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2-Bromo-5-cyanopyridine

2-Bromo-5-cyanopyridine structure

CAS No.: 139585-70-9

Chemical Name:: 2-Bromo-5-cyanopyridine

Synonyms: 2-Br-5-CN-pyridine;6-BroMonicotinitrile;6-Bromo-3-cynopyridine;2-BROMO-5-CYNOPYRIDINE;2-BROMO-5-CYANOPYRIDINE;6-BROMO-NICOTINONITRILE;5-Cyano-2-bromopyridine;6-Bromonicotinonitrile 95%;2-Bromo-5-cyanopyridine 97%;2-Bromo-5-cyanopyridine >

CBNumber:: CB4315452

Molecular Formula:: C6H3BrN2

Molecular Weight:: 183.01

MDL Number:: MFCD00234141

MOL File:: 139585-70-9.mol

MSDS File:: SDS

TDS File:: TDS

Last updated:2026-04-24 14:58:55

Product description	Number	Pack Size	Price
2-bromo-5-cyanopyridine AldrichCPR	CDS003693	250mg	$77.9
2-Bromo-5-cyanopyridine >97.0%(GC)	B4039	1g	$19
2-Bromo-5-cyanopyridine >97.0%(GC)	B4039	5g	$63
2-Bromo-5-cyanopyridine	B682833	1g	$75
2-Bromo-5-cyanopyridine	B682833	250mg	$55
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2-Bromo-5-cyanopyridine Properties

Melting point	136-140
Boiling point	261.6±20.0 °C(Predicted)
Density	1.72±0.1 g/cm3(Predicted)
storage temp.	Keep in dark place,Sealed in dry,Room Temperature
form	Solid
pka	-2.66±0.10(Predicted)
color	White to Yellow to Orange
InChI	1S/C6H3BrN2/c7-6-2-1-5(3-8)4-9-6/h1-2,4H
InChIKey	XHYGUDGTUJPSNX-UHFFFAOYSA-N
SMILES	Brc1ccc(cn1)C#N
CAS DataBase Reference	139585-70-9(CAS DataBase Reference)
UNSPSC Code	12352200

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS05,GHS06

Signal word

Danger

Hazard statements

H301-H315-H318-H335

Precautionary statements

P261-P264-P280-P301+P310-P302+P352-P305+P351+P338

target organs

Respiratory system

Hazard Codes

Xi,Xn

Risk Statements

36/37/38-41-37/38-22

Safety Statements

26-36/37/39-39-24/25

RIDADR

3439

WGK Germany

Hazard Note

Irritant/Keep Cold

HazardClass

IRRITANT

HazardClass

6.1

PackingGroup

Ⅲ

HS Code

29333990

Storage Class

6.1C - Combustible acute toxic Cat.3
toxic compounds or compounds which causing chronic effects

Hazard Classifications

Acute Tox. 3 Oral
Eye Dam. 1
Skin Irrit. 2
STOT SE 3

NFPA 704

	1
2		0

2-Bromo-5-cyanopyridine price More Price(31)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	CDS003693	2-bromo-5-cyanopyridine AldrichCPR	139585-70-9	250mg	$77.9	2026-04-30	Buy
TCI Chemical	B4039	2-Bromo-5-cyanopyridine >97.0%(GC)	139585-70-9	1g	$19	2026-04-30	Buy
TCI Chemical	B4039	2-Bromo-5-cyanopyridine >97.0%(GC)	139585-70-9	5g	$63	2026-04-30	Buy
TRC	B682833	2-Bromo-5-cyanopyridine	139585-70-9	1g	$75	2021-12-16	Buy
TRC	B682833	2-Bromo-5-cyanopyridine	139585-70-9	250mg	$55	2021-12-16	Buy

Product number	Packaging	Price	Buy
CDS003693	250mg	$77.9	Buy
B4039	1g	$19	Buy
B4039	5g	$63	Buy
B682833	1g	$75	Buy
B682833	250mg	$55	Buy

2-Bromo-5-cyanopyridine Chemical Properties,Uses,Production

Chemical Properties

White to yellow crystalline solid

Uses

6-Bromonicotinonitrile is a biochemical reagent that can be used as a biological material or organic compound for life science related research.

Synthesis Reference(s)

The Journal of Organic Chemistry, 66, p. 1500, 2001 DOI: 10.1021/jo005682n

Synthesis

33252-28-7

139585-70-9

The general procedure for the synthesis of 2-bromo-5-cyanopyridine from 2-chloro-5-cyanopyridine is as follows: Example 29 Synthesis of 6-bromonicotinonitrile. 6-Chloronicotinonitrile (13.8 g, 100 mmol) was mixed with phosphorus tribromide (150 mL) and the reaction was heated at 145°C for 32 hours. After completion of the reaction, the mixture was cooled and concentrated in vacuum. To the concentrated residue, phosphorus tribromide (150 mL) was added again and the reaction was heated at 145°C for 32 hours. At the end of the reaction, the mixture was cooled and concentrated under vacuum. The concentrated residue was slowly added to an ice-water mixture (500 mL) and the reaction mixture was neutralized with sodium bicarbonate. Subsequently, the product was extracted with ethyl acetate (3 x 250 mL). The organic phases were combined, washed with saturated brine and dried with anhydrous magnesium sulfate. The solvent was removed by distillation under reduced pressure and the residue was purified by column chromatography (eluent: hexane-ethyl acetate) to afford 14.9 g (81% yield) of 6-bromonicotinonitrile as a white solid. The product was characterized as follows: 1H NMR (400 MHz, CDCl3) δ 7.66 (d, J = 11.0 Hz, 1H), 7.80 (dd, J = 3.1, 11.0 Hz, 1H), 8.67 (d, J = 3.1 Hz, 1H); mass spectra (M + H)+ m/z = 183.0, 185.0.

References

[1] Patent: US2005/192302, 2005, A1. Location in patent: Page/Page column 30
[2] Patent: WO2012/114223, 2012, A1. Location in patent: Page/Page column 56
[3] Journal of Organic Chemistry, 2001, vol. 66, # 4, p. 1500 - 1502

2-Bromo-5-cyanopyridine Preparation Products And Raw materials

Raw materials

2-chloro-5-cyanopyridine

Preparation Products

3-Pyridinecarbonitrile,6-ethenyl-(9CI) 1-(6-BROMOPYRIDIN-3-YL)CYCLOPROPAN-1-AMINE 6-BROMONICOTINAMIDE

2-Bromo-5-cyanopyridine Suppliers

Global( 351)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Capot Chemical Co.,Ltd.	+86-（0）57185586718; +8613336195806	sales@capot.com	China	29640	60
Hi-Tech Chemistry Corp	0519-86626038	yuhh@hitechem.com	CHINA	810	58
Fluoropharm Co., Ltd.	+86-0571-85586753 +86-13336034509	sales@fluoropharm.com	China	1445	60
career henan chemical co	+86-0371-86658258 +8613203830695	sales@coreychem.com	China	29819	58
Zhejiang ZETian Fine Chemicals Co. LTD	+8618957127338	stella@zetchem.com	China	2994	58
Shenzhen Nexconn Pharmatechs Ltd	+86-755-89396905 +86-15013857715	admin@nexconn.com	China	10404	58
Nanjing Dolon Biotechnology Co.,Ltd.	18905173768	52513593@qq.com	CHINA	2972	58
Accela ChemBio Inc.	+1-858-6993322	info@accelachem.com	United States	21193	58
Alchem Pharmtech,Inc.	8485655694	sales@alchempharmtech.com	United States	63687	58
Wuhan Chemwish Technology Co., Ltd	027-67849912	sales@chemwish.com	CHINA	10821	58

Supplier	Advantage
Capot Chemical Co.,Ltd.	60
Hi-Tech Chemistry Corp	58
Fluoropharm Co., Ltd.	60
career henan chemical co	58
Zhejiang ZETian Fine Chemicals Co. LTD	58
Shenzhen Nexconn Pharmatechs Ltd	58
Nanjing Dolon Biotechnology Co.,Ltd.	58
Accela ChemBio Inc.	58
Alchem Pharmtech,Inc.	58
Wuhan Chemwish Technology Co., Ltd	58

View Lastest Price from 2-Bromo-5-cyanopyridine manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2025-11-18	2-Bromo-5-cyanopyridine 139585-70-9	US $1.10 / g	1g	99.00%	100 Tons Min	Dideu Industries Group Limited
2025-04-04	2-Bromo-5-cyanopyridine 139585-70-9	US $0.00-0.00 / KG	1KG	98%	1Ton	Henan Aochuang Chemical Co.,Ltd.
2021-07-13	2-Bromo-5-cyanopyridine 139585-70-9	US $15.00-10.00 / KG	1KG	99%+ HPLC	Monthly supply of 1 ton	Zhuozhou Wenxi import and Export Co., Ltd

2-Bromo-5-cyanopyridine
139585-70-9
US $1.10 / g
99.00%
Dideu Industries Group Limited

2-Bromo-5-cyanopyridine
139585-70-9
US $0.00-0.00 / KG
98%
Henan Aochuang Chemical Co.,Ltd.

2-Bromo-5-cyanopyridine
139585-70-9
US $15.00-10.00 / KG
99%+ HPLC
Zhuozhou Wenxi import and Export Co., Ltd

2-Bromo-5-cyanopyridine Spectrum

2-Bromo-5-cyanopyridine(139585-70-9)¹HNMR 2-Bromo-5-cyanopyridine(139585-70-9)FT-IR

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6-BroMonicotinitrile 5-(4-tetrahydropyranyl)-1,3-dibromobenzene 6-Bromonicotinonitrile 95% 3-PYRIDINECARBONITRILE, 6-BROMO- 6-BROMO-NICOTINONITRILE 2-Bromo-5-cyanopyridine, 6-Bromopyridine-3-carbonitrile 6-Bromopyridine-3-carbonitrile 6-broMopyridin-3-carbonitrile 2-Br-5-CN-pyridine 2-BROMO-5-CYANOPYRIDINE 6-Bromo-3-cynopyridine 2-Bromo-5-cyanopyridine 97% 2-Bromo-5-pyridinecarbonitrile 2-Bromo-5-cyanopyridine≥ 98.5% (HPLC) 5-Cyano-2-bromopyridine 2-BROMO-5-CYNOPYRIDINE 5-cyanopyridine Other Name 6-Bromonicotinonitrile 2-Bromo-5-cyanopyridine > 6-Bromo-3-pyridinecarbonitrile 2-Bromo-5-cyanopyridine ISO 9001：2015 REACH 6-Bromo-3-cyano pyrdine [2-Bromo-5-cyanopyridine] 139585-70-9 139585-70-1 Benzothiazoles Pyridine series Halides Boron, Nitrile, Thio,& TM-Cpds Heterocycles blocks Bromides Carboxes Pyridines Pyridine