Siponimod
- CAS No.
- 1378888-43-7
- Chemical Name:
- Siponimod
- Synonyms
- SIPO-013;Siponimod intermediate;1-(3-ethyl-4-hydroxymethyl)acetophenone;1-(3-Ethyl-4-(hydroxymethyl)phenyl)ethanone;1-(3-ethyl-4-(hydroxymethyl)phenyl)ethan-1-on;1-(3-ethyl-4-(hydroxymethyl)phenyl)ethan-1-one;Ethanone, 1-[3-ethyl-4-(hydroxymethyl)phenyl]-;1-(3-ethyl-4-(hydroxymethyl)phenyl)Phenyl)Ethanone;1-(3-Ethyl-4-(hydroxymethyl)phenyl)ethanone Ethanone;1-(3-Ethyl-4-hydroxymethylphenyl)ethanone （Siponimod）
- CBNumber:
- CB42741484
- Molecular Formula:
- C11H14O2
- Molecular Weight:
- 178.23
- MDL Number:
- MFCD18910891
- MOL File:
- 1378888-43-7.mol
- MSDS File:
- SDS
| Product description | Number | Pack Size | Price |
| 1-(3-Ethyl-4-(hydroxymethyl)phenyl)ethanone 95% | A790327 | 100mg | $20 |
| 1-(3-Ethyl-4-(hydroxymethyl)phenyl)ethanone 95% | A790327 | 250mg | $30 |
| 1-(3-Ethyl-4-(hydroxymethyl)phenyl)ethanone 95% | A790327 | 1g | $74 |
| 1-(3-Ethyl-4-(hydroxymethyl)phenyl)ethanone 95% | A790327 | 5g | $222 |
| 1-[3-ethyl-4-(hydroxymethyl)phenyl]ethan-1-one 97% | P48493 | 5G | $240 |
| More product size | |||
| Boiling point | 331.9±37.0 °C(Predicted) |
|---|---|
| Density | 1.063±0.06 g/cm3(Predicted) |
| storage temp. | Inert atmosphere,Room Temperature |
| pka | 14.26±0.10(Predicted) |
| Appearance | White to off-white Solid |
| InChI | InChI=1S/C11H14O2/c1-3-9-6-10(8(2)13)4-5-11(9)7-12/h4-6,12H,3,7H2,1-2H3 |
| InChIKey | UAOSVSMWAUFYMM-UHFFFAOYSA-N |
| SMILES | C(=O)(C1=CC=C(CO)C(CC)=C1)C |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302-H315-H319 |
| Precautionary statements | P261-P305+P351+P338 |
| HS Code | 2914409000 |
Siponimod price More Price(8)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Ambeed | A790327 | 1-(3-Ethyl-4-(hydroxymethyl)phenyl)ethanone 95% | 1378888-43-7 | 100mg | $20 | 2021-12-16 | Buy |
| Ambeed | A790327 | 1-(3-Ethyl-4-(hydroxymethyl)phenyl)ethanone 95% | 1378888-43-7 | 250mg | $30 | 2021-12-16 | Buy |
| Ambeed | A790327 | 1-(3-Ethyl-4-(hydroxymethyl)phenyl)ethanone 95% | 1378888-43-7 | 1g | $74 | 2021-12-16 | Buy |
| Ambeed | A790327 | 1-(3-Ethyl-4-(hydroxymethyl)phenyl)ethanone 95% | 1378888-43-7 | 5g | $222 | 2021-12-16 | Buy |
| ACHEMBLOCK | P48493 | 1-[3-ethyl-4-(hydroxymethyl)phenyl]ethan-1-one 97% | 1378888-43-7 | 5G | $240 | 2021-12-16 | Buy |
Siponimod Chemical Properties,Uses,Production
Physical Form
Solid
Uses
1-3-Ethyl-4-(hydroxymethyl)-phenyl)ethanone is a reagent used in the prepration of Siponimod, it''s salts ans solid forms of the compound.
Synthesis
1-Iodo-4-bromo-2-ethylbenzene was synthesized from 2-ethylaniline by a one-pot reaction of aminoprotection, bromination, deprotection and iodination, and then 4-bromo-2-ethylbenzyl alcohol was synthesized from 4-bromo-2-ethylbenzyl alcohol by a one-pot reaction of Gergel exchange aldolization and reduction, and 1-(3-ethyl-4-hydroxymethyl) was synthesized from 1-(3-ethyl-4-hydroxymethyl) phenyl ketone by a total reaction of hydroxylation, Gergel reaction, acetylation and deprotection in 9 steps. The total yield of the reaction was 50.9%, and the GC content of the product was 98.3%.
Siponimod Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Changzhou Guiding Bio-Tech. Co.,Ltd. | +86-519-519-86686860 +8618795626222 | ning@guiding-bio.com | China | 299 | 58 |
| Shijiazhuang Dingmin Pharmaceutical Sciences Co., Ltd. | +86-0311-67591193 +8613931880626 | sales02@dingminpharma.com | China | 305 | 58 |
| Guangzhou CATO Research Chemicals Inc. | +86-020-81960175-617 +8615602392859 | Intermediate@cato-chem.com | China | 3858 | 58 |
| Capot Chemical Co.,Ltd. | +86-（0）57185586718; +8613336195806 | sales@capot.com | China | 29640 | 60 |
| Shanghai Daken Advanced Materials Co.,Ltd | +86-2158073036 | info@dakenam.com | China | 13815 | 58 |
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 33024 | 60 |
| Shenzhen Nexconn Pharmatechs Ltd | +86-755-89396905 +86-15013857715 | admin@nexconn.com | China | 10404 | 58 |
| Shandong chuangyingchemical Co., Ltd. | 18853181302 | sale@chuangyingchem.com | CHINA | 5906 | 58 |
| career henan chemical co | +86-0371-86658258 +8613203830695 | factory@coreychem.com | China | 29795 | 58 |
| Guangzhou Yuheng Pharmaceutical Technology Co., Ltd | +8613580539051 | joe@yuhengpharm.com | CHINA | 21142 | 58 |
