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Isavuconazonium sulfate

Isavuconazonium sulfate Structure
Isavuconazonium sulfate structure
CAS No.
946075-13-4
Chemical Name:
Isavuconazonium sulfate
Synonyms
Isavuconazon;ISAVUCONAZOLE SULFATE;BAL 8557-002;Etoposide Sulfate;Edoxaban Free Base;Isaaconazole sulfate;Escaconazole sulfate;Elsa Conazole Sulfate;savuconazonium Sulfate;lsavuconazonium sulfate
CBNumber:
CB42748579
Molecular Formula:
C35H36F2N8O9S2
Molecular Weight:
814.84
MDL Number:
MFCD27987905
MOL File:
946075-13-4.mol
MSDS File:
SDS
TDS File:
TDS
Last updated:2026-04-22 18:57:36
Product description Number Pack Size Price
Isavuconazonium sulfate ≥95% (HPLC) SML3188 5MG $98.1
Isavuconazonium sulfate ≥95% (HPLC) SML3188 25MG $395
Isavuconazonium (sulfate) ≥95% 23950 500μg $62
Isavuconazonium (sulfate) ≥95% 23950 1mg $115
Isavuconazonium (sulfate) ≥95% 23950 5mg $477
More product size
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Isavuconazonium sulfate Properties

storage temp. Store at -20°C
solubility DMSO:93.34(Max Conc. mg/mL);114.55(Max Conc. mM)
DMSO:PBS (pH 7.2) (1:5):0.16(Max Conc. mg/mL);0.2(Max Conc. mM)
Ethanol:10.0(Max Conc. mg/mL);12.27(Max Conc. mM)
form A crystalline solid
color White to off-white
InChIKey LWXUIUUOMSMZKJ-XHOYWDQFNA-M
SMILES S(O)([O-])(=O)=O.[C@@](C1C=C(F)C=CC=1F)(O)(CN1N=C[N+](C(C)OC(=O)N(C2N=CC=CC=2COC(=O)CNC)C)=C1)[C@H](C1SC=C(C2C=CC(C#N)=CC=2)N=1)C |&1:5,41,r|
FDA UNII 31Q44514JV
UNSPSC Code 51111800
NACRES NA.77

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictogramsGHS hazard pictogramsGHS hazard pictograms
GHS07,GHS08,GHS09
Signal word  Danger
Hazard statements  H302-H361d-H372-H410
Precautionary statements  P202-P260-P264-P273-P301+P312-P308+P313
WGK Germany  WGK 3
Storage Class 6.1C - Combustible acute toxic Cat.3
toxic compounds or compounds which causing chronic effects
Hazard Classifications Acute Tox. 4 Oral
Aquatic Acute 1
Aquatic Chronic 1
Repr. 2
STOT RE 1
NFPA 704
0
2 0

Isavuconazonium sulfate price More Price(15)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich SML3188 Isavuconazonium sulfate ≥95% (HPLC) 946075-13-4 5MG $98.1 2026-03-19 Buy
Sigma-Aldrich SML3188 Isavuconazonium sulfate ≥95% (HPLC) 946075-13-4 25MG $395 2026-03-19 Buy
Cayman Chemical 23950 Isavuconazonium (sulfate) ≥95% 946075-13-4 500μg $62 2024-03-01 Buy
Cayman Chemical 23950 Isavuconazonium (sulfate) ≥95% 946075-13-4 1mg $115 2024-03-01 Buy
Cayman Chemical 23950 Isavuconazonium (sulfate) ≥95% 946075-13-4 5mg $477 2024-03-01 Buy
Product number Packaging Price Buy
SML3188 5MG $98.1 Buy
SML3188 25MG $395 Buy
23950 500μg $62 Buy
23950 1mg $115 Buy
23950 5mg $477 Buy

Isavuconazonium sulfate Chemical Properties,Uses,Production

Description

Isavuconazonium sulfate is an orally bioavailable, safe, second-generation triazole antifungal agent approved by the U.S. Food and Drug Administration (FDA) for the treatment of invasive Aspergillosis and invasive Mucormycosis in adults 18 years of age and older. Currently available under the brand name Cresemba, the most common side effects include liver test abnormalities, nausea, vomiting, dyspnea, abdominal pain, diarrhoea, injection site reactions, headache, hypokalemia and rash.

Uses

Isavuconazonium Sulfate can be prepared to be used as an antifungal drug.

Definition

ChEBI: An azaheterocycle sulfate salt that is a prodrug for isavuconazole, an antifungal agent used for the treatment of invasive aspergillosis and invasive mucormycosis.

in vivo

Isavuconazonium sulfate (215 mg/kg; p.o.; Three times a day for 4 days) has anti-R.delemar virus activity in ICR mice infected with mucormycosis[4].

Animal Model:Neutropenic male ICR mouse model of intratracheal infection[4]
Dosage:215 mg/kg
Administration:Oral gavage (p.o.); Three times a day for 4 days.
Result:Increased the survival rate of neutropenic mice infected with R. delemar.
Reduced fungal load in the lungs and brains of mice.

Metabolism

Isavuconazonium sulfate (Cresemba) is the water-soluble prodrug of isavuconazole, a broad-spectrum antifungal triazoles with activity against yeasts, molds, and dimorphic fungi and available as intravenous solution and as capsules for oral administration. Isavuconazonium sulfate is metabolized mainly by serum butylcholinesterase to isavuconazole. Isavuconazole is metabolized to inactive metabolites in the liver via CYP3A4 and CYP3A5 isoenzymes and uridine diphosphate-glucuronosyl transferase[1].

References

[1] Kumar, Sunil et al. “11. Thiazole: A privileged scaffold in drug discovery.” 2016. 0.

Isavuconazonium sulfate Preparation Products And Raw materials

Raw materials

Preparation Products

Isavuconazonium sulfate Suppliers

Global( 220)Suppliers
Supplier Tel Email Country ProdList Advantage
Hangzhou ICH Biofarm Co., Ltd
+86-0571-28186870; +undefined8613073685410 sales@ichemie.com China 1006 58
Beijing Hope Pharmaceutical Co., Ltd.
+86-010-67886402 +8613611125266 market@hopelife.cn China 72 58
Wuhan Fortuna Chemical Co., Ltd 		+86-27-59207850 info@fortunachem.com China 5975 58
Zhengzhou Anbu Chem Co.,Ltd 		+86-0371-88006763; +8615988602810 sales@anbuchem.com China 3014 58
Shaanxi TNJONE Pharmaceutical Co., Ltd 		+8618092446649 sarah@tnjone.com China 1143 58
BEIJING SJAR TECHNOLOGY DEVELOPMENT CO., LTD. 		+86-18600796368 sales@sjar-tech.com China 529 58
Moxin Chemicals 		+86-17320513646 +8617320513646 anna@molcoo.com China 10000 58
Hefei Lbao Physical & Chemical Science Co.,Ltd 		+15184799099 lbaochemicals@gmail.com China 671 58
Capot Chemical Co.,Ltd. 		+86-（0）57185586718; +8613336195806 sales@capot.com China 29640 60
Henan Tianfu Chemical Co.,Ltd. 		+86-0371-55170693 +86-19937530512 info@tianfuchem.com China 21592 55
Supplier Advantage
Hangzhou ICH Biofarm Co., Ltd
58
Beijing Hope Pharmaceutical Co., Ltd.
58
Wuhan Fortuna Chemical Co., Ltd 		58
Zhengzhou Anbu Chem Co.,Ltd 		58
Shaanxi TNJONE Pharmaceutical Co., Ltd 		58
BEIJING SJAR TECHNOLOGY DEVELOPMENT CO., LTD. 		58
Moxin Chemicals 		58
Hefei Lbao Physical & Chemical Science Co.,Ltd 		58
Capot Chemical Co.,Ltd. 		60
Henan Tianfu Chemical Co.,Ltd. 		55

View Lastest Price from Isavuconazonium sulfate manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
Isavuconazonium Sulfate pictures 2026-04-28 Isavuconazonium Sulfate
946075-13-4
 US $0.00 / g 1g More Than 99% 50kg/Month BEIJING SJAR TECHNOLOGY DEVELOPMENT CO., LTD.
Isavuconazonium sulfate pictures 2026-04-28 Isavuconazonium sulfate
946075-13-4
 US $0.00-0.00 / g 10g 99% 10kg WUHAN FORTUNA CHEMICAL CO., LTD
Isavuconazonium sulfate pictures 2026-04-24 Isavuconazonium sulfate
946075-13-4
 US $0.00 / kg 1kg 98% Customise Hefei Lbao Physical & Chemical Science Co.,Ltd

Isavuconazonium sulfate Spectrum

Isavuconazonium sulfate(946075-13-4)1HNMR

946075-13-4(Isavuconazonium sulfate)Related Search:

Efinaconazole (2R,3R)-3-(2,5-Difluorophenyl)-3-hydroxy-2-Methyl-4-(1H-1,2,4-triazol-1-yl)thiobutyraMide Isavuconazole Impurity (2R,3R)-3-(2,4-Difluorophenyl)-3-hydroxy-2-Methyl-4-(1H-1,2,4-triazol-1-yl)thiobutyraMide 4-(2-((2S,3S)-3-(2,5-difluorophenyl)-3-hydroxy-4-(1H-1,2,4-triazol-1-yl)butan-2-yl)thiazol-4-yl)benzonitrile
isavuconazonium chloride Isavuconazole Tiotropium bromide Aprepitant Voriconazole
Posaconazole

1of3

BAL 8557-002 N-Methylglycine [2-[[[1-[1-[(2R,3R)-3-[4-(4-cyanophenyl)-2-thiazolyl]-2-(2,5-difluorophenyl)-2-hydroxybutyl]-4H-1,2,4-triazolium-4-yl]ethoxy]carbonyl]methylamino]-3-pyridinyl]methyl ester sulfate (1:1) API-Antifungal Infection savuconazonium Sulfate Edoxaban Free Base ISAVUCONAZOLE SULFATE Isavuconazonium sulfate (BAL8557) Isavuconazonium sulfate,inhibit,antifungal,prodrug,aspergillosis,BAL8557-002,Fungal,mucormycosis,invasive,Isavuconazonium,Inhibitor,infections Isavuconazole Impurity 40 Sulphite 1-((2R,3R)-3-(4-(4-Cyanophenyl)thiazol-2-yl)-2-(2,5-difluorophenyl)-2-hydroxybutyl)-4-(1-((methyl(3-(((methylglycyl)oxy)methyl)pyridin-2-yl)carbamoyl)oxy)ethyl)-1H-1,2,4-triazol-4-ium hydrogen sulfate lsavuconazonium sulfate Isaaconazole sulfate Isavuconazonium sulfate Isavuconazole Impurity 45 Sulphite Isavuconaconiun sulfate Escaconazole sulfate 1-((2R,3R)-3-(4-(4-cyanophenyl)thiazol-2-yl)-2-(2,5-difluorophenyl)-2-hydroxybutyl)-4-(1-((methyl(3-(((methylglycyl)oxy)methyl)pyridin-2-yl)carbamoyl)oxy)ethyl)-1H-1,2,4-triazol-4-ium Elsa Conazole Sulfate Escaconazole sulfate ester Isavuconazon Etoposide Sulfate 946075-13-4 C35H35F2N8O5SHO4S C35H36F2N8O9S2 C35H35F2N8O5SHSO4 API