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ChemicalBook >> CAS DataBase List >>(S)-1-(3-methyl-2-oxobutyl)-8-((R)-3-methylmorpholino)-2-(trifluoromethyl)-3,4-dihydro-1H-pyrimido[1,2-a]pyrimidin-6(2H)-one

(S)-1-(3-methyl-2-oxobutyl)-8-((R)-3-methylmorpholino)-2-(trifluoromethyl)-3,4-dihydro-1H-pyrimido[1,2-a]pyrimidin-6(2H)-one

(S)-1-(3-methyl-2-oxobutyl)-8-((R)-3-methylmorpholino)-2-(trifluoromethyl)-3,4-dihydro-1H-pyrimido[1,2-a]pyrimidin-6(2H)-one Structure
(S)-1-(3-methyl-2-oxobutyl)-8-((R)-3-methylmorpholino)-2-(trifluoromethyl)-3,4-dihydro-1H-pyrimido[1,2-a]pyrimidin-6(2H)-one structure
CAS No.
1523404-29-6
Chemical Name:
(S)-1-(3-methyl-2-oxobutyl)-8-((R)-3-methylmorpholino)-2-(trifluoromethyl)-3,4-dihydro-1H-pyrimido[1,2-a]pyrimidin-6(2H)-one
Synonyms
129208;Vps34-IN-2;Vps34 inhibitor 2;Vps-34-IN-2,Vps34 IN 2,Vps34IN2;(S)-1-(3-Methyl-2-oxobutyl)-8-((R)-3-methylmorpholino)-2-(trifluoromethyl)-3,4-dihydro-1H-pyri;(S)-1-(3-methyl-2-oxobutyl)-8-((R)-3-methylmorpholino)-2-(trifluoromethyl)-3,4-dihydro-1H-pyrimido[1,2-a]pyrimidin-6(2H)-one;(S)-9-(3-Methyl-2-oxobutyl)-2-((R)-3-methylmorpholino)-8-(trifluoromethyl)-6,7,8,9-tetrahydro-4H-pyrimido[1,2-a]pyrimidin-4-one;(8S)-6,7,8,9-Tetrahydro-2-[(3R)-3-methyl-4-morpholinyl]-9-(3-methyl-2-oxobutyl)-8-(trifluoromethyl)-4H-pyrimido[1,2-a]pyrimidin-4-one;4H-Pyrimido[1,2-a]pyrimidin-4-one, 6,7,8,9-tetrahydro-2-[(3R)-3-methyl-4-morpholinyl]-9-(3-methyl-2-oxobutyl)-8-(trifluoromethyl)-, (8S)-
CBNumber:
CB42742380
Molecular Formula:
C18H25F3N4O3
Molecular Weight:
402.41
MDL Number:
MFCD28411355
MOL File:
1523404-29-6.mol
MSDS File:
SDS
TDS File:
TDS
Last updated:2026-07-27 17:00:41
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(S)-1-(3-methyl-2-oxobutyl)-8-((R)-3-methylmorpholino)-2-(trifluoromethyl)-3,4-dihydro-1H-pyrimido[1,2-a]pyrimidin-6(2H)-one Properties

Boiling point 466.4±55.0 °C(Predicted)
Density 1.40±0.1 g/cm3(Predicted)
storage temp. Sealed in dry,Room Temperature
solubility Ethanol: 50 mg/mL (124.25 mM)
pka 0.08±0.40(Predicted)
form Solid
color White to off-white

(S)-1-(3-methyl-2-oxobutyl)-8-((R)-3-methylmorpholino)-2-(trifluoromethyl)-3,4-dihydro-1H-pyrimido[1,2-a]pyrimidin-6(2H)-one price

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
ChemScene CS-8063 Vps34-IN-2 99.81% 1523404-29-6 1mg $206 2026-06-04 Buy
ChemScene CS-8063 Vps34-IN-2 99.81% 1523404-29-6 5mg $639 2026-06-04 Buy
ChemScene CS-8063 Vps34-IN-2 99.81% 1523404-29-6 10mg $964 2026-06-04 Buy
ChemScene CS-8063 Vps34-IN-2 99.81% 1523404-29-6 25mg $2058 2026-06-04 Buy
ChemScene CS-8063 Vps34-IN-2 99.81% 1523404-29-6 50mg $3683 2026-06-04 Buy
Product number Packaging Price Buy
CS-8063 1mg $206 Buy
CS-8063 5mg $639 Buy
CS-8063 10mg $964 Buy
CS-8063 25mg $2058 Buy
CS-8063 50mg $3683 Buy

(S)-1-(3-methyl-2-oxobutyl)-8-((R)-3-methylmorpholino)-2-(trifluoromethyl)-3,4-dihydro-1H-pyrimido[1,2-a]pyrimidin-6(2H)-one Chemical Properties, Uses, Production

Uses

(8S)-6,7,8,9-Tetrahydro-2-[(3R)-3-methyl-4-morpholinyl]-9-(3-methyl-2-oxobutyl)-8-(trifluoromethyl)-4H-pyrimido[1,2-a]pyrimidin-4-one, is a novel, potent and selective inhibitor of Vps34 with IC50s of 2 and 82 nM on the Vps34 enzymatic assay and the GFP-FYVE cellular assay, respectively.

in vivo

After administration by the intravenous (iv) route, Vps34-IN-2 (Compound 31) concentrations are quantifiable up to 6, 8, and 24 h (last sampling time) depending on animals. After oral administration (po), Vps34-IN-2 is rapidly absorbed with maximal plasma concentrations observed at 0.5 h and a bioavailability of 85%. Slight rebounds of concentrations are observed at 4 and 8 h after oral dosing with no obvious explanation. After iv injection of Vps34-IN-2 at 3 mg/kg, plasma clearance is found moderate (i.e., 2.3 L/h/kg), corresponding to 44% of hepatic blood flow in this species, volume of distribution at steady state is moderate, and terminal elimination half-life is short[1].

IC 50

Vps34: 2 nM (IC50); SARS-CoV-2: 3.1 μM (IC50); HCoV-229E: 0.7 μM (IC50)

(S)-1-(3-methyl-2-oxobutyl)-8-((R)-3-methylmorpholino)-2-(trifluoromethyl)-3,4-dihydro-1H-pyrimido[1,2-a]pyrimidin-6(2H)-one synthesis

16075-42-6
1523404-29-6
Synthesis of (S)-1-(3-methyl-2-oxobutyl)-8-((R)-3-methylmorpholino)-2-(trifluoromethyl)-3,4-dihydro-1H-pyrimido[1,2-a]pyrimidin-6(2H)-one from 2-Amino-4-(trifluoromethyl)pyrimidine

(S)-1-(3-methyl-2-oxobutyl)-8-((R)-3-methylmorpholino)-2-(trifluoromethyl)-3,4-dihydro-1H-pyrimido[1,2-a]pyrimidin-6(2H)-one Preparation Products And Raw materials

Raw materials

(S)-8-chloro-2-(trifluoromethyl)-3,4-dihydro-1H-pyrimido[1,2-a]pyrimidin-6(2H)-one 2-Amino-4-(trifluoromethyl)pyrimidine (S)-8-((R)-3-methylmorpholino)-2-(trifluoromethyl)-3,4-dihydro-1H-pyrimido[1,2-a]pyrimidin-6(2H)-one 1-Bromo-3-methyl-2-butanone

Preparation Products

(S)-1-(3-methyl-2-oxobutyl)-8-((R)-3-methylmorpholino)-2-(trifluoromethyl)-3,4-dihydro-1H-pyrimido[1,2-a]pyrimidin-6(2H)-one Suppliers

Global Suppliers ( 18)
Supplier Tel Email Country ProdList Advantage
ChemShuttle, Inc. 0510-83588313-811 18800520310 sales@chemshuttle.com China 2999 62
Sichuan Wei Keqi Biological Technology Co., Ltd. 028-81700200 18116577057 3003855609@qq.com China 7717 56
Taizhou Crene Biotechnology Co. Ltd. +86-0576-88813233 +86-13396860566 sales@pharm-intermediates.com China 1976 58
TargetMol Chemicals Inc. +1-781-999-5354; +1-00000000000 marketing@targetmol.com United States 32431 58
ChemeGen(Shanghai) Biotechnology Co.,Ltd. 18818260767 sales@chemegen.com China 11123 58
Shanghai hongqu biomedical technology co. LTD 88888888888 hongquchem@qq.com China 5123 58
Bide Pharmatech Ltd. 400-1647117 13681763483 product02@bidepharm.com China 59929 58
TargetMol Chemicals Inc. 4008200310 15002144251 marketing@tsbiochem.com China 24951 58
RD International Technology Co., Limited 18024082417 market@ubiochem.com China 9831 58
Guangzhou Ruidi Biotechnology Co., Ltd. 020-82099279 18988941402 sales@ubiochem.com China 9998 58
Supplier Advantage
ChemShuttle, Inc. 62
Sichuan Wei Keqi Biological Technology Co., Ltd. 56
Taizhou Crene Biotechnology Co. Ltd. 58
TargetMol Chemicals Inc. 58
ChemeGen(Shanghai) Biotechnology Co.,Ltd. 58
Shanghai hongqu biomedical technology co. LTD 58
Bide Pharmatech Ltd. 58
TargetMol Chemicals Inc. 58
RD International Technology Co., Limited 58
Guangzhou Ruidi Biotechnology Co., Ltd. 58

View Latest Price from (S)-1-(3-methyl-2-oxobutyl)-8-((R)-3-methylmorpholino)-2-(trifluoromethyl)-3,4-dihydro-1H-pyrimido[1,2-a]pyrimidin-6(2H)-one manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
Vps34-IN-2 pictures 2026-07-27 Vps34-IN-2
1523404-29-6
 $1670.00-2800.00 10g TargetMol Chemicals Inc.
Vps34-IN-2 pictures 2026-07-27 Vps34-IN-2
1523404-29-6
 $1670.00-2800.00 10g TargetMol Chemicals Inc.
Vps34-IN-2 pictures 2025-07-18 Vps34-IN-2
1523404-29-6
 $1670.00-2800.00 10g TargetMol Chemicals Inc.
  • Vps34-IN-2 pictures
  • Vps34-IN-2
    1523404-29-6
  • $1670.00-2800.00
  • TargetMol Chemicals Inc.
  • Vps34-IN-2 pictures
  • Vps34-IN-2
    1523404-29-6
  • $1670.00-2800.00
  • TargetMol Chemicals Inc.
  • Vps34-IN-2 pictures
  • Vps34-IN-2
    1523404-29-6
  • $1670.00-2800.00
  • TargetMol Chemicals Inc.

1523404-29-6 ((S)-1-(3-methyl-2-oxobutyl)-8-((R)-3-methylmorpholino)-2-(trifluoromethyl)-3,4-dihydro-1H-pyrimido[1,2-a]pyrimidin-6(2H)-one) Related Search:

Brequinar SARS-CoV-2 3CLpro/3C-like protease protein SARS-COV-2 S protein RBD (194A.A, HEK293, HIS) SARS-COV-2 S protein RBD (HEK293, FC) SARS-COV-2 S protein RBD (N501Y, K417N, E484K, HEK293, HIS)
SARS-CoV-2 S1 protein (HEK293)

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(S)-1-(3-methyl-2-oxobutyl)-8-((R)-3-methylmorpholino)-2-(trifluoromethyl)-3,4-dihydro-1H-pyrimido[1,2-a]pyrimidin-6(2H)-one (S)-1-(3-Methyl-2-oxobutyl)-8-((R)-3-methylmorpholino)-2-(trifluoromethyl)-3,4-dihydro-1H-pyri Vps34-IN-2 129208 Vps34 inhibitor 2 4H-Pyrimido[1,2-a]pyrimidin-4-one, 6,7,8,9-tetrahydro-2-[(3R)-3-methyl-4-morpholinyl]-9-(3-methyl-2-oxobutyl)-8-(trifluoromethyl)-, (8S)- (8S)-6,7,8,9-Tetrahydro-2-[(3R)-3-methyl-4-morpholinyl]-9-(3-methyl-2-oxobutyl)-8-(trifluoromethyl)-4H-pyrimido[1,2-a]pyrimidin-4-one Vps-34-IN-2,Vps34 IN 2,Vps34IN2 (S)-9-(3-Methyl-2-oxobutyl)-2-((R)-3-methylmorpholino)-8-(trifluoromethyl)-6,7,8,9-tetrahydro-4H-pyrimido[1,2-a]pyrimidin-4-one 1523404-29-6 C18H25F3N4O3 API