HJC-0123
- CAS No.
- 1430420-02-2
- Chemical Name:
- HJC-0123
- Synonyms
- HJC-0123;4-Quinolinecarboxamide, N-(1,1-dioxidobenzo[b]thien-6-yl)-2-phenyl-
- CBNumber:
- CB42731067
- Molecular Formula:
- C24H16N2O3S
- Molecular Weight:
- 412.46
- MDL Number:
- MOL File:
- 1430420-02-2.mol
- MSDS File:
- SDS
- TDS File:
- TDS
HJC-0123 price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| ChemScene | CS-0066320 | HJC0123 99.06% | 1430420-02-2 | 5mg | $81 | 2026-06-04 | Buy |
| ChemScene | CS-0066320 | HJC0123 99.06% | 1430420-02-2 | 10mg | $130 | 2026-06-04 | Buy |
| ChemScene | CS-0066320 | HJC0123 99.06% | 1430420-02-2 | 25mg | $260 | 2026-06-04 | Buy |
| ChemScene | CS-0066320 | HJC0123 99.06% | 1430420-02-2 | 50mg | $417 | 2026-06-04 | Buy |
| ChemScene | CS-0066320 | HJC0123 99.06% | 1430420-02-2 | 100mg | $666 | 2026-06-04 | Buy |
HJC-0123 Chemical Properties, Uses, Production
Description
Downregulate phosphorylation of STAT3, increase the expression of cleaved caspase-3, inhibit cell cycle progression and promote apoptosis in breast and pancreatic cancer cells with low micromolar to nanomolar IC50 values. Furthermore, HJC-0123 significantly suppressed estrogen receptor (ER)-negative breast cancer MDA-MB-231 xenograft tumor growth in vivo (p.o.), indicating its great potential as an efficacious and orally bioavailable drug candidate for human cancer therapy.
Uses
HJC0123 is a STAT3 inhibitor. HJC0123 inhibits the proliferation of hepatic stellate cells and induces cell cycle arrest and apoptosis. HJC0123 reduces the phosphorylation, nuclear translocation and transcriptional activities of STAT3, increases the production of IL-6, inhibits the phosphorylation of Smad2/3 and down-regulates SOCS3. HJC0123 can be used in the study of liver fibrosis[1].
IC 50
STAT3; IL-6
References
[1] Nunez Lopez O, et al. STAT3 Inhibition Suppresses Hepatic Stellate Cell Fibrogenesis: HJC0123, a Potential Therapeutic Agent for Liver Fibrosis. RSC Adv. 2016;6(102):100652-100663. DOI:10.1039/C6RA17459K
HJC-0123 Preparation Products And Raw materials
Raw materials
Preparation Products
HJC-0123 Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| BOC Sciences | 1-631-485-4226; 16314854226 | info@bocsci.com | United States | 9920 | 65 |
| Shanghai Beckham Medical Technology Co., Ltd | 13816613772 | huahero21@sina.com | China | 2994 | 55 |
| Guangzhou Younan Technology Co., Ltd | 020-82000279 18988941452 | YN_research@163.com | China | 2984 | 58 |
| TargetMol Chemicals Inc. | 15002134094 | marketing@targetmol.cn | China | 29873 | 58 |
| TargetMol Chemicals Inc. | 13564774135 | marketing@targetmol.com | United States | 19950 | 58 |
| Supplier | Advantage |
|---|---|
| BOC Sciences | 65 |
| Shanghai Beckham Medical Technology Co., Ltd | 55 |
| Guangzhou Younan Technology Co., Ltd | 58 |
| TargetMol Chemicals Inc. | 58 |
| TargetMol Chemicals Inc. | 58 |
