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ChemicalBook >> CAS DataBase List >>1-(4-Methyl-2-(methylamino)thiazol-5-yl)ethanone

1-(4-Methyl-2-(methylamino)thiazol-5-yl)ethanone

1-(4-Methyl-2-(methylamino)thiazol-5-yl)ethanone Structure
1-(4-Methyl-2-(methylamino)thiazol-5-yl)ethanone structure
CAS No.
94284-66-9
Chemical Name:
1-(4-Methyl-2-(methylamino)thiazol-5-yl)ethanone
Synonyms
2-methylamino-4-methyl-5-acetylthiazole;1-(4-Methyl-2-(methylamino)thiazol-5-yl)ethanone;1-[4-Methyl-2-(methylamino)-5-thiazolyl]ethanone;Ethanone, 1-[4-methyl-2-(methylamino)-5-thiazolyl]-;1-(4-Methyl-2-(methylamino)thiazol-5-yl)ethan-1-one
CBNumber:
CB4332826
Molecular Formula:
C7H10N2OS
Molecular Weight:
170.23
MDL Number:
MFCD08236737
MOL File:
94284-66-9.mol
MSDS File:
SDS
Last updated:2026-09-12 18:52:44
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1-(4-Methyl-2-(methylamino)thiazol-5-yl)ethanone Properties

Melting point 201-203 °C
Boiling point 281.9±32.0 °C(Predicted)
Density 1+-.0.06 g/cm3(Predicted)
storage temp. Keep in dark place,Inert atmosphere,Room temperature
pka 4.01±0.10(Predicted)
Appearance White to off-white Solid

SAFETY

Risk and Safety Statements

Symbol(GHS)  Exclamation Mark (GHS07)
GHS07
Signal word  Warning
Hazard statements  H302-H315-H319-H335
Precautionary statements  P261-P305+P351+P338

1-(4-Methyl-2-(methylamino)thiazol-5-yl)ethanone price More Price(30)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Matrix Scientific 299581 1-(4-Methyl-2-(methylamino)thiazol-5-yl)ethanone 94284-66-9 250.00mg $39 2026-05-19 Buy
Matrix Scientific 299581 1-(4-Methyl-2-(methylamino)thiazol-5-yl)ethanone 94284-66-9 1.00g $134 2026-05-19 Buy
Matrix Scientific 299581 1-(4-Methyl-2-(methylamino)thiazol-5-yl)ethanone 94284-66-9 5.00g $657 2026-05-19 Buy
aablocks AA00IHXW 1-(4-Methyl-2-(methylamino)thiazol-5-yl)ethanone 98% 94284-66-9 100mg $17 2026-05-29 Buy
aablocks AA00IHXW 1-(4-Methyl-2-(methylamino)thiazol-5-yl)ethanone 95% 94284-66-9 250mg $26 2026-05-29 Buy
Product number Packaging Price Buy
299581 250.00mg $39 Buy
299581 1.00g $134 Buy
299581 5.00g $657 Buy
AA00IHXW 100mg $17 Buy
AA00IHXW 250mg $26 Buy

1-(4-Methyl-2-(methylamino)thiazol-5-yl)ethanone Chemical Properties, Uses, Production

Synthesis

N-METHYLTHIOUREA

598-52-7

3-CHLORO-2,4-PENTANEDIONE

1694-29-7

1-(4-METHYL-2-(METHYLAMINO)THIAZOL-5-YL)ETHANONE

94284-66-9

General procedure for the synthesis of 1-(4-methyl-2-(methylamino)thiazol-5-yl)ethanone from N-methylthiourea and 3-chloro-2,4-pentanedione: 1-methylthiourea (6.00 g, 66.6 mmol) was dissolved in a mixture of methanol (130 mL) and pyridine (5 mL) and cooled in an ice bath. Subsequently, 3-chloropentane-2,4-dione (8.96 mL, 66.6 mmol) was added slowly and dropwise to this cooled solution. The reaction mixture was gradually warmed to room temperature and stirred continuously for 4 hours. Upon completion of the reaction, the resulting white solid precipitate was collected by filtration and washed with ether (20 mL) to give the final target product 1-(4-methyl-2-(methylamino)thiazol-5-yl)ethanone (8.94 g, 79% yield). The product was characterized by 1H-NMR (DMSO-d6): δ 2.39 (s, 3H, CH3), 2.49 (s, 3H, CH3), 2.91 (s, 3H, CH3), 9.12 (s, 1H, NH). Mass spectrometry (ESI) analysis showed a calculated value of 171.06 (C7H11N2OS+) for m/z [M+H]+ and a measured value of 171.06.

References

[1] European Journal of Medicinal Chemistry, 2017, vol. 139, p. 762 - 772
[2] Journal of Medicinal Chemistry, 2004, vol. 47, # 7, p. 1662 - 1675
[3] Journal of Medicinal Chemistry, 2010, vol. 53, # 11, p. 4367 - 4378
[4] Bioorganic and Medicinal Chemistry, 2011, vol. 19, # 10, p. 3135 - 3140
[5] Bioorganic and Medicinal Chemistry, 2011, vol. 19, # 24, p. 7349 - 7356

1-(4-Methyl-2-(methylamino)thiazol-5-yl)ethanone synthesis

598-52-7
1694-29-7
94284-66-9
Synthesis of 1-(4-Methyl-2-(methylamino)thiazol-5-yl)ethanone from N-Methylthiourea and 3-Chloro-2,4-pentanedione

1-(4-Methyl-2-(methylamino)thiazol-5-yl)ethanone Preparation Products And Raw materials

Raw materials

N-Methylthiourea 3-Chloro-2,4-pentanedione Methanol Pyridine

Preparation Products

1-(4-Methyl-2-(methylamino)thiazol-5-yl)ethanone Suppliers

Global Suppliers ( 30)
Supplier Tel Email Country ProdList Advantage
Shanghai JiYi Biotechnology Co. Ltd. 13621943973 sales@shjiyipharmatech.com China 1166 55
Shanghai Brain Biotechnology Co., Ltd. 13564638271 shhjiang1977@163.com China 2983 55
Amadis Chemical Company Limited 571-89925085 sales@amadischem.com China 131885 58
Aikon International Limited 025-66061636 19370895928 qqyang@aikonchem.com China 15810 58
Yujinpharma(Tianjin) Technology Co.,Ltd. 13370351217 kungfu1217@1 kungfu1217@163.com China 7991 58
Cool Pharm, Ltd 021-58581007 18019463053 sales@coolpharm.com China 9999 58
Labnetwork lnc. +86-27-50766799 +86-18062016861 contact@labnetwork.com China 19981 58
Henan Lien Chemical Products Co., Ltd. 0371-63357898 15378766539 535046669@qq.com China 5743 58
Baimei Jihua (Henan) Pharmaceutical Technology Co., Ltd 0371-88900765 18037465274 3430974218@qq.com China 14171 58
Jingmo (Xiamen) Biotechnology Co., Ltd 13621943973; 13621943973 sales@jamxmpharmatech.com China 1191 58
Supplier Advantage
Shanghai JiYi Biotechnology Co. Ltd. 55
Shanghai Brain Biotechnology Co., Ltd. 55
Amadis Chemical Company Limited 58
Aikon International Limited 58
Yujinpharma(Tianjin) Technology Co.,Ltd. 58
Cool Pharm, Ltd 58
Labnetwork lnc. 58
Henan Lien Chemical Products Co., Ltd. 58
Baimei Jihua (Henan) Pharmaceutical Technology Co., Ltd 58
Jingmo (Xiamen) Biotechnology Co., Ltd 58

1-(4-Methyl-2-(methylamino)thiazol-5-yl)ethanone Spectrum

1-(4-METHYL-2-(METHYLAMINO)THIAZOL-5-YL)ETHANONE(94284-66-9)1HNMR

94284-66-9 (1-(4-Methyl-2-(methylamino)thiazol-5-yl)ethanone) Related Search:

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N-(5-(2-Methylpropyl)-7-oxo(4,5,6-trihydrobenzothiazol-2-yl))-2-thienylformamide N-(5,5-Dimethyl-7-oxo(4,5,6-trihydrobenzothiazol-2-yl))(2-chloro(3-pyridyl))formamide N-(5-Methyl-7-oxo(4,5,6-trihydrobenzothiazol-2-yl))(2-phenoxy(3-pyridyl))formamide

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2-methylamino-4-methyl-5-acetylthiazole 1-(4-Methyl-2-(methylamino)thiazol-5-yl)ethan-1-one Ethanone, 1-[4-methyl-2-(methylamino)-5-thiazolyl]- 1-[4-Methyl-2-(methylamino)-5-thiazolyl]ethanone 1-(4-Methyl-2-(methylamino)thiazol-5-yl)ethanone 94284-66-9