Methyl 5-iodothiophene-2-carboxylate
- CAS No.
- 88105-22-0
- Chemical Name:
- Methyl 5-iodothiophene-2-carboxylate
- Synonyms
- Methyl 5-iodothiophene-2-carboxylate;5-iodo-2-Thiophenecarboxylic acid methyl ester;5-Iodo-thiophene-2-carboxylic acid methyl ester;2-Thiophenecarboxylic acid, 5-iodo-, methyl ester
- CBNumber:
- CB42710165
- Molecular Formula:
- C6H5IO2S
- Molecular Weight:
- 268.07
- MDL Number:
- MFCD18072497
- MOL File:
- 88105-22-0.mol
Methyl 5-iodothiophene-2-carboxylate price More Price(39)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Apolloscientific | OR315303 | Methyl 5-iodothiophene-2-carboxylate 97% | 88105-22-0 | 250mg | $21 | 2026-06-04 | Buy |
| Apolloscientific | OR315303 | Methyl 5-iodothiophene-2-carboxylate 97% | 88105-22-0 | 1g | $24 | 2026-06-04 | Buy |
| Apolloscientific | OR315303 | Methyl 5-iodothiophene-2-carboxylate 97% | 88105-22-0 | 5g | $70 | 2026-06-04 | Buy |
| Apolloscientific | OR315303 | Methyl 5-iodothiophene-2-carboxylate 97% | 88105-22-0 | 25g | $343 | 2026-06-04 | Buy |
| Activate Scientific | AS42599 | Methyl 5-iodothiophene-2-carboxylate 95% | 88105-22-0 | 1g | $46 | 2026-06-04 | Buy |
Methyl 5-iodothiophene-2-carboxylate Chemical Properties, Uses, Production
Synthesis
5380-42-7
![[Bis(trifluoroacetoxy)iodo]benzene](/CAS/GIF/2712-78-9.gif)
2712-78-9
88105-22-0
Steps for the synthesis of methyl 5-iodothiophene-2-carboxylate (P-1): methyl thiophene-2-carboxylate (5.0 g, 28.7 mmol) was dissolved in 35 mL of anhydrous carbon tetrachloride under nitrogen protection. Iodine (3.65 g, 14.37 mmol) and [bis(trifluoroacetoxy)iodo]benzene (6.67 g, 15.52 mmol) were then added sequentially. The reaction mixture was stirred overnight at room temperature. Upon completion of the reaction, it was diluted with the addition of dichloromethane and extracted with 10% sodium thiosulfate solution to remove unreacted iodine. The organic layer was separated, dried over anhydrous sodium sulfate and concentrated under reduced pressure to remove the solvent. The crude product was purified by fast column chromatography (eluent: 40% hexane/60% chloroform) to give a white solid. For further purification, the resulting solid was co-milled with pentane to remove residual feedstock, resulting in the target compound P-1 (4.8 g, 63% yield). The structure of the product was confirmed by 1H NMR (400 MHz, CDCl3): δ 3.89 (s, 3H), 7.28 (d, J = 3.9 Hz, 1H), 7.45 (d, J = 3.9 Hz, 1H).
References
[1] Patent: US6274620, 2001, B1
Methyl 5-iodothiophene-2-carboxylate Preparation Products And Raw materials
Raw materials
1of2
Preparation Products
Methyl 5-iodothiophene-2-carboxylate Suppliers
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