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IDO-IN-2

IDO-IN-2 Structure
IDO-IN-2 structure
CAS No.
1668565-74-9
Chemical Name:
IDO-IN-2
Synonyms
DO-IN-2;PCC0208009;IDO inhibitor 2;PCC0208009, 10 mM in DMSO;1-(4-(diisobutylamino)-2'-(1H-tetrazol-5-yl)biphenyl-3-yl)-3-p-tolylurea;1-(4-(Diisobutylamino)-2'-(2H-tetrazol-5-yl)-[1,1'-biphenyl]-3-yl)-3-(p-tolyl)urea;Urea, N-[4-[bis(2-methylpropyl)amino]-2'-(2H-tetrazol-5-yl)[1,1'-biphenyl]-3-yl]-N'-(4-methylphenyl)-;PCC0208009,IDO,PCC-0208009,Inhibitor,Indoleamine 2,3-Dioxygenase (IDO),PCC 0208009,inhibit,neuropathic
CBNumber:
CB43156650
Molecular Formula:
C29H35N7O
Molecular Weight:
497.63
MDL Number:
MOL File:
1668565-74-9.mol
Last updated:2025-04-29 09:03:59
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IDO-IN-2 Properties

Density 1.206±0.06 g/cm3(Predicted)
storage temp. Store at -20°C
solubility DMF: 10 mg/ml; DMSO: 10 mg/ml; Ethanol: 2 mg/ml; PBS (pH 7.2): insol
form A solid
pka 4.17±0.10(Predicted)
color White to off-white

IDO-IN-2 price

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
ChemScene CS-6165 PCC0208009 99.65% 1668565-74-9 2mg $70 2021-12-16 Buy
ChemScene CS-6165 PCC0208009 99.65% 1668565-74-9 5mg $120 2021-12-16 Buy
ChemScene CS-6165 PCC0208009 99.65% 1668565-74-9 10mg $190 2021-12-16 Buy
ChemScene CS-6165 PCC0208009 99.65% 1668565-74-9 50mg $590 2021-12-16 Buy
DC Chemicals DC10421 IDO-IN-2 >98% 1668565-74-9 100mg $650 2021-12-16 Buy
Product number Packaging Price Buy
CS-6165 2mg $70 Buy
CS-6165 5mg $120 Buy
CS-6165 10mg $190 Buy
CS-6165 50mg $590 Buy
DC10421 100mg $650 Buy

IDO-IN-2 Chemical Properties,Uses,Production

Uses

PCC0208009 is a potent IDO inhibitor with an IC50 value of 4.52 nM in HeLa cell. PCC0208009 alleviates neuropathic pain and comorbidities by regulating synaptic plasticity of anterior cingulate cortex (ACC) and amygdala [1][2].

in vivo

PCC0208009 (single oral gavage; 50 mg/kg) in adult male Sprague Dawley rats (180 g-200 g) is detected at 60, 120 and 240 min after drug administration in plasma and brain samples, and the highest concentrations of PCC0208009 in plasma and brain are observed at 60 min after administration. Concomitantly, the Kyn/Trp ratio decreases at 60, 120 and 240 min postdose, with the minimum level in the plasma and the brain seen at 60 min post-dose[1].
PCC0208009 (oral gavage; once; 12-50 mg/kg) in adult male Sprague Dawley rats (180 g-200 g) is detected at 30, 60 and 90min after administration to evaluate the antinociceptive effects of PCC0208009 on neuropathic pain[1].

Animal Model:Adult male Sprague Dawley rats (180 g-200 g) [1]
Dosage:50 mg/kg
Administration:Single oral gavage
Result:The highest concentrations of PCC0208009 in plasma and brain were observed at 60 min after administration.
Animal Model:Adult male Sprague-Dawley rats bearing spinal nerve ligation (SNL)[1]
Dosage:12.5 mg/kg, 25 mg/kg, 50 mg/kg
Administration:oral gavage; once
Result:Showed the behavioral tests and the timelines.

IC 50

IDO: 4.52 nM (IC50, in HeLa cell)

References

[1] Yu Wang, et al. PCC0208009, an indirect IDO1 inhibitor, alleviates neuropathic pain and co-morbidities by regulating synaptic plasticity of ACC and amygdala. Biochem Pharmacol. 2020 Jul;177:113926. DOI:10.1016/j.bcp.2020.113926
[2] David K Williams, et al. Development of a series of novel o-phenylenediamine-based indoleamine 2,3-dioxygenase 1 (IDO1) inhibitors. Bioorg Med Chem Lett. 2018 Feb 15;28(4):732-736. DOI:10.1016/j.bmcl.2018.01.010
[3] Shanyue Sun, et al. PCC0208009 enhances the anti-tumor effects of temozolomide through direct inhibition and transcriptional regulation of indoleamine 2,3-dioxygenase in glioma models. Int J Immunopathol Pharmacol. Jan-Dec 2018;32:2058738418787991. DOI:10.1177/2058738418787991

IDO-IN-2 Preparation Products And Raw materials

Raw materials

Preparation Products

IDO-IN-2 Suppliers

Global( 65)Suppliers
Supplier Tel Email Country ProdList Advantage
ATK CHEMICAL COMPANY LIMITED 		+undefined-21-51877795 ivan@atkchemical.com China 33024 60
career henan chemical co 		+86-0371-86658258 +8613203830695 factory@coreychem.com China 29807 58
TargetMol Chemicals Inc. 		+1-781-999-5354 +1-00000000000 marketing@targetmol.com United States 32268 58
InvivoChem 		+1-708-310-1919 +1-13798911105 sales@invivochem.cn United States 6391 58
Nanjing Doge Biomedical Technology Co., Ltd 		+86-25-58227606 +86-15305155328 sales@dogechemical.com China 4128 58
Hangzhou MolCore BioPharmatech Co.,Ltd. 		+86-057181025280; +8617767106207 sales@molcore.com China 49734 58
Nantong HI-FUTURE Biology Co., Ltd. 		+undefined18051384581 sales@chemhifuture.com China 3135 58
TargetMol Chemicals Inc. 		support@targetmol.com United States 38663 58
Shanghai Qianyi New Material Co., Ltd. 		+8618083322317 3391883138@qq.com China 878 58
Zibo Hangyu Biotechnology Development Co., Ltd 		+86-0533-2185556 +8615965530500 nickzhang@hangyubiotech.com China 10983 58
Supplier Advantage
ATK CHEMICAL COMPANY LIMITED 		60
career henan chemical co 		58
TargetMol Chemicals Inc. 		58
InvivoChem 		58
Nanjing Doge Biomedical Technology Co., Ltd 		58
Hangzhou MolCore BioPharmatech Co.,Ltd. 		58
Nantong HI-FUTURE Biology Co., Ltd. 		58
TargetMol Chemicals Inc. 		58
Shanghai Qianyi New Material Co., Ltd. 		58
Zibo Hangyu Biotechnology Development Co., Ltd 		58

View Lastest Price from IDO-IN-2 manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
PCC0208009 pictures 2025-04-29 PCC0208009
1668565-74-9
 US $54.00-153.00 / mg 99.89% 10g TargetMol Chemicals Inc.
IDO-IN-2 pictures 2020-02-01 IDO-IN-2
1668565-74-9
 US $1.00 / KG 1KG Min98% HPLC g/kg/ton Career Henan Chemical Co
  • PCC0208009 pictures
  • PCC0208009
    1668565-74-9
  • US $54.00-153.00 / mg
  • 99.89%
  • TargetMol Chemicals Inc.
  • IDO-IN-2 pictures
  • IDO-IN-2
    1668565-74-9
  • US $1.00 / KG
  • Min98% HPLC
  • Career Henan Chemical Co

IDO-IN-2 Spectrum

IDO-IN-2(1668565-74-9)1HNMR
DO-IN-2 IDO inhibitor 2 Urea, N-[4-[bis(2-methylpropyl)amino]-2'-(2H-tetrazol-5-yl)[1,1'-biphenyl]-3-yl]-N'-(4-methylphenyl)- PCC0208009 PCC0208009,IDO,PCC-0208009,Inhibitor,Indoleamine 2,3-Dioxygenase (IDO),PCC 0208009,inhibit,neuropathic 1-(4-(diisobutylamino)-2'-(1H-tetrazol-5-yl)biphenyl-3-yl)-3-p-tolylurea 1-(4-(Diisobutylamino)-2'-(2H-tetrazol-5-yl)-[1,1'-biphenyl]-3-yl)-3-(p-tolyl)urea PCC0208009, 10 mM in DMSO 1668565-74-9 C29H35N7O