ChemicalBook >> CAS DataBase List >>L-Alanine, N-[(2,3,4,5,6-pentafluorophenoxy)phenoxyphosphinyl]-, 1-Methylethyl ester

L-Alanine, N-[(2,3,4,5,6-pentafluorophenoxy)phenoxyphosphinyl]-, 1-Methylethyl ester

L-Alanine, N-[(2,3,4,5,6-pentafluorophenoxy)phenoxyphosphinyl]-, 1-Methylethyl ester structure

CAS No.: 1256490-52-4

Chemical Name:: L-Alanine, N-[(2,3,4,5,6-pentafluorophenoxy)phenoxyphosphinyl]-, 1-Methylethyl ester

Synonyms: Isopropyl ((perfluorophenoxy)(phenoxy)phosphoryl)-L-alaninate;Sofosbuvir-003-S;2-naphthalen-7-ylethanamine;Octanedioicacid,3,11-dioxo-,dimethylester;(S)-Sofosbuvir Pentafluorophenoxy Analogue;N-[(2,3,4,5,6-pentafluorophenoxy)phenoxyphosphinyl]-, 1-...;(2S)-Isopropyl 2-((perfluorophenoxy)(phenoxy)phosphorylamino...;N-[(2,3,4,5,6-pentafluorophenoxy)phenoxyphosphinyl]-, 1-Methylethyl ester;Isopropyl (2S)-2-[[(Perfluorophenoxy)(phenoxy)phosphoryl]amino]propanoate;propan-2-yl (2S)-2-{[pentafluorophenoxy(phenoxy)phosphoryl]amino}propanoate

CBNumber:: CB42704706

Molecular Formula:: C18H17F5NO5P

Molecular Weight:: 453.3

MDL Number:: MFCD22665799

MOL File:: 1256490-52-4.mol

MSDS File:: SDS

Last updated:2025-07-24 18:13:42

Product description	Number	Pack Size	Price
Isopropyl (2S)-2-[[(2,3,4,5,6-pentafluorophenoxy)-phenoxy-phosphoryl]amino]propanoate	122537	1.00g	$594
propan-2-yl (2S)-2-{[pentafluorophenoxy(phenoxy)phosphoryl]amino}propanoate 98%	P50903	25G	$290
(2S)-Isopropyl 2-(((perfluorophenoxy)(phenoxy)phosphoryl)amino)propanoate 95+%	CD21016722	5g	$90
(2S)-Isopropyl 2-(((perfluorophenoxy)(phenoxy)phosphoryl)amino)propanoate 95+%	CD21016722	10g	$145
(2S)-Isopropyl 2-(((perfluorophenoxy)(phenoxy)phosphoryl)amino)propanoate 95+%	CD21016722	25g	$310

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L-Alanine, N-[(2,3,4,5,6-pentafluorophenoxy)phenoxyphosphinyl]-, 1-Methylethyl ester Properties

Boiling point	442.6±55.0 °C(Predicted)
Density	1.405±0.06 g/cm3(Predicted)
storage temp.	under inert gas (nitrogen or Argon) at 2-8°C
pka	-3.81±0.70(Predicted)

L-Alanine, N-[(2,3,4,5,6-pentafluorophenoxy)phenoxyphosphinyl]-, 1-Methylethyl ester price More Price(32)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Matrix Scientific	122537	Isopropyl (2S)-2-[[(2,3,4,5,6-pentafluorophenoxy)-phenoxy-phosphoryl]amino]propanoate	1256490-52-4	1.00g	$594	2026-05-18	Buy
ACHEMBLOCK	P50903	propan-2-yl (2S)-2-{[pentafluorophenoxy(phenoxy)phosphoryl]amino}propanoate 98%	1256490-52-4	25G	$290	2026-05-27	Buy
Crysdot	CD21016722	(2S)-Isopropyl 2-(((perfluorophenoxy)(phenoxy)phosphoryl)amino)propanoate 95+%	1256490-52-4	5g	$90	2026-05-27	Buy
Crysdot	CD21016722	(2S)-Isopropyl 2-(((perfluorophenoxy)(phenoxy)phosphoryl)amino)propanoate 95+%	1256490-52-4	10g	$145	2026-05-27	Buy
Crysdot	CD21016722	(2S)-Isopropyl 2-(((perfluorophenoxy)(phenoxy)phosphoryl)amino)propanoate 95+%	1256490-52-4	25g	$310	2026-05-27	Buy

Product number	Packaging	Price	Buy
122537	1.00g	$594	Buy
P50903	25G	$290	Buy
CD21016722	5g	$90	Buy
CD21016722	10g	$145	Buy
CD21016722	25g	$310	Buy

L-Alanine, N-[(2,3,4,5,6-pentafluorophenoxy)phenoxyphosphinyl]-, 1-Methylethyl ester Chemical Properties,Uses,Production

Synthesis

L-Alanine, N-(chlorophenoxyphosphinyl)-, 1-Methylethyl ester

261909-49-3

771-61-9

L-Alanine, N-[(2,3,4,5,6-pentafluorophenoxy)phenoxyphosphinyl]-, 1-Methylethyl ester

1256490-52-4

GENERAL STEPS: In a reaction flask equipped with a mechanical stirrer, a reflux condenser tube, a thermometer, and under nitrogen protection, a solution of (L)-alanine isopropyl ester hydrochloride (Q) (2.8 g, 16.8 mmol) prepared in Example 1 was added with methylene chloride (21 mL). The mixture was stirred at room temperature until a homogeneous suspension was formed. Subsequently, the mixture was cooled to -65°C to -55°C using a dry ice-acetone bath and triethylamine (3.9 g, 38.8 mmol) was added slowly, ensuring that the temperature was maintained below -50°C. The mixture was then cooled to -65°C to -55°C using a dry ice-acetone bath. After addition, cooling was continued to -65°C to -55°C and a solution of dichloromethane (11 mL) of phenyl dichlorophosphate (3.3 g, 15.6 mmol) was added dropwise, controlling the temperature to below -50°C. The reaction mixture was stirred at -65°C to -55°C until the reaction was complete (about 1 h). In another reaction flask equipped with the same apparatus, pentafluorophenol (2.4 g, 13.0 mmol) and dichloromethane (28 mL) were added. The mixture was cooled to 0°C to 5°C and triethylamine (1.6 g, 15.8 mmol) was added slowly, keeping the temperature below 10°C. After the addition, the temperature was raised to 20°C to 25°C and maintained for 1 h. It was then added to the previously prepared mixture, which had to be cooled down to -15°C to -10°C and ensuring that the internal temperature did not exceed 5°C. After the addition, the reaction mixture was After addition, the reaction mixture is warmed to 0°C to 5°C and maintained until the reaction is complete (about 1 hour). Water (8.7 mL) was added to the reaction system and the temperature was controlled to be below 10°C. The reaction was then warmed to 20°C to 25°C, partitioned, and the organic phase was washed with water and concentrated to dryness under reduced pressure. The residual solvent was removed by azeotropic isopropyl acetate to give 9.0 g of residue (quantitative yield) with diastereoisomer ratio Sp:flp = 50:50.

References

[1] Patent: WO2016/151542, 2016, A1. Location in patent: Page/Page column 23; 24
[2] Patent: WO2014/62596, 2014, A1. Location in patent: Page/Page column 60
[3] Patent: US2014/206640, 2014, A1. Location in patent: Paragraph 0286; 0287
[4] Patent: CN106543253, 2017, A. Location in patent: Paragraph 0086-0089
[5] Patent: WO2018/48937, 2018, A1. Location in patent: Page/Page column 220; 221

L-Alanine, N-[(2,3,4,5,6-pentafluorophenoxy)phenoxyphosphinyl]-, 1-Methylethyl ester Preparation Products And Raw materials

Raw materials

pentafluorophenyl phosphorodichloridate Pentafluorophenol L-Alanine, N-(chlorophenoxyphosphinyl)-, 1-Methylethyl ester SODIUM PENTAFLUOROPHENOXIDE Phenyl dichlorophosphate

D-Alanine Isopropyl Ester HCl Phenol Dichloromethane Triethylamine

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Preparation Products

PSI 7851

L-Alanine, N-[(2,3,4,5,6-pentafluorophenoxy)phenoxyphosphinyl]-, 1-Methylethyl ester Suppliers

Global( 48)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
ATK CHEMICAL COMPANY LIMITED	+undefined-21-51877795	ivan@atkchemical.com	China	33024	60
Standardpharm Co. Ltd.	86-714-3992388	overseasales1@yongstandards.com	United States	14332	58
career henan chemical co	+86-0371-86658258 +8613203830695	factory@coreychem.com	China	29792	58
HANGZHOU CLAP TECHNOLOGY CO.,LTD	86-571-88216897,88216896 13588875226	sales@hzclap.com	CHINA	6312	58
BOC Sciences	16314854226; +16314854226	inquiry@bocsci.com	United States	19853	58
Hefei TNJ Chemical Industry Co.,Ltd.	+86-0551-65418684 +8618949823763	sales@tnjchem.com	China	25356	58
Aceschem Inc.	+1-817863-6948 +1-（817）863-6948	sales@aceschem.com	United States	19632	58
Henan Fengda Chemical Co., Ltd	+86-371-86557731 +86-13613820652	info@fdachem.com	China	20122	58
Suzhou ARTK Medchem Co., Ltd.	+8618118463618	sales1@artkmedchem.com	China	39021	58
SHANGHAI KEAN TECHNOLOGY CO., LTD.	+8613817748580	cooperation@kean-chem.com	China	40066	58

Supplier	Advantage
ATK CHEMICAL COMPANY LIMITED	60
Standardpharm Co. Ltd.	58
career henan chemical co	58
HANGZHOU CLAP TECHNOLOGY CO.,LTD	58
BOC Sciences	58
Hefei TNJ Chemical Industry Co.,Ltd.	58
Aceschem Inc.	58
Henan Fengda Chemical Co., Ltd	58
Suzhou ARTK Medchem Co., Ltd.	58
SHANGHAI KEAN TECHNOLOGY CO., LTD.	58

View Lastest Price from L-Alanine, N-[(2,3,4,5,6-pentafluorophenoxy)phenoxyphosphinyl]-, 1-Methylethyl ester manufacturers

Image	Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
	2020-02-19	L-Alanine, N-[(2,3,4,5,6-pentafluorophenoxy)phenoxyphosphinyl]-, 1-Methylethyl ester 1256490-52-4	$1.00	1KG	99%	200kgs	Career Henan Chemical Co

L-Alanine, N-[(2,3,4,5,6-pentafluorophenoxy)phenoxyphosphinyl]-, 1-Methylethyl ester
1256490-52-4
$1.00
99%
Career Henan Chemical Co

1256490-52-4(L-Alanine, N-[(2,3,4,5,6-pentafluorophenoxy)phenoxyphosphinyl]-, 1-Methylethyl ester)Related Search:

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L-Alanine, N-[(2,3,4,5,6-pentafluorophenoxy)phenoxyphosphinyl]-, 1-Methylethyl ester Isopropyl (2S)-2-[[(2,3,4,5,6-pentafluorophenoxy)-phenoxy-phosphoryl]amino]propanoate propan-2-yl (2S)-2-{[pentafluorophenoxy(phenoxy)phosphoryl]amino}propanoate N-[(2,3,4,5,6-pentafluorophenoxy)phenoxyphosphinyl]-, 1-Methylethyl ester Sofosbuvir-003-S Sofosbuvir impurity 1/2(S)-[(2,3,4,5,6-pentafluoro-phenoxy)-phenoxy-phosphorylamino]propionic acid isopropyl ester N-[(2,3,4,5,6-pentafluorophenoxy)phenoxyphosphinyl]-, 1-... (2S)-Isopropyl 2-((perfluorophenoxy)(phenoxy)phosphorylamino... (S)-Sofosbuvir Pentafluorophenoxy Analogue 2-naphthalen-7-ylethanamine Octanedioicacid,3,11-dioxo-,dimethylester Isopropyl (2S)-2-[[(Perfluorophenoxy)(phenoxy)phosphoryl]amino]propanoate Isopropyl ((perfluorophenoxy)(phenoxy)phosphoryl)-L-alaninate 1256490-52-4