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ChemicalBook >> CAS DataBase List >>tert-Butyl 4-broMo-1H-pyrrolo[2,3-b]pyridine-1-carboxylate

tert-Butyl 4-broMo-1H-pyrrolo[2,3-b]pyridine-1-carboxylate

tert-Butyl 4-broMo-1H-pyrrolo[2,3-b]pyridine-1-carboxylate Structure
tert-Butyl 4-broMo-1H-pyrrolo[2,3-b]pyridine-1-carboxylate structure
CAS No.
1228014-35-4
Chemical Name:
tert-Butyl 4-broMo-1H-pyrrolo[2,3-b]pyridine-1-carboxylate
Synonyms
1-Boc-4-bromo-7-azaindole;tert-butyl 4-bromopyrrolo[2,3-b]pyridine-1-carboxylate;tert-Butyl 4-broMo-1H-pyrrolo[2,3-b]pyridine-1-carboxylate;4-Bromo-pyrrolo[2,3-b]pyridine-1-carboxylic acid tert-butyl ester;1H-Pyrrolo[2,3-b]pyridine-1-carboxylic acid, 4-bromo-, 1,1-dimethylethyl ester
CBNumber:
CB42708113
Molecular Formula:
C12H13BrN2O2
Molecular Weight:
297.15
MDL Number:
MFCD20527472
MOL File:
1228014-35-4.mol
MSDS File:
SDS
Last updated:2026-05-28 05:15:43
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tert-Butyl 4-broMo-1H-pyrrolo[2,3-b]pyridine-1-carboxylate Properties

Boiling point 376.7±45.0 °C(Predicted)
Density 1.46±0.1 g/cm3(Predicted)
storage temp. under inert gas (nitrogen or Argon) at 2-8°C
pka 3.16±0.30(Predicted)
Appearance orange oil

SAFETY

Risk and Safety Statements

Symbol(GHS)  Exclamation Mark (GHS07)
GHS07
Signal word  Warning
Hazard statements  H302
Precautionary statements  P280-P305+P351+P338

tert-Butyl 4-broMo-1H-pyrrolo[2,3-b]pyridine-1-carboxylate price More Price(31)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Matrix Scientific 296642 tert-Butyl 4-bromo-1H-pyrrolo[2,3-b]pyridine-1-carboxylate 1228014-35-4 250.00mg $43 2026-05-19 Buy
Matrix Scientific 296642 tert-Butyl 4-bromo-1H-pyrrolo[2,3-b]pyridine-1-carboxylate 1228014-35-4 1.00g $87 2026-05-19 Buy
Matrix Scientific 296642 tert-Butyl 4-bromo-1H-pyrrolo[2,3-b]pyridine-1-carboxylate 1228014-35-4 5.00g $252 2026-05-19 Buy
Synthonix B17758 tert-Butyl 4-bromo-1H-pyrrolo[2,3-b]pyridine-1-carboxylate 97% 1228014-35-4 100mg $38 2026-05-06 Buy
Synthonix B17758 tert-Butyl 4-bromo-1H-pyrrolo[2,3-b]pyridine-1-carboxylate 97% 1228014-35-4 250mg $44 2026-05-06 Buy
Product number Packaging Price Buy
296642 250.00mg $43 Buy
296642 1.00g $87 Buy
296642 5.00g $252 Buy
B17758 100mg $38 Buy
B17758 250mg $44 Buy

tert-Butyl 4-broMo-1H-pyrrolo[2,3-b]pyridine-1-carboxylate Chemical Properties, Uses, Production

Synthesis

Di-tert-butyl dicarbonate

24424-99-5

4-Bromo-7-azaindole

348640-06-2

tert-Butyl 4-broMo-1H-pyrrolo[2,3-b]pyridine-1-carboxylate

1228014-35-4

4-Bromo-1H-pyrrolo[2,3-b]pyridine (XCI) (5 g, 25.4 mmol, 1 eq.) was used as a starting material, which was dissolved in dichloromethane (DCM) (100 mL), 4-dimethylaminopyridine (DMAP) (311 mg, 2.55 mmol, 0.1 eq.) and triethylamine (TEA) (5.3 mL) were added. Di-tert-butyl dicarbonate (Boc2O) (7.2 mL, 31 mmol, 1.2 eq.) was slowly added to the reaction mixture at 0 °C. The reaction system was gradually warmed to room temperature and stirred continuously for 2 hours. Upon completion of the reaction, it was quenched by addition of water (100 mL) and extracted twice with dichloromethane (DCM). The organic phases were combined and concentrated under reduced pressure to remove the solvent to afford tert-butyl 4-bromo-1H-pyrrolo[2,3-b]pyridine-1-carboxylate (XCII) as a colorless oil (6.95 g, 23.4 mmol, 92.1% yield). The product was confirmed by 1H NMR (CDCl3, 400 MHz): δ 1.60 (s, 9H), 6.50 (d, J = 4 Hz, 1H), 7.31 (d, J = 5.2 Hz, 1H), 7.63 (d, J = 4 Hz, 1H), 8.23 (d, J = 5.2 Hz, 1H); electrospray ionization mass spectrometry (ESIMS) analysis showed molecular ion peaks m/z 297.1 (M + H), consistent with the expected molecular formula C12H13BrN2O2.

References

[1] Patent: WO2017/24021, 2017, A1. Location in patent: Paragraph 0694; 0695
[2] Patent: WO2017/24004, 2017, A1. Location in patent: Paragraph 0676
[3] Patent: WO2017/23980, 2017, A1. Location in patent: Paragraph 0676
[4] Patent: WO2017/23996, 2017, A1. Location in patent: Paragraph 0676
[5] Patent: WO2012/101654, 2012, A2. Location in patent: Page/Page column 59

tert-Butyl 4-broMo-1H-pyrrolo[2,3-b]pyridine-1-carboxylate Preparation Products And Raw materials

Raw materials

Di-tert-butyl dicarbonate 4-Bromo-7-azaindole Triethylamine Dichloromethane 4-Dimethylaminopyridine

Preparation Products

tert-Butyl 4-broMo-1H-pyrrolo[2,3-b]pyridine-1-carboxylate Suppliers

Global Suppliers ( 36)
Supplier Tel Email Country ProdList Advantage
Shanghai HuanChuan Industry Co.,Ltd. 021-61478794 sales@hcshhai.com China 9781 50
Shanghai GaoDao Pharmaceutical Co., Ltd. 021-15001867143 15001867143 1095570358@qq.com China 915 55
SuZhou ShiYa Biopharmaceuticals, Inc. 0512-0512-52358471 17715136450 sales@shiyabiopharm.com China 9814 58
Amadis Chemical Company Limited 571-89925085 sales@amadischem.com China 131885 58
Aikon International Limited 025-66061636 19370895928 qqyang@aikonchem.com China 15810 58
Labnetwork lnc. +86-27-50766799 +86-18062016861 contact@labnetwork.com China 19981 58
Henan Weituxi Chemical Technology Co., Ltd. 0371-63284658 18135795563 3905209149@qq.com China 9705 58
Shanghai Lanle Bird Industrial Co., Ltd. 15021845385 765325601@qq.com China 3607 58
Nanjing xiangrui technology co. LTD 021-021-00000000 15715199582 njrich168@163.com China 500 58
Chongqing Chemdad Co., Ltd +86-023-6139-8061 +86-86-13650506873 sales@chemdad.com China 39866 58
Supplier Advantage
Shanghai HuanChuan Industry Co.,Ltd. 50
Shanghai GaoDao Pharmaceutical Co., Ltd. 55
SuZhou ShiYa Biopharmaceuticals, Inc. 58
Amadis Chemical Company Limited 58
Aikon International Limited 58
Labnetwork lnc. 58
Henan Weituxi Chemical Technology Co., Ltd. 58
Shanghai Lanle Bird Industrial Co., Ltd. 58
Nanjing xiangrui technology co. LTD 58
Chongqing Chemdad Co., Ltd 58

tert-Butyl 4-broMo-1H-pyrrolo[2,3-b]pyridine-1-carboxylate Spectrum

tert-Butyl 4-broMo-1H-pyrrolo[2,3-b]pyridine-1-carboxylate(1228014-35-4)1HNMR

1228014-35-4 (tert-Butyl 4-broMo-1H-pyrrolo[2,3-b]pyridine-1-carboxylate) Related Search:

4-Bromo-1-methyl-1H-pyrrolo[2,3-b]pyridine 4-Bromo-1-[(4-methylphenyl)sulfonyl]-1H-pyrrolo[2,3-b]pyridine 4-Bromo-7-azaindole tert-Butyl 3-bromo-1H-pyrrolo[2,3-b]pyridine-1-carboxylate 5-Bromo-pyrrolo[2,3-b]pyridine-1-carboxylicacidtert-butylester
1-Boc-7-azaindole

1of2

tert-Butyl 4-broMo-1H-pyrrolo[2,3-b]pyridine-1-carboxylate 4-Bromo-pyrrolo[2,3-b]pyridine-1-carboxylic acid tert-butyl ester 1H-Pyrrolo[2,3-b]pyridine-1-carboxylic acid, 4-bromo-, 1,1-dimethylethyl ester 1-Boc-4-bromo-7-azaindole tert-butyl 4-bromopyrrolo[2,3-b]pyridine-1-carboxylate 1228014-35-4