NIGERICIN SODIUM SALT
- CAS No.
- 28380-24-7
- Chemical Name:
- NIGERICIN SODIUM SALT
- Synonyms
- NIGERICIN;x-464;Helix c;HELIXIN C;Aids003767;Aids-003767;AZALOMYCIN M;NIGERICIN NA;POLYETHERIN A;Antibiotic M 2
- CBNumber:
- CB4331016
- Molecular Formula:
- C40H68O11
- Molecular Weight:
- 724.96
- MDL Number:
- MFCD00036825
- MOL File:
- 28380-24-7.mol
- MSDS File:
- SDS
| Product description | Number | Pack Size | Price |
| NIGERICIN 95.00% | API0003572 | 5MG | $673.61 |
| NIGERICIN 95.00% | API0003572 | 10MG | $686.65 |
| NIGERICIN 95.00% | API0003572 | 25MG | $737.58 |
| Nigericin | 2066 | 1g | $3250 |
| Nigericin | 2066 | 5mg | $45 |
| Melting point | 183.5-185° |
|---|---|
| alpha | D24 +36.2° (c = 0.842 in CHCl3) |
| Boiling point | 779.9±60.0 °C(Predicted) |
| Density | 1.19±0.1 g/cm3(Predicted) |
| storage temp. | 2-8°C |
| solubility | chloroform: 10 mg/mL, clear, colorless |
| pka | 4.39±0.10(Predicted) |
| form | Solid |
| color | White to off-white |
| InChIKey | DANUORFCFTYTSZ-ANZYULKNSA-N |
| EWG's Food Scores | 1 |
| FDA UNII | RRU6GY95IS |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS06 |
|---|---|
| Signal word | Danger |
| Hazard statements | H319-H335-H301-H315 |
| Precautionary statements | P264-P270-P301+P310-P321-P330-P405-P501-P264-P280-P302+P352-P321-P332+P313-P362-P264-P280-P305+P351+P338-P337+P313P |
| Hazard Codes | T,Xi |
| Risk Statements | 25-36/37/38 |
| Safety Statements | 26-36/37/39-45-36 |
| RIDADR | UN 3462 6.1/PG 3 |
| WGK Germany | 3 |
| RTECS | QT6840000 |
| F | 10 |
| HazardClass | 6.1(b) |
| PackingGroup | III |
| HS Code | 29419090 |
| Toxicity | LD50 in mice (mg/kg): 10-15 i.p. (Shoji); also reported as 2.5 i.p. (Harned) |
NIGERICIN SODIUM SALT price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| American Custom Chemicals Corporation | API0003572 | NIGERICIN 95.00% | 28380-24-7 | 5MG | $673.61 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | API0003572 | NIGERICIN 95.00% | 28380-24-7 | 10MG | $686.65 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | API0003572 | NIGERICIN 95.00% | 28380-24-7 | 25MG | $737.58 | 2021-12-16 | Buy |
| AvaChem | 2066 | Nigericin | 28380-24-7 | 1g | $3250 | 2021-12-16 | Buy |
| AvaChem | 2066 | Nigericin | 28380-24-7 | 5mg | $45 | 2021-12-16 | Buy |
NIGERICIN SODIUM SALT Chemical Properties,Uses,Production
Uses
Nigericin is a polyether antibiotic produced by Streptomyces, notably S. hygroscopicus, isolated in the 1950s. Its complex structure was finally elucidated in 1968. Nigericin is an ionophore, possessing very high affinity for monovalent cations such as Na+ and K+. Nigericin disrupts membrane potential and Golgi apparatus in mitochondria. Although nigericin can be isolated as the free acid (under acidic conditions), like most ionophores it is extracted into organic solvents and is most conveniently isolated as a salt. In vitro, nigericin has broad biological activity against Gram positive bacteria, fungi, tumour cell lines and some viruses, including HIV. Nigericin is the most common member of the polyether class which are common false positives in in vitro screening bioassays using crude microbial extracts. They are thus important standards for dereplication.
Definition
ChEBI: A polyether antibiotic which affects ion transport and ATPase activity in mitochondria. It is produced by Streptomyces hygroscopicus.
in vivo
Nigericin (1 mg/kg; i.p.; every 12 h for 3 D) reduces the infection of S. aureus USA300 in mice[4].
Nigericin (0.025 mg/kg; s.c.; every two days in 4 weeks) plus anti-PD-1 shows synergistic anti-cancer effect[6].
| Animal Model: | BALB/c Mice injected orthotopically with 4T1 cells[6] |
| Dosage: | 0.025 mg/kg |
| Administration: | Subcutaneous injection (s.c.) |
| Result: | Showed combination with anti-PD-1 antibody almost completely suppressed tumor growth. |
| Animal Model: | Mice Infected with S. aureus USA300[4] |
| Dosage: | 1 mg/kg |
| Administration: | Intraperitoneal injection (i.p.) |
| Result: | Showed reduction in the bacterial burden to 1,000-10,000-fold in the major organs. |
IC 50
NLRP3
NIGERICIN SODIUM SALT Preparation Products And Raw materials
Raw materials
Preparation Products
NIGERICIN SODIUM SALT Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Pure Research Chemicals | +86-13564847951 +86-18019592524 | info@purerechem.com | China | 1000 | 58 |
| Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | info@tianfuchem.com | China | 21592 | 55 |
| Shenzhen Excellent Biotech Co., Ltd. | 13480692018 | ramyan@ex-biotech.com | CHINA | 954 | 58 |
| career henan chemical co | +86-0371-86658258 +8613203830695 | factory@coreychem.com | China | 29794 | 58 |
| SHANGHAI T&W PHARMACEUTICAL CO., LTD. | +86-021-61551413 +8618813727289 | contact@trustwe.com | China | 5742 | 58 |
| SIMAGCHEM CORP | +86-5922680277 +86-13806087780 | sale@simagchem.com | China | 17346 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354; +17819995354 | marketing@targetmol.com | United States | 32469 | 58 |
| Zhejiang Huida Biotech Co., LTD | 008613515763466 8615669048680 | wendy@huidabiotech.com | CHINA | 87 | 58 |
| Baoji Guokang Healthchem co.,ltd | +8615604608665 15604608665 | dominicguo@gk-bio.com | CHINA | 9414 | 58 |
| Hebei Fengjia New Material Co., Ltd | +86-0311-87836622 +86-18712993135 | sales01@tairunfaz.com | China | 8051 | 58 |
View Lastest Price from NIGERICIN SODIUM SALT manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-04-09 | Nigericin
28380-24-7
|
US $179.00 / mg | 99.02% | 10g | TargetMol Chemicals Inc. | ||
 |
2020-01-13 | NIGERICIN SODIUM SALT
28380-24-7
|
US $1.00 / KG | 1KG | 98%-99.9% | 200kg | Career Henan Chemical Co |
-
- Nigericin
28380-24-7
- US $179.00 / mg
- 99.02%
- TargetMol Chemicals Inc.
-
- NIGERICIN SODIUM SALT
28380-24-7
- US $1.00 / KG
- 98%-99.9%
- Career Henan Chemical Co
