PARP
- CAS No.
- Chemical Name:
- PARP
- Synonyms
- PPOL;PARP;ARTD1;PARP-1;EC 2.4.2.30;BOVINE PARP;PARP (BOVINE);PARP-1 (HUMAN);PARP-1 (BOVINE);BOVINE PARP ENZYME
- CBNumber:
- CB4335241
- Molecular Formula:
- Molecular Weight:
- 0
- MDL Number:
- MFCD01324157
- MOL File:
- Mol file
| storage temp. | −70°C |
|---|---|
| form | buffered aqueous glycerol solution |
| biological source | rabbit |
| NCI Dictionary of Cancer Terms | PARP; PARP-1; poly (ADP-ribose) polymerase-1 |
| FDA UNII | U25G2OFC53 |
| UNSPSC Code | 12352204 |
| NACRES | NA.54 |
SAFETY
Risk and Safety Statements
| Hazard Codes | B,T,N,Xn |
|---|---|
| Risk Statements | 20/22-24-37/38-41-51/53-43-36-20/21/22 |
| Safety Statements | 23-24/25-45-36/37/39-26-61-36/37 |
| WGK Germany | 1 |
| Storage Class | 10 - Combustible liquids |
PARP price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | P0996 | PARP-1 human recombinant, expressed in E. coli | 1000UNITS | $797 | 2026-04-30 | Buy | |
| Sigma-Aldrich | SAB4500488 | Anti-PARP (Cleaved-Gly215) antibody produced in rabbit affinity isolated antibody | 100 μg | $522 | 2025-07-31 | Buy | |
| Sigma-Aldrich | SAB4500488 | Anti-PARP (Cleaved-Gly215) antibody produced in rabbit affinity isolated antibody | 100μg | $506 | 2024-03-01 | Buy | |
| Usbiological | 571472 | PARP1 Purifiedbyimmunoaffinitychromatography. | 50ug | $403 | 2026-06-03 | Buy | |
| Usbiological | 571472 | PARP1 Purifiedbyimmunoaffinitychromatography. | 100ug | $531 | 2026-06-03 | Buy |
PARP Chemical Properties, Uses, Production
Uses
PARP-1 is a nuclear enzyme that synthesizes ADP-ribose polymers from NAD+, specifically binds Zn2+ and DNA, and recognizes single-strand breaks in DNA. PARP1 has been used in a study to assess racial and tissue-specific cancer risk associated with polymorphism in the PARP1 gene. It has also been used in a study to investigate inhibitors of PARP-1 for potential cancer treatments.
General Description
Poly(ADP-ribose) polymerase 1 (PARP-1) is associated with the inflammation response during atherosclerosis.
Biochem/physiol Actions
PARP-1 is inactivated by cleavage into a 24kDA and 89kDA fragment by activated caspase-3 or caspase-7. This results in the decreased ability to repair DNA damage and an increase in apoptosis.
Description
PARP1 Human Recombinant produced in E.Coli is a single, non-glycosylated, polypeptide chain containing 354 amino acids (662-1014a.a.) and having a molecular mass of 39.6 kDa. PARP1 is purified by proprietary chromatographic techniques.
Source
Escherichia Coli
Background
PARP1 takes part in the base excision repair pathway, by catalyzing the poly ADP-ribosyl of a restricted number of acceptor proteins involved in chromatin architecture and in DNA metabolism.. PARP1 mediates the poly ADP-ribosy of APLF and CHFR. PARP1 positively regulates the transcription of MTUS1 and negatively regulates the transcription of MTUS2/TIP150. PARP1 is a chromatin-associated enzyme, poly (ADP-ribosyl) transferase, which modifies various nuclear proteins by poly ADP-ribosyl. PARP1 takes part in the regulation of various significant cellular processes such as differentiation, proliferation, and tumor transformation and also in the regulation of the molecular events involved in the recovery of cell from DNA damage. PARP1 is a site of mutation in Fanconi anemia, and is involved in the pathophysiology of type I diabetes.
PARP Preparation Products And Raw materials
Raw materials
Preparation Products
PARP Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Sigma-Aldrich | 021-61415566 800-8193336 | orderCN@merckgroup.com | China | 51389 | 80 |
| Guangzhou Tomums Life Science Co., Ltd. | 020-31155029 18902330969 | sales@tomums.cn | China | 4688 | 58 |
| Wuhan Chemstan Biotechnology Co., Ltd. | 027-65317797 15926423062 | 422450190@qq.com | China | 10305 | 58 |
| Shanghai Huzhen Industrial Co., LTD | 021-60345367 13916550749 | sales@shzbio.com | China | 9965 | 58 |
| Perfect mRNA | 4006682586 15252998975 | rd@perfectmRNA.com | China | 336 | 58 |
| Shanghai Yubo Biotechnology Co., Ltd | 021-60514606 18321282235 | sale1@shybsw.net | China | 8165 | 58 |
| shlmai | 021-67680335 13052188602 | sale1@shlmai.net | China | 10000 | 58 |
| Supplier | Advantage |
|---|---|
| Sigma-Aldrich | 80 |
| Guangzhou Tomums Life Science Co., Ltd. | 58 |
| Wuhan Chemstan Biotechnology Co., Ltd. | 58 |
| Shanghai Huzhen Industrial Co., LTD | 58 |
| Perfect mRNA | 58 |
| Shanghai Yubo Biotechnology Co., Ltd | 58 |
| shlmai | 58 |
