Stampidine
- CAS No.
- 217178-62-6
- Chemical Name:
- Stampidine
- Synonyms
- HI 113;Sampidine;Stampidine
- CBNumber:
- CB43210408
- Molecular Formula:
- C20H23BrN3O8P
- Molecular Weight:
- 544.289681
- MDL Number:
- MFCD34469329
- MOL File:
- 217178-62-6.mol
- MSDS File:
- SDS
| storage temp. | Store at -20°C |
|---|---|
| solubility | DMSO : 100 mg/mL (183.73 mM; Need ultrasonic) |
| form | Solid |
| color | White to off-white |
| FDA UNII | MHN9I3MQ1X |
Stampidine Chemical Properties,Uses,Production
Uses
Stampidine is a nucleoside reverse transcriptase inhibitor (NRTI) with potent and broad-spectrum anti-HIV activity. Stampidine inhibits the laboratory HIV-1 strain HTLVIIIB (B-envelope subtype) and primary clinical isolates with IC50s of 1 nM and 2 nM, respectively. Stampidine also inhibits NRTI-resistant primary clinical isolates and NNRTI-resistant clinical isolates with IC50s of 8.7 nM and 11.2 nM, respectively[1].
in vivo
Stampidine (50-100 mg/kg; p.o.) exhibits potent antiretroviral activity in chronically feline immunodeficiency virus (FIV)-infected cats[3].
Stampidine (100 mg/kg; p.o.) shows the average plasma Cmax, AUC, half-life (t1/2), and mean residence time (MRT) values of 15.4 μM, 23.1 μM h, 108.6 min and 119.4 min, respectively, in dogs[4].
Stampidine does not cause anemia, thrombocytopenia, neutropenia, or lymphopenia suggestive of hematologic toxicity, elevations of BUN or creatinine or electrolyte disturbances suggestive of renal toxicity or metabolic abnormalities, elevations of ALT, AST, Alk in adult beagle dogs[4].
| Animal Model: | SPF male or female domestic cats (2.9- 6.2 kg), with chronically FIV-infected[3] |
| Dosage: | 50 mg/kg, 100 mg/kg |
| Administration: | Oral administration (oral bolus dose) |
| Result: | Exhibited potent antiretroviral activity. |
| Animal Model: | Male beagle dogs (10-12 kg)[4] |
| Dosage: | 100 mg/kg (Pharmacokinetic Analysis) |
| Administration: | Oral administration |
| Result: | The estimated average plasma Cmax and AUC values were 15.4 μM and 23.1 μM·h, respectively. The average elimination half-life (t1/2) and mean residence time (MRT) were 108.6 min and 119.4 min, respectively. |
IC 50
HIV-1
References
[1] Osmond J D'Cruz, et al. Stampidine: a selective oculo-genital microbicide. J Antimicrob Chemother. 2005 Jul;56(1):10-9. DOI:10.1093/jac/dki168
[2] Osmond J D'Cruz, et al. Stampidine is a potential nonspermicidal broad-spectrum anti-human immunodeficiency virus microbicide. Fertil Steril. 2004 Mar;81 Suppl 1:831-41. DOI:10.1016/j.fertnstert.2003.08.037
[3] Fatih M Uckun, et al. In Vivo Antiretroviral Activity of Stampidine in Chronically Feline Immunodeficiency Virus-Infected Cats. Antimicrob Agents Chemother. 2003 Apr;47(4):1233-40. DOI:10.1128/AAC.47.4.1233-1240.2003
[4] Fatih M Uckun, et al. In Vivo Pharmacokinetics and Toxicity Profile of the anti-HIV Agent Stampidine in Dogs and Feline Immunodeficiency Virus-Infected Cats. Arzneimittelforschung. 2006 Feb;56(2A):176-92. DOI:10.1055/s-0031-1296805
Stampidine Preparation Products And Raw materials
Raw materials
Preparation Products
Stampidine Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| TargetMol Chemicals Inc. | +1-781-999-5354; +17819995354 | marketing@targetmol.com | United States | 32434 | 58 |
| AFINE CHEMICALS LIMITED | +86-0571-85134551 | sales@afinechem.com | China | 15142 | 58 |
| NewCan Biotech Limited | +86-0571-86912261 +8613735419629 | sales@newcanbio.com | China | 9985 | 58 |
| TargetMol Chemicals Inc. | +17819995354 | marketing@targetmol.com | United States | 19961 | 58 |
| Beijing Jin Ming Biotechnology Co., Ltd. | 010-60605840 18892239720 | psaitong@jm-bio.com | China | 12306 | 58 |
| Beijing Jin Ming Biotechnology Co., Ltd. | 010-60605840 15801484223; | psaitong@jm-bio.com | China | 29757 | 58 |
| TargetMol Chemicals Inc. | 4008200310 | marketing@tsbiochem.com | China | 24989 | 58 |
| Shanghai Yifei Biotechnology Co. , Ltd. | 021-65675885 18964387627 | customer_service@efebio.com | China | 11973 | 58 |
| Shanghai?Medlife?Pharm-Tech?Co.,?Ltd | 021-59167510 18117107507 | vip@med-life.cn | China | 5002 | 58 |
| RD International Technology Co., Limited | 18024082417 | market@ubiochem.com | China | 9835 | 58 |
View Lastest Price from Stampidine manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2025-08-21 | Stampidine
217178-62-6
|
US $2500.00-1780.00 / mg | 10g | TargetMol Chemicals Inc. |
-
- Stampidine
217178-62-6
- US $2500.00-1780.00 / mg
- TargetMol Chemicals Inc.
