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ChemicalBook >> CAS DataBase List >>4-[[(1,1-dimethylethoxy)carbonyl]amino]Butanoic acid methyl ester

4-[[(1,1-dimethylethoxy)carbonyl]amino]Butanoic acid methyl ester

4-[[(1,1-dimethylethoxy)carbonyl]amino]Butanoic acid methyl ester Structure
4-[[(1,1-dimethylethoxy)carbonyl]amino]Butanoic acid methyl ester structure
CAS No.
85909-04-2
Chemical Name:
4-[[(1,1-dimethylethoxy)carbonyl]amino]Butanoic acid methyl ester
Synonyms
Methyl 4-(Boc-amino)butanoate;4-(BOC-amino)butyric acid methyl ester;4-(Boc-amino)butanoic acid methyl ester;METHYL 4-(TERT-BUTOXYCARBONYLAMINO) BUTANOATE;methyl 4-[(2-methylpropan-2-yl)oxycarbonylamino]butanoate;4-[[(1,1-dimethylethoxy)carbonyl]amino]Butanoic acid methyl ester;Butanoic acid, 4-[[(1,1-dimethylethoxy)carbonyl]amino]-, methyl ester
CBNumber:
CB43053544
Molecular Formula:
C10H19NO4
Molecular Weight:
217.26
MDL Number:
MFCD18206247
MOL File:
85909-04-2.mol
MSDS File:
SDS
Last updated:2025-07-24 18:13:53
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4-[[(1,1-dimethylethoxy)carbonyl]amino]Butanoic acid methyl ester Properties

storage temp. 2-8°C
Appearance White to light yellow Solid

4-[[(1,1-dimethylethoxy)carbonyl]amino]Butanoic acid methyl ester price More Price(30)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Biosynth KDA90904 Methyl 4-((tert-butoxycarbonyl)amino)butanoate 85909-04-2 0.25g $250 2026-06-04 Buy
Biosynth KDA90904 Methyl 4-((tert-butoxycarbonyl)amino)butanoate 85909-04-2 2.5g $855.5 2026-06-04 Buy
Synthonix M31815 Methyl 4-(tert-butoxycarbonylamino)butanoate 97% 85909-04-2 250mg $60 2026-05-06 Buy
Synthonix M31815 Methyl 4-(tert-butoxycarbonylamino)butanoate 97% 85909-04-2 500mg $90 2026-05-06 Buy
Synthonix M31815 Methyl 4-(tert-butoxycarbonylamino)butanoate 97% 85909-04-2 1g $130 2026-05-06 Buy
Product number Packaging Price Buy
KDA90904 0.25g $250 Buy
KDA90904 2.5g $855.5 Buy
M31815 250mg $60 Buy
M31815 500mg $90 Buy
M31815 1g $130 Buy

4-[[(1,1-dimethylethoxy)carbonyl]amino]Butanoic acid methyl ester Chemical Properties, Uses, Production

Synthesis

BOC-GAMMA-ABU-OH

57294-38-9

Iodomethane

74-88-4

4-[[(1,1-dimethylethoxy)carbonyl]amino]Butanoic acid methyl ester

85909-04-2

General Steps: Step 1: Synthesis of 4-(tert-butoxycarbonylamino)butyric acid: 4-aminobutyric acid (25 g, 242 mmol) was dissolved in H2O (500 mL) at room temperature, Na2CO3 (75 g, 726 mmol) was added, followed by dropwise addition of a THF (200 mL) solution of Boc2O (95 g, 435 mmol). The reaction mixture was stirred at room temperature for 12 h and then concentrated under reduced pressure. The aqueous phase was extracted with Et2O, followed by adjusting the pH to 4-5 with citric acid and extracting with EtOAc. The organic layers were combined, dried over Na2SO4 and concentrated to give 4-(tert-butoxycarbonylamino)butyric acid (45 g, 90%) as a colorless oil.ESI-MS (EI+, m/z): 226 [M + Na]+. Step 2: Synthesis of methyl 4-(tert-butoxycarbonylamino)butyrate: 4-(tert-butoxycarbonylamino)butyric acid (7.0 g, 34.5 mmol) and K2CO3 (9.5 g, 68.9 mmol) were dissolved in acetone (70 mL) and MeI (7.5 g, 51.8 mmol) was added at room temperature. The reaction solution was stirred at 45 °C for 12 hours. Upon completion of the reaction, the mixture was washed with water and saturated NaCl solution, dried over Na2SO4 and concentrated to give methyl 4-(tert-butoxycarbonylamino)butyrate (6.2 g, 83%) as a yellow oil.ESI-MS (EI+, m/z): 240 [M + Na]+.

References

[1] Patent: WO2013/149121, 2013, A1. Location in patent: Page/Page column 75; 76
[2] Patent: US2015/111864, 2015, A1. Location in patent: Paragraph 0113; 0115
[3] Farmaco, 2004, vol. 59, # 5, p. 381 - 388
[4] Organic and Biomolecular Chemistry, 2012, vol. 10, # 4, p. 861 - 868

4-[[(1,1-dimethylethoxy)carbonyl]amino]Butanoic acid methyl ester synthesis

67-56-1
85909-08-6
85909-04-2
Synthesis of 4-[[(1,1-dimethylethoxy)carbonyl]amino]Butanoic acid methyl ester from Methanol and 1-(tert-Butoxycarbonyl)-2-pyrrolidinone

4-[[(1,1-dimethylethoxy)carbonyl]amino]Butanoic acid methyl ester Preparation Products And Raw materials

Raw materials

Boc-gamma-Abu-OH Methanol Iodomethane Potassium carbonate Acetone

Preparation Products

tert-Butyl 3-(methoxycarbonyl) propylmethylcarbamate

4-[[(1,1-dimethylethoxy)carbonyl]amino]Butanoic acid methyl ester Suppliers

Global Suppliers ( 32)
Supplier Tel Email Country ProdList Advantage
Taizhou Tianhong Biochemistry Technology Co., Ltd. 0523-86132544 15366717810 sales@thbiochem.com China 407 55
Creasyn Finechem(Tianjin) Co., Ltd. 022-83946278 13820372920 sales@creasyn.com China 968 68
Nanjing Norris-Pharm Technology Co., Ltd 13901585132 sales@norris-pharm.com China 8869 55
Shanghai Raise Chemical Technology Co.,Ltd 15026594951 rs@raise-chem.com China 4904 55
Beijing FYF Chemicals Co., Ltd 010-57903446 15869909019 168931144@qq.com China 2876 58
Amadis Chemical Company Limited 571-89925085 sales@amadischem.com China 131885 58
Amatek Scientific Co. Ltd. 0512-56316828 400-867-5858;400-867-5858 info@amateksci.com China 28760 58
Aikon International Limited 025-66113011 19370895928 qzhang@aikonchem.com China 15390 58
ANHUI WITOP BIOTECH CO., LTD +8618071025641 eric@witopchemical.com China 23504 58
Hahui (Shanghai) Pharmaceutical Technology Co., Ltd. 021-13472633-721 13472633721 454407203@qq.com China 254 58
Supplier Advantage
Taizhou Tianhong Biochemistry Technology Co., Ltd. 55
Creasyn Finechem(Tianjin) Co., Ltd. 68
Nanjing Norris-Pharm Technology Co., Ltd 55
Shanghai Raise Chemical Technology Co.,Ltd 55
Beijing FYF Chemicals Co., Ltd 58
Amadis Chemical Company Limited 58
Amatek Scientific Co. Ltd. 58
Aikon International Limited 58
ANHUI WITOP BIOTECH CO., LTD 58
Hahui (Shanghai) Pharmaceutical Technology Co., Ltd. 58

View Latest Price from 4-[[(1,1-dimethylethoxy)carbonyl]amino]Butanoic acid methyl ester manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
4-[[(1,1-dimethylethoxy)carbonyl]amino]Butanoic acid methyl ester pictures 2020-01-13 4-[[(1,1-dimethylethoxy)carbonyl]amino]Butanoic acid methyl ester
85909-04-2
 $1.00 1KG 98%-99.9% 100kg Career Henan Chemical Co

4-[[(1,1-dimethylethoxy)carbonyl]amino]Butanoic acid methyl ester Spectrum

4-[[(1,1-dimethylethoxy)carbonyl]amino]Butanoic acid methyl ester(85909-04-2)1HNMR

85909-04-2 (4-[[(1,1-dimethylethoxy)carbonyl]amino]Butanoic acid methyl ester) Related Search:

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Methyl 4-(Benzylamino)Butanoate Hydrochloride

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4-[[(1,1-dimethylethoxy)carbonyl]amino]Butanoic acid methyl ester METHYL 4-(TERT-BUTOXYCARBONYLAMINO) BUTANOATE Methyl 4-(Boc-amino)butanoate Butanoic acid, 4-[[(1,1-dimethylethoxy)carbonyl]amino]-, methyl ester methyl 4-[(2-methylpropan-2-yl)oxycarbonylamino]butanoate 4-(BOC-amino)butyric acid methyl ester 4-(Boc-amino)butanoic acid methyl ester 85909-04-2 CMLLYL