BMS-351
- CAS No.
- 1370001-71-0
- Chemical Name:
- BMS-351
- Synonyms
- BMS-351;1H-Benzimidazole, 4-(4-methyl-3-pyridinyl)-1-(2,2,2-trifluoroethyl)-
- CBNumber:
- CB43303243
- Molecular Formula:
- C15H12F3N3
- Molecular Weight:
- 291.27
- MDL Number:
- MOL File:
- 1370001-71-0.mol
- MSDS File:
- SDS
BMS-351 Chemical Properties, Uses, Production
Description
BMS-351 is a potent and selective, nonsteroidal CYP17A1 lyase inhibitor with robust selectivity over steroidogenic CYPs 21A2 and 11B1. BMS-351 emerges as an outstanding preclinical candidate to treat CRPC and is likely to minimize the side effects of current therapies due to its exceptional selectivity. BMS-351 is potentially useful for the Treatment of Prostate Cancer.
Uses
BMS-351 (compound 18) is a potent, oral active, nonsteroidal CYP17A1 lyase inhibitor with the IC50 values of 19 nM and 4 nM aganist human CYP17A1 and cynomolgus monkeys CYP17A1,respectively. BMS-351 can be used for the study of castration-resistant prostate cancer[1].
References
[1] Huang A, et al. Discovery of the Selective CYP17A1 Lyase Inhibitor BMS-351 for the Treatment of Prostate Cancer. ACS Med Chem Lett. 2015;7(1):40-45. Published 2015 Dec 2. DOI:10.1021/acsmedchemlett.5b00310
BMS-351 Preparation Products And Raw materials
Raw materials
Preparation Products
BMS-351 Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Shanghai Beckham Medical Technology Co., Ltd | 13816613772 | huahero21@sina.com | China | 2994 | 55 |
| BOC Sciences | 16314854226; +8616314854226 | inquiry@bocsci.com | United States | 19852 | 58 |
| TargetMol Chemicals Inc. | 15002134094 | marketing@targetmol.cn | China | 29874 | 58 |
| TargetMol Chemicals Inc. | 13564774135 | marketing@targetmol.com | United States | 19950 | 58 |
| Supplier | Advantage |
|---|---|
| Shanghai Beckham Medical Technology Co., Ltd | 55 |
| BOC Sciences | 58 |
| TargetMol Chemicals Inc. | 58 |
| TargetMol Chemicals Inc. | 58 |
