FILIPIN COMPLEX
- CAS No.
- 11078-21-0
- Chemical Name:
- FILIPIN COMPLEX
- Synonyms
- FILIPIN;filmirisin;filimirasin;FILIPIN COMPLEX;14-deoxylagosin;FILIPIN COMPLEX USP/EP/BP;FILIPIN COMPLEX FROM STREPTOMYCES &;filipin complex from streptomyces filipinensis;Filipin complex from Streptomyces filipinensis
- CBNumber:
- CB4291136
- Molecular Formula:
- C35H58O11
- Molecular Weight:
- 654.82842
- MDL Number:
- MFCD00131073
- MOL File:
- 11078-21-0.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Melting point | 195-205° |
|---|---|
| alpha | D22 -148.3° (c = 0.89 in methanol) |
| storage temp. | −20°C |
| solubility | methanol: 10 mg/mL, clear, very dark yellow |
| form | powder |
| color | yellow |
| biological source | Streptomyces sp. (Streptomyces filipinensis) |
| Merck | 13,4111 |
| InChIKey | IMQSIXYSKPIGPD-YQRUMEKGSA-N |
| EWG's Food Scores | 1 |
| FDA UNII | 87Z59R7D14 |
| UNSPSC Code | 12352202 |
| NACRES | NA.77 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H319-H335 | |||||||||
| Precautionary statements | P261-P264-P271-P280-P302+P352-P305+P351+P338 | |||||||||
| target organs | Respiratory system | |||||||||
| Hazard Codes | Xn,Xi | |||||||||
| Risk Statements | 36/37/38 | |||||||||
| Safety Statements | 26-36 | |||||||||
| WGK Germany | 3 | |||||||||
| RTECS | LK4400000 | |||||||||
| F | 10 | |||||||||
| HS Code | 2941900000 | |||||||||
| Storage Class | 11 - Combustible Solids | |||||||||
| Hazard Classifications | Eye Irrit. 2 Skin Irrit. 2 STOT SE 3 |
|||||||||
| NFPA 704 |
|
FILIPIN COMPLEX price More Price(27)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | F9765 | Filipin complex from Streptomyces filipinensis ≥70% (UV) | 11078-21-0 | 25mg | $235 | 2026-04-30 | Buy |
| Sigma-Aldrich | F9765 | Filipin complex from Streptomyces filipinensis ≥70% (UV) | 11078-21-0 | 50mg | $429 | 2026-04-30 | Buy |
| Cayman Chemical | 25073 | Filipin Complex ≥95% | 11078-21-0 | 5mg | $66 | 2026-04-30 | Buy |
| Cayman Chemical | 25073 | Filipin Complex ≥95% | 11078-21-0 | 25mg | $163 | 2026-04-30 | Buy |
| Cayman Chemical | 25073 | Filipin Complex ≥95% | 11078-21-0 | 50mg | $294 | 2026-04-30 | Buy |
FILIPIN COMPLEX Chemical Properties, Uses, Production
Uses
Filipin complex comprises a family of pentaene macrocyclic lactones first isolated from Streptomyces filipinensis and reported by researchers at Upjohn in 1955. Filipin complex consists of four analogues, with filipin III comprising the bulk (>70%) of the complex. Filipin complex is a potent broad spectrum antifungal agent that also exhibits antitumor and antiviral activities. Filipin complex acts by binding cell membrane sterols, disrupting membrane integrity.
Uses
Filipin complex from Streptomyces filipinensis has been used as a profluorescence probe to detect the free cholesterol in cell.
Definition
ChEBI: Filipin III is a macrolide that is the major component of a mixture of four isomeric polyene macrolides isolated from Streptomyces filipinensis. It has a role as a bacterial metabolite and a fluorescent probe. It is a macrolide, a polyol and an olefinic compound.
General Description
Chemical structure: macrolide
Biochem/physiol Actions
Filipin is a polyene macrolide antibiotic and antifungal. The antifungal mechanism of action is unclear but may be due to altering membrane permeability. Filipin binds to model crystalline phase lipid bilayers containing cholesterol, and to liquid phase bilayers with or without cholesterol, in an orientation that forms membrane pores.It both inhibits prion protein (PrP) endocytosis and causes the release of PrP from the plasma membrane.
IC 50
Macrolide
FILIPIN COMPLEX Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Hunan Hui Bai Shi Biotechnology Co., Ltd. | 0731-85526065 13308475853 | ivy@hnhbsj.com | China | 7236 | 62 |
| Dalian Meilun Biotech Co., Ltd. | 0411-62910999 13889544652 | sales@meilune.com | China | 4765 | 58 |
| Guangzhou Isun Pharmaceutical Co., Ltd | 020-39119399 18927568969 | isunpharm@qq.com | China | 4773 | 55 |
| Quality Control Solutions Ltd. | 0755-66853366 13670046396 | orders@qcsrm.com | China | 18188 | 56 |
| Shanghai Macklin Biochemical Co.,Ltd. | 15221275939 15221275939 | shenlinxing@macklin.cn | China | 15775 | 55 |
| Sigma-Aldrich | 021-61415566 800-8193336 | orderCN@merckgroup.com | China | 51389 | 80 |
| Shanghai Lollane Biological Technology Co.,Ltd. | 021-52996696，15000506266 15000506266 | China | 4859 | 55 | |
| Shanghai YuanYe Biotechnology Co., Ltd. | 15026964105 | 2881489226@qq.com | China | 89667 | 60 |
| Lynnchem | 86-(0)29-85992781 17792393971 | info@lynnchem.com | China | 4578 | 58 |
| Novachemistry | 44-20819178-90 02081917890 | info@novachemistry.com | United Kingdom | 4372 | 58 |
View Latest Price from FILIPIN COMPLEX manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2019-12-20 | FILIPINCOMPLEX
11078-21-0
|
$1.00 | 1KG | 99% | Career Henan Chemical Co |
-
- FILIPINCOMPLEX
11078-21-0
- $1.00
- 99%
- Career Henan Chemical Co
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