teixobactin
- CAS No.
- 1613225-53-8
- Chemical Name:
- teixobactin
- Synonyms
- teixobactin;L-Isoleucine, N-methyl-D-phenylalanyl-L-isoleucyl-L-seryl-D-glutaminyl-D-alloisoleucyl-L-isoleucyl-L-seryl-D-threonyl-L-alanyl-3-[(5S)-2-amino-4,5-dihydro-1H-imidazol-5-yl]-L-alanyl-, (11→8)-lactone
- CBNumber:
- CB43352276
- Molecular Formula:
- C58H95N15O15
- Molecular Weight:
- 1242.47
- MDL Number:
- MFCD32899000
- MOL File:
- 1613225-53-8.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Density | 1.39±0.1 g/cm3(Predicted) |
|---|---|
| pka | 12.18±0.70(Predicted) |
| FDA UNII | LC730GUE72 |
teixobactin Chemical Properties, Uses, Production
Uses
Teixobactin is a potent antibiotic. Teixobactin shows antibacterial activity for gram-negative bacteria. Teixobactin inhibits cell wall synthesis by binding to a highly conserved motif of lipid II and lipid III[1][2][3].
Definition
ChEBI: Teixobactin is a cyclodepsipeptide that is isolated from the previously unculturable bacterial species Eleftheria terrae and is active against gram-positive bacteria. It has a role as an antibacterial agent. It is a peptide antibiotic, a cyclodepsipeptide and a macrocycle.
in vivo
Teixobactin (1-20 mg/kg; i.v.; once) shows antibacterial activity in mice[3].
| Animal Model: | Female CD-1 mice (MRSA ATCC33591)[3] |
| Dosage: | 1, 2.5, 5, 10, 20 mg/kg |
| Administration: | i.v.; once; one hour post-infection |
| Result: | Showed good antibacterial activity and all treated animals survived. |
References
[1] Piddock LJ. Teixobactin, the first of a new class of antibiotics discovered by iChip technology J Antimicrob Chemother. 2015 Oct;70(10):2679-80. DOI:10.1093/jac/dkv175
[2] Parmar A, et al. Teixobactin analogues reveal enduracididine to be non-essential for highly potent antibacterial activity and lipid II binding. Chem Sci. 2017 Dec 1;8(12):8183-8192. DOI:10.1039/c7sc03241b
[3] Ling LL, et al. A new antibiotic kills pathogens without detectable resistance. Nature. 2015 Jan 22;517(7535):455-9. DOI:10.1038/nature14098
teixobactin Preparation Products And Raw materials
Raw materials
Preparation Products
teixobactin Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Wuxi Zhongkun Biochemical Technology Co., Ltd. | 0510-85629785 18013409632; | sales@reading-chemicals.com | China | 15165 | 58 |
| Amatek Scientific Co. Ltd. | 0512-56316828 400-867-5858;400-867-5858 | info@amateksci.com | China | 28760 | 58 |
| Hangzhou Peptidego Biotech Co.,Ltd. | 0571-87213919 15967184799 | Eric@peptidego.com | China | 7872 | 58 |
| Shenzhen Yuzhong Pharmaceutical Technology Co., Ltd. | 13632427122;13414494621 | chenchao02lzu@126.com | China | 137 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354; +1-00000000000 | marketing@targetmol.com | United States | 32431 | 58 |
| InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6378 | 58 |
| Career Henan Chemica Co | +86-0371-86658258 +86-13203830695 | laboratory@coreychem.com | China | 30203 | 58 |
| Wuxi Helen Biotechnology Co., Ltd., | 0510-85629785 18013409632 | sales@reading-chemicals.com | China | 14072 | 58 |
| Hubei Kele Fine Chemical Co., Ltd | 027-59101668 19945030958 | 2223443625@qq.com | China | 7998 | 58 |
| Hangzhou Sinoda Pharmaceutical Technology Co. LTD | 0571-87213919 17306812703 | 3007955328@qq.com | China | 7446 | 58 |
