Ethyl 5-bromo-3-ethoxy-1H-pyrazole-4-carboxylate
- CAS No.
- 1207431-91-1
- Chemical Name:
- Ethyl 5-bromo-3-ethoxy-1H-pyrazole-4-carboxylate
- Synonyms
- Ethyl 5-bromo-3-ethoxy-1H-pyrazole-4-carboxylate;Ethyl 3-bromo-5-ethoxy-1H-pyrazole-4-carboxylate;5-Bromo-3-ethoxy-1H-pyrazole-4-carboxylic acid ethyl ester;1H-Pyrazole-4-carboxylic acid, 3-bromo-5-ethoxy-, ethyl ester
- CBNumber:
- CB43367658
- Molecular Formula:
- C8H11BrN2O3
- Molecular Weight:
- 263.09
- MDL Number:
- MOL File:
- 1207431-91-1.mol
SAFETY
Risk and Safety Statements
| Symbol(GHS) |   GHS07,GHS08 |
|---|---|
| Signal word | Warning |
| Hazard statements | H315-H319-H341-H227 |
| Precautionary statements | P501-P202-P210-P201-P264-P280-P302+P352-P370+P378-P308+P313-P337+P313-P305+P351+P338-P362+P364-P332+P313-P403+P235-P405 |
Ethyl 5-bromo-3-ethoxy-1H-pyrazole-4-carboxylate price More Price(24)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Synthonix | E46870 | Ethyl 5-bromo-3-ethoxy-1H-pyrazole-4-carboxylate 97% | 1207431-91-1 | 5g | $700 | 2026-05-06 | Buy |
| Synthonix | E46870 | Ethyl 5-bromo-3-ethoxy-1H-pyrazole-4-carboxylate 97% | 1207431-91-1 | 1g | $830 | 2026-05-06 | Buy |
| Synthonix | E46870 | Ethyl 5-bromo-3-ethoxy-1H-pyrazole-4-carboxylate 97% | 1207431-91-1 | 100mg | $917 | 2026-05-06 | Buy |
| Synthonix | E46870 | Ethyl 5-bromo-3-ethoxy-1H-pyrazole-4-carboxylate 97% | 1207431-91-1 | 250mg | $999 | 2026-05-06 | Buy |
| aablocks | AA01EN3N | Ethyl 5-bromo-3-ethoxy-1H-pyrazole-4-carboxylate 97% | 1207431-91-1 | 250mg | $46 | 2026-05-30 | Buy |
Ethyl 5-bromo-3-ethoxy-1H-pyrazole-4-carboxylate Chemical Properties,Uses,Production
Synthesis
332066-58-7
1207431-91-1
General procedure for the synthesis of ethyl 5-bromo-3-ethoxy-1H-pyrazole-4-carboxylate from ethyl 3-ethoxy-1H-pyrazole-4-carboxylate: Ethyl 3-ethoxy-1H-pyrazole-4-carboxylate (0.74 g, 4.02 mmol) and N-bromosuccinimide (0.75 g, 4.22 mmol) or N-iodosuccinimide (0.94 g, 4.22 mmol) were dissolved in cyclohexane (50 mL) and the reaction was refluxed for 30 minutes or 24 hours. After completion of the reaction, the resulting suspension was concentrated to dryness and purified by silica gel column chromatography (eluent: dichloromethane/ethanol, 98:2) to afford ethyl 5-bromo-3-ethoxy-1H-pyrazole-4-carboxylate (12a, 0.75 g, 60% yield) or ethyl 3-bromo-5-ethoxy-1H-pyrazole-4-carboxylate (12b, 0.5 g, 47% yield). 3-bromo Ethyl 5-ethoxy-1H-pyrazole-4-carboxylate (12b) was white crystals.1H NMR (CDCl3): δ 1.40 (t, 3H, J = 7.0 Hz), 1.48 (t, 3H, J = 7.0 Hz), 4.33 (m, 4H), 9.5 (s, 1H).13C NMR (CDCl3; only two broad signals): δ 14.2, 14.5, 60.4, 65.7, 99.0, 119.5 (br), 161.6 (br), 162.0. HRMS (ESI): m/z Calculated value of C8H11BrN2O3 + H [M + H]+: 263.0031, measured value: 263.0049.
References
[1] Patent: EP2151434, 2010, A1. Location in patent: Page/Page column 8-9; 12
Ethyl 5-bromo-3-ethoxy-1H-pyrazole-4-carboxylate Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Wuhan TCASChem Technology Co., Ltd. | 027-86697669 13986148687 | sales@tcaschem.com | China | 3993 | 55 |
| Amadis Chemical Company Limited | 571-89925085 | sales@amadischem.com | China | 131885 | 58 |
| Jiangsu aikang biomedical research and development co., LTD | 025-58859352 17714375163 | qzhang@aikonchem.com | China | 15525 | 58 |
| Energy Chemical | 400-0056266 | marketing1@energy-chemical.com | China | 44927 | 58 |
| Bide Pharmatech Ltd. | 400-6005915 | sales@picasso-e.com | China | 39662 | 58 |
| Beijing Solarbio Science & Tecnology Co., Ltd. | 010-50973130 17801761073 | Gsiyu@solarbio.com | China | 50460 | 58 |
| Shanghai Jieshikai Biotechnology Co. , Ltd. | 021-57520305 13795461237 | zhuruyan@jskchem.com | China | 49221 | 58 |
| Ningbo Chaoming Biotechnology Co., Ltd | 13301662590 | mandy@atkchemical.com | China | 9539 | 58 |
| Taizhou Zhongzhi Biotechnology Co., Ltd | zhongzhipharma@126.c 15066129350 | zhongzhipharma@126.com | China | 9963 | 58 |
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 32997 | 60 |
