4-(2,5-Dimethyl-pyrrol-1-yl)-2-hydroxy-benzoic acid
- CAS No.
- 674782-30-0
- Chemical Name:
- 4-(2,5-Dimethyl-pyrrol-1-yl)-2-hydroxy-benzoic acid
- Synonyms
- EphA Antagonist;Benzoic acid, 4-(2,5-dimethyl-1H-pyrrol-1-yl)-2-hydroxy-
- CBNumber:
- CB43321311
- Molecular Formula:
- C13H13NO3
- Molecular Weight:
- 231.25
- MDL Number:
- MFCD01874283
- MOL File:
- 674782-30-0.mol
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302-H315-H319-H332-H335 |
| Precautionary statements | P264-P302+P352-P304+P340-P305+P351+P338-P332+P313-P337+P313 |
| WGK Germany | WGK 2 |
| Storage Class | 11 - Combustible Solids |
4-(2,5-Dimethyl-pyrrol-1-yl)-2-hydroxy-benzoic acid price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Chemenu | CM332880 | 4-(2,5-Dimethyl-1h-pyrrol-1-yl)-2-hydroxybenzoic acid 95%+ | 674782-30-0 | 1g | $217 | 2026-05-26 | Buy |
| Matrix Scientific | 010126 | 4-(2,5-Dimethyl-pyrrol-1-yl)-2-hydroxy-benzoic acid | 674782-30-0 | 1g | $595 | 2021-12-16 | Buy |
| CHESS | 1003312 | KP002148:4-(2,5-Dimethyl-pyrrol-1-yl)-2-hydroxy-benzoicacid 96 | 674782-30-0 | 1g | $336 | 2021-12-16 | Buy |
| CHESS | 1003312 | KP002148:4-(2,5-Dimethyl-pyrrol-1-yl)-2-hydroxy-benzoicacid 96 | 674782-30-0 | 5G | $1020 | 2021-12-16 | Buy |
4-(2,5-Dimethyl-pyrrol-1-yl)-2-hydroxy-benzoic acid Chemical Properties, Uses, Production
Uses
A pyrrolyl benzoic acid that effectively competes against ephrin-B3 for EphA4 binding as well as against ephrin-A1/-A2/-A3/-A5 for EphA2 and EphA4 binding by targeting EphA2/A4 high affinity ephrin-binding pocket in a reversible manner (Ki = 6-10 and 11-14 µM against ephrin-A5 binding to EphA4 and EphA2, respectively), exhibiting much reduced or no potency against ephrin-A4 for EphA2/EphA4 binding, ephrin-A5 for EphA3/A5/A6/A7 binding, ephrin-B2 for B1/B2/B3/B4/B6 binding, or ephrin-B2 for EphA4 binding. Shown to inhibit 0.1 µg/mL ephrin-A1-Fc fusion-induced EphA2 phosphorylation in COS7 (by 92% at 200 µM) and 0.5 µg/mL ephrin-A5-Fc fusion-induced EphA4 phosphorylation in HT22 neuronal cultures (by 42% and 79% respectively, at 300 and 400 µM) without any cytotoxicity (up to 400 µM and 3 days in HT22 cultures). Also effective toward chicken and zebrafish EphA4 orthologs as evidenced by its efficacy in preventing 1 µg/mL ephrin-A5-Fc-induced growth cone collapse of neurons in 6-d chicken embryo retina (by 100% at 400 µM) ex vivo and in fully rescuing human mutant SOD-1 A4V transgene-induced axonopathy in zebrafish embryos (500 µM; treatment period from 6 to 30 hpf) in vivo.
Biological Activity
Cell permeable: no', 'Primary Target
EphA', 'Reversible: yes
4-(2,5-Dimethyl-pyrrol-1-yl)-2-hydroxy-benzoic acid Preparation Products And Raw materials
Raw materials
Preparation Products
4-(2,5-Dimethyl-pyrrol-1-yl)-2-hydroxy-benzoic acid Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| BioPharmaMatrix,Inc. | 0510-86010668 13395169561; | sales@biopharmamatrix.com | China | 5010 | 55 |
| Amadis Chemical Company Limited | 571-89925085 | sales@amadischem.com | China | 131885 | 58 |
| Hangzhou FuRun Pharmaceutical Technology Co., Ltd | 15658004993 | 1900830611@qq.com | China | 980 | 58 |
| NewCan Biotech Limited | +86-0571-86912261 +86-15658003402 | sales@newcanbio.com | China | 1982 | 58 |
| Shanghai meikai technology co., ltd | 021-68689288 15300790979 | info@mkbio.com.cn | China | 9755 | 58 |
