SirReal2
- CAS No.
- 709002-46-0
- Chemical Name:
- SirReal2
- Synonyms
- SirReal2;SirReal2 ，S7845;SirReal2 >=98% (HPLC);SirReal2, 10 mM in DMSO;Sirtuin,Inhibitor,inhibit,SirReal2,SirReal 2,SirReal-2;2-[(4,6-Dimethyl-2-pyrimidinyl)thio]-N-[5-(1-naphthalenylmethyl)-2-thiazolyl]acetamide;2-((4,6-Dimethylpyrimidin-2-yl)thio)-N-(5-(naphthalen-1-ylmethyl)thiazol-2-yl)acetamide;Acetamide,2-[(4,6-dimethyl-2-pyrimidinyl)thio]-N-[5-(1-naphthalenylmethyl)-2-thiazolyl]-;2-(4,6-dimethylpyrimidin-2-yl)sulfanyl-N-[5-(naphthalen-1-ylmethyl)-1,3-thiazol-2-yl]acetamide
- CBNumber:
- CB43133754
- Molecular Formula:
- C22H20N4OS2
- Molecular Weight:
- 420.55
- MDL Number:
- MFCD04173051
- MOL File:
- 709002-46-0.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Product description | Number | Pack Size | Price |
| SirReal2 ≥98% (HPLC) | SML1514 | 25 mg | $329.8 |
| SirReal2 ≥98% (HPLC) | SML1514 | 5 mg | $117 |
| SirReal2 ≥98% | 18116 | 1mg | $37 |
| SirReal2 ≥98% | 18116 | 5mg | $116 |
| SirReal2 ≥98% | 18116 | 10mg | $178 |
| More product size | |||
| storage temp. | Store at -20°C |
|---|---|
| solubility | DMSO: 3 mg/ml; DMSO:PBS(pH 7.2) (1:2): 0.3 mg/ml |
| form | A crystalline solid |
| color | Off-white to light yellow |
| InChI | 1S/C22H20N4OS2/c1-14-10-15(2)25-22(24-14)28-13-20(27)26-21-23-12-18(29-21)11-17-8-5-7-16-6-3-4-9-19(16)17/h3-10,12H,11,13H2,1-2H3,(H,23,26,27) |
| InChIKey | MENNDDDTIIZDDN-UHFFFAOYSA-N |
| SMILES | CC1=NC(SCC(NC2=NC=C(S2)CC3=CC=CC4=C3C=CC=C4)=O)=NC(C)=C1 |
| UNSPSC Code | 12352200 |
| NACRES | NA.77 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302-H315-H319-H335 |
| Precautionary statements | P261-P305+P351+P338 |
| WGK Germany | WGK 3 |
| Storage Class | 11 - Combustible Solids |
SirReal2 price More Price(18)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | SML1514 | SirReal2 ≥98% (HPLC) | 709002-46-0 | 25 mg | $329.8 | 2026-03-19 | Buy |
| Sigma-Aldrich | SML1514 | SirReal2 ≥98% (HPLC) | 709002-46-0 | 5 mg | $117 | 2025-07-31 | Buy |
| Cayman Chemical | 18116 | SirReal2 ≥98% | 709002-46-0 | 1mg | $37 | 2024-03-01 | Buy |
| Cayman Chemical | 18116 | SirReal2 ≥98% | 709002-46-0 | 5mg | $116 | 2024-03-01 | Buy |
| Cayman Chemical | 18116 | SirReal2 ≥98% | 709002-46-0 | 10mg | $178 | 2024-03-01 | Buy |
SirReal2 Chemical Properties,Uses,Production
Description
Sirtuins (SIRTs) represent a distinct class of trichostatin A-insensitive lysyl-deacetylases (class III HDACs). SIRT2 deacetylates histone H4 and α-tubulin and functions as a regulator of cell cycle progression, a determinant of myelination, a modulator of autophagy, and a suppressor of brain inflammation. SirReal2 is an aminothiazole that acts as a SIRT-rearranging ligand to selectively inhibit SIRT2 (IC50 = 140 nM). SirReal2 is >1,000-fold more potent at inhibiting the activity of SIRT2 than that of SIRT1 or SIRT3-6. This compound has been shown to be active in HeLa cells by significantly increasing α-tubulin acetylation.
Uses
SirReal2 is an aminothiazole that is a potent and selective Sirt2 inhibitor.
in vivo
SirReal2 (4 mg/kg, i.p., every 3 days for 28 days) combined with VS-5584 (4mg/kg, i.p., every 3 days for 28 days) leads to an extension of the survival time of mice and exhibits significant anti-tumor effects[3].
SirReal2 (50 mg/kg, i.p., every 3 days for 19 days) inhibits the expression of SIRT2, resumes NK cell tumor infltration and suppresses melanoma progression in WT mice[4].
| Animal Model: | mouse tumor xenograft model[3] |
| Dosage: | 4 mg/kg |
| Administration: | i.p., every 3 days for 28 days |
| Result: | Restrained the growth of subcutaneous xenografts combined with VS-5584 in vivo. |
IC 50
SIRT2: 140 nM (IC50)
storage
Store at -20°C
References
[1] TOBIAS RUMPF. Selective Sirt2 inhibition by ligand-induced rearrangement of the active site.[J]. Nature Communications, 2015: 6263. DOI: 10.1038/ncomms7263
SirReal2 Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 33024 | 60 |
| InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6391 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354; | support@targetmol.com | United States | 39040 | 58 |
| HANGZHOU LEAP CHEM CO., LTD. | +86-571-87711850 | market18@leapchem.com | China | 43333 | 58 |
| Aladdin Scientific | tp@aladdinsci.com | United States | 57505 | 58 | |
| Nanjing Chemlin Chemical Co., Ltd | 025-83697070 13770331960 | info@chemlin.com.cn | China | 16059 | 64 |
| AdooQ Bioscience CHINA | 025-58849295 18951903616; | info@adooq.cn | China | 2990 | 60 |
| Shanghai EFE Biological Technology Co., Ltd. | 021-65675885 18964387627 | info@efebio.com | China | 9803 | 58 |
| Shanghai YuanYe Biotechnology Co., Ltd. | 021-61312847; 18021002903 | 3008007409@qq.com | China | 89689 | 60 |
| Shanghai Chaolan Chemical Technology Center | 021-QQ：65489617 15618227136 | Sales@ATKchemical.com | China | 9550 | 58 |
