Pasireotide Acetate
- CAS No.
- 396091-76-2
- Chemical Name:
- Pasireotide Acetate
- Synonyms
- Pasireotide Acetate;Pasireotide Acetate(acetate);Somatostatin Receptor,sst3,Inhibitor,SOM230,SOM 230,Pasireotide,proapoptotic,sst1,antiproliferative,inhibit,somatostatin,SSTRs,sst4,SOM-230,SSTR,sst5,antisecretory,Pasireotide Acetate,sst2
- CBNumber:
- CB43379918
- Molecular Formula:
- C60H70N10O11
- Molecular Weight:
- 1107.28
- MDL Number:
- MFCD32666205
- MOL File:
- 396091-76-2.mol
| Product description | Number | Pack Size | Price |
| PasireotideAcetate | B3596 | 1mg | $131 |
| PasireotideAcetate | B3596 | 5mg | $589 |
| PasireotideAcetate | B3596 | 10mg | $1045 |
| storage temp. | Store at -20°C, protect from light, stored under nitrogen |
|---|---|
| solubility | DMSO : 100 mg/mL (90.31 mM; Need ultrasonic) |
| form | Solid |
| color | White to off-white |
| Sequence | Cyclo[{4-(NH2-C2H4-NH-CO-O-)Pro}-Phg-{D-Trp}-Lys-{Tyr(4-Bzl)}-Phe] |
| FDA UNII | 662X0VFR9L |
Pasireotide Acetate price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| ApexBio Technology | B3596 | PasireotideAcetate | 396091-76-2 | 1mg | $131 | 2021-12-16 | Buy |
| ApexBio Technology | B3596 | PasireotideAcetate | 396091-76-2 | 5mg | $589 | 2021-12-16 | Buy |
| ApexBio Technology | B3596 | PasireotideAcetate | 396091-76-2 | 10mg | $1045 | 2021-12-16 | Buy |
Pasireotide Acetate Chemical Properties,Uses,Production
Uses
Pasireotide (SOM230) acetate, a long-acting cyclohexapeptide somatostatin analogue, can improve agonist activity at somatostatin receptors (subtypes sst1/2/3/4/5, pKi=8.2/9.0/9.1/<7.0/9.9, respectively). Pasireotide acetate can suppress GH, IGF-I and ACTH secretion, indicating potential efficacy in acromegaly and Cushing's disease. Pasireotide acetate also exhibits antisecretory, antiproliferative, and proapoptotic activity[1][2][3].
in vivo
Pasireotide acetate (160 mg/kg/month; s.c. for 4 months) significantly decreases the serum insulin, increases serum glucose, reduces the tumor size and increases apoptosis in Pdx1-Cre[2].
Pasireotide acetate (2-50 μg/kg; s.c. twice daily for 42 days) exerts the antinociceptive and antiinflammatory actions via the SSTR2 receptor in a mouse model of immune-mediated arthritis[4].
| Animal Model: | 12 month-old conditional Men1 knockout mice with insulinoma[2] |
| Dosage: | 160 mg/kg/mouth |
| Administration: | S.c. every month for 4 months |
| Result: | Decreased the serum insulin from 1.060 μg/L to 0.3653 μg/L and increased the serum glucose from 4.246 mM to 7.122 mM. Significantly reduced the tumor size and increased apoptosis. |
References
[1] Lewis I, et, al. A novel somatostatin mimic with broad somatotropin release inhibitory factor receptor binding and superior therapeutic potential. J Med Chem. 2003 Jun 5;46(12):2334-44. DOI:10.1021/jm021093t
[2] Quinn TJ, et, al. Pasireotide (SOM230) is effective for the treatment of pancreatic neuroendocrine tumors (PNETs) in a multiple endocrine neoplasia type 1 (MEN1) conditional knockout mouse model. Surgery. 2012 Dec;152(6):1068-77. DOI:10.1016/j.surg.2012.08.021
[3] Imhof AK, et, al. Differential antiinflammatory and antinociceptive effects of the somatostatin analogs octreotide and pasireotide in a mouse model of immune-mediated arthritis. Arthritis Rheum. 2011 Aug;63(8):2352-62. DOI:10.1002/art.30410
[4] Schmid HA, et, al. Pasireotide (SOM230): development, mechanism of action and potential applications. Mol Cell Endocrinol. 2008 May 14;286(1-2):69-74. DOI:10.1016/j.mce.2007.09.006
Pasireotide Acetate Preparation Products And Raw materials
Raw materials
Preparation Products
Pasireotide Acetate Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| BOC Sciences | +1-631-485-4226 | inquiry@bocsci.com | United States | 19552 | 58 |
| Chengdu Youngshe Chemical Co., Ltd. | +8618108235634 | Cecilia@youngshechem.com | China | 2345 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354; | support@targetmol.com | United States | 39031 | 58 |
| Shanghai Chaolan Chemical Technology Center | 021-QQ：65489617 15618227136 | Sales@ATKchemical.com | China | 9979 | 58 |
| Chengdu Youngshe Chemical Co., Ltd. | +86-17380623303 | Caroline@youngshechem.com | China | 4799 | 58 |
| Hangzhou Peptidego Biotech Co.,Ltd. | 0571-87213919 | Eric@peptidego.com | China | 7373 | 58 |
| Shanghai Luofa Biochemical Technology Co., Ltd. | 021-51111890 15317326293 | sales@molnova.com | China | 4195 | 58 |
| TargetMol Chemicals Inc. | 4008200310 | marketing@tsbiochem.com | China | 24989 | 58 |
| Hangzhou Sinoda Pharmaceutical Technology Co. LTD | 0571-87213919 17306812703 | 3007955328@qq.com | China | 6943 | 58 |
| Shanghai Yifei Biotechnology Co. , Ltd. | 021-65675885 18964387627 | customer_service@efebio.com | China | 11973 | 58 |
View Lastest Price from Pasireotide Acetate manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2025-10-16 | Pasireotide Acetate
396091-76-2
|
US $97.00-659.00 / mg | 99.87% | 10g | TargetMol Chemicals Inc. |
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- Pasireotide Acetate
396091-76-2
- US $97.00-659.00 / mg
- 99.87%
- TargetMol Chemicals Inc.
