hVEGF-IN-1
- CAS No.
- 1637443-98-1
- Chemical Name:
- hVEGF-IN-1
- Synonyms
- hVEGF-IN-1;hVEGF-IN-1, >98%;hVEGF inhibitor 1;hVEGF-IN-1, 10 mM in DMSO;1-Piperazinepropanamide, N-[2-[4-[[4-[2-(diethylamino)ethoxy]phenyl]amino]-2-quinazolinyl]phenyl]-4-methyl-;N-(2-(4-((4-(2-(Diethylamino)ethoxy)phenyl)amino)quinazolin-2-yl)phenyl)-3-(4-methylpiperazin-1-yl)propanamide;Inhibitor,quinazoline,IRES-A,migration,hVEGF IN 1,hVEGFIN1,tumor,G-rich,inhibit,VEGFR,Vascular endothelial growth factor receptor,VEGF-A
- CBNumber:
- CB43350595
- Molecular Formula:
- C34H43N7O2
- Molecular Weight:
- 581.75
- MDL Number:
- MFCD31560473
- MOL File:
- 1637443-98-1.mol
- MSDS File:
- SDS
| Product description | Number | Pack Size | Price |
| hVEGF-IN-1 ≥98% | 37550 | 1mg | $86 |
| hVEGF-IN-1 ≥98% | 37550 | 5mg | $406 |
| hVEGF-IN-1 ≥98% | 37550 | 10mg | $768 |
| hVEGF-IN-1 | MQC44398 | 25mg | $1009 |
| hVEGF-IN-1 | MQC44398 | 50mg | $1403.5 |
| More product size | |||
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H315-H319-H335 |
| Precautionary statements | P264-P280-P302+P352-P321-P332+P313-P362-P305+P351+P338-P337+P313-P261-P271-P304+P340-P312-P403+P233-P405-P501 |
hVEGF-IN-1 price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Cayman Chemical | 37550 | hVEGF-IN-1 ≥98% | 1637443-98-1 | 1mg | $86 | 2026-04-30 | Buy |
| Cayman Chemical | 37550 | hVEGF-IN-1 ≥98% | 1637443-98-1 | 5mg | $406 | 2026-04-30 | Buy |
| Cayman Chemical | 37550 | hVEGF-IN-1 ≥98% | 1637443-98-1 | 10mg | $768 | 2026-04-30 | Buy |
| Biosynth | MQC44398 | hVEGF-IN-1 | 1637443-98-1 | 25mg | $1009 | 2026-06-04 | Buy |
| Biosynth | MQC44398 | hVEGF-IN-1 | 1637443-98-1 | 50mg | $1403.5 | 2026-06-04 | Buy |
hVEGF-IN-1 Chemical Properties,Uses,Production
Uses
hVEGF-IN-1, a quinazoline derivative, could specifically bind to the G-rich sequence in the internal ribosome entry site A (IRES-A) and destabilize the G-quadruplex structure. hVEGF-IN-1 binds to the IRES-A (WT) with a Kd of 0.928 μM in SPR experiments. hVEGF-IN-1 could hinder tumor cells migration and repress tumor growth by decreasing VEGF-A protein expression[1].
in vivo
hVEGF-IN-1 (compound 1) (7.5 mg/kg; i.p. once daily for 20 d) inhibits tumor growth in a human breast tumor xenograft[1].
| Animal Model: | BALB/c female nude mice were implanted MCF-7 cells[1] |
| Dosage: | 7.5 mg/kg |
| Administration: | I.p. once daily for 20 days |
| Result: | Reduced the tumor volume to <300 mm3. Reduced the tumor weight around 60.1% to a final weight of 0.18 g. Decreased the VEGF-A level in tumor tissue. |
References
[1] Wang SK, et, al. Discovery of Small Molecules for Repressing Cap-Independent Translation of Human Vascular Endothelial Growth Factor (hVEGF) as Novel Antitumor Agents. J Med Chem. 2017 Jul 13;60(13):5306-5319. DOI:10.1021/acs.jmedchem.6b01444
hVEGF-IN-1 Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| TargetMol Chemicals Inc. | +1-781-999-5354; +1-00000000000 | marketing@targetmol.com | United States | 32431 | 58 |
| BOC Sciences | 16314854226; +8616314854226 | inquiry@bocsci.com | United States | 19852 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354; | support@targetmol.com | United States | 38999 | 58 |
| HANGZHOU LEAP CHEM CO., LTD. | +86-571-87711850 +86-15355479329 | market18@leapchem.com | China | 43303 | 58 |
| Aladdin Scientific | tp@aladdinsci.com | United States | 50108 | 58 | |
| Amadis Chemical Company Limited | 571-89925085 | sales@amadischem.com | China | 131885 | 58 |
| Shanghai YuanYe Biotechnology Co., Ltd. | 15026964105 | 2881489226@qq.com | China | 89667 | 60 |
| ShangHai Biochempartner Co.,Ltd | 177-54423994 17754423994 | 2853530910@QQ.com | China | 8000 | 62 |
| Shanghai Chaolan Chemical Technology Center | QQ：65489617 13301690235 | Sales@ATKchemical.com | China | 9695 | 58 |
| Angel Pharmatech, Ltd. | 17317130613 | 3358272972@qq.com | China | 3307 | 58 |
View Lastest Price from hVEGF-IN-1 manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-08-08 | hVEGF-IN-1
1637443-98-1
|
$35.00-113.00 | 99.76% | 10g | TargetMol Chemicals Inc. |
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- hVEGF-IN-1
1637443-98-1
- $35.00-113.00
- 99.76%
- TargetMol Chemicals Inc.
