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Pifithrin-α, p-nitro, cyclic

Pifithrin-α, p-nitro, cyclic structure

CAS No.: 60477-38-5

Chemical Name:: Pifithrin-α, p-nitro, cyclic

Synonyms: PFN-α;p-Nitro-CyclicPifithrin-α;p-Nitro-Cyclic Pifithrin-a;Cyclic pifithrin-α-p-nitro;p-nitro-Cyclic Pifithrin-α;Pifithrin-α, p-nitro, cyclic;Pifithrin-alpha, p-Nitro, Cyclic;p-nitro Cyclic Pifithrin-.alpha.;Pifithrin-α, p-Nitro, Cyclic;Pifithrin-α, p-Nitro, Cyclic, 10 mM in DMSO

CBNumber:: CB43136760

Molecular Formula:: C15H13N3O2S

Molecular Weight:: 299.35

MDL Number:

MOL File:: 60477-38-5.mol

MSDS File:: SDS

TDS File:: TDS

Last updated:2026-04-21 10:31:43

Product description	Number	Pack Size	Price
Pifithrin-α, p-Nitro, Cyclic - CAS 60477-38-5 - Calbiochem A cell-permeable p53 inhibitor that exhibits 10-fold higher potency and 50% longer half-life than Pifithrin-α.	506154	5mg	$190
p-nitro-Cyclic Pifithrin-α ≥95%	17848	1mg	$41
p-nitro-Cyclic Pifithrin-α ≥95%	17848	5mg	$119
p-nitro-Cyclic Pifithrin-α ≥95%	17848	10mg	$215
p-nitro-Cyclic Pifithrin-α ≥95%	17848	25mg	$437
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Pifithrin-α, p-nitro, cyclic Properties

Melting point	233-234 °C(Solv: N,N-dimethylformamide (68-12-2); water (7732-18-5))
Density	1.53±0.1 g/cm3(Predicted)
storage temp.	-20C
solubility	≤1mg/ml in dimethyl formamide
form	Yellow solid
pka	6.14±0.20(Predicted)
color	Light yellow to yellow
InChI	1S/C15H13N3O2S/c19-18(20)11-7-5-10(6-8-11)12-9-17-13-3-1-2-4-14(13)21-15(17)16-12/h5-9H,1-4H2
InChIKey	XMFNSEDROOHGBY-UHFFFAOYSA-N
SMILES	[s]1c2[n](c4c1CCCC4)cc(n2)c3ccc(cc3)[N+](=O)[O-]
UNSPSC Code	12352200
NACRES	NA.77

SAFETY

Risk and Safety Statements

WGK Germany	WGK 1
Storage Class	11 - Combustible Solids

Pifithrin-α, p-nitro, cyclic price More Price(32)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	506154	Pifithrin-α, p-Nitro, Cyclic - CAS 60477-38-5 - Calbiochem A cell-permeable p53 inhibitor that exhibits 10-fold higher potency and 50% longer half-life than Pifithrin-α.	60477-38-5	5mg	$190	2026-04-30	Buy
Cayman Chemical	17848	p-nitro-Cyclic Pifithrin-α ≥95%	60477-38-5	1mg	$41	2026-04-30	Buy
Cayman Chemical	17848	p-nitro-Cyclic Pifithrin-α ≥95%	60477-38-5	5mg	$119	2026-04-30	Buy
Cayman Chemical	17848	p-nitro-Cyclic Pifithrin-α ≥95%	60477-38-5	10mg	$215	2026-04-30	Buy
Cayman Chemical	17848	p-nitro-Cyclic Pifithrin-α ≥95%	60477-38-5	25mg	$437	2026-04-30	Buy

Product number	Packaging	Price	Buy
506154	5mg	$190	Buy
17848	1mg	$41	Buy
17848	5mg	$119	Buy
17848	10mg	$215	Buy
17848	25mg	$437	Buy

Pifithrin-α, p-nitro, cyclic Chemical Properties,Uses,Production

Uses

p-nitro-Cyclic Pifithrin-α is an inactivator of p53 that blocks p53-dependent transcriptional activation and apoptisis. Anti-cancer agent.

General Description

A cell-permeable p53 inhibitor that exhibits 10-fold higher potency (ED₅₀ = 30 nM in protecting etoposide-induced cortical neuron death) and 50% longer half-life (t_1/2 = 6h in neuron culture medium at 37°C) than Pifithrin-α (Cat. No. 506132). However, despite its in vitro efficacy, this inhibitor is not effective when adminstered in rats in vivo. For in vivo applications, please consider Pifithrin-α, p-Nitro (Cat. No. 506152).

Biological Activity

p-nitro-cyclic pifithrin-α is an inactivator of p53.the activation of the tumor suppressor gene p53 plays a key role in regulating the in-vitro death of neurons, following apoptotic stimuli molecules including glutamate and dna-damaging agents. thus, p53 inhibitors may prove effective in suppressing the degenerative processes in neurodegenerative disorders.

Biochem/physiol Actions

Cell permeable: yes

in vitro

pifithrin-α (pft-α) was identified as an inactivator of p53 blocking p53-dependent transcriptional activation and apoptosis. cyclic pft-α was a stable analog of pft-α. p-nitro-cyclic pft-α, a cell-permeable form of cyclic pft-α, was found to be one order of magnitude more active than pft-α in protecting cortical neurons exposed to etoposide. p-nitro-cyclic pft-α acted in a p53-dependently but did not block phosphorylation of p53 on ser15 in response to etoposide treatment, although it prevented p53 posttranscriptional activity [1].

in vivo

in a previou study, c57bl/6 mice were fed a high-fat (hfd) or control diet for 8 weeks; pft was administered three times per week. results showed that pft administration could suppress hfd-induced weight gain, steatosis, oxidative stress, alt elevation, and apoptosis. pft treatment also able to blunt the hfd-induced upregulation of mirna34a and increase sirt1 expression. in the livers of hfd-fed, pft-treated mice, activation of the sirt1/pgc1α/pparα axis increased the expression of malonyl-coa decarboxylase [2].

References

[1] . pietrancosta, n.,moumen, a.,dono, r., et al. imino-tetrahydro-benzothiazole derivatives as p53 inhibitors: discovery of a highly potent in vivo inhibitor and its action mechanism. journal of medicinal chemistry 49(12), 3645-3652 (2006).
[2] derdak z, villegas ka, harb r, wu am, sousa a, wands jr. inhibition of p53 attenuates steatosis and liver injury in a mouse model of non-alcoholic fatty liver disease. j hepatol. 2013 apr;58(4):785-91.

Pifithrin-α, p-nitro, cyclic Preparation Products And Raw materials

Raw materials

Preparation Products

Pifithrin-α, p-nitro, cyclic Suppliers

Global( 75)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
ATK CHEMICAL COMPANY LIMITED	+undefined-21-51877795	ivan@atkchemical.com	China	33024	60
TargetMol Chemicals Inc.	+1-781-999-5354; +17819995354	marketing@targetmol.com	United States	32466	58
TargetMol Chemicals Inc.	+1-781-999-5354;	support@targetmol.com	United States	39039	58
HANGZHOU LEAP CHEM CO., LTD.	+86-571-87711850	market18@leapchem.com	China	43333	58
Shanghai Acmec Biochemical Technology Co., Ltd.	+86-18621343501; +undefined18621343501	product@acmec-e.com	China	33324	58
Aladdin Scientific		tp@aladdinsci.com	United States	52923	58
SHANGHAI KEAN TECHNOLOGY CO., LTD.	+8613817748580	cooperation@kean-chem.com	China	40066	58
BOC Sciences	1-631-485-4226; 16314854226	info@bocsci.com	United States	9112	65
SHANGHAI FORTUNE CHEMICAL TECHNOLOGY CO., LTD	13816107857	sales@fortunechem-sh.com	China	982	58
Sigma-Aldrich	021-61415566 800-8193336	orderCN@merckgroup.com	China	51395	80

Supplier	Advantage
ATK CHEMICAL COMPANY LIMITED	60
TargetMol Chemicals Inc.	58
TargetMol Chemicals Inc.	58
HANGZHOU LEAP CHEM CO., LTD.	58
Shanghai Acmec Biochemical Technology Co., Ltd.	58
Aladdin Scientific	58
SHANGHAI KEAN TECHNOLOGY CO., LTD.	58
BOC Sciences	65
SHANGHAI FORTUNE CHEMICAL TECHNOLOGY CO., LTD	58
Sigma-Aldrich	80

View Lastest Price from Pifithrin-α, p-nitro, cyclic manufacturers

Image	Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
	2026-04-20	Pifithrin-α, p-Nitro, Cyclic 60477-38-5	$34.00-80.00		99.97%	10g	TargetMol Chemicals Inc.
	2026-04-20	Pifithrin-α, p-Nitro, Cyclic 60477-38-5	$34.00-80.00		99.97%	10g	TargetMol Chemicals Inc.

Pifithrin-α, p-Nitro, Cyclic
60477-38-5
$34.00-80.00
99.97%
TargetMol Chemicals Inc.

Pifithrin-α, p-Nitro, Cyclic
60477-38-5
$34.00-80.00
99.97%
TargetMol Chemicals Inc.

Pifithrin-α, p-nitro, cyclic Spectrum

Pifithrin-α, p-nitro, cyclic(60477-38-5)¹HNMR

Pifithrin-α, p-nitro, cyclic p-nitro-Cyclic Pifithrin-α Pifithrin-alpha, p-Nitro, Cyclic 2-(4-Nitro-phenyl)-5,6,7,8-tetrahydro-benzo[d]imidazo[2,1-b]thiazole p-nitro Cyclic Pifithrin-.alpha. Cyclic pifithrin-α-p-nitro Pifithrin-α, p-Nitro, Cyclic - CAS 60477-38-5 - Calbiochem p-Nitro-Cyclic Pifithrin-a Imidazo[2,1-b]benzothiazole, 5,6,7,8-tetrahydro-2-(4-nitrophenyl)- p-Nitro-CyclicPifithrin-α PFN-α MDM-2/p53,Inhibitor,expression,p21,neurons,cortical,WAF1,Pifithrinα, pNitro, Cyclic,inhibit,death,p53-triggered,posttranscriptional,cell,Pifithrin α, p Nitro, Cyclic Cyclic pifithrin-alpha-p-nitro, transcriptional p53 inhibitor Pifithrin-α, p-Nitro, Cyclic, 10 mM in DMSO Pifithrin-α, p-Nitro, Cyclic 60477-38-5