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2-Amino-3-picoline

2-Amino-3-picoline structure

CAS No.: 1603-40-3

Chemical Name:: 2-Amino-3-picoline

Synonyms: 3-METHYLPYRIDIN-2-AMINE;2-AMINO-3-METHYLPYRIDINE;3-METHYLPYRIDIN-2-YLAMINE;AURORA KA-876;2-Amino-β-picoline;2-AMINO-3-PICOLINE;TIMTEC-BB SBB004356;3-Picoline, 2-amino-;2-Amino-beta-picoline;2-AMINO-3-PICOLINE 96%

CBNumber:: CB4304533

Molecular Formula:: C6H8N2

Molecular Weight:: 108.14

MDL Number:: MFCD00006320

MOL File:: 1603-40-3.mol

MSDS File:: SDS

Last updated:2026-01-13 11:19:40

Product description	Number	Pack Size	Price
2-Amino-3-methylpyridine 95%	A75633	100g	$87.1
2-Amino-3-methylpyridine 95%	A75633	500g	$220
2-Amino-3-methylpyridine >98.0%(GC)	A0400	25g	$26
2-Amino-3-methylpyridine >98.0%(GC)	A0400	500g	$230
2-Amino-3-methylpyridine	A617630	50g	$55
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2-Amino-3-picoline Properties

Melting point	29-31 °C (lit.)
Boiling point	221-222 °C (lit.)
Density	1.073 g/mL at 25 °C (lit.)
refractive index	n20/D 1.5823(lit.)
Flash point	233 °F
storage temp.	Keep in dark place,Inert atmosphere,Room temperature
solubility	1000g/l
pka	pK1: 7.24(+1) (25°C)
form	Liquid After Melting
color	Clear yellow
Water Solubility	SOLUBLE
Sensitive	Hygroscopic
BRN	107892
InChI	1S/C6H8N2/c1-5-3-2-4-8-6(5)7/h2-4H,1H3,(H2,7,8)
InChIKey	RGDQRXPEZUNWHX-UHFFFAOYSA-N
SMILES	Cc1cccnc1N
CAS DataBase Reference	1603-40-3(CAS DataBase Reference)
EWG's Food Scores	1
FDA UNII	Y2WWD85QY6
NIST Chemistry Reference	2-Pyridinamine, 3-methyl-(1603-40-3)
EPA Substance Registry System	2-Pyridinamine, 3-methyl- (1603-40-3)
UNSPSC Code	12352100
NACRES	NA.22

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS06,GHS08

Signal word

Danger

Hazard statements

H301+H311+H331-H373

Precautionary statements

P280-P301+P310+P330-P302+P352+P312-P304+P340+P311-P314

PPE

Eyeshields, Faceshields, Gloves, type ABEK (EN14387) respirator filter

Hazard Codes

Risk Statements

23/24/25-33-36/37/38-25

Safety Statements

36/37/39-45-37/39-28A-26

RIDADR

UN 2811 6.1/PG 3

WGK Germany

RTECS

US1850000

TSCA

TSCA listed

HazardClass

6.1

PackingGroup

HS Code

29333999

Storage Class

6.1A - Combustible acute toxic Cat. 1 and 2
very toxic hazardous materials

Hazard Classifications

Acute Tox. 2 Dermal
Acute Tox. 3 Inhalation
Acute Tox. 3 Oral
Aquatic Chronic 3
Eye Dam. 1
Skin Corr. 1B

Limited Quantities

5.0 L (1.3 gallons) (liquid) or 5.0 kg (11 lbs) (solid)

Excepted Quantities

Max Inner Pack (30g or 30ml) and Max Outer Pack (1Kg or 1L)

NFPA 704

	1
3		0

2-Amino-3-picoline price More Price(33)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	A75633	2-Amino-3-methylpyridine 95%	1603-40-3	100g	$87.1	2026-03-19	Buy
Sigma-Aldrich	A75633	2-Amino-3-methylpyridine 95%	1603-40-3	500g	$220	2026-03-19	Buy
TCI Chemical	A0400	2-Amino-3-methylpyridine >98.0%(GC)	1603-40-3	25g	$26	2026-03-19	Buy
TCI Chemical	A0400	2-Amino-3-methylpyridine >98.0%(GC)	1603-40-3	500g	$230	2024-03-01	Buy
TRC	A617630	2-Amino-3-methylpyridine	1603-40-3	50g	$55	2021-12-16	Buy

Product number	Packaging	Price	Buy
A75633	100g	$87.1	Buy
A75633	500g	$220	Buy
A0400	25g	$26	Buy
A0400	500g	$230	Buy
A617630	50g	$55	Buy

2-Amino-3-picoline Chemical Properties,Uses,Production

Chemical Properties

2-Amino-3-picoline is CLEAR YELLOW LIQUID AFTER MELTING

Uses

2-Amino-3-picoline is used in the synthesis of ketones from aldehydes.

Synthesis Reference(s)

Journal of the American Chemical Society, 95, p. 4453, 1973 DOI: 10.1021/ja00794a070

Hazard

Toxic by ingestion.

Synthesis

108-99-6

1603-41-4

1603-40-3

1) Add 9021 g of toluene, 538 g of sodium metal, 70 g of ethanolamine and 1900 g of 3-methylpyridine to the autoclave. After sealing the autoclave, open the feeding ports of the autoclave inlet and drip tank, and make sure the valves of the drip tank and the kettle are open. A hose was extended through the inlet port to the bottom of the kettle, and nitrogen was passed in to displace the air for 1 min, followed by closing the inlet cover. Heat the mixture to 60°C and slowly add liquid ammonia dropwise, maintaining the pressure in the autoclave at 3 MPa, until the total amount of liquid ammonia added reaches 600 g. 2) Increase the reaction temperature to 170°C and fill the autoclave with nitrogen until the pressure reaches 5 MPa to ensure that the reaction is fully carried out. When the pressure in the autoclave rose to 5.5 MPa, the pressure was released to 5 MPa and the process was repeated until the pressure no longer rose due to the reaction, indicating that the reaction was complete. The reaction system was then cooled to room temperature. 3) The ammoniated liquid was slowly added dropwise to 9 kg of water and the mixture was stirred to promote hydrolysis and extraction. After standing, the phases were separated and the aqueous phase was subjected to secondary extraction with 3 L of toluene. All organic phases were combined and the oil phase was quantitatively analyzed by gas chromatography to yield 1928 g of 2-amino-5-methylpyridine and 144 g of 2-amino-3-methylpyridine.

Purification Methods

Recrystallise the picoline three times from *benzene, most of the residual *benzene being removed from the crystals by standing over paraffin wax chips in an evacuated desiccator. The amine is also transferred to a separating funnel under N2, and left in contact with NaOH pellets for 3hours with occasional shaking. It is then placed in a vacuum distilling flask where it is refluxed gently in a stream of dry N2 before fractionally distilling it. [Mod et al. J Phys Chem 60 1651 1956, Beilstein 22/9 V 212].

References

[1] Patent: US2456379, 1946,
[2] Patent: CN106496105, 2017, A. Location in patent: Paragraph 0024; 0025; 0026; 0027; 0028; 0029; 0030-0035

2-Amino-3-picoline Preparation Products And Raw materials

Raw materials

3-Picoline Toluene Sodium Monoethanolamine Ammonia

Preparation Products

Ethyl 2-aminopyridine-3-carboxylate 2-CHLORO-4-METHOXY-3-METHYLPYRIDINE 2-BROMO-3-METHYLPYRIDINE-5-BORONIC ACID 2,5-DIBROMONICOTINALDEHYDE 1H-PYRROLO[2,3-B]PYRIDINE, 2-METHYL-

2-Chloro-5-cyano-3-methylpyridine (2-Aminopyridin-3-yl)methanol 2-Amino-5-bromo-3-methylpyridine 2-(2,2,2-TRIFLUOROETHOXY)PYRIDINE-3-CARBOXYLIC ACID 2-Amino-5-hydroxypyridine

FMOC-2-AMINONICOTINIC ACID 6-AMINO-5-METHYLPYRIDINE-3-SULFONIC ACID 2-CHLORO-3-METHYL-4-NITROPYRIDINE N-OXIDE 2-AMINO-5-NITROPYRIDINE-3-CARBOXYLIC ACID 2-CHLORO-5-IODO-3-METHYLPYRIDINE

PEMIROLAST 3-Methyl-2-nitropyridine 2-CHLORO-3-METHYLPYRIDINE-5-BORONIC ACID 2-ACETAMIDO-3-PICOLINE 6-AMINO-5-METHYLNICOTINONITRILE

2-Amino-5-chloro-3-picoline 5-Amino-2-chloro-3-picoline 2-Chloro-3-methyl-5-bromopyridine 4-METHOXY-3-METHYLPYRIDIN-2-AMINE 2-AMINO-4-METHOXYPYRIDINE-3-CARBOXYLIC ACID

2-(Trifluoromethyl)nicotinic acid 2-Amino-3-methyl-5-nitropyridine 2-CHLORO-3-METHYL-4-METHOXYPYRIDINE N-OXIDE 2-ACETAMIDOPYRIDINE-3-CARBOXYLIC ACID 2-Bromo-3-methylpyridine

2-HYDROXY-3-METHYL-5-NITROPYRIDINE 2-NITRONICOTINIC ACID

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2-Amino-3-picoline Suppliers

Global( 587)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Shanghai Yongzeng Technology Co.,Ltd	+8613818947575	sales@yongzchem.com	China	142	58
Hebei Chuanghai Biotechnology Co., Ltd	+8615350571055	Sibel@chuanghaibio.com	China	8738	58
Hebei Chuanghai Biotechnology Co,.LTD	+86-86-13131129325 +8613131129325	sales1@chuanghaibio.com	China	5235	58
Frapp's ChemicalNFTZ Co., Ltd.	+86 (576) 8169-6106	sales@frappschem.com	China	880	50
Capot Chemical Co.,Ltd.	+86-（0）57185586718; +8613336195806	sales@capot.com	China	29640	60
Henan Tianfu Chemical Co.,Ltd.	+86-0371-55170693 +86-19937530512	info@tianfuchem.com	China	21592	55
Jiangsu Zhongbang Pharmaceutical Co., Ltd.	025-87151996	zbsales@chinaredsun.com	CHINA	32	55
career henan chemical co	+86-0371-86658258 +8613203830695	sales@coreychem.com	China	29822	58
Zhejiang ZETian Fine Chemicals Co. LTD	+8618957127338	stella@zetchem.com	China	2994	58
Shandong chuangyingchemical Co., Ltd.	18853181302	sale@chuangyingchem.com	CHINA	5906	58

Supplier	Advantage
Shanghai Yongzeng Technology Co.,Ltd	58
Hebei Chuanghai Biotechnology Co., Ltd	58
Hebei Chuanghai Biotechnology Co,.LTD	58
Frapp's ChemicalNFTZ Co., Ltd.	50
Capot Chemical Co.,Ltd.	60
Henan Tianfu Chemical Co.,Ltd.	55
Jiangsu Zhongbang Pharmaceutical Co., Ltd.	55
career henan chemical co	58
Zhejiang ZETian Fine Chemicals Co. LTD	58
Shandong chuangyingchemical Co., Ltd.	58

What is 2-Amino-3-picoline?
2-Amino-3-picoline is used as a chelation-assisted auxiliary in various transition metal-catalyzed C-H and C-C bond activation....
Apr 9，2024

View Lastest Price from 2-Amino-3-picoline manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2026-04-20	2-Amino-3-picoline 1603-40-3	US $30.00 / kg	1kg	98%	500kgs	Shanghai Yongzeng Technology Co.,Ltd
2026-03-20	2-Amino-3-picoline 1603-40-3	US $25.00 / ASSAYS	100ASSAYS	99.5%	100 mt	Hebei Chuanghai Biotechnology Co., Ltd
2025-05-26	2-Amino-3-picoline 1603-40-3	US $10.00 / KG	1KG	95%	10 ton	Hebei Chuanghai Biotechnology Co,.LTD

2-Amino-3-picoline
1603-40-3
US $30.00 / kg
98%
Shanghai Yongzeng Technology Co.,Ltd

2-Amino-3-picoline
1603-40-3
US $25.00 / ASSAYS
99.5%
Hebei Chuanghai Biotechnology Co., Ltd

2-Amino-3-picoline
1603-40-3
US $10.00 / KG
95%
Hebei Chuanghai Biotechnology Co,.LTD

2-Amino-3-picoline Spectrum

2-Amino-3-picoline(1603-40-3)MS 2-Amino-3-picoline(1603-40-3)¹HNMR 2-Amino-3-picoline(1603-40-3)¹³CNMR 2-Amino-3-picoline(1603-40-3)IR1 2-Amino-3-picoline(1603-40-3)Raman

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AURORA KA-876 2-AMINO-3-PICOLINE 96% 2-amino-3-methyl-pyridin 2-Amino-beta-picoline 2-Pyridinamine,3-methyl- 3-Methyl-2-aminopyridine 3-methyl-2-pyridinamin 3-Methyl-2-pyridinamine 3-Picoline, 2-amino- Pyridine, 2-amino-3-methyl- 2-Amino-3-methylpyridine,97% 2-Amino-3-picoline;2-Amino-3-methylpyridine 2-Pyridinamine,3-methyl-(9CI) A**2-Amino-3-methylpyridine 2-AMINO-3-METHYL-PYRIDIN,99% 2-AMINO-3-METHYL PYRIDINE 3-METHYLPYRIDIN-2-YLAMINE 2-AMINO-3-METHYLPYRIDINE (2-AMINO-3-PICOLINE) 2-Amino-3-methylpyridine ,99% 2-Amino-3-picoline,96% 2-Amino-3-methylpyridine ,98.5% 2-AMino-3-picoline, 96% 100GR 2-Amino-3-picoline, 3-Methylpyridin-2-amine 2-Amino-β-picoline 2-AMINO-3-PICOLINE 3-METHYL-2-PYRIDYLAMINE 3-METHYLPYRIDIN-2-YLAMINE Amino-3-methyl pyridine TIMTEC-BB SBB004356 2-Amino-3-methylpyridine> 2-Amino-3-picoline ISO 9001：2015 REACH 2-Amino-6-bromopyridine derivative 3-Methyl-2-pyridylamin 2-AMINO-3-METHYLPYRIDINE 3-METHYLPYRIDIN-2-AMINE 1603-40-3 1603-40-1 1630-40-3 504-29-1 Pyridines Heterocyclic Building Blocks Building Blocks C6 amine Pyridine Pyridines derivates Pyridine series Pyridines, Pyrimidines, Purines and Pteredines VARIOUSAMINE bc0001