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ERDAFITINIB

ERDAFITINIB structure

CAS No.: 1346242-81-6

Chemical Name:: ERDAFITINIB

Synonyms: JNJ-42756493;CS-2043;Erdafitinib;erdafitnnib;Suftalan Zine;Erdafitinib-d6;2H6]-Erdafitinib;Erdafitinib(JNJ-42756493);JNJ-42756493 (Erdafitinib);Erdafitinib, 10 mM in DMSO

CBNumber:: CB42725628

Molecular Formula:: C25H30N6O2

Molecular Weight:: 446.54

MDL Number:: MFCD28502040

MOL File:: 1346242-81-6.mol

Last updated:2025-11-10 14:44:25

Product description	Number	Pack Size	Price
JNJ-42756493 ≥98%	21813	1mg	$31
JNJ-42756493 ≥98%	21813	5mg	$85
JNJ-42756493 ≥98%	21813	10mg	$138
JNJ-42756493 ≥98%	21813	25mg	$269
Erdafitinib	E594600	1mg	$45
More product size

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ERDAFITINIB Properties

Melting point	136-140°C
Boiling point	662.3±55.0 °C(Predicted)
Density	1.20±0.1 g/cm3(Predicted)
storage temp.	-20°C Freezer, Under inert atmosphere
solubility	DMSO (Slightly), Methanol (Slightly)
pka	9.45±0.29(Predicted)
form	Solid
color	Yellow
InChI	InChI=1S/C25H30N6O2/c1-17(2)26-8-9-31(20-10-21(32-4)13-22(11-20)33-5)19-6-7-23-24(12-19)29-25(15-27-23)18-14-28-30(3)16-18/h6-7,10-17,26H,8-9H2,1-5H3
InChIKey	OLAHOMJCDNXHFI-UHFFFAOYSA-N
SMILES	C(N(C1=CC(OC)=CC(OC)=C1)C1=CC=C2C(=C1)N=C(C1=CN(C)N=C1)C=N2)CNC(C)C
NCI Dictionary of Cancer Terms	erdafitinib
FDA UNII	890E37NHMV
NCI Drug Dictionary	erdafitinib
ATC code	L01EX16

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS07,GHS08,GHS05

Signal word

Danger

Hazard statements

H302-H318-H361-H413-H372-H317

Precautionary statements

P201-P202-P281-P308+P313-P405-P501-P261-P272-P280-P302+P352-P333+P313-P321-P363-P501-P264-P270-P301+P312-P330-P501-P260-P264-P270-P314-P501-P280-P305+P351+P338-P310

NFPA 704

	0
3		0

ERDAFITINIB price More Price(19)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Cayman Chemical	21813	JNJ-42756493 ≥98%	1346242-81-6	1mg	$31	2024-03-01	Buy
Cayman Chemical	21813	JNJ-42756493 ≥98%	1346242-81-6	5mg	$85	2024-03-01	Buy
Cayman Chemical	21813	JNJ-42756493 ≥98%	1346242-81-6	10mg	$138	2024-03-01	Buy
Cayman Chemical	21813	JNJ-42756493 ≥98%	1346242-81-6	25mg	$269	2024-03-01	Buy
TRC	E594600	Erdafitinib	1346242-81-6	1mg	$45	2021-12-16	Buy

Product number	Packaging	Price	Buy
21813	1mg	$31	Buy
21813	5mg	$85	Buy
21813	10mg	$138	Buy
21813	25mg	$269	Buy
E594600	1mg	$45	Buy

ERDAFITINIB Chemical Properties,Uses,Production

Description

Erdafitinib is an oral pan-FGFR (1-4) inhibitor with has demonstrated promising activity in patients with metastatic or unresectable UC and other histologies (eg, cholangiocarcinoma) with FGFR alterations. It is used in the therapy of locally advanced, unresectable or metastatic urothelial carcinoma. Erdafitinib has been associated with a high rate of serum enzyme elevations during therapy, but has not been linked to cases of clinically apparent acute liver injury.

History

In early April of 2019, the US FDA approved Janssen Pharmaceutical Companies' brand name Balversa (erdafitinib) as the first-ever fibroblast growth factor receptor (FGFR) kinase inhibitor indicated for patients with locally advanced or metastatic urothelial carcinoma, with susceptible FGFR3 or FGFR2 genetic alterations, that has progressed during or following platinum-containing chemotherapy, including within 12 months of neoadjuvant or adjuvant platinum-containing chemotherapy. At the same time, the FDA also approved the therascreen FGFR RGQ RT-PCR Kit (Qiagen) for utilization as a companion diagnostic with erdafitinib for selecting patients for the indicated therapy.

Uses

Erdafitinib is a fibroblast growth factor receptor inhibitor.

brand name

Balversa

General Description

Class: receptor tyrosine kinase; Treatment: metastatic urothelial carcinoma; Other name: JNJ-4275693; Elimination half-life = 59 h; Protein binding = 99.8%

Biological Activity

Erdafitinib binds to and inhibits the enzymatic activity of FGFR1−4, preventing phosphorylation and cell signaling. In addition, Erdafitinib also binds to Fms-related tyrosine kinase 4 (FLT4), tyrosine-protein kinase c-KIT, and vascular endothelial growth factor receptor 2 (VEGFR-2).

Synthesis

Synthesis of Erdafitinib

target

Primary targets: Pan-FGFR

References

[1] Patent: WO2011/135376, 2011, A1. Location in patent: Page/Page column 253

ERDAFITINIB Preparation Products And Raw materials

Raw materials

2-((3,5-dimethoxyphenyl)(3-(1-methyl-1H-pyrazol-4-yl)quinoxalin-6-yl)amino)ethyl methanesulfonate Isopropylamine

Preparation Products

ERDAFITINIB Suppliers

Global( 193)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Apeloa production Co.,Limited	+8619933239880	admin@apcl.com.cn	China	861	58
BEIJING SJAR TECHNOLOGY DEVELOPMENT CO., LTD.	+86-18600796368	sales@sjar-tech.com	China	504	58
ATK CHEMICAL COMPANY LIMITED	+undefined-21-51877795	ivan@atkchemical.com	China	33024	60
BOC Sciences	+1-631-485-4226	inquiry@bocsci.com	United States	19552	58
career henan chemical co	+86-0371-86658258 +8613203830695	factory@coreychem.com	China	29798	58
TargetMol Chemicals Inc.	+1-781-999-5354; +17819995354	marketing@targetmol.com	United States	32435	58
Hubei Ipure Biology Co., Ltd	+8613367258412	ada@ipurechemical.com	China	10237	58
HANGZHOU CLAP TECHNOLOGY CO.,LTD	86-571-88216897,88216896 13588875226	sales@hzclap.com	CHINA	6312	58
Changzhou Xuanming Pharmaceutical Technology Co., Ltd.	+86-519-85525359 +86-15995072465	sales@xuanmingchem.com	China	912	58
Finetech Industry Limited	+86-27-8746-5837 +8619945049750	info@finetechnology-ind.com	China	9629	58

Supplier	Advantage
Apeloa production Co.,Limited	58
BEIJING SJAR TECHNOLOGY DEVELOPMENT CO., LTD.	58
ATK CHEMICAL COMPANY LIMITED	60
BOC Sciences	58
career henan chemical co	58
TargetMol Chemicals Inc.	58
Hubei Ipure Biology Co., Ltd	58
HANGZHOU CLAP TECHNOLOGY CO.,LTD	58
Changzhou Xuanming Pharmaceutical Technology Co., Ltd.	58
Finetech Industry Limited	58

Erdafitinib can be used to treat urothelial cancer
Erdafitinib, also known as JNJ-42756493, is a first-in-class pan-fibroblast growth factor receptor (FGFR) kinase inhibitor dis....
Jan 19，2024

View Lastest Price from ERDAFITINIB manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2025-11-10	Erdafitinib 1346242-81-6	US $39.00-97.00 / mg		99.07%	10g	TargetMol Chemicals Inc.
2025-09-11	Erdafitinib 1346242-81-6	US $0.00 / g	1g	More Than 99%	100kg/Month	BEIJING SJAR TECHNOLOGY DEVELOPMENT CO., LTD.
2025-08-22	Erdafitinib	US $0.00-0.00 / kg	1kg	99%	1	Jinan Ruitong Biotech Co., Ltd.

Erdafitinib
1346242-81-6
US $39.00-97.00 / mg
99.07%
TargetMol Chemicals Inc.

Erdafitinib
1346242-81-6
US $0.00 / g
More Than 99%
BEIJING SJAR TECHNOLOGY DEVELOPMENT CO., LTD.

Erdafitinib
US $0.00-0.00 / kg
99%
Jinan Ruitong Biotech Co., Ltd.

ERDAFITINIB Spectrum

ERDAFITINIB(1346242-81-6)¹HNMR

1346242-81-6(ERDAFITINIB)Related Search:

Panitumumab

JNJ-42756493 Erdafitinib Erdafitinib(JNJ-42756493) N-(3,5-dimethoxyphenyl)-N'-(1-methylethyl)-N-[3-(1-methyl-1H-pyrazol-4-yl)quinoxalin-6-yl]ethane-1,2-diamine N1-(3,5-Dimethoxyphenyl)-N2-(1-methylethyl)-N1-[3-(1-methyl-1H-pyrazol-4-yl)-6-quinoxalinyl]-1,2-ethanediamine Suftalan Zine N-(3,5-Dimethoxyphenyl)-N'-isopropyl-N-[3-(1-methyl-1H-pyrazol-4-yl)-6-quinoxalinyl]-1,2-ethanediamine N1-(3,5-dimethoxyphenyl)-N2-isopropyl-N1-(3-(1-methyl-1H-pyrazol-4-yl)quinoxalin-6-yl)ethane-1,2-diamine ERDAFITINIB;JNJ-42756493 ;JNJ 42756493 ;JNJ42756493 CS-2043 JNJ-42756493; JNJ 42756493; JNJ42756493; ERDAFITINIB 1,2-Ethanediamine, N1-(3,5-dimethoxyphenyl)-N2-(1-methylethyl)-N1-[3-(1-methyl-1H-pyrazol-4-yl)-6-quinoxalinyl]- Erdafitinib-d6 JNJ-42756493 (Erdafitinib) 5-amino-6-fluoropyridine-7-carbonitrile 2H6]-Erdafitinib erdafitnnib Erdafitinib, 10 mM in DMSO N1-(3,5-Dimethoxyphenyl)-N2-isopropyl-N1-[3-(1-methyl-4-pyrazolyl)-6-quinoxalinyl]-1,2-ethanediamine 1346242-81-6 API