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N,N'-Diisopropylcarbodiimide

N,N'-Diisopropylcarbodiimide structure

CAS No.: 693-13-0

Chemical Name:: N,N'-Diisopropylcarbodiimide

Synonyms: DIC;Diisopropylcarbodiimide;DIPC;DIPCI;DIPCDI;N,N-DIISOPROPYLCARBODIIMIDE;PCI;DICI;1,3-DIISOPROPYLCARBODIIMIDE;Diisopropylcarbodiimide solution

CBNumber:: CB4301572

Molecular Formula:: C7H14N2

Molecular Weight:: 126.2

MDL Number:: MFCD00065689

MOL File:: 693-13-0.mol

MSDS File:: SDS

Last updated:2025-12-14 10:02:33

Product description	Number	Pack Size	Price
DIC purum, ≥98.0% (GC)	38370	25ml	$92.4
DIC purum, ≥98.0% (GC)	38370	100ml	$232
N,N′-Diisopropylcarbodiimide for synthesis	8.03649	10ml	$51.3
N,N′-Diisopropylcarbodiimide for synthesis	8.03649	25mL	$99.5
N,N′-Diisopropylcarbodiimide for synthesis	8.03649	100mL	$261
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N,N'-Diisopropylcarbodiimide Properties

Melting point	210-2120C (dec)
Boiling point	145-148 °C(lit.)
Density	0.815 g/mL at 20 °C(lit.)
vapor pressure	34.9hPa at 55.46℃
refractive index	n20/D 1.433(lit.)
Flash point	93 °F
storage temp.	Store below +30°C.
solubility	Soluble in chloroform, methylene chloride, acetonitrile, dioxane, dimethylformamide andtetrahydrofuran.
form	Liquid
color	Clear colorless to yellow
Sensitive	Moisture Sensitive
BRN	878281
Stability	Volatile
InChIKey	BDNKZNFMNDZQMI-UHFFFAOYSA-N
LogP	4.11 at 20℃
Toxicology and Carcinogenesis	Toxicology and Carcinogenesis Studies of Diisopropylcarbodiimide (CASRN 693-13-0) in F344/N Rats and B6C3F1 Mice (Dermal Studies)
CAS DataBase Reference	693-13-0(CAS DataBase Reference)
EWG's Food Scores	1
FDA UNII	OQO20I6TWH
NIST Chemistry Reference	2-Propanamine, N,N'-methanetetraylbis-(693-13-0)
EPA Substance Registry System	2-Propanamine, N,N'-methanetetraylbis- (693-13-0)
UNSPSC Code	12352200
NACRES	NA.22

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS02,GHS05,GHS06,GHS08

Signal word

Danger

Hazard statements

H226-H317-H318-H330-H334

Precautionary statements

P210-P233-P280-P303+P361+P353-P304+P340+P310-P305+P351+P338

Hazard Codes

T+,T,F,Xn

Risk Statements

10-26-36/37/38-41-42/43-37/38

Safety Statements

26-36/37/39-45-38-28A-16-22

RIDADR

UN 2929 6.1/PG 1

WGK Germany

RTECS

FF2175000

10-21

Hazard Note

Flammable/Highly Toxic/

TSCA

TSCA listed

HazardClass

6.1

PackingGroup

HS Code

29252000

Hazardous Substances Data

693-13-0(Hazardous Substances Data)

Limited Quantities

100ml (liquid) or 0.5 Kg (solid)

Excepted Quantities

Max Inner Pack (1g or 1ml) and Max Outer Pack (500g or 500ml)

NFPA 704

	2
4		1

N,N'-Diisopropylcarbodiimide price More Price(63)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	38370	DIC purum, ≥98.0% (GC)	693-13-0	25ml	$92.4	2025-07-31	Buy
Sigma-Aldrich	38370	DIC purum, ≥98.0% (GC)	693-13-0	100ml	$232	2025-07-31	Buy
Sigma-Aldrich	8.03649	N,N′-Diisopropylcarbodiimide for synthesis	693-13-0	10ml	$51.3	2024-03-01	Buy
Sigma-Aldrich	8.03649	N,N′-Diisopropylcarbodiimide for synthesis	693-13-0	25mL	$99.5	2024-03-01	Buy
Sigma-Aldrich	8.03649	N,N′-Diisopropylcarbodiimide for synthesis	693-13-0	100mL	$261	2024-03-01	Buy

Product number	Packaging	Price	Buy
38370	25ml	$92.4	Buy
38370	100ml	$232	Buy
8.03649	10ml	$51.3	Buy
8.03649	25mL	$99.5	Buy
8.03649	100mL	$261	Buy

N,N'-Diisopropylcarbodiimide Chemical Properties,Uses,Production

Description

Diisopropylcarbodiimide (DIC) is a clear liquid that can be easily dispensed by volume. It slowly reacts with moisture from the air, so for long term storage the bottle should be flushed with dry air or inert gas and sealed tightly. It is used in peptide chemistry as a coupling reagent. It is very toxic and caused contact dermatitis in a laboratory worker.

Chemical Properties

N,N'-Diisopropylcarbodiimide is colorless to pale yellow liquid. Insoluble in water, soluble in benzene, ethanol, ether.

Uses

N,N'-Diisopropylcarbodiimide is used as a reagent in synthetic organic chemistry. It serves as a chemical intermediate and as a stabilizer for Sarin (chemical weapon). It is also used in the synthesis of peptide and nucleic acid. Further, it is used as an antineoplastic and involved in the treatment of malignant melanoma and sarcomas. It is mainly used in amikacin, glutathione dehydrants, as well as in synthesis of acid anhydride, aldehyde, ketone, isocyanate; when it is used as dehydrating condensing agent, it reacts to dicyclohexylurea through short-time reaction under normal temperature.

Definition

ChEBI: A carbodiimide compound having an isopropyl substituent on both nitrogen atoms.

General Description

N,N′-Diisopropylcarbodiimide (DIC) is a carbodiimide used as a coupling reagent in the synthesis of amides, peptides, ureas, heterocycles, and unsymmetrical carbodiimides. It is also used in the polymerization reactions as an activator.

reaction suitability

reaction type: Coupling Reactions

Contact allergens

It is used in peptide chemistry as a coupling reagent. It is very toxic and causes contact dermatitis in labora- tory workers.

Synthesis

Add N, N'diisopropylthiourea to the autoclave and use xylene as the solvent. The mass ratio of N, N'diisopropylthiourea to xylene solvent is 2:1. Add Sb2O4 catalyst (the amount of the catalyst is 1% of the total material), and oxygen is introduced. The temperature is increased to 115°C under a pressure of 8MPa for 4h, then lowered. Suction filtration at 15°C, decolorization, and vacuum distillation were used to obtain N, N'-Diisopropylcarbodiimide. The yield is 94.55%, and the purity is 99.55%.
N,N'-Diisopropylcarbodiimide

N,N'-Diisopropylcarbodiimide synthesis

Synthesis of N,N'-Diisopropylcarbodiimide from N,N'-DIISOPROPYLTHIOUREA

N,N'-Diisopropylcarbodiimide Preparation Products And Raw materials

Raw materials

MOLECULAR SIEVES PACK 4A 1,2-DIETHOXYDISULFANE LEAD CARBONATE Benzene Dichloromethane

N,N'-DIISOPROPYLTHIOUREA

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Preparation Products

4-(PIPERIDINE-1-CARBONYL)PHENYLBORONIC ACID 4-(2-CYANOETHYLAMINOCARBONYL)PHENYLBORONIC ACID 3-(2-CYANOETHYLAMINOCARBONYL)PHENYLBORONIC ACID 4-(3-TERT-BUTYL-1,2,4-OXADIAZOL-5-YL)PHENYLBORONIC ACID 3-TERT-BUTYL-5-(4-BROMOPHENYL)-1,2,4-OXADIAZOLE

4-(3-TERT-BUTYL-1,2,4-OXADIAZOL-5-YL)BENZALDEHYDE 2-TERT-BUTYL-1,3-DIISOPROPYLISOUREA 4,5-Imidazolidinedione, 2,2-dichloro-1,3-bis(1-methylethyl)- BIS(N N'-DIISOPROPYLACETAMIDINATO)NICKE&

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N,N'-Diisopropylcarbodiimide Suppliers

Global( 681)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Suzhou Highfine Biotech Co.,Ltd.	+86-0512-68071238 +86-13771819922	june@highfine.com	China	458	58
Shanghai Z&T Chemical Co., Ltd	+86-021-33561011 +8613818804961	Sales@ztchemical.com.cn	China	546	58
Hangzhou Verychem Science And Technology Co.Ltd	+86-86-57188162785 13606544505	lucy@verychem.com	China	1170	58
Changzhou Zechong Biopharma Co., Ltd.	+undefined18621330623	sales@zechongchem.com	China	28	58
Hebei Chuanghai Biotechnology Co., Ltd	+86-15350571055	Sibel@chuanghaibio.com	China	6085	58
Hebei Chuanghai Biotechnology Co., Ltd	+8615531151365	mina@chuanghaibio.com	China	18126	58
Nantong Chem-land Co.,Ltd.	+undefined13862903883	sales@chem-land.com	China	61	58
.GZ HONESTCHEM CO.,LTD	+8615013270415	honestchemical@foxmail.com	China	298	58
Shaanxi Dideu Medichem Co. Ltd	+86-29-87569262 +86-15003564040	1061@dideu.com	China	3983	58
Hebei Chuanghai Biotechnology Co,.LTD	+86-13131129325	sales1@chuanghaibio.com	China	5242	58

Supplier	Advantage
Suzhou Highfine Biotech Co.,Ltd.	58
Shanghai Z&T Chemical Co., Ltd	58
Hangzhou Verychem Science And Technology Co.Ltd	58
Changzhou Zechong Biopharma Co., Ltd.	58
Hebei Chuanghai Biotechnology Co., Ltd	58
Hebei Chuanghai Biotechnology Co., Ltd	58
Nantong Chem-land Co.,Ltd.	58
.GZ HONESTCHEM CO.,LTD	58
Shaanxi Dideu Medichem Co. Ltd	58
Hebei Chuanghai Biotechnology Co,.LTD	58

Study on the versatility and application of N,N'-diisopropylcarbodiimide (DIC) in chemical synthesis
As an important organic synthesis reagent, DIChas a wide application prospect in the field of chemical synthesis.
Jun 24，2024

What is N,N'-Diisopropylcarbodiimide?
This product is mainly used in amikacin, glutathione dehydrants, as well as in synthesis of acid anhydride, aldehyde, ketone, ....
May 13，2021

View Lastest Price from N,N'-Diisopropylcarbodiimide manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2026-01-08	1,3-diisopropylcarbodiimide 693-13-0	US $1.00 / KG	1KG	99.9%	500KG	.GZ HONESTCHEM CO.,LTD
2026-01-07	N,N'-Diisopropylcarbodiimide 693-13-0	US $100.00-75.00 / kg	1kg	99%	5000Ton	HEBEI SHENGSUAN CHEMICAL INDUSTRY CO.,LTD
2026-01-05	N,N'-Diisopropylcarbodiimide 693-13-0	US $120.00-1200.00 / g	1g	98%min	200tons	Shaanxi Dideu Medichem Co. Ltd

1,3-diisopropylcarbodiimide
693-13-0
US $1.00 / KG
99.9%
.GZ HONESTCHEM CO.,LTD

N,N'-Diisopropylcarbodiimide
693-13-0
US $100.00-75.00 / kg
99%
HEBEI SHENGSUAN CHEMICAL INDUSTRY CO.,LTD

N,N'-Diisopropylcarbodiimide
693-13-0
US $120.00-1200.00 / g
98%min
Shaanxi Dideu Medichem Co. Ltd

N,N'-Diisopropylcarbodiimide Spectrum

N,N'-Diisopropylcarbodiimide(693-13-0)MS N,N'-Diisopropylcarbodiimide(693-13-0)¹HNMR N,N'-Diisopropylcarbodiimide(693-13-0)¹³CNMR N,N'-Diisopropylcarbodiimide(693-13-0)IR1 N,N'-Diisopropylcarbodiimide(693-13-0)Raman

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Carbodiimide, diisopropyl- diisopropyl-carbodiimid Diisopropylcarbodiimide N,N'-Diisopropylcarbodiimide≥ 99% (Assay) N,N'-Diisopropylcarbodiimide for synthesis n,n'-methanetetraylbis(2-propanamine) N,N-DIISOPROPYLCARBODIIMIDE PCI 1,3-DIISOPROPLYCARBODIIMIDE N,N'-DIISOROPYL CARBODIMIDE extrapure DIC impregnated tablets, ChemDose(R), N,Nμ-Diisopropylcarbodiimide tablets, N,Nμ-Diisopropylcarbodiimide impregnated tablets N,Nμ-Diisopropylcarbodiimide, ChemDose(R) tablets N,N'-Di(propan-2-yl)methanediimine N,N'-Diisopropylcarbodiimide ,99% 2,6-Dimethyl-3,5-diaza-heptane-3,4-diene N,N'-Diisopropylmethanediimine 1,3-Di(prop-2-yl)carbodiimide DIC (1,3 Diisopropyl Carbodiimide) N,N'-Diisopropylcarbodiimide 99.5% Ultrapure N,N'-diisopropylcarb DIC (liquid) N,N’-Diisopropylcarbodiimide Diisopropylcarbodiimide solution N,N'-Methantetraylbis(1-methylethylamin) n,n’-methanetetraylbis-2-propanamin 1,3-DIISOPROPYLCARBODIIMIDE DIPCI DIPC DIPCDI DICI DIC N N'-DIISOPROPYLCARBODIIMIDE 99% N,N'-DIISOPROPYLCARBODIIMIDE, CHEMDOSE & DIC [N,N'-DIISOPROPYLCARBODIIMIDE] N,N-Diisopropylcarbodiimide98% N,N'-Diisopropylcarbodidimide N,N-DIISOPROPYLCARBODIIMIDE PEPTIDE N,N'-Dissopropylcarbodiimide N,N'-Diisopropyl carbodiimide(DIC) 2-Propanamine, N,N-methanetetraylbis- 1,3-Diisopropylcarbodiimide 99% DIISOIPROPYL-CARBODIIMIDE 100ML/500ML/2L DIC/DIPCDI N,N'-DiisopropylcarbodiiMide, 99%, AcroSeal N,N''-DIISOPROPYLCARBODIIMIDE FOR SYNTHES NSC 42080 1,3-Bis(prop-2-yl)carbodiimide, DIC N,N'-Bis(isopropyl)carbodiimide 99% N,N'-two isopropylcarbon twoiMide DIC puruM, >=98.0% (GC) Bosutinib Impurity 11 N,N′-Diisopropylcarbodiimide, ChemDose? tablets Plasma serine protease inhibitor Plasminogen activator inhibitor 3 Serpin A5 N,N'-Diisopropylcarbodiimide N'-Diisopropylcarbodiimide N,N'-Diisopropylcarbodiimide >