methyl)phenyl)isoxazol-5-yl)pyrazin-2-amine 302746 10.00mg $86
5-(4-(Isopropylsulfonyl)phenyl)-3-(3-(4-((methylamino)methyl)phenyl)isoxazol-5-yl)pyrazin-2-amine 302746 25.00mg $165
5-(4-(Isopropylsulfonyl)phenyl)-3-(3-(4-((methylamino)methyl)phenyl)isoxazol-5-yl)pyrazin-2-amine 302746 50.00mg $265
More product size
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VE 822 Properties

Melting point >197°C (dec.)
Boiling point 674.4±55.0 °C(Predicted)
Density 1.263±0.06 g/cm3(Predicted)
storage temp. Refrigerator
solubility DMSO (Slightly), Methanol (Slightly)
pka 8.88±0.10(Predicted)
form Solid
color Light Yellow
InChIKey JZCWLJDSIRUGIN-UHFFFAOYSA-N
SMILES C1(N)=NC=C(C2=CC=C(S(C(C)C)(=O)=O)C=C2)N=C1C1ON=C(C2=CC=C(CNC)C=C2)C=1
FDA UNII L423PRV3V3
NCI Drug Dictionary berzosertib

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS07
Signal word  Warning
Hazard statements  H302
Precautionary statements  P280-P305+P351+P338

VE 822 price More Price(29)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Cayman Chemical 24198 VE-822 ≥98% 1232416-25-9 5mg $30 2021-12-16 Buy
Cayman Chemical 24198 VE-822 ≥98% 1232416-25-9 10mg $57 2021-12-16 Buy
Matrix Scientific 302746 5-(4-(Isopropylsulfonyl)phenyl)-3-(3-(4-((methylamino)methyl)phenyl)isoxazol-5-yl)pyrazin-2-amine 1232416-25-9 10.00mg $86 2026-05-19 Buy
Matrix Scientific 302746 5-(4-(Isopropylsulfonyl)phenyl)-3-(3-(4-((methylamino)methyl)phenyl)isoxazol-5-yl)pyrazin-2-amine 1232416-25-9 25.00mg $165 2026-05-19 Buy
Matrix Scientific 302746 5-(4-(Isopropylsulfonyl)phenyl)-3-(3-(4-((methylamino)methyl)phenyl)isoxazol-5-yl)pyrazin-2-amine 1232416-25-9 50.00mg $265 2026-05-19 Buy
Product number Packaging Price Buy
24198 5mg $30 Buy
24198 10mg $57 Buy
302746 10.00mg $86 Buy
302746 25.00mg $165 Buy
302746 50.00mg $265 Buy

VE 822 Chemical Properties,Uses,Production

Uses

3-[3-[4-[(Methylamino)methyl]phenyl]-5-isoxazolyl]-5-[4-[(1-methylethyl)sulfonyl]phenyl]-2-pyrazinamine is a novel ATR (ATM-Rad3-related) inhibitor for in vitro and in vivo radiosensatization.

Definition

ChEBI: 3-[3-[4-(methylaminomethyl)phenyl]-5-isoxazolyl]-5-(4-propan-2-ylsulfonylphenyl)-2-pyrazinamine is a sulfonamide.

in vivo

PSN-1 xenografts are treated with Berzosertib (VE-822) (60 mk/kg; d0, 1), NSC 613327 (100 mg/kg; d0) and/or XRT (6 Gy; d1). Tumors are then harvested 2 h post-XRT. Berzosertib (VE-822) inhibits p-Ser-345-Chk1 in xenografts after DNA-damaging agents, establishing VE-822 as a potent inhibitor of ATR in vivo. Besides, Berzosertib (VE-822) enhances the therapeutic efficacy of radiation (XRT) in MiaPaCa-2 and PSN-1 xenograft models[1].

IC 50

ATR: 0.2 nM (Ki); ATM: 34 nM (Ki); PI3Kγ: 220 nM (Ki)

VE 822 Preparation Products And Raw materials

Raw materials

Preparation Products

VE 822 Suppliers

Global( 157)Suppliers
Supplier Tel Email Country ProdList Advantage
career henan chemical co 		+86-0371-86658258 +8613203830695 sales@coreychem.com China 29816 58
Zhengzhou Alfa Chemical Co.,Ltd 		+8618530059196 sale04@alfachem.cn China 9538 58
TargetMol Chemicals Inc. 		+1-781-999-5354; +17819995354 marketing@targetmol.com United States 32467 58
HANGZHOU CLAP TECHNOLOGY CO.,LTD 		86-571-88216897,88216896 13588875226 sales@hzclap.com CHINA 6312 58
Dideu Industries Group Limited 		+86-29-89586680 +86-15129568250 1026@dideu.com China 18895 58
Zhejiang J&C Biological Technology Co.,Limited 		+1-2135480471 +1-2135480471; sales@sarms4muscle.com China 10473 58
InvivoChem 		+1-708-310-1919 +1-13798911105 sales@invivochem.cn United States 6391 58
HANGZHOU LEAP CHEM CO., LTD. 		+86-571-87711850 market18@leapchem.com China 24597 58
Nantong HI-FUTURE Biology Co., Ltd. 		+undefined18051384581 sales@chemhifuture.com China 3135 58
ShenZhen Trendseen Biological Technology Co.,Ltd. 		13417589054 trendseenbio@gmail.com China 11681 58
Supplier Advantage
career henan chemical co 		58
Zhengzhou Alfa Chemical Co.,Ltd 		58
TargetMol Chemicals Inc. 		58
HANGZHOU CLAP TECHNOLOGY CO.,LTD 		58
Dideu Industries Group Limited 		58
Zhejiang J&C Biological Technology Co.,Limited 		58
InvivoChem 		58
HANGZHOU LEAP CHEM CO., LTD. 		58
Nantong HI-FUTURE Biology Co., Ltd. 		58
ShenZhen Trendseen Biological Technology Co.,Ltd. 		58

View Lastest Price from VE 822 manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
Berzosertib pictures 2026-05-11 Berzosertib
1232416-25-9
 US $30.00-93.00 / mg 99.61% 10g TargetMol Chemicals Inc.
VE 822 pictures 2025-12-01 VE 822
1232416-25-9
 US $0.00-0.00 / KG 1KG 98.0% 10000KGS Shaanxi Dideu New Materials Co. Ltd
VE 822 pictures 2019-07-06 VE 822
1232416-25-9
 US $2.00 / kg 1kg 99% 100kg Career Henan Chemical Co
  • Berzosertib pictures
  • Berzosertib
    1232416-25-9
  • US $30.00-93.00 / mg
  • 99.61%
  • TargetMol Chemicals Inc.
  • VE 822 pictures
  • VE 822
    1232416-25-9
  • US $0.00-0.00 / KG
  • 98.0%
  • Shaanxi Dideu New Materials Co. Ltd
  • VE 822 pictures
  • VE 822
    1232416-25-9
  • US $2.00 / kg
  • 99%
  • Career Henan Chemical Co

VE 822 Spectrum

VE 822(1232416-25-9)MSVE 822(1232416-25-9)1HNMR

1232416-25-9(VE 822)Related Search:

Y-27632 dihydrochloride VX-745 (S)-1-((S)-2-(4-amino-3-chlorobenzamido)-3,3-dimethylbutanoyl)-N-((2R,3S)-2-ethoxy-5-oxotetrahydrofuran-3-yl)pyrrolidine-2-carboxamide AVN-944 Telaprevir
VX-770 Pimodivir NU7441 (KU-57788) Bortezomib VE-821
KU-60019 Olaparib

1of3

VX970 (VE-822) 2-Pyrazinamine, 3-[3-[4-[(methylamino)methyl]phenyl]-5-isoxazolyl]-5-[4-[(1-methylethyl)sulfonyl]phenyl]- VX970 3-[3-[4-[(Methylamino)methyl]phenyl]-5-isoxazolyl]-5-[4-[(1-methylethyl)sulfonyl]phenyl]-2-pyrazinamine VE-822 VE 822 3-[3-[4-[(Methylamino)methyl]phenyl]-5-isoxazolyl]-5-[4-[(1-methylethyl)sulfonyl]phenyl]-2-pyrazinamine VE 822 3-[3-[4-[(Methylamino)methyl]phenyl]-5-isoxazolyl]-5-[4-[(1-methylethyl)sulfonyl]phenyl]-2-pyrazinamine VE822; VE 822 CS-1487 VE-822 (VX-970) Berzosertib (Synonyms: VE-822 M 6620 M6620 M-6620 M6620; M-6620; M 6620; VE822; VE-822; VE 822; VX970; VX-970; VX 970; 3-[3-[4-(methylaminomethyl)phenyl]-1,2-oxazol-5-yl]-5-(4-propan-2-ylsulfonylphenyl)pyrazin-2-amine VE-822 (Berzosertib) Berzosertib Berzosertib(VE-822) 3-(3-{4-[(methylamino)methyl]phenyl}-1,2-oxazol-5-yl)-5-[4-(propane-2-sulfonyl)phenyl]pyrazin-2-amine VE 822 USP/EP/BP 5-(4-(Isopropylsulfonyl)phenyl)-3-(3-(4-((methylamino)methyl)phenyl)isoxazol-5-yl)pyrazin-2-amine VE822 ATR inhibitor VE-822 2-Amino-5-[4-(isopropylsulfonyl)phenyl]-3-[3-[4-[(methylamino)methyl]phenyl]-5-isoxazolyl]pyrazine Berzosertib, 10 mM in DMSO 3-[3-[4-[(Methylamino)methyl]phenyl]-5-isoxazolyl]-5-[4-[(1-methylethyl)sulfonyl]phenyl]-2-pyrazinam M-66207 1232416-25-9 C24H25N5O3S Inhibitors