2-Adamantone-5-carboxylic acid
- CAS No.
- 56674-87-4
- Chemical Name:
- 2-Adamantone-5-carboxylic acid
- Synonyms
- 4-OXO-1-ADAMANTANECARBOXYLIC ACID;AKOS BC-0516;Adamantane Impurity 15;5-Carboxy-2-Adamantanone;1-Carboxy-4-adamantanone;1-Carboxy-4-oxoadamantane;2-Adamantone-5-carboxylic acid;2-ADAMANTANONE-5-CARBOXYLIC ACID;4-KETO-1-ADAMANTANECARBOXYLIC ACID;4-ketoadamantane-1-carboxylic acid
- CBNumber:
- CB4289043
- Molecular Formula:
- C11H14O3
- Molecular Weight:
- 194.23
- MDL Number:
- MFCD01825769
- MOL File:
- 56674-87-4.mol
- MSDS File:
- SDS
| Product description | Number | Pack Size | Price |
| 2-Adamantanone-5-carboxylicAcid | A208240 | 500mg | $50 |
| 2-Adamantanone-5-carboxylicacid | W7035 | 250mg | $63 |
| 4-Oxoadamantane-1-carboxylic acid 97% | 2229-1-26 | 10g | $77 |
| 2-Adamantanone-5-carboxylicacid | W7035 | 5g | $89 |
| 2-Adamantanone-5-carboxylic acid | 077965 | 250mg | $10 |
| More product size | |||
| Melting point | 169.5-171.0 °C(Solv: ethyl ether (60-29-7)) |
|---|---|
| Boiling point | 367.6±35.0 °C(Predicted) |
| Density | 1.358±0.06 g/cm3(Predicted) |
| storage temp. | Sealed in dry,Room Temperature |
| pka | 4.45±0.20(Predicted) |
| Appearance | Off-white to light yellow Solid |
| InChI | InChI=1S/C11H14O3/c12-9-7-1-6-2-8(9)5-11(3-6,4-7)10(13)14/h6-8H,1-5H2,(H,13,14) |
| InChIKey | VFNJWHFPIRNNRQ-UHFFFAOYSA-N |
| SMILES | C12(C(O)=O)CC3CC(CC(C3=O)C1)C2 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302-H315-H319-H332-H335 |
| Precautionary statements | P261-P280-P305+P351+P338 |
| HazardClass | IRRITANT |
| HS Code | 2916399090 |
2-Adamantone-5-carboxylic acid price More Price(13)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| TRC | A208240 | 2-Adamantanone-5-carboxylicAcid | 56674-87-4 | 500mg | $50 | 2021-12-16 | Buy |
| AK Scientific | W7035 | 2-Adamantanone-5-carboxylicacid | 56674-87-4 | 250mg | $63 | 2021-12-16 | Buy |
| SynQuest Laboratories | 2229-1-26 | 4-Oxoadamantane-1-carboxylic acid 97% | 56674-87-4 | 10g | $77 | 2021-12-16 | Buy |
| AK Scientific | W7035 | 2-Adamantanone-5-carboxylicacid | 56674-87-4 | 5g | $89 | 2021-12-16 | Buy |
| Oakwood | 077965 | 2-Adamantanone-5-carboxylic acid | 56674-87-4 | 250mg | $10 | 2021-12-16 | Buy |
2-Adamantone-5-carboxylic acid Chemical Properties,Uses,Production
Uses
2-Adamantanone-5-carboxylic Acid is a reactant used in the synthesis of potent inhibitors targeting the drug-resistant mutant of Influenze A. Starting material for Saxagliptin impurities.
Synthesis
56674-88-5
56674-87-4
General procedure for the synthesis of 2-adamantanone-5-carboxylic acid from methyl 5-formate-2-adamantanone: To a mixture of 1.92 g (9.22 mmol) of methyl 5-formate-2-adamantanone (for preparation, see US20050245534) in THF (9 mL) and methanol (3 mL), an aqueous solution of 3N sodium hydroxide (6.15 mL. 18.4 mmol). The reaction mixture was stirred at room temperature for 16 hours. Upon completion of the reaction, methanol and THF were removed by concentration. the residue was cooled in an ice bath and the pH was adjusted slowly by addition of 6N aqueous HCl solution to about 1. After continued stirring for 30 min, the precipitate was collected by filtration, washed with water and partially dried over a filter. The resulting solid was dissolved in dichloromethane (400 mL) and dried by adding anhydrous sodium sulfate. After filtration, the filtrate was concentrated and dried under vacuum to give 1.50 g (84% yield) of 2-adamantanone-5-carboxylic acid as a white solid.HPLC analysis (Condition B): retention time 1.61 min.LCMS analysis (Condition B): m/z 193.3 [M+H]+.
References
[1] Patent: WO2012/125886, 2012, A1. Location in patent: Page/Page column 93
[2] Chemical and Pharmaceutical Bulletin, 1982, vol. 30, # 1, p. 67 - 73
[3] Patent: WO2009/156092, 2009, A2. Location in patent: Page/Page column 49
2-Adamantone-5-carboxylic acid Preparation Products And Raw materials
Raw materials
1of2
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Henan Fengda Chemical Co., Ltd | +86-371-86557731 +86-13613820652 | info@fdachem.com | China | 20175 | 58 |
| Shenzhen Nexcon Pharmatechs Ltd. | +86-0755-89396905 +86-18025329037 | admin@nexconn.com | China | 3218 | 58 |
| Capot Chemical Co.,Ltd. | +86-（0）57185586718; +8613336195806 | sales@capot.com | China | 29734 | 60 |
| Shanghai Daken Advanced Materials Co.,Ltd | +86-2158073036 | info@dakenam.com | China | 13451 | 58 |
| career henan chemical co | +86-0371-86658258 +8613203830695 | sales@coreychem.com | China | 29850 | 58 |
| Shanghai Arbor Chemical Co., Ltd. | 021-60451682 | act@arborchemical.com | CHINA | 904 | 58 |
| Alchem Pharmtech,Inc. | 8485655694 | sales@alchempharmtech.com | United States | 63687 | 58 |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | sales@conier.com | China | 49975 | 58 |
| Shaanxi Dideu Medichem Co. Ltd | +86-29-87569266 +86-17392581500 | 1015@dideu.com | China | 3965 | 58 |
| QINGDAO KAIENSI INTERNATIONAL TRADE CO.,LTD. | +86-0532-8699-9256 +8615254267723 | kaley@cnfdevelop.com | China | 1410 | 58 |
View Lastest Price from 2-Adamantone-5-carboxylic acid manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
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2025-09-25 | 2-Adamantone-5-carboxylic acid
56674-87-4
|
US $3.00-0.20 / KG | 1KG | 98% | g-kg-tons, free sample is available | Henan Fengda Chemical Co., Ltd | |
 |
2025-09-23 | 2-Adamantone-5-carboxylic acid
56674-87-4
|
US $0.00-0.00 / KG | 1KG | 98% | 2000 | Shenzhen Nexcon Pharmatechs Ltd. | |
 |
2025-07-25 | 2-Adamantone-5-carboxylic acid
56674-87-4
|
US $0.00 / kg | 1kg | 99% | 10000KGS | Shaanxi Dideu New Materials Co. Ltd |
-
- 2-Adamantone-5-carboxylic acid
56674-87-4
- US $3.00-0.20 / KG
- 98%
- Henan Fengda Chemical Co., Ltd
-
- 2-Adamantone-5-carboxylic acid
56674-87-4
- US $0.00-0.00 / KG
- 98%
- Shenzhen Nexcon Pharmatechs Ltd.
-
- 2-Adamantone-5-carboxylic acid
56674-87-4
- US $0.00 / kg
- 99%
- Shaanxi Dideu New Materials Co. Ltd
