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BOC-L-Phenylglycinol

BOC-L-Phenylglycinol structure

CAS No.: 117049-14-6

Chemical Name:: BOC-L-Phenylglycinol

Synonyms: BOC-PHG-OL;(S)-N-(TERT-BUTOXYCARBONYL)-2-PHENYLGLYCINOL;tert-butyl (S)-(2-hydroxy-1-phenylethyl)carbamate;Boc-L-Phg-OL;CAS:117049-14-6;Boc-L-phenyglycol;BOC-PHENYLGLYCINOL;BOC-L-PHENYLGLYCINOL;TBOC-L-PHENYLGLYCINOL;Asciminib Impurity 19

CBNumber:: CB4287458

Molecular Formula:: C13H19NO3

Molecular Weight:: 237.3

MDL Number:: MFCD00274206

MOL File:: 117049-14-6.mol

MSDS File:: SDS

TDS File:: TDS

Last updated:2026-05-28 05:47:08

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BOC-L-Phenylglycinol Properties

Melting point	136-139 °C(lit.)
alpha	+37°(19℃, c=1, CHCl3)
Boiling point	382.4±35.0 °C(Predicted)
Density	1.101±0.06 g/cm3(Predicted)
storage temp.	Inert atmosphere,Room Temperature
form	powder to crystal
pka	11.55±0.46(Predicted)
color	White to Orange to Green
optical activity	[α]19/D +37°, c = 1 in chloroform
Water Solubility	Insoluble in water.
BRN	4316842
Major Application	peptide synthesis
InChI	1S/C13H19NO3/c1-13(2,3)17-12(16)14-11(9-15)10-7-5-4-6-8-10/h4-8,11,15H,9H2,1-3H3,(H,14,16)/t11-/m1/s1
InChIKey	IBDIOGYTZBKRGI-LLVKDONJSA-N
SMILES	CC(C)(C)OC(=O)N[C@H](CO)c1ccccc1
CAS DataBase Reference	117049-14-6(CAS DataBase Reference)
FDA UNII	T4CBC55RQN
UNSPSC Code	12352209
NACRES	NA.22

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS07

Signal word

Warning

Hazard statements

H302-H332

Precautionary statements

P261-P264-P270-P271-P301+P312-P304+P340-P312-P330-P501

Safety Statements

22-24/25

WGK Germany

HS Code

29051990

Storage Class

11 - Combustible Solids

NFPA 704

	1
0		0

BOC-L-Phenylglycinol price More Price(67)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	429821	(+)-N-Boc-L-α-phenylglycinol 99%	117049-14-6	1g	$57.9	2026-04-30	Buy
TCI Chemical	B3272	N-(tert-Butoxycarbonyl)-L-2-phenylglycinol >98.0%(GC)	117049-14-6	1g	$17	2026-04-30	Buy
TCI Chemical	B3272	N-(tert-Butoxycarbonyl)-L-2-phenylglycinol >98.0%(GC)	117049-14-6	5g	$45	2026-04-30	Buy
Usbiological	263965	N-Boc-L-alpha-phenylglycinol Asreported	117049-14-6	1g	$300	2026-06-03	Buy
Usbiological	263965	N-Boc-L-alpha-phenylglycinol Asreported	117049-14-6	2g	$403	2026-06-03	Buy

Product number	Packaging	Price	Buy
429821	1g	$57.9	Buy
B3272	1g	$17	Buy
B3272	5g	$45	Buy
263965	1g	$300	Buy
263965	2g	$403	Buy

BOC-L-Phenylglycinol Chemical Properties,Uses,Production

Chemical Properties

White solid

Uses

N-Boc-L-alpha-phenylglycinol is an important raw material and intermediate used in organic Synthesis, pharmaceuticals, agrochemicals and dye fields. Phenylglycinol-derived oxazolopiperidone lactams is used as starting materials for the enantioselective synthesis of piperidine-containing alkaloids.

reaction suitability

reaction type: Boc solid-phase peptide synthesis

Synthesis

24424-99-5

56613-80-0

67341-01-9

GENERAL STEPS: Di-tert-butyl dicarbonate (31.82 g, 146.8 mmol) was slowly added to a solution of anhydrous tetrahydrofuran (292 mL) containing (R)-(-)-2-phenylglycinol (20.00 g, 145.8 mmol) and triethylamine (24.4 mL, 175.0 mmol) at 0 °C. The reaction mixture was stirred continuously for 3 hours at 0 °C. Upon completion of the reaction, the reaction mixture was concentrated under reduced pressure by rotary evaporator. The concentrated residue was dissolved in dichloromethane (200 mL) and washed with 1N hydrochloric acid (240 mL). The aqueous layer was back-extracted with dichloromethane (2 x 100 mL). All organic layers were combined, dried with anhydrous sodium sulfate, filtered and concentrated again by rotary evaporator under reduced pressure to give a white solid product ((R)-tert-butyl 2-hydroxy-1-phenylethyl)carbamate (34.59 g, yield >99%). The product was characterized by 1H NMR (CDCl3): δ 1.43 (s, 9H), 2.29 (br s, 1H), 3.84-3.87 (m, 2H), 4.79 (br s, 1H), 7.29-7.39 (m, 5H).

References

[1] Tetrahedron Asymmetry, 2007, vol. 18, # 23, p. 2758 - 2767
[2] Patent: WO2007/22371, 2007, A2. Location in patent: Page/Page column 28
[3] Journal of Medicinal Chemistry, 2013, vol. 56, # 20, p. 8049 - 8065
[4] Comptes Rendus Chimie, 2010, vol. 13, # 5, p. 544 - 547
[5] Letters in Organic Chemistry, 2011, vol. 8, # 1, p. 38 - 42

BOC-L-Phenylglycinol Preparation Products And Raw materials

Raw materials

Di-tert-butyl dicarbonate D-Phenylglycinol Triethylamine Tetrahydrofuran

Preparation Products

BOC-L-Phenylglycinol Suppliers

Global( 275)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
J & K SCIENTIFIC LTD.	18210857532 18210857532	jkinfo@jkchemical.com	China	96815	76
Meryer (Shanghai) Chemical Technology Co., Ltd.	4006356688 18621169109	market03@meryer.com	China	40202	62
INTATRADE GmbH	+49 3493/605464	sales@intatrade.de	Germany	3563	66
3B Pharmachem (Wuhan) International Co.,Ltd.	18930552037	3bsc@sina.com	China	15813	69
Alfa Aesar	400-6106006	saleschina@alfa-asia.com	China	30103	84
TCI (Shanghai) Development Co., Ltd.	021-67121386	Sales-CN@TCIchemicals.com	China	24512	81
ShangHai DEMO Chemical Co.,Ltd	400-021-7337 2355568890	sales@demochem.com	China	2569	57
Energy Chemical	400-0056266	sales8178@energy-chemical.com	China	44850	61
Capot Chemical Co., Ltd	+86 (0) 571 85 58 67 18		China	18187	66
Adamas Reagent, Ltd.	400-6009262 15618770481	yhx@titansci.com	China	14098	59

Supplier	Advantage
J & K SCIENTIFIC LTD.	76
Meryer (Shanghai) Chemical Technology Co., Ltd.	62
INTATRADE GmbH	66
3B Pharmachem (Wuhan) International Co.,Ltd.	69
Alfa Aesar	84
TCI (Shanghai) Development Co., Ltd.	81
ShangHai DEMO Chemical Co.,Ltd	57
Energy Chemical	61
Capot Chemical Co., Ltd	66
Adamas Reagent, Ltd.	59

View Lastest Price from BOC-L-Phenylglycinol manufacturers

Image	Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
	2026-09-11	Boc-L-Phg-Ol 117049-14-6		1kg	98%	1T+	Sichuan HongRi Pharma-Tech Co.,Ltd
	2019-07-06	BOC-L-Phenylglycinol 117049-14-6	$7.00	1kg	99%	100KG	Career Henan Chemical Co

Boc-L-Phg-Ol
117049-14-6
98%
Sichuan HongRi Pharma-Tech Co.,Ltd

BOC-L-Phenylglycinol
117049-14-6
$7.00
99%
Career Henan Chemical Co

BOC-L-Phenylglycinol Spectrum

BOC-L-Phenylglycinol(117049-14-6)¹HNMR BOC-L-Phenylglycinol(117049-14-6)IR

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1of4

TBOC-L-PHENYLGLYCINOL (S)-N-BOC-2-PHENYLGLYCINOL (S)-(+)-N-(TERT-BUTOXYCARBONYL)-2-PHENYLGLYCINOL (S)-N-(TERT-BUTOXYCARBONYL)-2-PHENYLGLYCINOL (S)-N-(TERT-BUTOXYCARBONYL)-PHENYLGLYCINOL S(+)-2-(BOC)-AMINO-2-PHENYLETHANOL ((S)-2-HYDROXY-1-PHENYL-ETHYL)-CARBAMIC ACID TERT-BUTYL ESTER (S)-2-(TERT-BUTOXYCARBONYLAMINO)-2-PHENYLETHANOL N-T-BOC-L-PHENYLGLYCINOL N-T-BUTOXYCARBONYL-L-PHENYLGLYCINOL N-ALPHA-T-BOC-L-PHENYLGLYCINOL N-BOC-L-ALPHA-PHENYLGLYCINOL N-BOC-L-PHENYLGLYCINOL N-Boc- L -2-phenylglycinol CARBAMIC ACID, [(1S)-2-HYDROXY-1-PHENYLETHYL]-, 1,1-DIMETHYLETHYL ESTER BOC-L-PHENYLGLYCINOL BOC-PHENYLGLYCINOL (S)-(+)-2-(Boc-amino)-2-phenylethanol~Boc-Phg-ol~N-(tert-Butoxycarbonyl)-L-alpha-phenylgycinol Boc-L-Alpha-Phenylglycinol (S)-(+)-N-(TERT-BUTOXYCARBONYL)-2-PHENYL GLYCINOL, 99% (99% EE/GLC) N-BOC-(S)-phenylglycinol n-boc-l-à-phenylglycinol N-(2-hydroxy-1-phenylethyl)carbamic acid tert-butyl ester Boc-L-2-phenylglycinol Boc-(S)-2-phenylglycinol N-tert-Butoxycarbonyl-L-phenylglycinol Boc-L-Phg-OL Boc-L-phenylglycinol99.0 +% tert-butyl (S)-(2-hydroxy-1-phenylethyl)carbamate N-Boc-L-ɑ-phenylglycinol, 98% NALPHA-tert-Butoxycarbonyl-L-phenylglycinol N-(tert-Butoxycarbonyl)-L-2-phenylglycinol N-Boc-L-^a-phenylglycinol, 98% N-Boc-L-2-phenylglycinol (S)-2-(tert-Butoxycarbonylamino)-2-phenylethanol (S)-N-(t-butoxycarbonyl)-2-phenylglycinol (S)-tert-butyl 2-hydroxy-1-phenylethylcarbaMate Boc-l-phenylglycine glycol N-(tert-Butoxycarbonyl)-L-2-phenylglycinol > (S)-(+)-2-(Boc-amino)-2-phenyL Carbamic acid, N-[(1S)-2-hydroxy-1-phenylethyl]-, 1,1-dimethylethyl ester BOC-L-Phenylglycinol USP/EP/BP N-Boc-(S)-2-phenylglycinol N-boc-L-α-phenylglycinol Boc-L-phenyglycol Asciminib Impurity 19 (+)-N-boc-L-alpha-phenylglycinol CAS:117049-14-6 (+)-N-Boc-L-α-phenylglycinol (+)-N-Boc-L-α-phenylglycinol BOC-PHG-OL 117049-14-6 Amino Alcohols Amino Acid Derivatives Specialty Synthesis Peptide Synthesis Amino Acid Derivatives Amino Acids