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ChemicalBook >> CAS DataBase List >>1-(4-METHYL-2-(METHYLAMINO)THIAZOL-5-YL)ETHANONE

1-(4-METHYL-2-(METHYLAMINO)THIAZOL-5-YL)ETHANONE

1-(4-METHYL-2-(METHYLAMINO)THIAZOL-5-YL)ETHANONE Structure
1-(4-METHYL-2-(METHYLAMINO)THIAZOL-5-YL)ETHANONE structure
CAS No.
94284-66-9
Chemical Name:
1-(4-METHYL-2-(METHYLAMINO)THIAZOL-5-YL)ETHANONE
Synonyms
2-methylamino-4-methyl-5-acetylthiazole;1-(4-METHYL-2-(METHYLAMINO)THIAZOL-5-YL)ETHANONE;1-[4-Methyl-2-(methylamino)-5-thiazolyl]ethanone;Ethanone, 1-[4-methyl-2-(methylamino)-5-thiazolyl]-;1-(4-Methyl-2-(methylamino)thiazol-5-yl)ethan-1-one
CBNumber:
CB4332826
Molecular Formula:
C7H10N2OS
Molecular Weight:
170.23
MDL Number:
MFCD08236737
MOL File:
94284-66-9.mol
MSDS File:
SDS
Last updated:2025-07-24 18:13:44
Product description Number Pack Size Price
1-(4-Methyl-2-(methylamino)thiazol-5-yl)ethan-1-one CS-0059746 250mg $107
1-(4-Methyl-2-(methylamino)thiazol-5-yl)ethanone 97% P000199330 250mg $121
1-(4-Methyl-2-(methylamino)thiazol-5-yl)ethan-1-one CS-0059746 1g $266
1-(4-methyl-2-(methylamino)thiazol-5-yl)ethanone 5578AQ 100mg $291.2
1-(4-Methyl-2-(methylamino)thiazol-5-yl)ethanone 97% P000199330 1g $302
Request For Quotation

1-(4-METHYL-2-(METHYLAMINO)THIAZOL-5-YL)ETHANONE Properties

Melting point 201-203 °C
Boiling point 281.9±32.0 °C(Predicted)
Density 1+-.0.06 g/cm3(Predicted)
storage temp. Keep in dark place,Inert atmosphere,Room temperature
pka 4.01±0.10(Predicted)
Appearance White to off-white Solid

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS07
Signal word  Warning
Hazard statements  H302-H315-H319-H335
Precautionary statements  P261-P305+P351+P338

1-(4-METHYL-2-(METHYLAMINO)THIAZOL-5-YL)ETHANONE price More Price(17)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
ChemScene CS-0059746 1-(4-Methyl-2-(methylamino)thiazol-5-yl)ethan-1-one 94284-66-9 250mg $107 2021-12-16 Buy
Ark Pharm P000199330 1-(4-Methyl-2-(methylamino)thiazol-5-yl)ethanone 97% 94284-66-9 250mg $121 2021-12-16 Buy
ChemScene CS-0059746 1-(4-Methyl-2-(methylamino)thiazol-5-yl)ethan-1-one 94284-66-9 1g $266 2021-12-16 Buy
AK Scientific 5578AQ 1-(4-methyl-2-(methylamino)thiazol-5-yl)ethanone 94284-66-9 100mg $291.2 2021-12-16 Buy
Ark Pharm P000199330 1-(4-Methyl-2-(methylamino)thiazol-5-yl)ethanone 97% 94284-66-9 1g $302 2021-12-16 Buy
Product number Packaging Price Buy
CS-0059746 250mg $107 Buy
P000199330 250mg $121 Buy
CS-0059746 1g $266 Buy
5578AQ 100mg $291.2 Buy
P000199330 1g $302 Buy

1-(4-METHYL-2-(METHYLAMINO)THIAZOL-5-YL)ETHANONE Chemical Properties,Uses,Production

Synthesis

N-METHYLTHIOUREA

598-52-7

3-CHLORO-2,4-PENTANEDIONE

1694-29-7

1-(4-METHYL-2-(METHYLAMINO)THIAZOL-5-YL)ETHANONE

94284-66-9

General procedure for the synthesis of 1-(4-methyl-2-(methylamino)thiazol-5-yl)ethanone from N-methylthiourea and 3-chloro-2,4-pentanedione: 1-methylthiourea (6.00 g, 66.6 mmol) was dissolved in a mixture of methanol (130 mL) and pyridine (5 mL) and cooled in an ice bath. Subsequently, 3-chloropentane-2,4-dione (8.96 mL, 66.6 mmol) was added slowly and dropwise to this cooled solution. The reaction mixture was gradually warmed to room temperature and stirred continuously for 4 hours. Upon completion of the reaction, the resulting white solid precipitate was collected by filtration and washed with ether (20 mL) to give the final target product 1-(4-methyl-2-(methylamino)thiazol-5-yl)ethanone (8.94 g, 79% yield). The product was characterized by 1H-NMR (DMSO-d6): δ 2.39 (s, 3H, CH3), 2.49 (s, 3H, CH3), 2.91 (s, 3H, CH3), 9.12 (s, 1H, NH). Mass spectrometry (ESI) analysis showed a calculated value of 171.06 (C7H11N2OS+) for m/z [M+H]+ and a measured value of 171.06.

References

[1] European Journal of Medicinal Chemistry, 2017, vol. 139, p. 762 - 772
[2] Journal of Medicinal Chemistry, 2004, vol. 47, # 7, p. 1662 - 1675
[3] Journal of Medicinal Chemistry, 2010, vol. 53, # 11, p. 4367 - 4378
[4] Bioorganic and Medicinal Chemistry, 2011, vol. 19, # 10, p. 3135 - 3140
[5] Bioorganic and Medicinal Chemistry, 2011, vol. 19, # 24, p. 7349 - 7356

1-(4-METHYL-2-(METHYLAMINO)THIAZOL-5-YL)ETHANONE synthesis

598-52-7
1694-29-7
94284-66-9
Synthesis of 1-(4-METHYL-2-(METHYLAMINO)THIAZOL-5-YL)ETHANONE from N-METHYLTHIOUREA and 3-CHLORO-2,4-PENTANEDIONE

1-(4-METHYL-2-(METHYLAMINO)THIAZOL-5-YL)ETHANONE Preparation Products And Raw materials

Raw materials

N-METHYLTHIOUREA 3-CHLORO-2,4-PENTANEDIONE Methanol Pyridine

Preparation Products

1-(4-METHYL-2-(METHYLAMINO)THIAZOL-5-YL)ETHANONE Suppliers

Global( 29)Suppliers
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Labnetwork lnc. 		+86-27-50766799 +8618062016861 contact@labnetwork.com China 19987 58
Hangzhou MolCore BioPharmatech Co.,Ltd. 		+86-057181025280; +8617767106207 sales@molcore.com China 49734 58
ShenZhen Trendseen Biological Technology Co.,Ltd. 		13417589054 trendseenbio@gmail.com China 11681 58
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Amadis Chemical Company Limited 		571-89925085 sales@amadischem.com China 131957 58
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Shanghai Brain Biotechnology Co., Ltd. 13564638271 shhjiang1977@163.com China 2989 55
Aikon International Limited 025-66061636 18013972705 qqyang@aikonchem.com China 15813 58
Yujinpharma(Tianjin) Technology Co.,Ltd. 13370351217 kungfu1217@1 kungfu1217@163.com China 2721 58
Cool Pharm, Ltd 021-58581007 18019463053 sales@coolpharm.com China 9732 58
Supplier Advantage
Labnetwork lnc. 		58
Hangzhou MolCore BioPharmatech Co.,Ltd. 		58
ShenZhen Trendseen Biological Technology Co.,Ltd. 		58
Jilin Chinese Academy of Sciences-yanshen Technology 		58
Amadis Chemical Company Limited 		58
Shanghai JiYi Biotechnology Co. Ltd. 55
Shanghai Brain Biotechnology Co., Ltd. 55
Aikon International Limited 58
Yujinpharma(Tianjin) Technology Co.,Ltd. 58
Cool Pharm, Ltd 58

1-(4-METHYL-2-(METHYLAMINO)THIAZOL-5-YL)ETHANONE Spectrum

1-(4-METHYL-2-(METHYLAMINO)THIAZOL-5-YL)ETHANONE(94284-66-9)1HNMR

94284-66-9(1-(4-METHYL-2-(METHYLAMINO)THIAZOL-5-YL)ETHANONE)Related Search:

N-(5,5-DIMETHYL-7-OXO-4,5,6-TRIHYDROBENZOTHIAZOL-2-YL)ETHANAMIDE 1-(3-((2-CHLOROPHENYL)AMINO)-5-METHYL-2,4-THIAZOLYL)ETHAN-1-ONE 1-(4-METHYL-2-PHENYLAMINO-THIAZOL-5-YL)-ETHANONE 1-(4-METHYL-2-MORPHOLINO-1,3-THIAZOL-5-YL)-3-(2-THIENYL)PROP-2-EN-1-ONE N-(5,5-DIMETHYL-7-OXO(4,5,6-TRIHYDROBENZOTHIAZOL-2-YL))-2-(4-CHLOROPHENYLTHIO)PROPANAMIDE
(2-CHLORO(3-PYRIDYL))-N-(5-METHYL-7-OXO(4,5,6-TRIHYDROBENZOTHIAZOL-2-YL))FORMAMIDE N-(5,5-DIMETHYL-7-OXO(4,5,6-TRIHYDROBENZOTHIAZOL-2-YL))(3-(TRIFLUOROMETHYL)PHENYL)FORMAMIDE N-(5,5-DIMETHYL-7-OXO(4,5,6-TRIHYDROBENZOTHIAZOL-2-YL))-4-METHYLPENT-2-ENAMIDE N-(5-METHYL-7-OXO(4,5,6-TRIHYDROBENZOTHIAZOL-2-YL))(4-METHYLPHENYL)FORMAMIDE N-(5,5-DIMETHYL-7-OXO(4,5,6-TRIHYDROBENZOTHIAZOL-2-YL))(4-METHOXYPHENYL)FORMAMIDE
N-(5-METHYL-7-OXO(4,5,6-TRIHYDROBENZOTHIAZOL-2-YL))(2-PHENOXY(3-PYRIDYL))FORMAMIDE N-(5-METHYL-7-OXO-4,5,6-TRIHYDROBENZOTHIAZOL-2-YL)ETHANAMIDE 2-(4-CHLOROPHENYLTHIO)-N-(7-OXO-5-PHENYL(4,5,6-TRIHYDROBENZOTHIAZOL-2-YL))PROPANAMIDE N-(5,5-DIMETHYL-7-OXO(4,5,6-TRIHYDROBENZOTHIAZOL-2-YL))-3-PYRIDYLFORMAMIDE N-(5-(2-METHYLPROPYL)-7-OXO(4,5,6-TRIHYDROBENZOTHIAZOL-2-YL))-2-THIENYLFORMAMIDE
2-(2,4-DICHLOROPHENOXY)-N-(5,5-DIMETHYL-7-OXO(4,5,6-TRIHYDROBENZOTHIAZOL-2-YL))ETHANAMIDE N-(5,5-DIMETHYL-7-OXO(4,5,6-TRIHYDROBENZOTHIAZOL-2-YL))(2-CHLORO(3-PYRIDYL))FORMAMIDE N-(3-ACETYL-4-METHYL(2,5-THIAZOLYL))-2,2,2-TRIFLUOROETHANAMIDE

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1-(4-METHYL-2-(METHYLAMINO)THIAZOL-5-YL)ETHANONE 2-methylamino-4-methyl-5-acetylthiazole 1-(4-Methyl-2-(methylamino)thiazol-5-yl)ethan-1-one Ethanone, 1-[4-methyl-2-(methylamino)-5-thiazolyl]- 1-[4-Methyl-2-(methylamino)-5-thiazolyl]ethanone 94284-66-9