1A-116
- CAS No.
- 1430208-73-3
- Chemical Name:
- 1A-116
- Synonyms
- 1A-116;1A-116, 10 mM in DMSO;1A-116; 1A 116; 1A116;1430208-73-3;1-(3,5-Dimethylphenyl)-3-(2-(trifluoromethyl)phenyl)guanidine;N-(3,5-Dimethylphenyl)-N'-[2-(trifluoromethyl)phenyl]-guanidine;Guanidine, N-(3,5-dimethylphenyl)-N'-[2-(trifluoromethyl)phenyl]-;1-(3,5-Dimethylphenyl)-3-(2-(trifluoromethyl)phenyl)guanidine , 1A-116;TIAM1,inhibit,1A 116,Ras,Rho GTPases,EGF,Apoptosis,1A-116,circadian rhythms,1A116,Inhibitor
- CBNumber:
- CB43386440
- Molecular Formula:
- C16H16F3N3
- Molecular Weight:
- 307.31
- MDL Number:
- MOL File:
- 1430208-73-3.mol
- MSDS File:
- SDS
- TDS File:
- TDS
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H315-H319-H335 |
| Precautionary statements | P280-P305+P351+P338 |
1A-116 price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Cayman Chemical | 40781 | 1A-116 ≥98% | 1430208-73-3 | 5mg | $109 | 2026-04-30 | Buy |
| Cayman Chemical | 40781 | 1A-116 ≥98% | 1430208-73-3 | 10mg | $207 | 2026-04-30 | Buy |
| Cayman Chemical | 40781 | 1A-116 ≥98% | 1430208-73-3 | 50mg | $600 | 2026-04-30 | Buy |
| Biosynth | BA171670 | 1A-116 | 1430208-73-3 | 5mg | $373.25 | 2026-06-04 | Buy |
| Biosynth | BA171670 | 1A-116 | 1430208-73-3 | 10mg | $634.6 | 2026-06-04 | Buy |
1A-116 Chemical Properties, Uses, Production
Uses
A1-116 is a novel specific Rac1 inhibitor.
in vivo
1A-116 (3 mg/kg; i.v.; once a day for 21 days) demonstrates a high antimetastatic activity with about 60% formation reduction of total metastatic lung colonies in vivo and shows no apparent toxicity[1].
1A-116 (20 mg/kg; i.p.; once a day, 73 days for ZT12, 68 days for ZT3) increases survival time when treated at ZT12 compare to ZT3 in tumor-bearing mice. (ZT: Zeitgeber time 12 (ZT12) defined as the time of lights off (local time 7 p.m.) and ZT0 defined as lights on (local time 7 a.m.))[2].
1A-116 shows good oral availability[3].
| Animal Model: | Female BALB/c inbred mice (8 to 10-week-old; average 20 g)[1] |
| Dosage: | 3 mg/kg |
| Administration: | Intravenous injection; once a day for 21 days. |
| Result: | Demonstrated a high antimetastatic activity. |
| Animal Model: | Male NIH Swiss foxN1(/) nude mice (2-month-old; GBM model)[2]. |
| Dosage: | 20 mg/kg |
| Administration: | Intraperitoneal injection (at ZT3, ZT12); once a day, 73 days for ZT12, 68 days for ZT3. |
| Result: | Increased survival time when treated at ZT12 compared to ZT3 in tumor-bearing mice. |
storage
Store at -20°C
1A-116 Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Sichuan Wei Keqi Biological Technology Co., Ltd. | 028-81700200 18116577057 | 3003855609@qq.com | China | 7717 | 56 |
| Shanghai Lollane Biological Technology Co.,Ltd. | 021-52996696，15000506266 15000506266 | China | 4859 | 55 | |
| Shanghai EFE Biological Technology Co., Ltd. | 021-65675885 18964387627 | info@efebio.com | China | 9799 | 58 |
| Shanghai YuanYe Biotechnology Co., Ltd. | 15026964105 | 2881489226@qq.com | China | 89667 | 60 |
| ShangHai Biochempartner Co.,Ltd | 177-54423994 17754423994 | 2853530910@QQ.com | China | 8000 | 62 |
| Shanghai Rechem science Co., Ltd. | 021-31433387 15618786686 | sales@rechemscience.com | China | 2969 | 58 |
| Fan De(Beijing) Biotechnology Co., Ltd. | 15911056312 | liming@bio-fount.com | China | 9718 | 58 |
| Taizhou Crene Biotechnology Co. Ltd. | +86-0576-88813233 +86-13396860566 | sales@pharm-intermediates.com | China | 1976 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354; +1-00000000000 | marketing@targetmol.com | United States | 32431 | 58 |
| Shanghai Zeye Biotechnology Co., Ltd. | 021-57896695 13122526631 | 2885575445@qq.com | China | 9777 | 58 |
