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Hesperetin

Hesperetin Structure
Hesperetin structure
CAS No.
520-33-2
Chemical Name:
Hesperetin
Synonyms
(S)-2,3-dihydro-5,7-dihydroxy-2-(3-hydroxy-4-methoxyphenyl)-4-benzopyrone;2,3-DIHYDRO-5,7-DIHYDROXY-2S-(3-HYDROXY-4-METHOXPHENYL)-4H-1-BENZOPYRAN-4-ONE;4H-1-Benzopyran-4-one, 2,3-dihydro-5,7-dihydroxy-2-(3-hydroxy-4-methoxyphenyl)-, (2S)-;YSO2;NSC 57654;HESPERETIN;HESPERETINE;HESPERETIN(P);Hesperetin>Prestwick_908
CBNumber:
CB4304735
Molecular Formula:
C16H14O6
Molecular Weight:
302.28
MDL Number:
MFCD00075646
MOL File:
520-33-2.mol
MSDS File:
SDS
Last updated:2026-03-06 19:22:19
Product description Number Pack Size Price
Hesperetin >97.0%(HPLC)(T) H0721 5g $20
Hesperetin >97.0%(HPLC)(T) H0721 25g $52
Hesperetin 10006084 25000mg $50
Hesperetin 10006084 50000mg $94
Hesperetin 10006084 100000mg $177
More product size
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Hesperetin Properties

Melting point 230-232°C
Boiling point 363.32°C (rough estimate)
Density 1.2514 (rough estimate)
refractive index -4 ° (C=1.8, EtOH)
storage temp. Inert atmosphere,Room Temperature
solubility DMSO (Slightly), Methanol (Slightly)
pka 7.49±0.40(Predicted)
form Solid
color White to Pale Yellow
Water Solubility Soluble in water (partly), dilute alkalis, and ethanol (50 mg/ml).
Merck 14,4670
BRN 309850
Cosmetics Ingredients Functions ANTIOXIDANT
SKIN CONDITIONING
InChIKey AIONOLUJZLIMTK-AWEZNQCLSA-N
LogP 2.90
CAS DataBase Reference 520-33-2(CAS DataBase Reference)
Substances Added to Food (formerly EAFUS) 5,7-DIHYDROXY-2-(3-HYDROXY-4-METHXY-PHENYL)-CHROMAN-4-ONE
EWG's Food Scores 1
FDA UNII Q9Q3D557F1

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS07
Signal word  Warning
Hazard statements  H315-H319-H335
Precautionary statements  P261-P280a-P304+P340-P305+P351+P338-P405-P501a-P264-P280-P302+P352+P332+P313+P362+P364-P305+P351+P338+P337+P313
Hazard Codes  Xi
Risk Statements  36/37/38
Safety Statements  26-36/37/39-27-37
WGK Germany  3
HS Code  29329990
NFPA 704
1
2 0

Hesperetin price More Price(39)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
TCI Chemical H0721 Hesperetin >97.0%(HPLC)(T) 520-33-2 5g $20 2025-07-31 Buy
TCI Chemical H0721 Hesperetin >97.0%(HPLC)(T) 520-33-2 25g $52 2025-07-31 Buy
Cayman Chemical 10006084 Hesperetin 520-33-2 25000mg $50 2024-03-01 Buy
Cayman Chemical 10006084 Hesperetin 520-33-2 50000mg $94 2024-03-01 Buy
Cayman Chemical 10006084 Hesperetin 520-33-2 100000mg $177 2024-03-01 Buy
Product number Packaging Price Buy
H0721 5g $20 Buy
H0721 25g $52 Buy
10006084 25000mg $50 Buy
10006084 50000mg $94 Buy
10006084 100000mg $177 Buy

Hesperetin Chemical Properties,Uses,Production

Description

Hesperetin is a flavonoid that has been found in citrus fruits and has diverse biological activities. It reduces ApoB protein levels, ACAT2 expression, and LDL degradation in HepG2 cells when used at a concentrations ranging from 10 to 200 μM. Hesperetin inhibits IgG-induced β-hexosaminidase release from RBL-2H3 cells (IC50 = 0.099 mg/ml). It inhibits LPS-induced nitric oxide (NO) production and reduces levels of inducible nitric oxide synthase (iNOS), IL-6, and IL-1β in BV-2 microglial cells. Hesperetin (5 mg/kg) inhibits passive cutaneous anaphylaxis in mice. It reduces body weight loss, colon shortening, and ulcer severity in a mouse model of TNBS-induced ulcerative colitis. Hesperetin reduces cortical and hippocampal neuronal apoptosis and increases time spent in the target quadrant in the Morris water maze in a mouse model of LPS-induced neuronal inflammation.

Chemical Properties

Beige to Light Brown Crystalline Solid

Uses

The aglucon of Hesperidin (H281185), a flavanone found in citrus fruits.

Uses

antiallergic

Uses

(±)-Hesperetin is an antioxidant flavonoid. Induces G1-phase cell cycle arrest. Anti-inflammatory. (±)-Hesperetin suppresses NF-κB activation. Reduces cholesterol biosynthesis. Inhibits lipid peroxidation. Neuroprotective against neuronal oxidative damage.

Definition

ChEBI: Hesperetin is a trihydroxyflavanone having the three hydroxy gropus located at the 3'-, 5- and 7-positions and an additional methoxy substituent at the 4'-position. It has a role as an antioxidant, an antineoplastic agent and a plant metabolite. It is a monomethoxyflavanone, a trihydroxyflavanone, a member of 3'-hydroxyflavanones and a member of 4'-methoxyflavanones. It is a conjugate acid of a hesperetin(1-).

Synthesis

Hesperidin

520-26-3

Hesperetin

520-33-2

Generic method: compound 2 was synthesized by the method reported in the literature. The raw material (S)-5-hydroxy-2-(3-hydroxy-4-methoxyphenyl)-7-(((2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-((((2R,3R,4R,5R,6S)-3,4,5-trihydroxy-6-methyltetrahydro-2H-pyran-2-yl)oxy)methyl)tetrahydro-2H-pyran-2-yl)oxy )benzodihydropyran-4-one (3.5 g, 5.7 mmol) was mixed with 10 mL of concentrated sulfuric acid in 280 mL of anhydrous methanol and the reaction was stirred at 60 °C for 7.5 hours. Upon completion of the reaction, 1.2 L of ethyl acetate was added to the reaction mixture and extracted at 20 °C. Subsequently, the organic phase was washed with 420 mL of water and dried over anhydrous sodium sulfate. The solvent was evaporated under reduced pressure to give a light yellow powdery crude product. The crude product was dissolved in 70 mL of acetone and then slowly added dropwise (over 60 minutes) to a pre-stirred 700 mL solution consisting of water and acetic acid mixed at 150:1 by volume, maintaining the temperature at 95°C. After dropwise addition, the mixed slurry was cooled to 45°C, the product was collected by filtration and dried under vacuum.

Purification Methods

Crystallise it from EtOAc or ethanol. The natural S(-) form crystallises from EtOH and has m 216-218o and [] D -37.6o (c 2, EtOH). Note that C2 is chiral. [Beilstein 18 II 204, 18 III/IV 3215, 18/5 V 214.]

References

[1] Journal of Medicinal Chemistry, 2011, vol. 54, # 1, p. 95 - 106
[2] Medicinal Chemistry Research, 2011, vol. 20, # 8, p. 1200 - 1205
[3] Bioorganic and Medicinal Chemistry Letters, 2012, vol. 22, # 23, p. 7194 - 7197
[4] Patent: CN105693682, 2016, A. Location in patent: Paragraph 0024; 0025
[5] Journal of Chemical Research, 2014, vol. 38, # 7, p. 396 - 398

Hesperetin synthesis

520-26-3
520-33-2
Synthesis of Hesperetin from Hesperidin

Hesperetin Preparation Products And Raw materials

Raw materials

4-Methylumbelliferone Hesperidin Sulfuric acid Methanol

Preparation Products

BETA-PHENYLPROPIOPHENONE Neosperidin dihydrochalcone rac-Hesperetin 3’,7-Diacetate

Hesperetin Suppliers

Global( 528)Suppliers
Supplier Tel Email Country ProdList Advantage
Changsha Staherb Natural Ingredients Co., Ltd.
+86-0731-84213302 +86-18374838656 info@staherb.cn China 1027 58
RongNa Biotechnology Co.,Ltd 		+86-86-13583358881 +8618560316533 Brad@rongnabiotech.com China 3376 58
Wuhan Fortuna Chemical Co., Ltd 		+86-027-59207850 +86-13986145403; info@fortunachem.com China 6011 58
Hebei Chuanghai Biotechnology Co,.LTD 		+86-86-13131129325 +8613131129325 sales1@chuanghaibio.com China 5240 58
Chongqing Zhihe Biopharmaceutical Co., Ltd. 		+86-18580541567 +86-17782035140 sales@zhswyy.com China 240 58
Hebei Zhuanglai Chemical Trading Co Ltd 		+86-16264648883 niki@zlchemi.com China 7245 58
Henan Tianfu Chemical Co.,Ltd. 		+86-0371-55170693 +86-19937530512 info@tianfuchem.com China 21595 55
Shanghai Zheyan Biotech Co., Ltd. 		18017610038 zheyansh@163.com CHINA 3619 58
career henan chemical co 		+86-0371-86658258 +8613203830695 sales@coreychem.com China 29830 58
Chengdu Biopurify Phytochemicals Ltd. 		+86-28-82633860; +8618080483897 sales@biopurify.com China 3751 58
Supplier Advantage
Changsha Staherb Natural Ingredients Co., Ltd.
58
RongNa Biotechnology Co.,Ltd 		58
Wuhan Fortuna Chemical Co., Ltd 		58
Hebei Chuanghai Biotechnology Co,.LTD 		58
Chongqing Zhihe Biopharmaceutical Co., Ltd. 		58
Hebei Zhuanglai Chemical Trading Co Ltd 		58
Henan Tianfu Chemical Co.,Ltd. 		55
Shanghai Zheyan Biotech Co., Ltd. 		58
career henan chemical co 		58
Chengdu Biopurify Phytochemicals Ltd. 		58

Related articles

View Lastest Price from Hesperetin manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
Hesperetin pictures 2026-03-06 Hesperetin
520-33-2
 US $64.00-36.00 / mg 98.45% 10g TargetMol Chemicals Inc.
Hesperetin pictures 2026-03-06 Hesperetin
520-33-2
 US $10.00 / ASSAYS 1ASSAYS 99% 1 ton RongNa Biotechnology Co.,Ltd
Hesperetin pictures 2026-03-06 Hesperetin
520-33-2
 US $10.00 / kg 1kg 90%,95%,98%HPLC 10000 Changsha Staherb Natural Ingredients Co., Ltd.
  • Hesperetin pictures
  • Hesperetin
    520-33-2
  • US $64.00-36.00 / mg
  • 98.45%
  • TargetMol Chemicals Inc.
  • Hesperetin pictures
  • Hesperetin
    520-33-2
  • US $10.00 / ASSAYS
  • 99%
  • RongNa Biotechnology Co.,Ltd
  • Hesperetin pictures
  • Hesperetin
    520-33-2
  • US $10.00 / kg
  • 90%,95%,98%HPLC
  • Changsha Staherb Natural Ingredients Co., Ltd.

Hesperetin Spectrum

HESPERETIN(520-33-2)MSHESPERETIN(520-33-2)1HNMRHESPERETIN(520-33-2)13CNMRHESPERETIN(520-33-2)IR1HESPERETIN(520-33-2)IR2

520-33-2(Hesperetin)Related Search:

HESPERETIN-7-NEOHESPERIDOSIDE hplc,Neohesperidin，Hesperetin 7-neohesperidoside,HESPERETIN-7-NEOHESPERIDOSIDE,HESPERETIN-7-O-NEOHESPERIDOSIDE Paeoniflorin Quercetin dihydrate Naringin Resveratrol
Ferulic Acid Luteolin Citric acid (+/-)-HESPERETIN,HESPERETIN HESPERETIN LAURATE
4'-METHOXYFLAVANONE Hesperidin 4'-METHOXYFLAVANONE hesperetin 5-O-glucoside HESPERETIN, [3H(G)]
HESPERETIN CHALCONE HESPERETIN DIHYDROCHALCONE HESPERETIN DIHYDROCHALCONE(RG)

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4'-METHOXY-3',5,7-TRIHYDROXYFLAVANONE (+/-)-3',5,7-TRIHYDROXY-4'-METHOXYFLAVANONE 3',5,7-TRIHYDROXY-4'-METHOXYFLAVANONE 3',5,7-TRIHYDROXY-4-METHOXYFLAVANONE 2,3-DIHYDRO-5,7-DIHYDROXY-2S-(3-HYDROXY-4-METHOXPHENYL)-4H-1-BENZOPYRAN-4-ONE 5,7,3'-TRIHYDROXY-4'-METHOXYFLAVANONE HESPERETINE (+/-)-HESPERETIN HESPERETIN (S)-2,3-dihydro-5,7-dihydroxy-2-(3-hydroxy-4-methoxyphenyl)-4-benzopyrone HESPERETIN 97% 5,7-DIHYDROXY-2-(3-HYDROXY-4-METHOXY-PHENYL)-CHROMAN-4-ONE (2S)-5,7-dihydroxy-2-(3-hydroxy-4-methoxy-phenyl)chroman-4-one HESPERETIN(P) HESPERETIN hplc HESPERETIN WITH HPLC 4H-1-Benzopyran-4-one, 2,3-dihydro-5,7-dihydroxy-2-(3-hydroxy-4-methoxyphenyl)-, (2S)- Nano Liposomal Hesperetin Hesperetin 520-33-2 Diosmin ep imp G (2S)-2-(3-Hydroxy-4-methoxyphenyl)-5,7-dihydroxy-2,3-dihydro-4H-1-benzopyran-4-one (2S)-2-(3-Hydroxy-4-methoxyphenyl)-5,7-dihydroxy-2H-1-benzopyran-4(3H)-one (S)-3',5,7-Trihydroxy-4'-methoxyflavanone [S,(-)]-2,3-Dihydro-5,7-dihydroxy-2-(3-hydroxy-4-methoxyphenyl)-4H-1-benzopyran-4-one Eriodictyol 4'-monomethyl ether (2S)-2,3-Dihydro-5,7-dihydroxy-2-(3-hydroxy-4-Methoxyphenyl)-4H-1-benzopyran-4-one NSC 57654 (S)-5,7-Dihydroxy-2-(3-hydroxy-4-methoxyphenyl)chroman-4-one 2,3-Dihydro-5,7-dihydroxy-2-(3-hydroxy-4-methoxyphenyl)-4H-1-benzopyran-4-one Diosmin Impurity G Hesperetin> (S)-Hesperetin Hesperetin Discontinued. Please see H289480 or H289501 (2S)-5,7-dihydroxy-2-(3-hydroxy-4-methoxyphenyl)-2,3-dihydrochromen-4-one hesperetin extract (S)-2,3-Dihydro-5,7-dihydroxy-2-(3-hydroxy-4-methoxyphenyl)-4-benzopyron Hesperitin（mixture of isomers） 13C,2H3]-Hesperetin Hesperetin (6CI) (2S)-5,7-dihydroxy-2-(3-hydroxy-4-methoxyphenyl)-2,3-dihydro-4H-1-benzopyran-4-one (hesperetin). Hesperetin (diosmine EP impurity G) Prestwick_908 YSO2 Hesperetin, 10 mM in DMSO Hesperetin (Diosmin EP Impurity G) NanoActive Hesperetin (Liposomal Hesperetin) 520-33-2 C16H14O6 Flavonoids HA -HT Analytical Standards Alphabetic Analytical Chromatography Product Catalog natural product chemical reagent pharmaceutical intermediate phytochemical reference standards from Chinese medicinal herbs (TCM).