Ethyl 2,4,5-trifluorobenzoylacetate
- CAS No.
- 98349-24-7
- Chemical Name:
- Ethyl 2,4,5-trifluorobenzoylacetate
- Synonyms
- ETHYL 3-OXO-3-(2,4,5-TRIFLUOROPHENYL)PROPANOATE;Sitafloxacin Impurity 39;2,4,5-Triflurobenzoflacetate;ethyl 2,4,5-trifluorobenzoylacetat;ETHYL 3-OXO-3(2,4,5-TRIFLUOROPHENY;Ethyl 2,4,5-Triflurobenzoflacetate;ETHYL 2,4,5-TRIFLUOROBENZOYLACETATE;2,4,5-trifluorobenzoyl ethyl acetate;Butyric 2,4,5-trifluorobenzoic anhydride;Ethyl 2,4,5-Trifluoro-β-oxobenzenepropanoate
- CBNumber:
- CB4351926
- Molecular Formula:
- C11H9F3O3
- Molecular Weight:
- 246.18
- MDL Number:
- MFCD00792431
- MOL File:
- 98349-24-7.mol
- MSDS File:
- SDS
| Product description | Number | Pack Size | Price |
| Ethyl (2,4,5-Trifluorobenzoyl)acetate | E1425 | 1G | $28 |
| Ethyl (2,4,5-Trifluorobenzoyl)acetate | E1425 | 5G | $107 |
| ETHYL 2,4,5-TRIFLUOROBENZOYLACETATE 97% | 60708 | 1G | $16 |
| ETHYL 2,4,5-TRIFLUOROBENZOYLACETATE 97% | 60708 | 5G | $50 |
| ETHYL 2,4,5-TRIFLUOROBENZOYLACETATE 97% | 60708 | 25G | $150 |
| More product size | |||
| Melting point | 66-68°C |
|---|---|
| Boiling point | 92 °C(Press: 0.08 Torr) |
| Density | 1.319±0.06 g/cm3(Predicted) |
| storage temp. | under inert gas (nitrogen or Argon) at 2-8°C |
| solubility | soluble in Toluene |
| form | powder to crystal |
| pka | 10.26±0.50(Predicted) |
| color | White to Almost white |
| InChI | InChI=1S/C11H9F3O3/c1-2-17-11(16)5-10(15)6-3-8(13)9(14)4-7(6)12/h3-4H,2,5H2,1H3 |
| InChIKey | OTCJYVJORKMTHX-UHFFFAOYSA-N |
| SMILES | C1(C(=O)CC(=O)OCC)C=C(C(F)=CC=1F)F |
| CAS DataBase Reference | 98349-24-7(CAS DataBase Reference) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H315-H319-H335 |
| Precautionary statements | P261-P271-P280 |
| Hazard Codes | C,Xi,T |
| Risk Statements | 36/37/38 |
| Safety Statements | 26-36/37/39 |
| RIDADR | UN2811 6.1 |
| HazardClass | IRRITANT |
| HS Code | 2918300090 |
Ethyl 2,4,5-trifluorobenzoylacetate price More Price(69)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| TCI Chemical | E1425 | Ethyl (2,4,5-Trifluorobenzoyl)acetate | 98349-24-7 | 1G | $28 | 2026-04-30 | Buy |
| TCI Chemical | E1425 | Ethyl (2,4,5-Trifluorobenzoyl)acetate | 98349-24-7 | 5G | $107 | 2026-04-30 | Buy |
| AstaTech | 60708 | ETHYL 2,4,5-TRIFLUOROBENZOYLACETATE 97% | 98349-24-7 | 1G | $16 | 2026-04-30 | Buy |
| AstaTech | 60708 | ETHYL 2,4,5-TRIFLUOROBENZOYLACETATE 97% | 98349-24-7 | 5G | $50 | 2026-04-30 | Buy |
| AstaTech | 60708 | ETHYL 2,4,5-TRIFLUOROBENZOYLACETATE 97% | 98349-24-7 | 25G | $150 | 2026-04-30 | Buy |
Ethyl 2,4,5-trifluorobenzoylacetate Chemical Properties,Uses,Production
Chemical Properties
off-white crystall powder
Uses
Ethyl 2,4,5-Trifluoro-β-oxobenzenepropanoate can be used to prepare aminopyrrolidinyl)quinolinecarboxylates with antitumor activities.
Synthesis
1071-46-1
88419-56-1
98349-24-7
Step 2. Synthesis of ethyl 3-oxo-3-(2,4,5-trifluorophenyl)propionate (B). Referring to the literature method [Wierenga, W.; Skulnick, H. I. J. Org. Chem. 1979, 44, 310-311], a mixture of monoethyl malonate (0.18 mL, 1.50 mmol) with bipyridine (1 crystal) was dissolved in tetrahydrofuran (THF, 10 mL) and cooled to -75 °C under argon protection . At -75 °C, n-butyllithium (n-BuLi, 2.8 mL, 4.48 mmol, 5.9 eq.) was slowly added. The reaction mixture was warmed to -50 °C and held for about 2 minutes until the pink color no longer faded (to ensure that the amount of n-butyllithium was sufficient to form a divalent anion), and then cooled to -75 °C again. Subsequently, a THF solution (2-3 mL) of 2,4,5-trifluorobenzoyl chloride (0.75 mmol) was slowly added. The reaction mixture was gradually warmed to room temperature, diluted with ethyl acetate (50 mL) and acidified with 1N hydrochloric acid under stirring. The organic phase was washed sequentially with 5% sodium bicarbonate solution (30 mL x 2) and saturated saline (50 mL x 2), dried with anhydrous sodium sulfate and concentrated. The oil obtained was purified by silica gel column chromatography (40 g silica gel column, 20% ethyl acetate in hexane solution, 40 min gradient) to give 185 mg (89% yield) of target product B as a white solid.
References
[1] Journal of Medicinal Chemistry, 1999, vol. 42, # 19, p. 3899 - 3909
[2] Patent: WO2008/36420, 2008, A2. Location in patent: Page/Page column 45-46
[3] Journal of Medicinal Chemistry, 1991, vol. 34, # 1, p. 168 - 174
Ethyl 2,4,5-trifluorobenzoylacetate Preparation Products And Raw materials
Raw materials
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Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Suzhou Chukai Pharma Tech Co.,Ltd | +86-15151706780; +8615062531973 | 2279973922@qq.com | China | 404 | 58 |
| Hebei Yanxi Chemical Co., Ltd. | +8618531123677 | faithe@yan-xi.com | China | 5853 | 58 |
| Hebei Chuanghai Biotechnology Co,.LTD | +86-86-13131129325 +8613131129325 | sales1@chuanghaibio.com | China | 5229 | 58 |
| Hebei Fengjia New Material Co., Ltd | +86-0311-87836622 +86-18712993135 | sales01@tairunfaz.com | China | 8051 | 58 |
| Hebei Chuanghai Biotechnology Co., Ltd | +8615531151365 | mina@chuanghaibio.com | China | 18126 | 58 |
| Henan Fengda Chemical Co., Ltd | +86-371-86557731 +86-13613820652 | info@fdachem.com | China | 20122 | 58 |
| Capot Chemical Co.,Ltd. | +86-（0）57185586718 +86-13336195806 | sales@capot.com | China | 29640 | 60 |
| Beijing Cooperate Pharmaceutical Co.,Ltd | 010-60279497 | sales01@cooperate-pharm.com | CHINA | 1803 | 55 |
| Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | info@tianfuchem.com | China | 21587 | 55 |
| Fluoropharm Co., Ltd. | +86-0571-85586753 +86-13336034509 | sales@fluoropharm.com | China | 1445 | 60 |
View Lastest Price from Ethyl 2,4,5-trifluorobenzoylacetate manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-05-28 | Ethyl 2, 4, 5-Trifluorobenzoylacetate
98349-24-7
|
$2.00-5.00 | 1KG | 99% | 10000kg | Hebei Chuanghai Biotechnology Co,.LTD | |
 |
2025-12-01 | Ethyl 2,4,5-trifluorobenzoylacetate
98349-24-7
|
1kg | 99% | 10000KGS | Shaanxi Dideu New Materials Co. Ltd | ||
 |
2025-09-25 | Ethyl 3-oxo-3-(2,4,5-trifluorophenyl)propanoate
98349-24-7
|
$1.00-200.00 | 1KG | 99%, 99.5% Sublimated | Henan Fengda Chemical Co., Ltd |
-
- Ethyl 2, 4, 5-Trifluorobenzoylacetate
98349-24-7
- $2.00-5.00
- 99%
- Hebei Chuanghai Biotechnology Co,.LTD
-
- Ethyl 2,4,5-trifluorobenzoylacetate
98349-24-7
- $0.00
- 99%
- Shaanxi Dideu New Materials Co. Ltd
-
- Ethyl 3-oxo-3-(2,4,5-trifluorophenyl)propanoate
98349-24-7
- $1.00-200.00
- 99%, 99.5% Sublimated
- Henan Fengda Chemical Co., Ltd
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