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Ethyl 1-benzylpiperidine-4-carboxylate

Ethyl 1-benzylpiperidine-4-carboxylate Structure
Ethyl 1-benzylpiperidine-4-carboxylate structure
CAS No.
24228-40-8
Chemical Name:
Ethyl 1-benzylpiperidine-4-carboxylate
Synonyms
ETHYL 1-BENZYL-4-PIPERIDINECARBOXYLATE;1-BENZYLPIPERIDINE-4-CARBOXYLIC ACID ETHYL ESTER;AKOS 225-01;BUTTPARK 33\04-91;RSYY（Avanafil)-28;RARECHEM AH CK 0037;SDCCGMLS-0066147.P001;Ethyl 1-Benzylisonipecotate;Ethyl N-benzylisonipecotate;1-benzyl-ethyl Isonipecotate
CBNumber:
CB4276544
Molecular Formula:
C15H21NO2
Molecular Weight:
247.33
MDL Number:
MFCD00040748
MOL File:
24228-40-8.mol
MSDS File:
SDS
TDS File:
TDS
Last updated:2026-05-28 05:41:14
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Ethyl 1-benzylpiperidine-4-carboxylate Properties

Boiling point 122°C (0.5 mmHg)
Density 1.037 g/mL at 25 °C
refractive index 1.5120-1.5160
Flash point >110℃
storage temp. Inert atmosphere,Room Temperature
solubility Chloroform (Slightly), Hexanes (Slightly), Methanol (Slightly)
form clear liquid
pka 7.93±0.10(Predicted)
color Colorless to Light red
InChI InChI=1S/C15H21NO2/c1-2-18-15(17)14-8-10-16(11-9-14)12-13-6-4-3-5-7-13/h3-7,14H,2,8-12H2,1H3
InChIKey ASQCOPJFYLJCGD-UHFFFAOYSA-N
SMILES N1(CC2=CC=CC=C2)CCC(C(OCC)=O)CC1
CAS DataBase Reference 24228-40-8(CAS DataBase Reference)
FDA UNII KCJ9YTK89G

SAFETY

Risk and Safety Statements

Symbol(GHS)  Skull and Crossbones (GHS06)
GHS06
Signal word  Danger
Hazard statements  H301
Precautionary statements  P301+P310
Hazard Codes  Xi,T
Risk Statements  36/37/38-25
Safety Statements  24/25-45
RIDADR  UN 2810 6.1 / PGIII
Hazard Note  Irritant
HS Code  29333990
NFPA 704
1
0 0

Ethyl 1-benzylpiperidine-4-carboxylate price More Price(66)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
TCI Chemical E0862 Ethyl 1-Benzyl-4-piperidinecarboxylate >95.0%(GC)(T) 24228-40-8 5g $57 2023-06-20 Buy
TCI Chemical E0862 Ethyl 1-Benzyl-4-piperidinecarboxylate >95.0%(GC)(T) 24228-40-8 25g $203 2021-12-16 Buy
TRC TRC-B233660-25G N-Benzyl-4-carboethoxypiperidine 24228-40-8 25g $231 2026-06-03 Buy
Biosynth FB18358 N-Benzyl-4-carboethoxypiperidine 24228-40-8 100g $590 2026-06-04 Buy
Apolloscientific OR6926 Ethyl 1-benzylpiperidine-4-carboxylate 96% 24228-40-8 5g $21 2026-06-04 Buy
Product number Packaging Price Buy
E0862 5g $57 Buy
E0862 25g $203 Buy
TRC-B233660-25G 25g $231 Buy
FB18358 100g $590 Buy
OR6926 5g $21 Buy

Ethyl 1-benzylpiperidine-4-carboxylate Chemical Properties,Uses,Production

Uses

Ethyl 1-benzyl-4-piperidinecarboxylate and its derivatives are important pharmaceutical intermediates with high biological activity. Ethyl 1-benzyl-4-piperidinecarboxylate can be used to synthesize anti-inflammatory drug trypsin inhibitors, antagonizing inflammatory mediators at the receptor level. It can also be used to synthesize antitumor drugs such as matrix metalloproteinase inhibitors and farnesyltransferase inhibitors. In summary, ethyl 1-benzyl-4-piperidinecarboxylate and its derivatives possess excellent biological activity and can be used not only to synthesize GABA uptake inhibitors and antitumor drugs, but also to synthesize growth hormone secretagogues, anti-inflammatory and analgesic drugs, cardiovascular drugs, nootropic drugs, antiviral drugs, and bone disease drugs.

Synthesis

Ethyl isonipecotate (50 g, 0.31 mol) was dissolved in toluene (150 mL) in a round bottom flask, charged with potassium carbonate (60 g, 0.43 mol) and stirred for 15 min. Benzyl chloride (42 g, 0.31 mol) was charged and the reaction mass was refluxed for 4 h at 100 °C. Upon completion of the reaction as marked by TLC (hexane:ethyl acetate; 2:1), the reaction mass was cooled to room temperature and quenched with water (100 mL), stirred and the organic phase was separated. The aqueous phase was again extracted with toluene (100 mL). Combined organic phase was washed twice with saturated brine solution (50 mL). Remove toluene in vacuo to obtain Ethyl N-benzylpiperidine-4-carboxylate ( 6.97 g, 91 %) as a yellow liquid.
Ethyl 1-benzylpiperidine-4-carboxylate

Chemical Properties

Colourless Oil

References

[1] Bioorganic and Medicinal Chemistry Letters, 2012, vol. 22, # 22, p. 6938 - 6942,5
[2] Journal of medicinal chemistry, 1980, vol. 23, # 8, p. 848 - 851
[3] Patent: WO2010/12611, 2010, A1. Location in patent: Page/Page column 28
[4] Journal of Medicinal Chemistry, 1996, vol. 39, # 3, p. 749 - 756
[5] Organic Preparations and Procedures International, 1994, vol. 26, # 3, p. 421 - 428

Ethyl 1-benzylpiperidine-4-carboxylate Preparation Products And Raw materials

Raw materials

Ethyl 4-piperidinecarboxylate Benzyl bromide Benzyl chloride Potassium carbonate N,N-Dimethylformamide

Preparation Products

Ethyl 1-benzylpiperidine-4-carboxylate Suppliers

Global( 273)Suppliers
Supplier Tel Email Country ProdList Advantage
Anhui Dexinjia Biopharm Co., Ltd 0531-82375893 15553111391 phoebe@jndxj.com China 285 58
SHANGHAI FDC-CHEMICAL CO.,LTD 021-61469567 13774476675 sales@fdc-chemical.com China 10000 58
J & K SCIENTIFIC LTD. 18210857532 18210857532 jkinfo@jkchemical.com China 96815 76
future industrial shanghai co., ltd 400-0066400 13621662912 sales@jonln.com China 1989 65
Alfa Aesar 400-6106006 saleschina@alfa-asia.com China 30103 84
TCI (Shanghai) Development Co., Ltd. 021-67121386 Sales-CN@TCIchemicals.com China 24512 81
Energy Chemical 400-0056266 sales8178@energy-chemical.com China 44850 61
Shijiazhuang Sdyano Fine Chemical Co., Ltd. 0311-89250318 13582355795 master@sjzsdyn.com China 2776 65
Wuhan Chemwish Technology Co., Ltd 86-027-67849912 sales@chemwish.com China 35884 56
Capot Chemical Co., Ltd +86 (0) 571 85 58 67 18 China 18187 66
Supplier Advantage
Anhui Dexinjia Biopharm Co., Ltd 58
SHANGHAI FDC-CHEMICAL CO.,LTD 58
J & K SCIENTIFIC LTD. 76
future industrial shanghai co., ltd 65
Alfa Aesar 84
TCI (Shanghai) Development Co., Ltd. 81
Energy Chemical 61
Shijiazhuang Sdyano Fine Chemical Co., Ltd. 65
Wuhan Chemwish Technology Co., Ltd 56
Capot Chemical Co., Ltd 66

View Lastest Price from Ethyl 1-benzylpiperidine-4-carboxylate manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
Ethyl 1-benzylpiperidine-4-carboxylate pictures 2025-04-04 Ethyl 1-benzylpiperidine-4-carboxylate
24228-40-8
 1KG 98% 1ton Henan Aochuang Chemical Co.,Ltd.
Ethyl 1-benzylpiperidine-4-carboxylate pictures 2024-04-02 Ethyl 1-benzylpiperidine-4-carboxylate
24228-40-8
 $10.00-100.00 1kg 99% 5000 Metric Ton/Month Wuhan Xinhao Biotechnology Co., Ltd
Ethyl N-benzyl piperidine-4-carboxylate pictures 2023-09-11 Ethyl N-benzyl piperidine-4-carboxylate
24228-40-8
 $100.00 1bag 99 5000 Hebei Fengqiang Trading Co., LTD

Ethyl 1-benzylpiperidine-4-carboxylate Spectrum

Ethyl 1-benzylpiperidine-4-carboxylate(24228-40-8)1HNMR

24228-40-8(Ethyl 1-benzylpiperidine-4-carboxylate)Related Search:

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1of4

RARECHEM AH CK 0037 AKOS 225-01 ETHYL 1-BENZYLPIPERIDINE-4-CARBOXYLATE BUTTPARK 33\04-91 1-(Phenylmethyl)-4-piperidinecarboxylic Acid Ethyl Ester 1-(Phenylmethyl)piperidine-4-carboxylic Acid Ethyl Ester Ethyl 1-Benzylisonipecotate Ethyl 1-Benzylpiperidine-4-carboxylat N-Benzyl-4-carboethoxypiperidine 1-Benzyl-4-piperidinecarboxyli N-Benzyl-4-piperidinecarboxylicacidethylester Methyl(ethyl) 1-benzyl-Piperidine-4-carboxylate 1-BENZYL-PIPERIDINE-4-CARBOXYLIC ACID ETHYL ESTER >98% Benzylpiperidinecarboxylicacidethylester N-Benzyl-4-cabethoxypiperidine Ethyl 1-benzylpiperidine-4-carboxylate, 97+% 4-Piperidinecarboxylic acid, 1-(phenylMethyl)-, ethyl ester N-Ethyl N-benzylpiperidine-4-carboxylate Ethyl N-benzylpiperidine-4-carboxylate Ethyl-benzylpiperidine-4-carboxylate 1-Benzyl-4-piperidinecarboxylic Acid Ethyl Ester Ethyl 1-Benzylisonipecotate 1-Benzylisonipecotic Acid Ethyl Ester Ethyl 1-benzylisonipecotate, 1-Benzyl-4-(ethoxycarbonyl)piperidine N-benzyl -4-piperidine forMic acid ethyl ester 1 - benzyl - 4 - piperidine ethyl forMate Ethyl N-benzyl-4-piperidinecarboxylate CAS NO.24228-40-8 Ethyl N-benzylpiperidine-4-carboxylate SDCCGMLS-0066147.P001 Ethyl1-Benzyl-4-piperidinecarboxylate> Ethyl N-benzylisonipecotinate N-benzyl isonipecotic ethyl ester N-benzylpiperidine-4-carboxylate, ethyl ester 1-Benzylisonipecotic Acid Ethyl Ester 1-benzyl-ethyl Isonipecotate 1-Benzyl-piperidine-4-carboxylic a RSYY（Avanafil)-28 Ethyl N-benzylisonipecotate 1-BENZYLPIPERIDINE-4-CARBOXYLIC ACID ETHYL ESTER ETHYL 1-BENZYL-4-PIPERIDINECARBOXYLATE Ethyl 1-(phenylmethyl)-4-piperidinecarboxylate 24228-40-8 24228-04-8 12001-70-3 C24H29NO3HCl Piperidine Heterocyclic Compounds Aromatics Heterocycles