3-nitro-N-acrylphenylamine
- CAS No.
- 17090-15-2
- Chemical Name:
- 3-nitro-N-acrylphenylamine
- Synonyms
- Alflutinib Impurity 12;3-nitro-N-acrylphenylamine;N-(3-nitrophenyl)prop-2-enamide;2-Propenamide, N-(3-nitrophenyl)-;3-nitro-N-acrylphenylamine ISO 9001：2015 REACH
- CBNumber:
- CB43037829
- Molecular Formula:
- C9H8N2O3
- Molecular Weight:
- 192.17
- MDL Number:
- MFCD00595891
- MOL File:
- 17090-15-2.mol
- MSDS File:
- SDS
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302-H315-H319-H335 |
| Precautionary statements | P261-P301+P312-P302+P352-P304+P340-P305+P351+P338 |
3-nitro-N-acrylphenylamine price More Price(26)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Activate Scientific | AS116477 | N-(3-Nitrophenyl)acrylamide 97% | 17090-15-2 | 1g | $25 | 2026-06-04 | Buy |
| Activate Scientific | AS116477 | N-(3-Nitrophenyl)acrylamide 97% | 17090-15-2 | 5g | $53 | 2026-06-04 | Buy |
| Activate Scientific | AS116477 | N-(3-Nitrophenyl)acrylamide 97% | 17090-15-2 | 25g | $151 | 2026-06-04 | Buy |
| Activate Scientific | AS116477 | N-(3-Nitrophenyl)acrylamide 97% | 17090-15-2 | 100g | $560 | 2026-06-04 | Buy |
| Synthonix | N51415 | N-(3-Nitrophenyl)acrylamide 97% | 17090-15-2 | 1g | $52 | 2026-05-06 | Buy |
3-nitro-N-acrylphenylamine Chemical Properties, Uses, Production
Synthesis
814-68-6
99-09-2
17090-15-2
1. 3-Nitroaniline (6.90 g, 50 mmol) was weighed in a 250 mL round bottom flask, dichloromethane (100 mL) was added as solvent and stirring was initiated. 2. The reaction system was cooled to -78 °C and diisopropylethylamine (12.92 g, 100 mmol) was subsequently added to the reaction system. 3. Acryloyl chloride (6.80 g, 75 mmol) was slowly added dropwise to the reaction system under stirring conditions. 4. 4. After the dropwise addition, the reaction mixture was gradually warmed up to room temperature and the reaction was continued with stirring for 2 hours. 5. After completion of the reaction, the solvent was removed by concentration under reduced pressure to give the crude product. 6. The crude product was purified using column chromatography with the eluent being petroleum ether/ethyl acetate (4:1, v/v). 7. The target component was collected and the solvent was removed under reduced pressure to afford N-(3-nitrophenyl)acrylamide (9.6 g, 80% yield) as a yellow solid.
References
[1] Bioorganic and Medicinal Chemistry, 2016, vol. 24, # 21, p. 5505 - 5512
[2] European Journal of Medicinal Chemistry, 2017, vol. 126, p. 444 - 455
[3] Bioorganic and Medicinal Chemistry, 2018, vol. 26, # 14, p. 4179 - 4186
[4] Bioorganic and Medicinal Chemistry, 2017, vol. 25, # 2, p. 765 - 772
[5] European Journal of Medicinal Chemistry, 2018, vol. 143, p. 1847 - 1857
3-nitro-N-acrylphenylamine Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Adamas Reagent, Ltd. | 400-6009262 15618770481 | yhx@titansci.com | China | 14098 | 59 |
| AN PharmaTech Co Ltd | 86(21)68097365 | sales@anpharma.net | China | 4875 | 55 |
| Pharmacodia (Beijing) Co.,Ltd | +86-400-851-9921 | sales@pharmacodia.com | China | 2308 | 55 |
| Amadis Chemical Company Limited | 571-89925085 | sales@amadischem.com | China | 131885 | 58 |
| Aikon International Limited | 025-58859352 19370895928 | sales01@aikonchem.com | China | 15078 | 58 |
| Shandong Zouping Xinlong Technology Co., Ltd. | 0543-17705431882 13696309696 | 5042407@qq.com | China | 113 | 58 |
| Dideu Industries Group Limited | +8617392712697 | 1022@dideu.com | China | 29089 | 58 |
| Career Henan Chemica Co | +86-0371-86658258 +86-13203830695 | laboratory@coreychem.com | China | 30203 | 58 |
| Guangzhou Yuheng Pharmaceutical Technology Co., Ltd | +8613580539051 | joe@yuhengpharm.com | CHINA | 21135 | 58 |
| Wuhan Taiyicheng Biopharmaceutical Co., Ltd. | 027-88320699 ;15307126061; | tycshyy@126.com | China | 997 | 58 |
