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ChemicalBook >> CAS DataBase List >>7-(3,4-Dimethoxyphenyl)-4-(2-fluorophenyl)-1,4,5,6,7,8-hexahydro-2-methyl-5-oxo-3-quinolinecarboxylic acid propyl ester

7-(3,4-Dimethoxyphenyl)-4-(2-fluorophenyl)-1,4,5,6,7,8-hexahydro-2-methyl-5-oxo-3-quinolinecarboxylic acid propyl ester

7-(3,4-Dimethoxyphenyl)-4-(2-fluorophenyl)-1,4,5,6,7,8-hexahydro-2-methyl-5-oxo-3-quinolinecarboxylic acid propyl ester Structure
7-(3,4-Dimethoxyphenyl)-4-(2-fluorophenyl)-1,4,5,6,7,8-hexahydro-2-methyl-5-oxo-3-quinolinecarboxylic acid propyl ester structure
CAS No.
421571-66-6
Chemical Name:
7-(3,4-Dimethoxyphenyl)-4-(2-fluorophenyl)-1,4,5,6,7,8-hexahydro-2-methyl-5-oxo-3-quinolinecarboxylic acid propyl ester
Synonyms
SJ000025081;SJ000025081 >=98% (HPLC);propyl 7-(3,4-dimethoxyphenyl)-4-(2-fluorophenyl)-2-methyl-5-oxo-1,4,5,6,7,8-hexahydroquinoline-3-carboxylate;7-(3,4-Dimethoxyphenyl)-4-(2-fluorophenyl)-1,4,5,6,7,8-hexahydro-2-methyl-5-oxo-3-quinolinecarboxylic acid propyl ester;3-Quinolinecarboxylic acid, 7-(3,4-dimethoxyphenyl)-4-(2-fluorophenyl)-1,4,5,6,7,8-hexahydro-2-methyl-5-oxo-, propyl ester
CBNumber:
CB42750420
Molecular Formula:
C28H30FNO5
Molecular Weight:
479.54
MDL Number:
MFCD02224187
MOL File:
421571-66-6.mol
Last updated:2025-07-31 22:42:24
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7-(3,4-Dimethoxyphenyl)-4-(2-fluorophenyl)-1,4,5,6,7,8-hexahydro-2-methyl-5-oxo-3-quinolinecarboxylic acid propyl ester Properties

storage temp. 2-8°C
solubility DMSO: ≥40mg/mL
form powder
color pale yellow

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictogramsGHS hazard pictograms
GHS06,GHS09
Signal word  Danger
Hazard statements  H301-H410
Precautionary statements  P273-P301+P310-P501
Hazard Codes  T,N
Risk Statements  25-50/53
Safety Statements  45-60-61
RIDADR  UN 2811 6.1 / PGIII
WGK Germany  3

7-(3,4-Dimethoxyphenyl)-4-(2-fluorophenyl)-1,4,5,6,7,8-hexahydro-2-methyl-5-oxo-3-quinolinecarboxylic acid propyl ester price More Price(1)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
American Custom Chemicals Corporation API0007858 7-(3,4-DIMETHOXYPHENYL)-4-(2-FLUOROPHENYL)-1,4,5,6,7,8-HEXAHYDRO-2-METHYL-5-OXO-3-QUINOLINECARBOXYLIC ACID PROPYL ESTER 95.00% 421571-66-6 25MG $993.25 2021-12-16 Buy
Product number Packaging Price Buy
API0007858 25MG $993.25 Buy

7-(3,4-Dimethoxyphenyl)-4-(2-fluorophenyl)-1,4,5,6,7,8-hexahydro-2-methyl-5-oxo-3-quinolinecarboxylic acid propyl ester Chemical Properties,Uses,Production

Uses

SJ000025081 is a dihydropyridine and acts as a potent antimalarial agent. SJ000025081 results in an obvious suppression of the parasitemia in a murine malaria model infected with?P. yoelii[1].

in vivo

SJ000025081 (intraperitoneal injection; 25 mg/kg; single dose; suspension in 1% methylcellulose) exhibits a good PK profile, the Cmax, Cmax/Dose, Tmax and AUC values are 0.224 μg/ml, 0.0113 μg/ml per mg/ml, 1.0 h and 0.224 μg.h/ml, respectively[1].SJ000025081 (intraperitoneal injection; 5-100 mg/kg; twice-daily; 3 days) exhibits an antimalarial activity in a dose-dependent manner and displays efficacy in a murine malaria model infected with?P. yoelii.?SJ000025081 can result in a 90% suppression of the parasitemia[1].

Animal Model:6 weeks old CD-1 mice[1]
Dosage:5 mg/kg; 10 mg/kg; 25 mg/kg; 50 mg/kg; 100 mg/kg
Administration:Intraperitoneal injection; 5-100 mg/kg; twice-daily; 3 days
Result:Was active in a malaria murine model infected with P. yoelii.

IC 50

Plasmodium

References

[1] W Armand Guiguemde, et al. Chemical genetics of Plasmodium falciparum. Nature.. 2010 May 20;465(7296):311-5 DOI:10.1038/nature09099

7-(3,4-Dimethoxyphenyl)-4-(2-fluorophenyl)-1,4,5,6,7,8-hexahydro-2-methyl-5-oxo-3-quinolinecarboxylic acid propyl ester Preparation Products And Raw materials

Raw materials

Preparation Products

7-(3,4-Dimethoxyphenyl)-4-(2-fluorophenyl)-1,4,5,6,7,8-hexahydro-2-methyl-5-oxo-3-quinolinecarboxylic acid propyl ester Suppliers

Global( 6)Suppliers
Supplier Tel Email Country ProdList Advantage
TargetMol Chemicals Inc. 		+17819995354 marketing@targetmol.com United States 19939 58
Energy Chemical 021-58432009 400-005-6266 marketing@energy-chemical.com China 44918 58
TargetMol Chemicals Inc. 15002134094 marketing@targetmol.cn China 26070 58
Supplier Advantage
TargetMol Chemicals Inc. 		58
Energy Chemical 58
TargetMol Chemicals Inc. 58

View Lastest Price from 7-(3,4-Dimethoxyphenyl)-4-(2-fluorophenyl)-1,4,5,6,7,8-hexahydro-2-methyl-5-oxo-3-quinolinecarboxylic acid propyl ester manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
SJ000025081 pictures 2025-07-31 SJ000025081
421571-66-6
 US $1980.00-2500.00 / mg 10g TargetMol Chemicals Inc.
  • SJ000025081 pictures
  • SJ000025081
    421571-66-6
  • US $1980.00-2500.00 / mg
  • TargetMol Chemicals Inc.
7-(3,4-Dimethoxyphenyl)-4-(2-fluorophenyl)-1,4,5,6,7,8-hexahydro-2-methyl-5-oxo-3-quinolinecarboxylic acid propyl ester SJ000025081 propyl 7-(3,4-dimethoxyphenyl)-4-(2-fluorophenyl)-2-methyl-5-oxo-1,4,5,6,7,8-hexahydroquinoline-3-carboxylate 3-Quinolinecarboxylic acid, 7-(3,4-dimethoxyphenyl)-4-(2-fluorophenyl)-1,4,5,6,7,8-hexahydro-2-methyl-5-oxo-, propyl ester SJ000025081 >=98% (HPLC) 421571-66-6