hRspo2
- CAS No.
- Chemical Name:
- hRspo2
- Synonyms
- RSPO2;hRspo2;R-spondin-2;UNQ9384/PRO34209;R-SPONDIN-2 human;Mouse R-spondin-2 elisa kit;Roof plate-specific spondin-2;ANTI-RSPO2 (C-TERM) antibody produced in rabbit
- CBNumber:
- CB42902179
- Molecular Formula:
- Molecular Weight:
- 0
- MDL Number:
- MOL File:
- Mol file
hRspo2 price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | SRP3322 | R-SPONDIN-2 human recombinant, expressed in CHO cells, ≥95% (SDS-PAGE), ≥95% (HPLC) | 20μG | $359 | 2026-04-30 | Buy | |
| Usbiological | 366478 | R-Spondin 2 | 96Tests | $918 | 2021-12-16 | Buy | |
| Usbiological | 366479 | R-Spondin 2 | 96Tests | $935 | 2021-12-16 | Buy | |
| Biorbyt Ltd | orb527752 | RSPO2 | 10μg | $290.7 | 2021-12-16 | Buy |
hRspo2 Chemical Properties, Uses, Production
Uses
Recombinant human R-Spondin-2 (R-Spo2) is a 24.4kDa protein consisting of 212 amino acid residues. R-Spo2 is encoded by the gene mapped to human chromosome 8q23.1. The encoded protein belongs to the R-spondin family of secreted proteins. Members of RSpo family contain two furin-like cysteine-rich domains at N- terminal end and thrombospondin structural domain and a basic charged C- terminal domain.
Biological Activity
R-Spondin 2 (R-Spo2) plays a vital role in the activation of canonical Wnt signaling pathway, which is essential for normal morphogenesis of the respiratory tract and limbs. R-Spo2 positively regulates Wnt-dependent mineralization of osteoblasts, myogenic differentiation and hypertrophic myotube formation. R-Spo2 is also involved in skeletal development. Aberration in the expression of RSPO2 causes ossification of the posterior longitudinal ligament of the spine (OPLL), resulted by the altered differentiation of spinal ligament MSCs (mesenchymal stem cells) into chondrocytes. R-Spo2 is associated with various developmental processes, such as myogenesis, craniofacial morphogenesis, keratinocyte proliferation, osteoblast maturation, lung and limb development. R-Spo2 interacts with leucine-rich-repeat-containing G-protein-coupled receptor 5 (Lgr5) and stimulates acetylcholine receptor (AChR) clustering at the neuromuscular junction (NMJ).
hRspo2 Preparation Products And Raw materials
Raw materials
Preparation Products
hRspo2 Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Shanghai fantai biology science and technology co., ltd | 15601885736 | 2114786541@qq.com | China | 206 | 58 |
| Shanghai Jinshi Biochemical Technology Co., Ltd | 18601717983 18601717983 | 291017736@qq.com | China | 499 | 58 |
| Shanghai Yubo Biotechnology Co., Ltd | 021-60514606 18321282235 | sale1@shybsw.net | China | 8165 | 58 |
| shlmai | 021-67680335 13052188602 | sale1@shlmai.net | China | 10000 | 58 |
