METHYL 4-(BROMOMETHYL)-3-METHOXYBENZOATE
- CAS No.
- 70264-94-7
- Chemical Name:
- METHYL 4-(BROMOMETHYL)-3-METHOXYBENZOATE
- Synonyms
- METHYL 3-METHOXY-4-BROMOMETHYLBENZOATE;)-3-methoxybenzoate;Methyl 4-(Bromomethyl)-m-anisate;4-(bromomethyl)-3-methoxybenzoate;METHYL4-BROMOETHYL-3-METHOXYBENZOATE;4-bromethyl-3-methoxymethyl benzoate;METHYL3-METHOXY-4-(BROMOMETHYL)BENZONATE;METHYL 4-(BROMOMETHYL)-3-METHOXYBENZOATE;Methyl 4-(bromomethyl)-3-methoxybenzonate;Methyl4-(Bromomethyl)-3-methoxybenzoate>
- CBNumber:
- CB4342137
- Molecular Formula:
- C10H11BrO3
- Molecular Weight:
- 259.1
- MDL Number:
- MFCD00270115
- MOL File:
- 70264-94-7.mol
- MSDS File:
- SDS
| Product description | Number | Pack Size | Price |
| Methyl 4-(bromomethyl)-3-methoxybenzoate 97% | 681180 | 5g | $189 |
| Methyl 4-(bromomethyl)-3-methoxybenzoate 97% | 681180 | 1g | $69.8 |
| Methyl 4-(Bromomethyl)-3-methoxybenzoate >97.0%(GC) | M2356 | 5g | $96 |
| Methyl 4-(Bromomethyl)-3-methoxybenzoate >97.0%(GC) | M2356 | 25g | $383 |
| Methyl 4-(Bromomethyl)-3-methoxybenzoate | 455375 | 1g | $326 |
| More product size | |||
| Melting point | 92-94°C |
|---|---|
| Boiling point | 324.2±32.0 °C(Predicted) |
| Density | 1.432 |
| storage temp. | under inert gas (nitrogen or Argon) at 2-8°C |
| solubility | Chloroform (Sparingly), Methanol (Slightly) |
| form | powder to crystal |
| color | White to Light yellow |
| InChI | InChI=1S/C10H11BrO3/c1-13-9-5-7(10(12)14-2)3-4-8(9)6-11/h3-5H,6H2,1-2H3 |
| InChIKey | UXSNXOMMJXTFEG-UHFFFAOYSA-N |
| SMILES | C(OC)(=O)C1=CC=C(CBr)C(OC)=C1 |
| CAS DataBase Reference | 70264-94-7(CAS DataBase Reference) |
| UNSPSC Code | 12352100 |
| NACRES | NA.22 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |    GHS05,GHS07,GHS09 |
|---|---|
| Signal word | Danger |
| Hazard statements | H315-H317-H318-H410 |
| Precautionary statements | P261-P264-P273-P280-P302+P352-P305+P351+P338 |
| PPE | dust mask type N95 (US), Eyeshields, Faceshields, Gloves |
| Hazard Codes | Xi,N |
| Risk Statements | 36/37/38-50/53-43-41-38 |
| Safety Statements | 26-36/37/39-61-60 |
| RIDADR | UN 2811 6.1/PG 3 |
| WGK Germany | 3 |
| HazardClass | IRRITANT |
| PackingGroup | Ⅲ |
| HS Code | 2918999090 |
| Storage Class | 6.1C - Combustible acute toxic Cat.3 toxic compounds or compounds which causing chronic effects |
| Hazard Classifications | Aquatic Acute 1 Aquatic Chronic 1 Eye Dam. 1 Skin Irrit. 2 Skin Sens. 1 |
| REACH Registrations | Inactive |
METHYL 4-(BROMOMETHYL)-3-METHOXYBENZOATE price More Price(57)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 681180 | Methyl 4-(bromomethyl)-3-methoxybenzoate 97% | 70264-94-7 | 5g | $189 | 2026-04-30 | Buy |
| Sigma-Aldrich | 681180 | Methyl 4-(bromomethyl)-3-methoxybenzoate 97% | 70264-94-7 | 1g | $69.8 | 2023-06-20 | Buy |
| TCI Chemical | M2356 | Methyl 4-(Bromomethyl)-3-methoxybenzoate >97.0%(GC) | 70264-94-7 | 5g | $96 | 2026-04-30 | Buy |
| TCI Chemical | M2356 | Methyl 4-(Bromomethyl)-3-methoxybenzoate >97.0%(GC) | 70264-94-7 | 25g | $383 | 2026-04-30 | Buy |
| Usbiological | 455375 | Methyl 4-(Bromomethyl)-3-methoxybenzoate | 70264-94-7 | 1g | $326 | 2026-06-03 | Buy |
METHYL 4-(BROMOMETHYL)-3-METHOXYBENZOATE Chemical Properties,Uses,Production
Preparation
Methyl 4-(bromomethyl)-3-methoxybenzoate is prepared by the following steps:A mixture of methyl 3-methoxy-4-methylbenzoate 37 (5 g, 27.8 mmol), NBS (4.94 g, 27.8 mmol), and benoyl peroxide (0.0008 g, 0.003 mmol) was refluxed in CCl4 (25 ml) for 10 hours. The reaction mixture was allowed to cool and filtered. The residue was washed with CCl4 and the combined filtrate concentrated in vacuo. Purification by column chromatography over silica gel (5-10% EtOAc-pet ether) furnished a colourless solid (7.19 g).Yield : 100%
Uses
Methyl 4-(Bromomethyl)-3-methoxybenzoate is an intermediate used to prepare heteroarylphenyloxoacetyl and heteroarylphenylsulfonyl benzoylpiperazine analogs of BMS 378806 as HIV entry inhibitors. It is also used to synthesize steroid 5α-reductase inhibiting acylpiperidines.
Synthesis
3556-83-0
70264-94-7
Step 1: Methyl 4-methyl-3-methoxybenzoate (1.00 g, 5.55 mmol), N-bromosuccinimide (1.09 g, 6.10 mmol) and catalytic amount of 2,2'-azobisisobutyronitrile (AIBN) were mixed in carbon tetrachloride (40 ml) and the reaction was carried out at reflux for 16 hours. After completion of the reaction, the reaction mixture was filtered and the resulting filtrate was washed with brine (25 ml), dried over anhydrous sodium sulfate and concentrated under reduced pressure to give methyl 4-bromomethyl-3-methoxybenzoate (1.4 g, 97% yield).
References
[1] European Journal of Medicinal Chemistry, 1997, vol. 32, # 7-8, p. 547 - 570
[2] Patent: WO2009/55077, 2009, A1. Location in patent: Page/Page column 391-392
[3] Synlett, 2014, vol. 25, # 17, p. 2485 - 2487
[4] Patent: WO2005/105802, 2005, A1. Location in patent: Page/Page column 120-121
[5] Patent: US6391901, 2002, B1
METHYL 4-(BROMOMETHYL)-3-METHOXYBENZOATE Preparation Products And Raw materials
Raw materials
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Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | info@tianfuchem.com | China | 21531 | 55 |
| Shanghai Time Chemicals CO., Ltd. | +86-021-57951555 +8618017249410 | jack.li@time-chemicals.com | China | 1796 | 55 |
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 32997 | 60 |
| career henan chemical co | +86-0371-86658258 | sales@coreychem.com | China | 29766 | 58 |
| Changzhou Ditong Chemical Co.,Ltd | +86-0519-88298848 | info@edengenechem.com | China | 2163 | 58 |
| Alchem Pharmtech,Inc. | 8485655694 | sales@alchempharmtech.com | United States | 63645 | 58 |
| Wuhan Chemwish Technology Co., Ltd | 027-67849912 | sales@chemwish.com | CHINA | 10817 | 58 |
| Dayang Chem (Hangzhou) Co.,Ltd. | +86-0571-88938639 17705817739 | info@dycnchem.com | China | 52693 | 58 |
| CD Chemical Group Limited | +86-13651442114 | info@codchem.com | China | 17253 | 58 |
| Changzhou Fullone Chemical Co., Ltd. | +86-13328197671 +86-13861172460 | sales@borenchem.cn | China | 1052 | 58 |
View Lastest Price from METHYL 4-(BROMOMETHYL)-3-METHOXYBENZOATE manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
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2019-07-06 | METHYL 4-(BROMOMETHYL)-3-METHOXYBENZOATE
70264-94-7
|
$1.00 | 1G | 98% | 100KG | Career Henan Chemical Co |
-
- METHYL 4-(BROMOMETHYL)-3-METHOXYBENZOATE
70264-94-7
- $1.00
- 98%
- Career Henan Chemical Co
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